KEGG   PATHWAY: dme04145Help
Entry
dme04145                    Pathway                                

Name
Phagosome - Drosophila melanogaster (fruit fly)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
dme04145

All organismsOrtholog table
Module
Sec61 complex [PATH:dme04145]
Other DBs
BSID: 
GO: 
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Syx7; Syntaxin 7 [KO:K08488]
Act57B; Actin 57B [KO:K05692]
Act42A; Actin 42A [KO:K05692]
Act87E; Actin 87E [KO:K05692]
Act5C; Actin 5C [KO:K05692]
Act88F; Actin 88F [KO:K05692]
Syx18; Syntaxin 18 [KO:K08492]
Sec22; CG7359 gene product from transcript CG7359-RB [KO:K08517]
Rab5; CG3664 gene product from transcript CG3664-RC [KO:K07889]
Pi3K59F; Phosphotidylinositol 3 kinase 59F [KO:K00914] [EC:2.7.1.137]
Hrs; Hepatocyte growth factor regulated tyrosine kinase substrate [KO:K12182]
Vha68-2; V-ATPase 69 kDa subunit 2 [KO:K02145] [EC:3.6.3.14]
Vha68-3; Vacuolar H[+] ATPase subunit 68-3 [KO:K02145] [EC:3.6.3.14]
Vha68-1; Vacuolar H[+] ATPase subunit 68-1 [KO:K02145] [EC:3.6.3.14]
Vha55; Vacuolar H[+]-ATPase 55kD B subunit [KO:K02147]
Vha44; Vacuolar H[+] ATPase 44kD C subunit [KO:K02148]
Vha36-3; Vacuolar H[+] ATPase subunit 36-3 [KO:K02149]
Vha36-1; Vacuolar H[+] ATPase subunit 36-1 [KO:K02149]
Vha36-2; Vacuolar H[+] ATPase subunit 36-2 [KO:K02149]
Vha26; Vacuolar H[+]-ATPase 26kD E subunit [KO:K02150]
Vha14-1; Vacuolar H[+] ATPase subunit 14-1 [KO:K02151]
Vha14-2; Vacuolar H[+] ATPase subunit 14-2 [KO:K02151]
Vha13; Vacuolar H[+] ATPase G-subunit [KO:K02152]
VhaM9.7-b; Vacuolar H[+] ATPase subunit M9.7-b [KO:K02153]
VhaM9.7-a; Vacuolar H[+] ATPase subunit M9.7-a [KO:K02153]
VhaM9.7-c; Vacuolar H[+] ATPase subunit M9.7-c [KO:K02153]
VhaM9.7-d; Vacuolar H[+] ATPase subunit M9.7-d [KO:K02153]
Vha100-5; Vacuolar H[+] ATPase subunit 100-5 [KO:K02154]
Vha100-3; Vacuolar H[+] ATPase subunit 100-3 [KO:K02154]
Vha100-1; Vacuolar H[+] ATPase subunit 100-1 [KO:K02154]
Vha100-4; Vacuolar H[+] ATPase subunit 100-4 [KO:K02154]
Vha100-2; Vacuolar H[+] ATPase subunit 100-2 [KO:K02154]
VhaAC39-1; Vacuolar H[+] ATPase subunit AC39-1 [KO:K02146]
VhaSFD; Vacuolar H[+]-ATPase SFD subunit [KO:K02144]
Vha16-1; Vacuolar H[+] ATPase subunit 16-1 [KO:K02155]
Vha16-5; Vacuolar H[+] ATPase subunit 16-5 [KO:K02155]
Vha16-4; Vacuolar H[+] ATPase subunit 16-4 [KO:K02155]
Vha16-3; Vacuolar H[+] ATPase subunit 16-3 [KO:K02155]
Vha16-2; Vacuolar H[+] ATPase subunit 16-2 [KO:K02155]
VhaPPA1-1; Vacuolar H[+] ATPase subunit PPA1-1 [KO:K03661]
VhaPPA1-2; Vacuolar H[+] ATPase subunit PPA1-2 [KO:K03661]
VhaAC45; Vacuolar H[+] ATPase accessory protein AC45 [KO:K03662]
Rab7; CG5915 gene product from transcript CG5915-RA [KO:K07897]
Dhc64C; Dynein heavy chain 64C [KO:K10413]
btv; beethoven [KO:K10414]
sw; short wing [KO:K10415]
Sdic3; Sperm-specific dynein intermediate chain 3 [KO:K10415]
Sdic2; Sperm-specific dynein intermediate chain 2 [KO:K10415]
Sdic4; Sperm-specific dynein intermediate chain 4 [KO:K10415]
Sdic1; Sperm-specific dynein intermediate chain 1 [KO:K10415]
Dlic; Dynein light intermediate chain [KO:K10416]
alphaTub84B; alpha-Tubulin at 84B [KO:K07374]
alphaTub85E; alpha-Tubulin at 85E [KO:K07374]
alphaTub67C; alpha-Tubulin at 67C [KO:K07374]
betaTub56D; beta-Tubulin at 56D [KO:K07375]
CG32396 gene product from transcript CG32396-RA; K07375 tubulin beta [KO:K07375]
betaTub60D; beta-Tubulin at 60D [KO:K07375]
betaTub97EF; beta-Tubulin at 97EF [KO:K07375]
betaTub85D; beta-Tubulin at 85D [KO:K07375]
Lamp1; CG3305 gene product from transcript CG3305-RA [KO:K06528]
fab1; CG6355 gene product from transcript CG6355-RA [KO:K00921] [EC:2.7.1.150]
CG11459 gene product from transcript CG11459-RA; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
Cp1; Cysteine proteinase-1 [KO:K01365] [EC:3.4.22.15]
Sec61alpha; CG9539 gene product from transcript CG9539-RA [KO:K10956]
Sec61beta; CG10130 gene product from transcript CG10130-RA [KO:K09481]
CG8860 gene product from transcript CG8860-RA; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
Sec61gamma; CG14214 gene product from transcript CG14214-RA [KO:K07342]
Crc; Calreticulin [KO:K08057]
Cnx99A; Calnexin 99A [KO:K08054]
Cnx14D; Calnexin 14D [KO:K08054]
mys; myospheroid [KO:K05719]
Tsp; Thrombospondin [KO:K04659]
Rac1; CG2248 gene product from transcript CG2248-RB [KO:K04392]
Mtl; Mig-2-like [KO:K04392]
Compound
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
KO pathway
 

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