KEGG   PATHWAY: cbg03440
Entry
cbg03440                    Pathway                                
Name
Homologous recombination - Coxiella burnetii CbuG_Q212
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
cbg03440  Homologous recombination
cbg03440

Other DBs
GO: 0000724
Organism
Coxiella burnetii CbuG_Q212 [GN:cbg]
Gene
CbuG_1506  recJ; single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
CbuG_1737  ssb; single-strand DNA binding protein [KO:K03111]
CbuG_0004  recF; DNA replication and repair protein [KO:K03629]
CbuG_0508  recO; DNA repair protein [KO:K03584]
CbuG_1350  recR; recombination protein [KO:K06187]
CbuG_0950  recA; RecA [KO:K03553]
CbuG_0173  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
CbuG_0444  ruvA; holliday junction DNA helicase [KO:K03550]
CbuG_0442  ruvB; holliday junction DNA helicase [KO:K03551] [EC:5.6.2.4]
CbuG_0445  ruvC; crossover junction endodeoxyribonuclease [KO:K01159] [EC:3.1.21.10]
CbuG_1700  recG; ATP-dependent DNA helicase [KO:K03655] [EC:5.6.2.4]
CbuG_0671  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
CbuG_0003  DNA polymerase III, beta chain [KO:K02338] [EC:2.7.7.7]
CbuG_1348  dnaX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
CbuG_1440  holA; DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
CbuG_1513  holB; DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
CbuG_1687  dnaQ; DNA polymerase III, epsilon chain [KO:K02342] [EC:2.7.7.7]
CbuG_0188  priA; primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG GENES (18)   
All databases (19)   

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