KEGG   PATHWAY: dme04145Help
dme04145                    Pathway                                

Phagosome - Drosophila melanogaster (fruit fly)
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Cellular Processes; Transport and catabolism
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All organismsOrtholog table
Sec61 complex [PATH:dme04145]
Other DBs
Drosophila melanogaster (fruit fly) [GN:dme]
Syx7; syntaxin 7, isoform A [KO:K08488]
Act57B; actin 57B [KO:K05692]
Act42A; actin 42A [KO:K05692]
Act87E; actin 87E, isoform C [KO:K05692]
Act5C; actin 5C, isoform D [KO:K05692]
Act88F; actin 88F [KO:K05692]
Act79B; actin 79B, isoform B [KO:K05692]
Arp53D; Actin-related protein 53D [KO:K05692]
Syx18; syntaxin 18 [KO:K08492]
Sec22; secretory 22, isoform B [KO:K08517]
Rab5; Rab5, isoform G [KO:K07889]
Pi3K59F; phosphotidylinositol 3 kinase 59F [KO:K00914] [EC:]
Hrs; hepatocyte growth factor regulated tyrosine kinase substrate, isoform B [KO:K12182]
Vha68-2; vacuolar H[+] ATPase 68 kDa subunit 2, isoform D [KO:K02145] [EC:]
Vha68-3; vacuolar H[+] ATPase 68kD subunit 3 [KO:K02145] [EC:]
Vha68-1; vacuolar H[+] ATPase 68kD subunit 1, isoform B [KO:K02145] [EC:]
Vha55; vacuolar H[+]-ATPase 55kD subunit, isoform C [KO:K02147]
Vha44; vacuolar H[+] ATPase 44kD subunit, isoform F [KO:K02148]
Vha36-3; vacuolar H[+] ATPase 36kD subunit 3, isoform C [KO:K02149]
Vha36-1; vacuolar H[+] ATPase 36kD subunit 1 [KO:K02149]
Vha36-2; vacuolar H[+] ATPase 36kD subunit 2 [KO:K02149]
Vha26; vacuolar H[+]-ATPase 26kD subunit, isoform C [KO:K02150]
Vha14-1; vacuolar H[+] ATPase 14kD subunit 1 [KO:K02151]
Vha14-2; vacuolar H[+] ATPase 14kD subunit 2, isoform A [KO:K02151]
CG15719; uncharacterized protein, isoform D [KO:K02151]
Vha13; vacuolar H[+] ATPase 13kD subunit, isoform B [KO:K02152]
VhaM9.7-b; vacuolar H[+] ATPase M9.7 subunit b, isoform B [KO:K02153]
VhaM9.7-a; vacuolar H[+] ATPase M9.7 subunit a, isoform B [KO:K02153]
VhaM9.7-c; vacuolar H[+] ATPase M9.7 subunit c [KO:K02153]
VhaM9.7-d; vacuolar H[+] ATPase M9.7 subunit d [KO:K02153]
Vha100-5; vacuolar H[+] ATPase 100kD subunit 5, isoform B [KO:K02154]
Vha100-3; vacuolar H[+] ATPase 100kD subunit 3 [KO:K02154]
Vha100-1; vacuolar H[+] ATPase 100kD subunit 1, isoform I [KO:K02154]
Vha100-4; vacuolar H[+] ATPase 100kD subunit 4 [KO:K02154]
Vha100-2; vacuolar H[+] ATPase 100kD subunit 2, isoform B [KO:K02154]
VhaAC39-1; vacuolar H[+] ATPase AC39 subunit 1 [KO:K02146]
VhaAC39-2; vacuolar H[+] ATPase AC39 subunit 2 [KO:K02146]
VhaSFD; vacuolar H[+]-ATPase SFD subunit, isoform E [KO:K02144]
Vha16-1; vacuolar H[+] ATPase 16kD subunit 1, isoform A [KO:K02155]
Vha16-5; vacuolar H[+] ATPase 16kD subunit 5 [KO:K02155]
Vha16-4; vacuolar H[+] ATPase 16kD subunit 4 [KO:K02155]
Vha16-3; vacuolar H[+] ATPase 16kD subunit 3, isoform B [KO:K02155]
Vha16-2; vacuolar H[+] ATPase 16kD subunit 2 [KO:K02155]
VhaPPA1-1; vacuolar H[+] ATPase PPA1 subunit 1, isoform B [KO:K03661]
VhaPPA1-2; vacuolar H[+] ATPase PPA1 subunit 2 [KO:K03661]
VhaAC45; vacuolar H[+] ATPase AC45 accessory subunit, isoform B [KO:K03662]
Rab7; Rab7, isoform B [KO:K07897]
Dhc64C; dynein heavy chain 64C, isoform A [KO:K10413]
btv; beethoven [KO:K10414]
sw; short wing, isoform J [KO:K10415]
Sdic3; Sperm-specific dynein intermediate chain 3, isoform F [KO:K10415]
Sdic2; Sperm-specific dynein intermediate chain 2, isoform B [KO:K10415]
Sdic4; Sperm-specific dynein intermediate chain 4 [KO:K10415]
Sdic1; Sperm-specific dynein intermediate chain 1, isoform C [KO:K10415]
CG46275; uncharacterized protein [KO:K10415]
CG46276; uncharacterized protein [KO:K10415]
CG46277; uncharacterized protein [KO:K10415]
Dlic; dynein light intermediate chain, isoform A [KO:K10416]
alphaTub84B; alpha-Tubulin at 84B [KO:K07374]
alphaTub85E; alpha-Tubulin at 85E [KO:K07374]
alphaTub67C; alpha-Tubulin at 67C [KO:K07374]
alphaTub84D; alpha-Tubulin at 84D [KO:K07374]
CG7794 [KO:K07374]
betaTub56D; beta-Tubulin at 56D, isoform B [KO:K07375]
CG32396; uncharacterized protein [KO:K07375]
betaTub60D; beta-Tubulin at 60D, isoform A [KO:K07375]
betaTub97EF; beta-Tubulin at 97EF, isoform B [KO:K07375]
betaTub85D; beta-Tubulin at 85D [KO:K07375]
Lamp1; Lamp1 [KO:K06528]
fab1; fab1 kinase, isoform A [KO:K00921] [EC:]
Nos; nitric oxide synthase, isoform A [KO:K13240] [EC:]
CG11459; uncharacterized protein, isoform B [KO:K01365] [EC:]
Cp1; cysteine proteinase-1, isoform C [KO:K01365] [EC:]
Sec61alpha; Sec61 alpha subunit, isoform B [KO:K10956]
Sec61beta; Sec61 beta subunit [KO:K09481]
CG8860 [KO:K07342]
Sec61gamma; Sec61 gamma subunit, isoform B [KO:K07342]
CG13426; uncharacterized protein [KO:K07342]
Calr; calreticulin, isoform B [KO:K08057]
Cnx99A; calnexin 99A, isoform E [KO:K08054]
Cnx14D; calnexin 14D [KO:K08054]
CG1924 [KO:K08054]
mys; myospheroid, isoform C [KO:K05719]
Itgbn; integrin betanu subunit, isoform B [KO:K05719]
Tsp; thrombospondin, isoform F [KO:K04659]
Rac1; Rac1, isoform B [KO:K04392]
RhoL; Rho-like, isoform A [KO:K04392]
Mtl; Mig-2-like, isoform B [KO:K04392]
Rac2; Rac2, isoform B [KO:K04392]
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Stuart LM, Ezekowitz RA
Phagocytosis: elegant complexity.
Immunity 22:539-50 (2005)
Tjelle TE, Lovdal T, Berg T
Phagosome dynamics and function.
Dupuy AG, Caron E
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
J Cell Sci 121:1773-83 (2008)
Brumell JH, Grinstein S
Salmonella redirects phagosomal maturation.
Curr Opin Microbiol 7:78-84 (2004)
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
LAMP proteins are required for fusion of lysosomes with phagosomes.
EMBO J 26:313-24 (2007)
Luzio JP, Pryor PR, Bright NA
Lysosomes: fusion and function.
Nat Rev Mol Cell Biol 8:622-32 (2007)
Sumimoto H
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
FEBS J 275:3249-77 (2008)
KO pathway

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