KEGG   PATHWAY: cdu04113Help
cdu04113                    Pathway                                

Meiosis - yeast - Candida dubliniensis
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Cellular Processes; Cell growth and death
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Meiosis - yeast

All organismsOrtholog table
Origin recognition complex [PATH:cdu04113]
MCM complex [PATH:cdu04113]
Other DBs
Candida dubliniensis [GN:cdu]
CLN2; G1/S-specific cyclin, putative [KO:K06646]
Cdc28 homologue, putative [KO:K04563] [EC:]
transcriptional SBF complex/cell-cycle-box DNA binding subunit, putative [KO:K06649]
hypothetical protein [KO:K09235]
HGT6; hexose transporter, putative [KO:K08139]
HGT8; hexose transporter, putative [KO:K08139]
HGT7; hexose transporter, putative [KO:K08139]
glucose sensor, putative [KO:K08139]
SNF1; carbon catabolite derepressing protein kinase, putative [KO:K12761] [EC:]
GPR1; plasma membrane G-protein coupled receptor (GPCR), putative [KO:K12762]
CYR1; adenylate cyclase, putative [KO:K01768] [EC:]
cAMP-dependent protei kinase catalytic subunit, putative [KO:K04345] [EC:]
CaTPK2; Catalytic subunit of cAMP-dependent protein kinase (PKA), putative [KO:K04345] [EC:]
transcription factor, putative [KO:K09468]
EFG1; enhanced filamentous growth protein, putative [KO:K12763]
nuclear regulator/transcription factor, cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway, pseudohyphal differentiation, putative [KO:K12763]
meiosis induction protein kinase, putative [KO:K12765] [EC:]
DNA replication licensing factor, putative [KO:K02213]
origin recognition complex subunit 1, putative [KO:K02603]
origin recognition complex subunit 2, putative [KO:K02604]
subunit of the origin recognition complex, putative [KO:K02605]
origin recognition complex subunit, putative [KO:K02606]
origin recognition complex subunit, putative [KO:K02607]
hypothetical protein [KO:K02608]
DNA replication licensing factor, putative [KO:K02540] [EC:]
Protein involved in DNA replication, putative [KO:K02541] [EC:]
pre-replication complex helicase subunit, putative [KO:K02212] [EC:]
DNA licensing factor helicase subunit, putative [KO:K02209] [EC:]
DNA replication licensing factor, putative [KO:K02542] [EC:]
DNA replication licensing factor CDC47 homologue, putative [KO:K02210] [EC:]
DNA replication initiation factor, putative [KO:K06628]
CDC7; cell division control protein, putative [KO:K02214] [EC:]
HSK1 kinase regulatory subunit, putative [KO:K02309]
serine/threonine-protein kinase, putative [KO:K12767] [EC:]
zinc cluster transcription factor, putative [KO:K09243]
hypothetical protein [KO:K09243]
meiosis-specific protein, putative [KO:K10878]
DNA double-strand-break repair and homologue-pairing meiosis protein (DMC1/RAD51 homologue), putative [KO:K10872]
meiosis-specific transcription factor, putative [KO:K12769]
meiosis-specific transcription factor, putative [KO:K12769]
serine/threonine protein kinase, putative [KO:K12771] [EC:]
sporulation-specific protein, putative [KO:K12772]
G2/mitotic-specific (B-type) cyclin, putative [KO:K06659]
cell cycle serine/threonine-protein kinase, putative [KO:K06660] [EC:]
CDC14; protein phosphatase required for mitotic exit, putative [KO:K06639] [EC:]
serine/threonine-protein phosphatase, putative [KO:K06269] [EC:]
serine/threonine-protein phosphatase, putative [KO:K06269] [EC:]
serine/threonine-protein phosphatase, putative [KO:K06269] [EC:]
meiosis-specific serine/threonine-protein kinase MEK1, putative [KO:K12776] [EC:]
meiosis-specific HOP1-related protein, putative [KO:K12778]
protein kinase, putative [KO:K03114] [EC:]
hypothetical protein [KO:K02544]
DNA damage checkpoint protein, putative [KO:K06663]
DNA damage checkpoint control protein, putative [KO:K02830] [EC:]
hypothetical protein [KO:K06662]
DNA-damage checkpoint kinase, ATR homologue, putative [KO:K02543]
DNA repair protein Rad9 homologue, putative [KO:K06661]
serine/threonine-protein kinase Rad53 homologue, putative [KO:K02831] [EC:2.7.11.-]
separase, putative [KO:K02365] [EC:]
chromosomal ATPase, putative [KO:K06636]
structural maintenance of chromosomes protein, putative [KO:K06669]
hypothetical protein [KO:K12780]
cohesin complex subunit, putative [KO:K06671]
mitotic spindle checkpoint component (MAD2), putative [KO:K02537]
spindle assembly checpkoint protein, putative [KO:K06679]
Anaphase-Promoting Complex/Cyclosome (APC/C) largest subunit, putative [KO:K03348]
anaphase-promoting complex (APC) subunit, putative [KO:K03349]
anaphase-promoting complex subunit, putative [KO:K03350]
hypothetical protein [KO:K03351]
Anaphase Promoting Complex subunit, putative [KO:K03352]
subunit of the anaphase-promoting complex/cyclosome (APC/C, putative) [KO:K03353]
20S cyclosome/Anaphase Protein Complex complex subunit, putative [KO:K03355]
anaphase promoting complex subunit, putative [KO:K03357]
anaphase-promoting complex subunit, putative [KO:K03358]
APC/C activator protein, putative [KO:K03363]
checkpoint serine/threonine-protein kinase, putative [KO:K02178] [EC:]
serine/threonine-protein phosphatase B-type regulatory subunit, putative [KO:K11584]
serine/threonine-protein phosphatase type 2A, catalytic subunit, putative [KO:K04382] [EC:]
protein phosphatase regulatory subunit, putative [KO:K03456]
activator of meiotic anaphase promoting complex (APC/C), putative [KO:K12782]
cell division control protein, putative [KO:K06683] [EC:]
3',5'-Cyclic AMP
Honigberg SM, Purnapatre K
Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
J Cell Sci 116:2137-47 (2003)
Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
Transcriptional regulation of meiosis in budding yeast.
Int Rev Cytol 224:111-71 (2003)
Honigberg SM
Ime2p and Cdc28p: co-pilots driving meiotic development.
J Cell Biochem 92:1025-33 (2004)
Hochwagen A, Amon A
Checking your breaks: surveillance mechanisms of meiotic recombination.
Curr Biol 16:R217-28 (2006)
Hollingsworth NM
Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
Genes Dev 22:2596-600 (2008)
Sourirajan A, Lichten M
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
Genes Dev 22:2627-32 (2008)
Roeder GS, Bailis JM
The pachytene checkpoint.
Trends Genet 16:395-403 (2000)
Barr FA, Sillje HH, Nigg EA
Polo-like kinases and the orchestration of cell division.
Nat Rev Mol Cell Biol 5:429-40 (2004)
Lee BH, Amon A
Polo kinase--meiotic cell cycle coordinator.
Cell Cycle 2:400-2 (2003)
Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
Dev Cell 4:727-39 (2003)
Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
Cell 120:773-88 (2005)
Dai W, Wang X
The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
Cell Div 1:9 (2006)
Clift D, Bizzari F, Marston AL
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
Genes Dev 23:766-80 (2009)
Pesin JA, Orr-Weaver TL
Regulation of APC/C activators in mitosis and meiosis.
Annu Rev Cell Dev Biol 24:475-99 (2008)
Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
Mol Biol Cell 20:134-45 (2009)
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