KEGG   PATHWAY: ccr03440
Entry
ccr03440                    Pathway                                
Name
Homologous recombination - Caulobacter vibrioides CB15
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ccr03440  Homologous recombination
ccr03440

Other DBs
GO: 0000724
Organism
Caulobacter vibrioides CB15 [GN:ccr]
Gene
CC_1386  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
CC_1468  single-strand binding protein [KO:K03111]
CC_0159  recF protein [KO:K03629]
CC_1564  conserved hypothetical protein [KO:K03584]
CC_0269  recombination protein RecR [KO:K06187]
CC_1087  recA protein [KO:K03553]
CC_3464  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
CC_3237  Holliday junction DNA helicase RuvA [KO:K03550]
CC_3236  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
CC_3238  Holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
CC_1437  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
CC_1926  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
CC_0156  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
CC_0267  DNA polymerase III, gamma and tau subunits [KO:K02343] [EC:2.7.7.7]
CC_3751  hypothetical protein [KO:K02340] [EC:2.7.7.7]
CC_1823  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
CC_0005  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
CC_1523  exonuclease [KO:K02342] [EC:2.7.7.7]
CC_1693  DNA polymerase III, chi subunit, putative [KO:K02339] [EC:2.7.7.7]
CC_0346  primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG GENES (20)   
All databases (21)   

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