KEGG   PATHWAY: ath00901
Entry
ath00901                    Pathway                                
Name
Indole alkaloid biosynthesis - Arabidopsis thaliana (thale cress)
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
ath00901  Indole alkaloid biosynthesis
ath00901

Other DBs
GO: 0009709
Organism
Arabidopsis thaliana (thale cress) [GN:ath]
Gene
AT2G20340  AAS; Pyridoxal phosphate (PLP)-dependent transferases superfamily protein [KO:K01593] [EC:4.1.1.28 4.1.1.105]
AT1G74010  Calcium-dependent phosphotriesterase superfamily protein [KO:K01757] [EC:3.5.99.13]
AT1G74020  SS2; strictosidine synthase 2 [KO:K01757] [EC:3.5.99.13]
AT1G74000  SS3; strictosidine synthase 3 [KO:K01757] [EC:3.5.99.13]
Compound
C00031  D-Glucose
C00078  L-Tryptophan
C00132  Methanol
C00398  Tryptamine
C01091  Deacetylvindoline
C01626  Vindoline
C01761  Vomilenine
C01852  Secologanin
C02074  Raucaffricine
C02151  Geissoschizine
C02673  Desacetoxyvindoline
C03309  Strictosidine aglycone
C03470  3-alpha(S)-Strictosidine
C03677  4,21-Dehydrogeissoschizine
C04290  4-(3-Methylbut-2-enyl)-L-tryptophan
C04578  16-Methoxy-2,3-dihydro-3-hydroxytabersonine
C06068  Elymoclavine
C06522  Strychnine
C06535  Physostigmine
C06536  Harmaline
C06538  Harmine
C06542  Ajmaline
C07201  Vinblastine
C07204  Vincristine
C07541  Lysergic acid
C07544  Ergotamine
C07576  Psilocybin
C08312  Psilocin
C09023  Agroclavine
C09024  Ajmalicine
C09028  Alstonine
C09089  Calligonine
C09107  Catharanthine
C09131  Chanoclavine-I
C09209  Harman
C09239  Sarpagine
C09241  Serpentine
C09243  Tetrahydroharmine
C09244  Tabersonine
C11632  Polyneuridine aldehyde
C11633  16-Epivellosimine
C11634  Vellosimine
C11635  10-Deoxysarpagine
C11641  3',4'-Anhydrovinblastine
C11642  19-Hydroxytabersonine
C11643  16-Hydroxytabersonine
C11675  16-Methoxytabersonine
C11676  Lochnericine
C11677  Horhammericine
C11678  Dialdehyde
C11679  4,21-Dehydrocorynantheine aldehyde
C11680  Cathenamine
C11681  19-epi-Cathenamine
C11682  Tetrahydroalstonine
C11683  19-epi-Ajmalicine
C11691  Stemmadenine
C11783  Minovincinine
C11784  Echitovenine
C11807  Vinorine
C11808  1,2-Dihydrovomilenine
C11809  17-O-Acetylnorajmaline
C11810  Norajmaline
C11812  Lochnerinine
C15985  17-O-Acetylajmaline
C20379  Chanoclavine-I aldehyde
C20408  Festuclavine
C20409  6,8-Dimethyl-6,7-didehydroergoline
C20410  4-Dimethylallyl-L-abrine
C20436  Fumigaclavine A
C20437  Fumigaclavine B
C20438  Fumigaclavine C
C20457  6,8-Dimethyl-6,7,8,9-tetradehydroergoline
C21678  (3R)-3-Hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine
C21682  (3R)-3-Hydroxy-2,3-dihydrotabersonine
C21683  (3R)-3-Hydroxy-1,2-didehydro-2,3-dihydrotabersonine
C21762  4-Hydroxytryptamine
C21777  4-Hydroxy-L-tryptophan
C21778  Norbaeocystin
C21779  Baeocystin
C21897  Dihydrochanoclavine-I aldehyde
C22432  Paspalic acid
Reference
PMID:9622525
  Authors
Rijhwani SK, Shanks JV.
  Title
Effect of elicitor dosage and exposure time on biosynthesis of indole alkaloids by Catharanthus roseus hairy root cultures.
  Journal
Biotechnol Prog 14:442-9 (1998)
DOI:10.1021/bp980029v
Reference
PMID:4698228
  Authors
Madyastha KM, Guarnaccia R, Baxter C, Coscia CJ.
  Title
S-Adenosyl-L-methionine: loganic acid methyltransferase. A carboxyl-alkylating enzyme from Vinca rosea.
  Journal
J Biol Chem 248:2497-501 (1973)
Reference
PMID:510306
  Authors
Treimer JF, Zenk MH.
  Title
Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation.
  Journal
Eur J Biochem 101:225-33 (1979)
DOI:10.1111/j.1432-1033.1979.tb04235.x
Reference
PMID:10652285
  Authors
Geerlings A, Ibanez MM, Memelink J, van Der Heijden R, Verpoorte R.
  Title
Molecular cloning and analysis of strictosidine beta-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus.
  Journal
J Biol Chem 275:3051-6 (2000)
DOI:10.1074/jbc.275.5.3051
Reference
PMID:11128
  Authors
Stockigt J, Treimer J, Zenk MH.
  Title
Synthesis of ajmalicine and related indole alkaloids by cell free extracts of Catharanthus roseus cell suspension cultures.
  Journal
FEBS Lett 70:267-70 (1976)
DOI:10.1016/0014-5793(76)80772-7
Reference
PMID:12228585
  Authors
St-Pierre B, De Luca V.
  Title
A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus.
  Journal
Plant Physiol 109:131-139 (1995)
DOI:10.1104/pp.109.1.131
Reference
PMID:10481044
  Authors
Schroder G, Unterbusch E, Kaltenbach M, Schmidt J, Strack D, De Luca V, Schroder J.
  Title
Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: tabersonine 16-hydroxylase.
  Journal
FEBS Lett 458:97-102 (1999)
DOI:10.1016/S0014-5793(99)01138-2
Reference
PMID:9654153
  Authors
Sottomayor M, Lopez-Serrano M, DiCosmo F, Ros Barcelo A.
  Title
Purification and characterization of alpha-3',4'-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G. Don.
  Journal
FEBS Lett 428:299-303 (1998)
DOI:10.1016/S0014-5793(98)00551-1
Reference
PMID:1368411
  Authors
Furuya T, Sakamoto K, Iida K, Asada Y, Yoshikawa T, Sakai S, Aimi N.
  Title
Biotransformation of tabersonine in cell suspension cultures of Catharanthus roseus.
  Journal
Phytochemistry 31:3065-8 (1992)
DOI:10.1016/0031-9422(92)83447-7
Reference
PMID:11154328
  Authors
Laflamme P, St-Pierre B, De Luca V.
  Title
Molecular and biochemical analysis of a madagascar periwinkle root-specific minovincinine-19-hydroxy-o-acetyltransferase.
  Journal
Plant Physiol 125:189-98 (2001)
DOI:10.1104/pp.125.1.189
Reference
PMID:12150812
  Authors
Jain S, Sinha A, Bhakuni DS.
  Title
The biosynthesis of beta-carboline and quinolizidine alkaloids of Alangium lamarckii.
  Journal
Phytochemistry 60:853-9 (2002)
DOI:10.1016/S0031-9422(02)00057-2
Reference
PMID:28763571
  Authors
Fricke J, Blei F, Hoffmeister D
  Title
Enzymatic Synthesis of Psilocybin.
  Journal
Angew Chem Int Ed Engl 56:12352-12355 (2017)
DOI:10.1002/anie.201705489
Related
pathway
ath00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ath00902  Monoterpenoid biosynthesis
KO pathway
ko00901   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG GENES (4)   
All databases (5)   

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