KEGG   PATHWAY: cgl03440
Entry
cgl03440                    Pathway                                
Name
Homologous recombination - Corynebacterium glutamicum ATCC 13032 (Kyowa Hakko)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
cgl03440  Homologous recombination
cgl03440

Other DBs
GO: 0000724
Organism
Corynebacterium glutamicum ATCC 13032 (Kyowa Hakko) [GN:cgl]
Gene
Cgl1737  Cgl1737; Single-stranded DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
Cgl1863  Cgl1863; Single-stranded DNA-binding protein [KO:K03111]
Cgl2455  Cgl2455; Single-stranded DNA-binding protein [KO:K03111]
Cgl2982  Cgl2982; Single-stranded DNA-binding protein [KO:K03111]
Cgl0004  Cgl0004; Recombinational DNA repair ATPase [KO:K03629]
Cgl2284  Cgl2284; Recombinational DNA repair protein [KO:K03584]
Cgl0244  Cgl0244; Recombinational DNA repair protein [KO:K06187]
Cgl1955  Cgl1955; RecA/RadA recombinase [KO:K03553]
Cgl1353  Cgl1353; DNA polymerase I - 3'-5' exonuclease and polymerase domains [KO:K02335] [EC:2.7.7.7]
Cgl1661  Cgl1661; Holliday junction resolvasome DNA-binding subunit [KO:K03550]
Cgl1660  Cgl1660; Holliday junction resolvasome helicase subunit [KO:K03551] [EC:5.6.2.4]
Cgl1662  Cgl1662; Holliday junction resolvasome endonuclease subunit [KO:K01159] [EC:3.1.21.10]
Cgl0025  Cgl0025; Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [KO:K03655] [EC:5.6.2.4]
Cgl1326  Cgl1326; RecG-like helicases [KO:K03655] [EC:5.6.2.4]
Cgl1243  Cgl1243; Hypothetical protein [KO:K02337] [EC:2.7.7.7]
Cgl2130  Cgl2130; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
Cgl0003  Cgl0003; DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
Cgl0242  Cgl0242; DNA polymerase III, gamma/tau subunits [KO:K02343] [EC:2.7.7.7]
Cgl2346  Cgl2346; DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
Cgl0312  Cgl0312; ATPase involved in DNA replication [KO:K02341] [EC:2.7.7.7]
Cgl0247  Cgl0247; DNA polymerase III epsilon subunit and related 3'-5' exonucleases [KO:K02342] [EC:2.7.7.7]
Cgl1289  Cgl1289; DNA polymerase III epsilon subunit and related 3'-5' exonucleases [KO:K02342] [EC:2.7.7.7]
Cgl2116  Cgl2116; DNA polymerase III epsilon subunit and related 3'-5' exonucleases [KO:K02342] [EC:2.7.7.7]
Cgl1602  Cgl1602; Primosomal protein N' (replication factor Y) - superfamily II helicase [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG GENES (24)   
All databases (25)   

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