Entry
Name
Wnt signaling pathway - Bos taurus (cow)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Bos taurus (cow) [GN:
bta ]
Gene
541161 DKK2; dickkopf-related protein 2 precursor [KO:K02165 ]
281386 SERPINF1; pigment epithelium-derived factor precursor [KO:K19614 ]
282068 SFRP1; secreted frizzled-related protein 1 precursor [KO:K02166 ]
510821 SFRP2; secreted frizzled-related protein 2 precursor [KO:K02176 ]
281170 FRZB; secreted frizzled-related protein 3 precursor [KO:K25481 ]
518004 SFRP4; secreted frizzled-related protein 4 precursor [KO:K02185 ]
282069 SFRP5; secreted frizzled-related protein 5 precursor [KO:K02222 ]
505423 LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 precursor [KO:K04309 ]
520189 LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 precursor [KO:K04308 ]
100336662 LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1 [KO:K08399 ]
536328 LRP6; low-density lipoprotein receptor-related protein 6 isoform X2 [KO:K03068 ]
534450 LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
530147 BAMBI; BMP and activin membrane-bound inhibitor homolog precursor [KO:K10162 ]
523325 DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
539203 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353 ]
614312 DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
101905713 CXXC4; LOW QUALITY PROTEIN: CXXC-type zinc finger protein 4 [KO:K03344 ]
526572 APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085 ]
515303 TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490 ]
504411 LZTS2; leucine zipper putative tumor suppressor 2 [KO:K26471 ]
614630 CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493 ]
507111 CHD8; chromodomain-helicase-DNA-binding protein 8 [KO:K04494 ] [EC:5.6.2.-]
507114 CCAR2; cell cycle and apoptosis regulator protein 2 [KO:K25816 ]
505120 TLE7; transducin-like enhancer protein 7 isoform X2 [KO:K04497 ]
533595 TLE2; transducin-like enhancer protein 2 isoform X3 [KO:K04497 ]
511478 TLE6; transducin-like enhancer protein 6 isoform X1 [KO:K04497 ]
540248 SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501 ]
515125 SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605 ]
353106 PPARD; peroxisome proliferator-activated receptor delta [KO:K04504 ]
615427 SKP1; S-phase kinase-associated protein 1 [KO:K03094 ]
614346 TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508 ]
515972 TBL1X; F-box-like/WD repeat-containing protein TBL1X [KO:K04508 ]
534072 BTRC; F-box/WD repeat-containing protein 1A [KO:K03362 ]
540642 FBXW11; F-box/WD repeat-containing protein 11 isoform X3 [KO:K03362 ]
783965 ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1 [KO:K05122 ] [EC:2.7.10.1 ]
785924 ROR2; tyrosine-protein kinase transmembrane receptor ROR2 precursor [KO:K05123 ] [EC:2.7.10.1 ]
537192 PRICKLE2; prickle-like protein 2 isoform X2 [KO:K04511 ]
509780 PRICKLE3; prickle planar cell polarity protein 3 [KO:K04511 ]
783665 DAAM2; disheveled-associated activator of morphogenesis 2 isoform X2 [KO:K04512 ]
513742 DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512 ]
281440 RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
327671 RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
619066 RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861 ]
287026 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
281985 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
515669 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
508888 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
282162 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515 ] [EC:2.7.11.17 ]
525416 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515 ] [EC:2.7.11.17 ]
530719 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
532713 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515 ] [EC:2.7.11.17 ]
533527 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
790867 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348 ] [EC:3.1.3.16 ]
511224 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
530401 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
541127 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
788119 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
Compound
Reference
Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title
Beta-catenin and Tcfs in mammary development and cancer.
Journal
Reference
Authors
Yang Y.
Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal
Reference
Authors
Kalderon D.
Title
Similarities between the Hedgehog and Wnt signaling pathways.
Journal
Reference
Authors
Nusse R.
Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal
Reference
Authors
Jope RS, Johnson GV.
Title
The glamour and gloom of glycogen synthase kinase-3.
Journal
Reference
Authors
Veeman MT, Axelrod JD, Moon RT.
Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal
Reference
Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal
Reference
Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title
The way Wnt works: Components and mechanism.
Journal
Reference
Authors
Carethers JM
Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal
Reference
Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal
Reference
Authors
Niehrs C
Title
The complex world of WNT receptor signalling.
Journal
Reference
Authors
Abou Ziki MD, Mani A
Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal
Reference
Authors
He Y, Ki H, Kim H, Kim K
Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal
Reference
Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal
Reference
Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal
Related pathway
KO pathway