KEGG   PATHWAY: bpj03440
Entry
bpj03440                    Pathway                                
Name
Homologous recombination - Brachyspira pilosicoli B2904
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
bpj03440  Homologous recombination
bpj03440

Other DBs
GO: 0000724
Organism
Brachyspira pilosicoli B2904 [GN:bpj]
Gene
B2904_orf2223  recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
B2904_orf1982  single-strand binding protein [KO:K03111]
B2904_orf407  ssb; single-strand-binding protein [KO:K03111]
B2904_orf1886  single-strand binding protein [KO:K03111]
B2904_orf1933  recF; DNA replication and repair protein RecF [KO:K03629]
B2904_orf1119  DNA repair protein RecO [KO:K03584]
B2904_orf1638  recR; recombination protein RecR [KO:K06187]
B2904_orf2010  recA; recA protein [KO:K03553]
B2904_orf1233  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
B2904_orf2056  ruvA; Holliday junction DNA helicase RuvA [KO:K03550]
B2904_orf513  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
B2904_orf2661  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
B2904_orf409  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
B2904_orf1052  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
B2904_orf1891  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
B2904_orf362  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
B2904_orf2231  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
B2904_orf548  priA; primosomal protein N [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG GENES (18)   
All databases (19)   

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