KEGG   PATHWAY: dme04145Help
Entry
dme04145                    Pathway                                

Name
Phagosome - Drosophila melanogaster (fruit fly)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
dme04145  Phagosome
dme04145

Ortholog table
Module
dme_M00401  Sec61 complex [PATH:dme04145]
Other DBs
BSID: 153863
GO: 0045335
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG5081  Syx7; syntaxin 7, isoform A [KO:K08488]
Dmel_CG10067  Act57B; actin 57B [KO:K05692]
Dmel_CG12051  Act42A; actin 42A [KO:K05692]
Dmel_CG18290  Act87E; actin 87E, isoform C [KO:K05692]
Dmel_CG4027  Act5C; actin 5C, isoform D [KO:K05692]
Dmel_CG5178  Act88F; actin 88F [KO:K05692]
Dmel_CG7478  Act79B; actin 79B, isoform B [KO:K05692]
Dmel_CG5409  Arp53D; Actin-related protein 53D [KO:K05692]
Dmel_CG13626  Syx18; syntaxin 18 [KO:K08492]
Dmel_CG7359  Sec22; secretory 22, isoform B [KO:K08517]
Dmel_CG3664  Rab5; Rab5, isoform G [KO:K07889]
Dmel_CG5373  Pi3K59F; phosphotidylinositol 3 kinase 59F [KO:K00914] [EC:2.7.1.137]
Dmel_CG2903  Hrs; hepatocyte growth factor regulated tyrosine kinase substrate, isoform B [KO:K12182]
Dmel_CG3762  Vha68-2; vacuolar H[+] ATPase 68 kDa subunit 2, isoform D [KO:K02145] [EC:3.6.3.14]
Dmel_CG5075  Vha68-3; vacuolar H[+] ATPase 68kD subunit 3 [KO:K02145] [EC:3.6.3.14]
Dmel_CG12403  Vha68-1; vacuolar H[+] ATPase 68kD subunit 1, isoform B [KO:K02145] [EC:3.6.3.14]
Dmel_CG17369  Vha55; vacuolar H[+]-ATPase 55kD subunit, isoform C [KO:K02147]
Dmel_CG8048  Vha44; vacuolar H[+] ATPase 44kD subunit, isoform F [KO:K02148]
Dmel_CG8310  Vha36-3; vacuolar H[+] ATPase 36kD subunit 3, isoform C [KO:K02149]
Dmel_CG8186  Vha36-1; vacuolar H[+] ATPase 36kD subunit 1 [KO:K02149]
Dmel_CG13167  Vha36-2; vacuolar H[+] ATPase 36kD subunit 2 [KO:K02149]
Dmel_CG1088  Vha26; vacuolar H[+]-ATPase 26kD subunit, isoform C [KO:K02150]
Dmel_CG8210  Vha14-1; vacuolar H[+] ATPase 14kD subunit 1 [KO:K02151]
Dmel_CG1076  Vha14-2; vacuolar H[+] ATPase 14kD subunit 2, isoform A [KO:K02151]
Dmel_CG15719  CG15719; uncharacterized protein, isoform D [KO:K02151]
Dmel_CG6213  Vha13; vacuolar H[+] ATPase 13kD subunit, isoform B [KO:K02152]
Dmel_CG7625  VhaM9.7-b; vacuolar H[+] ATPase M9.7 subunit b, isoform B [KO:K02153]
Dmel_CG1268  VhaM9.7-a; vacuolar H[+] ATPase M9.7 subunit a, isoform B [KO:K02153]
Dmel_CG11589  VhaM9.7-c; vacuolar H[+] ATPase M9.7 subunit c [KO:K02153]
Dmel_CG14909  VhaM9.7-d; vacuolar H[+] ATPase M9.7 subunit d [KO:K02153]
Dmel_CG12602  Vha100-5; vacuolar H[+] ATPase 100kD subunit 5, isoform B [KO:K02154]
Dmel_CG30329  Vha100-3; vacuolar H[+] ATPase 100kD subunit 3 [KO:K02154]
Dmel_CG1709  Vha100-1; vacuolar H[+] ATPase 100kD subunit 1, isoform I [KO:K02154]
Dmel_CG7678  Vha100-4; vacuolar H[+] ATPase 100kD subunit 4 [KO:K02154]
Dmel_CG18617  Vha100-2; vacuolar H[+] ATPase 100kD subunit 2, isoform B [KO:K02154]
Dmel_CG2934  VhaAC39-1; vacuolar H[+] ATPase AC39 subunit 1 [KO:K02146]
Dmel_CG4624  VhaAC39-2; vacuolar H[+] ATPase AC39 subunit 2 [KO:K02146]
Dmel_CG17332  VhaSFD; vacuolar H[+]-ATPase SFD subunit, isoform E [KO:K02144]
Dmel_CG3161  Vha16-1; vacuolar H[+] ATPase 16kD subunit 1, isoform A [KO:K02155]
Dmel_CG6737  Vha16-5; vacuolar H[+] ATPase 16kD subunit 5 [KO:K02155]
Dmel_CG9013  Vha16-4; vacuolar H[+] ATPase 16kD subunit 4 [KO:K02155]
Dmel_CG32090  Vha16-3; vacuolar H[+] ATPase 16kD subunit 3, isoform B [KO:K02155]
Dmel_CG32089  Vha16-2; vacuolar H[+] ATPase 16kD subunit 2 [KO:K02155]
Dmel_CG7007  VhaPPA1-1; vacuolar H[+] ATPase PPA1 subunit 1, isoform B [KO:K03661]
Dmel_CG7026  VhaPPA1-2; vacuolar H[+] ATPase PPA1 subunit 2 [KO:K03661]
Dmel_CG8029  VhaAC45; vacuolar H[+] ATPase AC45 accessory subunit, isoform B [KO:K03662]
Dmel_CG5915  Rab7; Rab7, isoform B [KO:K07897]
Dmel_CG7507  Dhc64C; dynein heavy chain 64C, isoform A [KO:K10413]
Dmel_CG15148  btv; beethoven [KO:K10414]
Dmel_CG18000  sw; short wing, isoform J [KO:K10415]
Dmel_CG32823  Sdic3; Sperm-specific dynein intermediate chain 3, isoform F [KO:K10415]
Dmel_CG33497  Sdic2; Sperm-specific dynein intermediate chain 2, isoform B [KO:K10415]
Dmel_CG33499  Sdic4; Sperm-specific dynein intermediate chain 4 [KO:K10415]
Dmel_CG9580  Sdic1; Sperm-specific dynein intermediate chain 1, isoform C [KO:K10415]
Dmel_CG46275  CG46275; uncharacterized protein [KO:K10415]
Dmel_CG46276  CG46276; uncharacterized protein [KO:K10415]
Dmel_CG46277  CG46277; uncharacterized protein [KO:K10415]
Dmel_CG1938  Dlic; dynein light intermediate chain, isoform A [KO:K10416]
Dmel_CG1913  alphaTub84B; alpha-Tubulin at 84B [KO:K07374]
Dmel_CG9476  alphaTub85E; alpha-Tubulin at 85E [KO:K07374]
Dmel_CG8308  alphaTub67C; alpha-Tubulin at 67C [KO:K07374]
Dmel_CG2512  alphaTub84D; alpha-Tubulin at 84D [KO:K07374]
Dmel_CG7794  CG7794 [KO:K07374]
Dmel_CG9277  betaTub56D; beta-Tubulin at 56D, isoform B [KO:K07375]
Dmel_CG32396  CG32396; uncharacterized protein [KO:K07375]
Dmel_CG3401  betaTub60D; beta-Tubulin at 60D, isoform A [KO:K07375]
Dmel_CG4869  betaTub97EF; beta-Tubulin at 97EF, isoform B [KO:K07375]
Dmel_CG9359  betaTub85D; beta-Tubulin at 85D [KO:K07375]
Dmel_CG3305  Lamp1; Lamp1 [KO:K06528]
Dmel_CG6355  fab1; fab1 kinase, isoform A [KO:K00921] [EC:2.7.1.150]
Dmel_CG6713  Nos; nitric oxide synthase, isoform A [KO:K13240] [EC:1.14.13.39]
Dmel_CG11459  CG11459; uncharacterized protein, isoform B [KO:K01365] [EC:3.4.22.15]
Dmel_CG6692  Cp1; cysteine proteinase-1, isoform C [KO:K01365] [EC:3.4.22.15]
Dmel_CG9539  Sec61alpha; Sec61 alpha subunit, isoform B [KO:K10956]
Dmel_CG10130  Sec61beta; Sec61 beta subunit [KO:K09481]
Dmel_CG8860  CG8860 [KO:K07342]
Dmel_CG14214  Sec61gamma; Sec61 gamma subunit, isoform B [KO:K07342]
Dmel_CG13426  CG13426; uncharacterized protein [KO:K07342]
Dmel_CG9429  Calr; calreticulin, isoform B [KO:K08057]
Dmel_CG11958  Cnx99A; calnexin 99A, isoform E [KO:K08054]
Dmel_CG9906  Cnx14D; calnexin 14D [KO:K08054]
Dmel_CG1924  CG1924 [KO:K08054]
Dmel_CG1560  mys; myospheroid, isoform C [KO:K05719]
Dmel_CG1762  Itgbn; integrin betanu subunit, isoform B [KO:K05719]
Dmel_CG11326  Tsp; thrombospondin, isoform F [KO:K04659]
Dmel_CG2248  Rac1; Rac1, isoform B [KO:K04392]
Dmel_CG9366  RhoL; Rho-like, isoform A [KO:K04392]
Dmel_CG5588  Mtl; Mig-2-like, isoform B [KO:K04392]
Dmel_CG8556  Rac2; Rac2, isoform B [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
ko04145   

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