KEGG   PATHWAY: cdu04113Help
Entry
cdu04113                    Pathway                                

Name
Meiosis - yeast - Candida dubliniensis
Description
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
Meiosis - yeast
cdu04113

All organismsOrtholog table
Module
Origin recognition complex [PATH:cdu04113]
MCM complex [PATH:cdu04113]
Other DBs
BSID: 
GO: 
Organism
Candida dubliniensis [GN:cdu]
Gene
CLN2; G1/S-specific cyclin, putative [KO:K06646]
Cdc28 homologue, putative [KO:K04563] [EC:2.7.11.22]
transcriptional SBF complex/cell-cycle-box DNA binding subunit, putative [KO:K06649]
hypothetical protein [KO:K09235]
HGT6; hexose transporter, putative [KO:K08139]
HGT8; hexose transporter, putative [KO:K08139]
HGT7; hexose transporter, putative [KO:K08139]
glucose sensor, putative [KO:K08139]
SNF1; carbon catabolite derepressing protein kinase, putative [KO:K12761] [EC:2.7.11.1]
GPR1; plasma membrane G-protein coupled receptor (GPCR), putative [KO:K12762]
CYR1; adenylate cyclase, putative [KO:K01768] [EC:4.6.1.1]
cAMP-dependent protei kinase catalytic subunit, putative [KO:K04345] [EC:2.7.11.11]
CaTPK2; Catalytic subunit of cAMP-dependent protein kinase (PKA), putative [KO:K04345] [EC:2.7.11.11]
transcription factor, putative [KO:K09468]
EFG1; enhanced filamentous growth protein, putative [KO:K12763]
nuclear regulator/transcription factor, cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway, pseudohyphal differentiation, putative [KO:K12763]
meiosis induction protein kinase, putative [KO:K12765] [EC:2.7.11.1]
DNA replication licensing factor, putative [KO:K02213]
origin recognition complex subunit 1, putative [KO:K02603]
origin recognition complex subunit 2, putative [KO:K02604]
subunit of the origin recognition complex, putative [KO:K02605]
origin recognition complex subunit, putative [KO:K02606]
origin recognition complex subunit, putative [KO:K02607]
hypothetical protein [KO:K02608]
DNA replication licensing factor, putative [KO:K02540] [EC:3.6.4.12]
Protein involved in DNA replication, putative [KO:K02541] [EC:3.6.4.12]
pre-replication complex helicase subunit, putative [KO:K02212] [EC:3.6.4.12]
DNA licensing factor helicase subunit, putative [KO:K02209] [EC:3.6.4.12]
DNA replication licensing factor, putative [KO:K02542] [EC:3.6.4.12]
DNA replication licensing factor CDC47 homologue, putative [KO:K02210] [EC:3.6.4.12]
DNA replication initiation factor, putative [KO:K06628]
CDC7; cell division control protein, putative [KO:K02214] [EC:2.7.11.1]
HSK1 kinase regulatory subunit, putative [KO:K02309]
serine/threonine-protein kinase, putative [KO:K12767] [EC:2.7.11.1]
zinc cluster transcription factor, putative [KO:K09243]
hypothetical protein [KO:K09243]
meiosis-specific protein, putative [KO:K10878]
DNA double-strand-break repair and homologue-pairing meiosis protein (DMC1/RAD51 homologue), putative [KO:K10872]
meiosis-specific transcription factor, putative [KO:K12769]
meiosis-specific transcription factor, putative [KO:K12769]
serine/threonine protein kinase, putative [KO:K12771] [EC:2.7.11.1]
sporulation-specific protein, putative [KO:K12772]
G2/mitotic-specific (B-type) cyclin, putative [KO:K06659]
cell cycle serine/threonine-protein kinase, putative [KO:K06660] [EC:2.7.11.21]
CDC14; protein phosphatase required for mitotic exit, putative [KO:K06639] [EC:3.1.3.48 3.1.3.16]
serine/threonine-protein phosphatase, putative [KO:K06269] [EC:3.1.3.16]
serine/threonine-protein phosphatase, putative [KO:K06269] [EC:3.1.3.16]
serine/threonine-protein phosphatase, putative [KO:K06269] [EC:3.1.3.16]
meiosis-specific serine/threonine-protein kinase MEK1, putative [KO:K12776] [EC:2.7.11.1]
meiosis-specific HOP1-related protein, putative [KO:K12778]
protein kinase, putative [KO:K03114] [EC:2.7.11.1]
hypothetical protein [KO:K02544]
DNA damage checkpoint protein, putative [KO:K06663]
DNA damage checkpoint control protein, putative [KO:K02830] [EC:3.1.11.2]
hypothetical protein [KO:K06662]
DNA-damage checkpoint kinase, ATR homologue, putative [KO:K02543]
DNA repair protein Rad9 homologue, putative [KO:K06661]
serine/threonine-protein kinase Rad53 homologue, putative [KO:K02831] [EC:2.7.11.-]
separase, putative [KO:K02365] [EC:3.4.22.49]
chromosomal ATPase, putative [KO:K06636]
structural maintenance of chromosomes protein, putative [KO:K06669]
hypothetical protein [KO:K12780]
cohesin complex subunit, putative [KO:K06671]
mitotic spindle checkpoint component (MAD2), putative [KO:K02537]
spindle assembly checpkoint protein, putative [KO:K06679]
Anaphase-Promoting Complex/Cyclosome (APC/C) largest subunit, putative [KO:K03348]
anaphase-promoting complex (APC) subunit, putative [KO:K03349]
anaphase-promoting complex subunit, putative [KO:K03350]
hypothetical protein [KO:K03351]
Anaphase Promoting Complex subunit, putative [KO:K03352]
subunit of the anaphase-promoting complex/cyclosome (APC/C, putative) [KO:K03353]
20S cyclosome/Anaphase Protein Complex complex subunit, putative [KO:K03355]
anaphase promoting complex subunit, putative [KO:K03357]
anaphase-promoting complex subunit, putative [KO:K03358]
APC/C activator protein, putative [KO:K03363]
checkpoint serine/threonine-protein kinase, putative [KO:K02178] [EC:2.7.11.1]
serine/threonine-protein phosphatase B-type regulatory subunit, putative [KO:K11584]
serine/threonine-protein phosphatase type 2A, catalytic subunit, putative [KO:K04382] [EC:3.1.3.16]
protein phosphatase regulatory subunit, putative [KO:K03456]
activator of meiotic anaphase promoting complex (APC/C), putative [KO:K12782]
cell division control protein, putative [KO:K06683] [EC:2.7.11.1]
Compound
C00031  
D-Glucose
C00288  
HCO3-
C00575  
3',5'-Cyclic AMP
Reference
  Authors
Honigberg SM, Purnapatre K
  Title
Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
  Journal
J Cell Sci 116:2137-47 (2003)
Reference
  Authors
Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
  Title
Transcriptional regulation of meiosis in budding yeast.
  Journal
Int Rev Cytol 224:111-71 (2003)
Reference
  Authors
Honigberg SM
  Title
Ime2p and Cdc28p: co-pilots driving meiotic development.
  Journal
J Cell Biochem 92:1025-33 (2004)
Reference
  Authors
Hochwagen A, Amon A
  Title
Checking your breaks: surveillance mechanisms of meiotic recombination.
  Journal
Curr Biol 16:R217-28 (2006)
Reference
  Authors
Hollingsworth NM
  Title
Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
  Journal
Genes Dev 22:2596-600 (2008)
Reference
  Authors
Sourirajan A, Lichten M
  Title
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
  Journal
Genes Dev 22:2627-32 (2008)
Reference
  Authors
Roeder GS, Bailis JM
  Title
The pachytene checkpoint.
  Journal
Trends Genet 16:395-403 (2000)
Reference
  Authors
Barr FA, Sillje HH, Nigg EA
  Title
Polo-like kinases and the orchestration of cell division.
  Journal
Nat Rev Mol Cell Biol 5:429-40 (2004)
Reference
  Authors
Lee BH, Amon A
  Title
Polo kinase--meiotic cell cycle coordinator.
  Journal
Cell Cycle 2:400-2 (2003)
Reference
  Authors
Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
  Title
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
  Journal
Dev Cell 4:727-39 (2003)
Reference
  Authors
Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
  Title
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
  Journal
Cell 120:773-88 (2005)
Reference
  Authors
Dai W, Wang X
  Title
The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
  Journal
Cell Div 1:9 (2006)
Reference
  Authors
Clift D, Bizzari F, Marston AL
  Title
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
  Journal
Genes Dev 23:766-80 (2009)
Reference
  Authors
Pesin JA, Orr-Weaver TL
  Title
Regulation of APC/C activators in mitosis and meiosis.
  Journal
Annu Rev Cell Dev Biol 24:475-99 (2008)
Reference
  Authors
Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
  Title
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
  Journal
Mol Biol Cell 20:134-45 (2009)
KO pathway
 

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