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cdu04113                    Pathway                                

Meiosis - yeast - Candida dubliniensis
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Cellular Processes; Cell growth and death
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Meiosis - yeast

All organismsOrtholog table
Origin recognition complex [PATH:cdu04113]
MCM complex [PATH:cdu04113]
Other DBs
Candida dubliniensis [GN:cdu]
Cdc28 homologue; K04563 cyclin-dependent kinase [EC:] [KO:K04563] [EC:]
transcriptional SBF complex/cell-cycle-box DNA binding subunit; K06649 regulatory protein SWI4 [KO:K06649]
hypothetical protein; K09235 zinc finger protein RME1 [KO:K09235]
HGT6; hexose transporter, putative [KO:K08139]
HGT8; hexose transporter, putative [KO:K08139]
HGT7; hexose transporter, putative [KO:K08139]
glucose sensor; K08139 MFS transporter, SP family, sugar:H+ symporter [KO:K08139]
SNF1; carbon catabolite derepressing protein kinase, putative [KO:K12761] [EC:]
GPR1; plasma membrane G-protein coupled receptor (GPCR), putative [KO:K12762]
CYR1; adenylate cyclase, putative [KO:K01768] [EC:]
cAMP-dependent protei kinase catalytic subunit; K04345 protein kinase A [EC:] [KO:K04345] [EC:]
CaTPK2; Catalytic subunit of cAMP-dependent protein kinase (PKA), putative [KO:K04345] [EC:]
transcription factor; K09468 zinc finger protein MSN2/4 [KO:K09468]
EFG1; enhanced filamentous growth protein, putative [KO:K12763]
nuclear regulator/transcription factor; K12763 protein SOK2 [KO:K12763]
meiosis induction protein kinase; K12765 meiosis induction protein kinase IME2/SME1 [EC:] [KO:K12765] [EC:]
DNA replication licensing factor; K02213 cell division control protein 6 [KO:K02213]
origin recognition complex subunit 1; K02603 origin recognition complex subunit 1 [KO:K02603]
origin recognition complex subunit 2; K02604 origin recognition complex subunit 2 [KO:K02604]
subunit of the origin recognition complex; K02605 origin recognition complex subunit 3 [KO:K02605]
origin recognition complex subunit; K02606 origin recognition complex subunit 4 [KO:K02606]
origin recognition complex subunit; K02607 origin recognition complex subunit 5 [KO:K02607]
hypothetical protein; K02608 origin recognition complex subunit 6 [KO:K02608]
DNA replication licensing factor; K02540 DNA replication licensing factor MCM2 [EC:] [KO:K02540] [EC:]
Protein involved in DNA replication; K02541 DNA replication licensing factor MCM3 [EC:] [KO:K02541] [EC:]
pre-replication complex helicase subunit; K02212 DNA replication licensing factor MCM4 [EC:] [KO:K02212] [EC:]
DNA licensing factor helicase subunit; K02209 DNA replication licensing factor MCM5 [EC:] [KO:K02209] [EC:]
DNA replication licensing factor; K02542 DNA replication licensing factor MCM6 [EC:] [KO:K02542] [EC:]
DNA replication licensing factor CDC47 homologue; K02210 DNA replication licensing factor MCM7 [EC:] [KO:K02210] [EC:]
DNA replication initiation factor; K06628 cell division control protein 45 [KO:K06628]
CDC7; cell division control protein, putative [KO:K02214] [EC:]
HSK1 kinase regulatory subunit; K02309 regulatory subunit for Cdc7p protein kinase [KO:K02309]
serine/threonine-protein kinase; K12767 serine/threonine-protein kinase RIM15 [EC:] [KO:K12767] [EC:]
zinc cluster transcription factor; K09243 transcriptional regulatory protein UME6 [KO:K09243]
hypothetical protein; K09243 transcriptional regulatory protein UME6 [KO:K09243]
meiosis-specific protein; K10878 meiotic recombination protein SPO11 [KO:K10878]
DNA double-strand-break repair and homologue-pairing meiosis protein (DMC1/RAD51 homologue); K10872 meiotic recombination protein DMC1 [KO:K10872]
meiosis-specific transcription factor; K12769 meiosis-specific transcription factor NDT80 [KO:K12769]
meiosis-specific transcription factor; K12769 meiosis-specific transcription factor NDT80 [KO:K12769]
serine/threonine protein kinase; K12771 sporulation-specific protein 1 [EC:] [KO:K12771] [EC:]
sporulation-specific protein; K12772 sporulation-specific protein 4 [KO:K12772]
G2/mitotic-specific (B-type) cyclin; K06659 G2/mitotic-specific cyclin 3/4 [KO:K06659]
cell cycle serine/threonine-protein kinase; K06660 cell cycle serine/threonine-protein kinase CDC5/MSD2 [EC:] [KO:K06660] [EC:]
CDC14; protein phosphatase required for mitotic exit, putative [KO:K06639] [EC:]
serine/threonine-protein phosphatase; K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:] [KO:K06269] [EC:]
serine/threonine-protein phosphatase; K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:] [KO:K06269] [EC:]
serine/threonine-protein phosphatase; K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:] [KO:K06269] [EC:]
meiosis-specific serine/threonine-protein kinase MEK1; K12776 meiosis-specific serine/threonine-protein kinase MEK1 [EC:] [KO:K12776] [EC:]
meiosis-specific HOP1-related protein; K12778 meiosis-specific protein HOP1 [KO:K12778]
protein kinase; K03114 mitosis inhibitor protein kinase SWE1 [EC:] [KO:K03114] [EC:]
hypothetical protein; K02544 G2-specific checkpoint protein [KO:K02544]
DNA damage checkpoint protein; K06663 DNA damage checkpoint protein [KO:K06663]
DNA damage checkpoint control protein; K02830 cell cycle checkpoint protein [EC:] [KO:K02830] [EC:]
hypothetical protein; K06662 cell cycle checkpoint protein [KO:K06662]
DNA-damage checkpoint kinase; K02543 cell cycle checkpoint protein MEC1 [KO:K02543]
DNA repair protein Rad9 homologue; K06661 DNA repair protein RAD9 [KO:K06661]
serine/threonine-protein kinase Rad53 homologue; K02831 ser/thr/tyr protein kinase RAD53 [EC:2.7.11.-] [KO:K02831] [EC:2.7.11.-]
separase; K02365 separase [EC:] [KO:K02365] [EC:]
chromosomal ATPase; K06636 structural maintenance of chromosome 1 [KO:K06636]
structural maintenance of chromosomes protein; K06669 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) [KO:K06669]
hypothetical protein; K12780 meiotic recombination protein REC8, fungi type [KO:K12780]
cohesin complex subunit; K06671 cohesin complex subunit SA-1/2 [KO:K06671]
mitotic spindle checkpoint component (MAD2); K02537 mitotic spindle assembly checkpoint protein MAD2 [KO:K02537]
spindle assembly checpkoint protein; K06679 mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
Anaphase-Promoting Complex/Cyclosome (APC/C) largest subunit; K03348 anaphase-promoting complex subunit 1 [KO:K03348]
anaphase-promoting complex (APC) subunit; K03349 anaphase-promoting complex subunit 2 [KO:K03349]
anaphase-promoting complex subunit; K03350 anaphase-promoting complex subunit 3 [KO:K03350]
hypothetical protein; K03351 anaphase-promoting complex subunit 4 [KO:K03351]
Anaphase Promoting Complex subunit; K03352 anaphase-promoting complex subunit 5 [KO:K03352]
subunit of the anaphase-promoting complex/cyclosome (APC/C; K03353 anaphase-promoting complex subunit 6 [KO:K03353]
20S cyclosome/Anaphase Protein Complex complex subunit; K03355 anaphase-promoting complex subunit 8 [KO:K03355]
anaphase promoting complex subunit; K03357 anaphase-promoting complex subunit 10 [KO:K03357]
anaphase-promoting complex subunit; K03358 anaphase-promoting complex subunit 11 [KO:K03358]
APC/C activator protein; K03363 cell division cycle 20, cofactor of APC complex [KO:K03363]
checkpoint serine/threonine-protein kinase; K02178 checkpoint serine/threonine-protein kinase [EC:] [KO:K02178] [EC:]
serine/threonine-protein phosphatase B-type regulatory subunit; K11584 serine/threonine-protein phosphatase 2A regulatory subunit B' [KO:K11584]
serine/threonine-protein phosphatase type 2A; K04382 serine/threonine-protein phosphatase 2A catalytic subunit [EC:] [KO:K04382] [EC:]
protein phosphatase regulatory subunit; K03456 serine/threonine-protein phosphatase 2A regulatory subunit A [KO:K03456]
activator of meiotic anaphase promoting complex (APC/C); K12782 meiosis-specific APC/C activator protein AMA1 [KO:K12782]
cell division control protein; K06683 cell division control protein CDC15 [EC:] [KO:K06683] [EC:]
3',5'-Cyclic AMP
Honigberg SM, Purnapatre K
Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
J Cell Sci 116:2137-47 (2003)
Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
Transcriptional regulation of meiosis in budding yeast.
Int Rev Cytol 224:111-71 (2003)
Honigberg SM
Ime2p and Cdc28p: co-pilots driving meiotic development.
J Cell Biochem 92:1025-33 (2004)
Hochwagen A, Amon A
Checking your breaks: surveillance mechanisms of meiotic recombination.
Curr Biol 16:R217-28 (2006)
Hollingsworth NM
Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
Genes Dev 22:2596-600 (2008)
Sourirajan A, Lichten M
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
Genes Dev 22:2627-32 (2008)
Roeder GS, Bailis JM
The pachytene checkpoint.
Trends Genet 16:395-403 (2000)
Barr FA, Sillje HH, Nigg EA
Polo-like kinases and the orchestration of cell division.
Nat Rev Mol Cell Biol 5:429-40 (2004)
Lee BH, Amon A
Polo kinase--meiotic cell cycle coordinator.
Cell Cycle 2:400-2 (2003)
Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
Dev Cell 4:727-39 (2003)
Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
Cell 120:773-88 (2005)
Dai W, Wang X
The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
Cell Div 1:9 (2006)
Clift D, Bizzari F, Marston AL
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
Genes Dev 23:766-80 (2009)
Pesin JA, Orr-Weaver TL
Regulation of APC/C activators in mitosis and meiosis.
Annu Rev Cell Dev Biol 24:475-99 (2008)
Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
Mol Biol Cell 20:134-45 (2009)
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