KEGG   PATHWAY: cim04146
Entry
cim04146                    Pathway                                
Name
Peroxisome - Coccidioides immitis
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
cim04146  Peroxisome
cim04146

Other DBs
GO: 0005777
Organism
Coccidioides immitis [GN:cim]
Gene
CIMG_02536  peroxisomal membrane protein pex16 [KO:K13335]
CIMG_05982  peroxin 3 [KO:K13336]
CIMG_03783  peroxin 19 [KO:K13337]
CIMG_07548  peroxisome biosynthesis protein [KO:K13338]
CIMG_02347  peroxisomal biogenesis factor 6 [KO:K13339]
CIMG_03324  peroxisome biosynthesis protein [KO:K13341]
CIMG_04272  peroxisomal targeting signal-1 receptor [KO:K13342]
CIMG_03565  peroxin 14 [KO:K13343]
CIMG_02172  peroxisomal membrane protein [KO:K13344]
CIMG_09448  peroxisome biosynthesis protein [KO:K13345]
CIMG_07527  peroxin 10 [KO:K13346]
CIMG_04593  peroxisomal biogenesis factor 2 [KO:K06664]
CIMG_08093  protein sym1 [KO:K13348]
CIMG_02153  peroxisomal membrane protein [KO:K13350]
CIMG_01269  peroxisomal biogenesis factor PEX11 [KO:K13352]
CIMG_06318  peroxisomal membrane protein Pmp47 [KO:K13354]
CIMG_04305  2-hydroxyphytanoyl-CoA lyase [KO:K12261] [EC:4.1.2.63]
CIMG_06590  alpha-methylacyl-CoA racemase [KO:K01796] [EC:5.1.99.4]
CIMG_05604  phytanoyl-CoA dioxygenase [KO:K00477] [EC:1.14.11.18]
CIMG_13106  CIMG07097; acyl-CoA oxidase [KO:K00232] [EC:1.3.3.6]
CIMG_12750  CIMG01877; acyl-CoA oxidase [KO:K00232] [EC:1.3.3.6]
CIMG_10832  CIMG01874; acyl-CoA oxidase [KO:K00232] [EC:1.3.3.6]
CIMG_04177  nonspecific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
CIMG_02988  sterol carrier protein [KO:K08764] [EC:2.3.1.176]
CIMG_04391  acetyl-CoA C-acetyltransferase [KO:K07513] [EC:2.3.1.16]
CIMG_06860  acetyl-CoA C-acetyltransferase [KO:K07513] [EC:2.3.1.16]
CIMG_01533  acetyl-CoA C-acetyltransferase [KO:K07513] [EC:2.3.1.16]
CIMG_06119  sporulation protein SPS19 [KO:K13237] [EC:1.3.1.124]
CIMG_07353  enoyl-CoA hydratase/isomerase [KO:K12663] [EC:5.3.3.21]
CIMG_04919  peroxisomal ABC transporter [KO:K15628] [EC:7.6.2.4]
CIMG_05910  ABC fatty acid transporter [KO:K15628] [EC:7.6.2.4]
CIMG_07819  fatty acid activator Faa4 [KO:K01897] [EC:6.2.1.3]
CIMG_11724  CIMG06305; AMP-binding enzyme [KO:K01897] [EC:6.2.1.3]
CIMG_10208  peroxisomal D3,D2-enoyl-CoA isomerase [KO:K13239] [EC:5.3.3.8]
CIMG_06522  NADH pyrophosphatase [KO:K03426] [EC:3.6.1.22]
CIMG_06895  carnitine acetyl transferase [KO:K00624] [EC:2.3.1.7]
CIMG_05196  carnitine acetyl transferase [KO:K00624] [EC:2.3.1.7]
CIMG_05726  mevalonate kinase [KO:K00869] [EC:2.7.1.36]
CIMG_07122  aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CIMG_09124  D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
CIMG_05805  hypothetical protein [KO:K00273] [EC:1.4.3.3]
CIMG_08541  hypothetical protein [KO:K00273] [EC:1.4.3.3]
CIMG_07673  isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
CIMG_03554  fructosyl amino acid oxidasesarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
CIMG_05209  hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
CIMG_03167  (S)-2-hydroxy-acid oxidase [KO:K11517] [EC:1.1.3.15]
CIMG_10158  catalase A [KO:K03781] [EC:1.11.1.6]
CIMG_04336  catalase [KO:K03781] [EC:1.11.1.6]
CIMG_06677  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
CIMG_01587  superoxide dismutase [KO:K04564] [EC:1.15.1.1]
CIMG_07987  Fe superoxide dismutase [KO:K04564] [EC:1.15.1.1]
CIMG_01495  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
cim00071  Fatty acid degradation
cim00230  Purine metabolism
cim00564  Glycerophospholipid metabolism
cim00565  Ether lipid metabolism
cim00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (52)   
   KEGG GENES (52)   
All databases (53)   

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