KEGG   PATHWAY: cdu04113Help
Entry
cdu04113                    Pathway                                

Name
Meiosis - yeast - Candida dubliniensis
Description
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
cdu04113  Meiosis - yeast
cdu04113

Ortholog table
Module
cdu_M00284  Origin recognition complex [PATH:cdu04113]
cdu_M00285  MCM complex [PATH:cdu04113]
Other DBs
BSID: 130903
GO: 0051321
Organism
Candida dubliniensis [GN:cdu]
Gene
CD36_51220  CLN2; G1/S-specific cyclin, putative [KO:K06646]
CD36_31500  Cdc28 homologue, putative [KO:K04563] [EC:2.7.11.22]
CD36_01630  transcriptional SBF complex/cell-cycle-box DNA binding subunit, putative [KO:K06649]
CD36_06830  hypothetical protein [KO:K09235]
CD36_15940  HGT6; hexose transporter, putative [KO:K08139]
CD36_15930  HGT8; hexose transporter, putative [KO:K08139]
CD36_15920  HGT7; hexose transporter, putative [KO:K08139]
CD36_84900  glucose sensor, putative [KO:K08139]
CD36_51010  SNF1; carbon catabolite derepressing protein kinase, putative [KO:K12761] [EC:2.7.11.1]
CD36_51080  GPR1; plasma membrane G-protein coupled receptor (GPCR), putative [KO:K12762]
CD36_72730  CYR1; adenylate cyclase, putative [KO:K01768] [EC:4.6.1.1]
CD36_09610  cAMP-dependent protei kinase catalytic subunit, putative [KO:K04345] [EC:2.7.11.11]
CD36_21480  CaTPK2; Catalytic subunit of cAMP-dependent protein kinase (PKA), putative [KO:K04345] [EC:2.7.11.11]
CD36_08440  transcription factor, putative [KO:K09468]
CD36_33560  EFG1; enhanced filamentous growth protein, putative [KO:K12763]
CD36_20730  nuclear regulator/transcription factor, cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway, pseudohyphal differentiation, putative [KO:K12763]
CD36_28430  meiosis induction protein kinase, putative [KO:K12765] [EC:2.7.11.1]
CD36_11450  DNA replication licensing factor, putative [KO:K02213]
CD36_02870  origin recognition complex subunit 1, putative [KO:K02603]
CD36_24600  origin recognition complex subunit 2, putative [KO:K02604]
CD36_83740  subunit of the origin recognition complex, putative [KO:K02605]
CD36_51970  origin recognition complex subunit, putative [KO:K02606]
CD36_32490  origin recognition complex subunit, putative [KO:K02607]
CD36_00950  hypothetical protein [KO:K02608]
CD36_29060  DNA replication licensing factor, putative [KO:K02540] [EC:3.6.4.12]
CD36_21620  Protein involved in DNA replication, putative [KO:K02541] [EC:3.6.4.12]
CD36_11730  pre-replication complex helicase subunit, putative [KO:K02212] [EC:3.6.4.12]
CD36_20640  DNA licensing factor helicase subunit, putative [KO:K02209] [EC:3.6.4.12]
CD36_27030  DNA replication licensing factor, putative [KO:K02542] [EC:3.6.4.12]
CD36_23200  DNA replication licensing factor CDC47 homologue, putative [KO:K02210] [EC:3.6.4.12]
CD36_33370  DNA replication initiation factor, putative [KO:K06628]
CD36_19800  CDC7; cell division control protein, putative [KO:K02214] [EC:2.7.11.1]
CD36_72610  HSK1 kinase regulatory subunit, putative [KO:K02309]
CD36_70680  serine/threonine-protein kinase, putative [KO:K12767] [EC:2.7.11.1]
CD36_42450  zinc cluster transcription factor, putative [KO:K09243]
CD36_05880  hypothetical protein [KO:K09243]
CD36_22990  meiosis-specific protein, putative [KO:K10878]
CD36_11740  DNA double-strand-break repair and homologue-pairing meiosis protein (DMC1/RAD51 homologue), putative [KO:K10872]
CD36_15120  meiosis-specific transcription factor, putative [KO:K12769]
CD36_29580  meiosis-specific transcription factor, putative [KO:K12769]
CD36_03260  serine/threonine protein kinase, putative [KO:K12771] [EC:2.7.11.1]
CD36_35035  sporulation-specific protein, putative [KO:K12772]
CD36_73620  G2/mitotic-specific (B-type) cyclin, putative [KO:K06659]
CD36_00900  cell cycle serine/threonine-protein kinase, putative [KO:K06660] [EC:2.7.11.21]
CD36_60580  CDC14; protein phosphatase required for mitotic exit, putative [KO:K06639] [EC:3.1.3.48 3.1.3.16]
CD36_33270  serine/threonine-protein phosphatase, putative [KO:K06269] [EC:3.1.3.16]
CD36_31870  serine/threonine-protein phosphatase, putative [KO:K06269] [EC:3.1.3.16]
CD36_64340  serine/threonine-protein phosphatase, putative [KO:K06269] [EC:3.1.3.16]
CD36_21800  meiosis-specific serine/threonine-protein kinase MEK1, putative [KO:K12776] [EC:2.7.11.1]
CD36_01110  meiosis-specific HOP1-related protein, putative [KO:K12778]
CD36_09410  protein kinase, putative [KO:K03114] [EC:2.7.11.1]
CD36_20610  hypothetical protein [KO:K02544]
CD36_82520  DNA damage checkpoint protein, putative [KO:K06663]
CD36_65610  DNA damage checkpoint control protein, putative [KO:K02830] [EC:3.1.11.2]
CD36_42580  hypothetical protein [KO:K06662]
CD36_53760  DNA-damage checkpoint kinase, ATR homologue, putative [KO:K02543]
CD36_52380  DNA repair protein Rad9 homologue, putative [KO:K06661]
CD36_83790  serine/threonine-protein kinase Rad53 homologue, putative [KO:K02831] [EC:2.7.11.-]
CD36_01530  separase, putative [KO:K02365] [EC:3.4.22.49]
CD36_28880  chromosomal ATPase, putative [KO:K06636]
CD36_82710  structural maintenance of chromosomes protein, putative [KO:K06669]
CD36_04440  hypothetical protein [KO:K12780]
CD36_13200  cohesin complex subunit, putative [KO:K06671]
CD36_03840  mitotic spindle checkpoint component (MAD2), putative [KO:K02537]
CD36_11840  spindle assembly checpkoint protein, putative [KO:K06679]
CD36_00530  Anaphase-Promoting Complex/Cyclosome (APC/C) largest subunit, putative [KO:K03348]
CD36_86780  anaphase-promoting complex (APC) subunit, putative [KO:K03349]
CD36_26240  anaphase-promoting complex subunit, putative [KO:K03350]
CD36_50100  hypothetical protein [KO:K03351]
CD36_44880  Anaphase Promoting Complex subunit, putative [KO:K03352]
CD36_45000  subunit of the anaphase-promoting complex/cyclosome (APC/C, putative) [KO:K03353]
CD36_34220  20S cyclosome/Anaphase Protein Complex complex subunit, putative [KO:K03355]
CD36_07370  anaphase promoting complex subunit, putative [KO:K03357]
CD36_35415  anaphase-promoting complex subunit, putative [KO:K03358]
CD36_61260  APC/C activator protein, putative [KO:K03363]
CD36_42970  checkpoint serine/threonine-protein kinase, putative [KO:K02178] [EC:2.7.11.1]
CD36_20780  serine/threonine-protein phosphatase B-type regulatory subunit, putative [KO:K11584]
CD36_81510  serine/threonine-protein phosphatase type 2A, catalytic subunit, putative [KO:K04382] [EC:3.1.3.16]
CD36_86870  protein phosphatase regulatory subunit, putative [KO:K03456]
CD36_84840  activator of meiotic anaphase promoting complex (APC/C), putative [KO:K12782]
CD36_19640  cell division control protein, putative [KO:K06683] [EC:2.7.11.1]
Compound
C00031  D-Glucose
C00288  HCO3-
C00575  3',5'-Cyclic AMP
Reference
  Authors
Honigberg SM, Purnapatre K
  Title
Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
  Journal
J Cell Sci 116:2137-47 (2003)
DOI:10.1242/jcs.00460
Reference
  Authors
Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
  Title
Transcriptional regulation of meiosis in budding yeast.
  Journal
Int Rev Cytol 224:111-71 (2003)
DOI:10.1016/S0074-7696(05)24004-4
Reference
  Authors
Honigberg SM
  Title
Ime2p and Cdc28p: co-pilots driving meiotic development.
  Journal
J Cell Biochem 92:1025-33 (2004)
DOI:10.1002/jcb.20131
Reference
  Authors
Hochwagen A, Amon A
  Title
Checking your breaks: surveillance mechanisms of meiotic recombination.
  Journal
Curr Biol 16:R217-28 (2006)
DOI:10.1016/j.cub.2006.03.009
Reference
  Authors
Hollingsworth NM
  Title
Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
  Journal
Genes Dev 22:2596-600 (2008)
DOI:10.1101/gad.1727508
Reference
  Authors
Sourirajan A, Lichten M
  Title
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
  Journal
Genes Dev 22:2627-32 (2008)
DOI:10.1101/gad.1711408
Reference
  Authors
Roeder GS, Bailis JM
  Title
The pachytene checkpoint.
  Journal
Trends Genet 16:395-403 (2000)
DOI:10.1016/S0168-9525(00)02080-1
Reference
  Authors
Barr FA, Sillje HH, Nigg EA
  Title
Polo-like kinases and the orchestration of cell division.
  Journal
Nat Rev Mol Cell Biol 5:429-40 (2004)
DOI:10.1038/nrm1401
Reference
  Authors
Lee BH, Amon A
  Title
Polo kinase--meiotic cell cycle coordinator.
  Journal
Cell Cycle 2:400-2 (2003)
DOI:10.4161/cc.2.5.475
Reference
  Authors
Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
  Title
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
  Journal
Dev Cell 4:727-39 (2003)
DOI:10.1016/S1534-5807(03)00129-1
Reference
  Authors
Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
  Title
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
  Journal
Cell 120:773-88 (2005)
DOI:10.1016/j.cell.2005.01.032
Reference
  Authors
Dai W, Wang X
  Title
The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
  Journal
Cell Div 1:9 (2006)
DOI:10.1186/1747-1028-1-9
Reference
  Authors
Clift D, Bizzari F, Marston AL
  Title
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
  Journal
Genes Dev 23:766-80 (2009)
DOI:10.1101/gad.507509
Reference
  Authors
Pesin JA, Orr-Weaver TL
  Title
Regulation of APC/C activators in mitosis and meiosis.
  Journal
Annu Rev Cell Dev Biol 24:475-99 (2008)
DOI:10.1146/annurev.cellbio.041408.115949
Reference
  Authors
Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
  Title
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
  Journal
Mol Biol Cell 20:134-45 (2009)
DOI:10.1091/mbc.E08-06-0615
KO pathway
ko04113   

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