KEGG   PATHWAY: cfa04310
Entry
cfa04310                    Pathway                                
Name
Wnt signaling pathway - Canis lupus familiaris (dog)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
cfa04310  Wnt signaling pathway
cfa04310

Other DBs
GO: 0016055
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
480903  PORCN; protein-serine O-palmitoleoyltransferase porcupine isoform X1 [KO:K00181] [EC:2.3.1.250]
486560  WNT1; proto-oncogene Wnt-1 [KO:K03209]
483220  WNT2B; protein Wnt-2b [KO:K00182]
612141  WNT2; protein Wnt-2 [KO:K00182]
609107  WNT3; proto-oncogene Wnt-3 [KO:K00312]
482208  WNT3A; protein Wnt-3a [KO:K00312]
612367  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
484721  WNT5A; protein Wnt-5a precursor [KO:K00444]
486756  WNT5B; protein Wnt-5b [KO:K00444]
488527  WNT6; protein Wnt-6 [KO:K00445]
481206  WNT7B; protein Wnt-7b isoform X4 [KO:K00572]
607180  WNT7A; protein Wnt-7a [KO:K00572]
486841  WNT8B; protein Wnt-8b [KO:K00714]
100855884  WNT8A; protein Wnt-8a isoform X2 [KO:K00714]
482209  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
490919  WNT9B; protein Wnt-9b [KO:K01064]
488528  WNT10A; protein Wnt-10a [KO:K01357]
486561  WNT10B; protein Wnt-10b [KO:K01357]
485183  WNT11; protein Wnt-11 [KO:K01384]
612328  WNT16; protein Wnt-16 isoform X3 [KO:K01558]
611037  CER1; cerberus [KO:K01645]
483374  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
481148  WIF1; wnt inhibitory factor 1 isoform X1 [KO:K01691]
490948  SOST; sclerostin isoform X1 [KO:K16834]
609600  DKK1; dickkopf-related protein 1 [KO:K02165]
478502  DKK2; dickkopf-related protein 2 [KO:K02165]
607210  DKK4; dickkopf-related protein 4 [KO:K02165]
611276  SERPINF1; pigment epithelium-derived factor [KO:K19614]
482844  SFRP1; secreted frizzled-related protein 1 [KO:K02166]
475471  SFRP2; secreted frizzled-related protein 2 [KO:K02176]
478827  FRZB; secreted frizzled-related protein 3 [KO:K25481]
483258  SFRP4; secreted frizzled-related protein 4 [KO:K02185]
486826  SFRP5; secreted frizzled-related protein 5 isoform X3 [KO:K02222]
608179  RSPO1; R-spondin-1 precursor [KO:K19471]
482004  RSPO2; R-spondin-2 isoform X1 [KO:K23097]
476287  RSPO3; R-spondin-3 isoform X3 [KO:K23098]
485813  RSPO4; R-spondin-4 [KO:K23099]
476896  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X5 [KO:K04309]
609478  LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308]
490231  LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 isoform X3 [KO:K08399]
491114  RNF43; E3 ubiquitin-protein ligase RNF43 isoform X1 [KO:K15694] [EC:2.3.2.27]
486339  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 isoform X2 [KO:K16273] [EC:2.3.2.27]
482294  FZD1; frizzled-1 [KO:K02432]
488478  FZD7; frizzled-7 [KO:K02432]
490937  FZD2; frizzled-2 [KO:K02235]
486093  FZD3; frizzled-3 isoform X1 [KO:K02329]
485149  FZD4; frizzled-4 [KO:K02354]
487073  FZD8; frizzled-8 [KO:K02375]
119863906  LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
403610  FZD6; frizzled-6 precursor [KO:K02376]
486232  FZD10; frizzled-10 [KO:K02842]
489809  FZD9; frizzled-9 [KO:K02842]
477692  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100306933  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
487081  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
480209  APCDD1; protein APCDD1 [KO:K25812]
611907  APCDD1L; protein APCDD1-like [KO:K25812]
474510  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
480418  CCDC88C; protein Daple isoform X1 [KO:K25811]
478650  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
489464  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X4 [KO:K02353]
100855811  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
486819  FRAT1; proto-oncogene FRAT1 [KO:K03069]
106557930  LOW QUALITY PROTEIN: GSK-3-binding protein FRAT2-like [KO:K03096]
477185  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
478108  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
474844  CSNK2B; casein kinase II subunit beta isoform X2 [KO:K03115]
487288  NKD1; protein naked cuticle homolog 1 isoform X3 [KO:K03213]
488070  NKD2; protein naked cuticle homolog 2 [KO:K03213]
610189  CXXC4; CXXC-type zinc finger protein 4 [KO:K03344]
478661  SENP2; sentrin-specific protease 2 isoform X4 [KO:K03345] [EC:3.4.22.68]
478575  GSK3B; glycogen synthase kinase-3 beta isoform X13 [KO:K03083] [EC:2.7.11.26]
477032  CTNNB1; catenin beta-1 [KO:K02105]
490099  AXIN1; axin-1 isoform X1 [KO:K02157]
490903  AXIN2; axin-2 isoform X1 [KO:K04385]
479139  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
485084  APC2; adenomatous polyposis coli protein 2 isoform X3 [KO:K02085]
479331  CSNK1A1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
481506  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
612070  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
486894  TCF7L2; transcription factor 7-like 2 isoform X22 [KO:K04491]
478507  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
486846  LZTS2; leucine zipper putative tumor suppressor 2 isoform X1 [KO:K26471]
481252  CBY1; protein chibby homolog 1 [KO:K23402]
475401  CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
611208  MCC; colorectal mutant cancer protein isoform X2 [KO:K26734]
486122  CCAR2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816]
489012  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X2 [KO:K11411] [EC:2.3.1.286]
486955  SOX17; transcription factor SOX-17 [KO:K04495]
100684514  CTBP2; C-terminal-binding protein 2 isoform X4 [KO:K04496] [EC:1.1.1.428]
479662  TLE7; transducin-like enhancer protein 7 isoform X1 [KO:K04497]
100687252  TLE2; transducin-like enhancer protein 2 isoform X3 [KO:K04497]
487624  TLE3; transducin-like enhancer protein 3 isoform X1 [KO:K04497]
476314  TLE1; transducin-like enhancer protein 1 isoform X1 [KO:K04497]
476317  TLE4; transducin-like enhancer protein 4 isoform X1 [KO:K04497]
485066  TLE6; transducin-like enhancer protein 6 isoform X4 [KO:K04497]
488048  CTNND2; catenin delta-2 isoform X1 [KO:K23491]
479866  CREBBP; CREB-binding protein isoform X8 [KO:K04498] [EC:2.3.1.48]
100684945  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
476512  RUVBL1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
476196  SMAD4; mothers against decapentaplegic homolog 4 isoform X2 [KO:K04501]
610902  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
102156745  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
491160  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
403924  MYC; myc proto-oncogene protein [KO:K04377]
609429  JUN; transcription factor AP-1 [KO:K04448]
483724  FOSL1; fos-related antigen 1 [KO:K04502]
449028  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
611782  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
608847  CCND3; G1/S-specific cyclin-D3 isoform X3 [KO:K10152]
482048  CCN4; CCN family member 4 isoform X1 [KO:K22471]
481756  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
489432  MMP7; matrilysin precursor [KO:K01397] [EC:3.4.24.23]
403408  PSEN1; presenilin-1 isoform 1 [KO:K04505] [EC:3.4.23.-]
403556  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
479975  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
403869  TP53; cellular tumor antigen p53 [KO:K04451]
100856496  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
480062  CACYBP; calcyclin-binding protein isoform X2 [KO:K04507]
474682  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
111090648  S-phase kinase-associated protein 1-like [KO:K03094]
488176  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
611017  TBL1X; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
479291  FBXW11; F-box/WD repeat-containing protein 11 isoform X5 [KO:K03362]
486851  BTRC; F-box/WD repeat-containing protein 1A isoform X2 [KO:K03362]
475512  CUL1; cullin-1 [KO:K03347]
474494  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X2 [KO:K03868] [EC:2.3.2.32]
492144  GPC4; glypican-4 isoform X2 [KO:K08110]
489557  ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1 [KO:K05122] [EC:2.7.10.1]
484193  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 [KO:K05123] [EC:2.7.10.1]
477074  RYK; tyrosine-protein kinase RYK isoform X3 [KO:K05128] [EC:2.7.10.1]
483133  VANGL1; vang-like protein 1 [KO:K04510]
610037  VANGL2; vang-like protein 2 [KO:K04510]
484699  PRICKLE2; prickle-like protein 2 isoform X11 [KO:K04511]
100856007  PRICKLE1; prickle-like protein 1 [KO:K04511]
481795  PRICKLE4; prickle-like protein 4 isoform X1 [KO:K04511]
491874  PRICKLE3; prickle planar cell polarity protein 3 isoform X2 [KO:K04511]
442950  INVS; inversin [KO:K19626]
481783  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
490714  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
403954  RHOA; transforming protein RhoA [KO:K04513]
482970  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
403955  RAC1; ras-related C3 botulinum toxin substrate 1 precursor [KO:K04392]
481271  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
106559217  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
477746  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
478464  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
474652  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
477160  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
485773  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
476034  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
100856190  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
489050  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
610764  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
612941  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
482687  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
609027  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
403486  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
479248  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
612559  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
610453  PPP3R2; calcineurin subunit B type 2 isoform X5 [KO:K06268]
490904  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
489968  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100855828  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
483925  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X3 [KO:K04446]
485930  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
479678  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
480272  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
cfa04010  MAPK signaling pathway
cfa04110  Cell cycle
cfa04115  p53 signaling pathway
cfa04120  Ubiquitin mediated proteolysis
cfa04350  TGF-beta signaling pathway
cfa04510  Focal adhesion
cfa04520  Adherens junction
cfa05010  Alzheimer disease
KO pathway
ko04310   

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Genome (1)   
   KEGG GENOME (1)   
Gene (168)   
   KEGG GENES (168)   
All databases (169)   

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