KEGG   PATHWAY: dre00350
Entry
dre00350                    Pathway                                
Name
Tyrosine metabolism - Danio rerio (zebrafish)
Class
Metabolism; Amino acid metabolism
Pathway map
dre00350  Tyrosine metabolism
dre00350

Module
dre_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:dre00350]
dre_M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:dre00350]
dre_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:dre00350]
Other DBs
GO: 0006570
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
406330  got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
791730  got1l1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
335974  got2b; glutamic-oxaloacetic transaminase 2b, mitochondrial [KO:K14455] [EC:2.6.1.1]
406688  got2a; aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
561410  tat; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
337166  si:dkey-40g16.6; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
394142  hpda; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
445287  hpdb; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
259189  hgd; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
436754  gstz1; maleylacetoacetate isomerase isoform 2 [KO:K01800] [EC:5.2.1.2]
322372  fah; fumarylacetoacetase [KO:K01555] [EC:3.7.1.2]
30207  tyr; tyrosinase precursor [KO:K00505] [EC:1.14.18.1]
30384  th; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
414844  th2; tyrosine hydroxylase 2 [KO:K00501] [EC:1.14.16.2]
58074  dct; L-dopachrome tautomerase precursor [KO:K01827] [EC:5.3.3.12]
437022  tyrp1b; tyrosinase-related protein 1b precursor [KO:K00506] [EC:1.14.18.-]
100333145  tyrp1a; 5,6-dihydroxyindole-2-carboxylic acid oxidase isoform X1 [KO:K00506] [EC:1.14.18.-]
406651  ddc; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
30505  dbh; dopamine beta-hydroxylase [KO:K00503] [EC:1.14.17.1]
100332609  phenylethanolamine N-methyltransferase [KO:K00553] [EC:2.1.1.28]
565370  comtb; catechol O-methyltransferase B precursor [KO:K00545] [EC:2.1.1.6]
561372  comta; catechol O-methyltransferase A precursor [KO:K00545] [EC:2.1.1.6]
110437932  tomt; transmembrane O-methyltransferase homolog [KO:K00545] [EC:2.1.1.6]
404730  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
558050  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A isoform X2 [KO:K00274] [EC:1.4.3.4]
541429  aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
282559  aldh3b1; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
557008  aldh3b2; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
116517  adh5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
322482  adh8a; alcohol dehydrogenase 8a [KO:K00121] [EC:1.1.1.284 1.1.1.1]
393427  adh5l; Alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
402841  adh8b; alcohol dehydrogenase 8b [KO:K00121] [EC:1.1.1.284 1.1.1.1]
402939  zgc:77938; Alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
569363  tpo; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
100331172  epx; eosinophil peroxidase [KO:K00431] [EC:1.11.1.8]
570457  aox6; aldehyde oxidase 6 [KO:K00157] [EC:1.2.3.1]
64265  aox5; aldehyde oxidase 5 [KO:K00157] [EC:1.2.3.1]
553762  fahd1; acylpyruvase FAHD1, mitochondrial [KO:K01557] [EC:3.7.1.5]
751093  mif; macrophage migration inhibitory factor [KO:K07253] [EC:5.3.2.1]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
dre00020  Citrate cycle (TCA cycle)
dre00360  Phenylalanine metabolism
dre00400  Phenylalanine, tyrosine and tryptophan biosynthesis
dre00620  Pyruvate metabolism
dre00650  Butanoate metabolism
KO pathway
ko00350   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (39)   
   KEGG GENES (39)   
All databases (40)   

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