KEGG   PATHWAY: ecb04921
Entry
ecb04921                    Pathway                                
Name
Oxytocin signaling pathway - Equus caballus (horse)
Description
Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation.
Class
Organismal Systems; Endocrine system
Pathway map
ecb04921  Oxytocin signaling pathway
ecb04921

Organism
Equus caballus (horse) [GN:ecb]
Gene
111767489  OXT; oxytocin-neurophysin 1 [KO:K05243]
106781784  OXTR; oxytocin receptor [KO:K04229]
100063136  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100059469  NRAS; GTPase NRas [KO:K07828]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100071038  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100033889  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100071062  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
100071016  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
100071025  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
791253  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
100052849  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X8 [KO:K04463] [EC:2.7.12.2]
100073174  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
100067469  JUN; transcription factor AP-1 [KO:K04448]
100051632  FOS; proto-oncogene c-Fos [KO:K04379]
100065153  MEF2C; myocyte-specific enhancer factor 2C isoform X7 [KO:K04454]
102149114  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100051388  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100034090  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
100057437  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
100071830  RYR3; ryanodine receptor 3 [KO:K04963]
100068959  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100056810  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
100052953  KCNJ2; inward rectifier potassium channel 2 [KO:K04996]
100147042  KCNJ12; ATP-sensitive inward rectifier potassium channel 12 [KO:K05005]
100070031  KCNJ4; inward rectifier potassium channel 4 [KO:K04998]
100146909  KCNJ14; ATP-sensitive inward rectifier potassium channel 14 [KO:K05007]
100057315  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100051558  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100055407  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100051485  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100058387  EEF2K; eukaryotic elongation factor 2 kinase isoform X2 [KO:K08292] [EC:2.7.11.20]
100061437  EEF2; elongation factor 2 [KO:K03234]
100049924  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100051186  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100062861  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100034092  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100055054  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
100055971  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X3 [KO:K04863]
100051367  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X4 [KO:K04864]
100057916  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
100057533  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
100061645  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
100059197  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
100630648  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
100053535  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
100054570  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
100068407  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
106780860  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
100063388  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
100147407  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
100062937  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
100147684  CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
100052808  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100064557  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100053019  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100057133  CALML5; calmodulin-like protein 5 [KO:K02183]
100062752  CALM1; calmodulin-1 [KO:K02183]
100070422  calmodulin-like protein 3 [KO:K02183]
100071150  CALM3; calmodulin-3 [KO:K02183]
100629145  CALM2; calmodulin-2 [KO:K02183]
100064482  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100052798  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
100057357  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100067434  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100072862  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100061874  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102148270  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100065378  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100052657  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
100053856  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100054213  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100051067  RGS2; regulator of G-protein signaling 2 [KO:K18154]
100062432  RCAN1; calcipressin-1 isoform X2 [KO:K17901]
100058510  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
100034159  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100009710  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100034094  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
100034095  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
100034098  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
100034096  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
100034099  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
100056611  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
100056740  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X2 [KO:K08794] [EC:2.7.11.17]
100052300  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
100064138  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13 [KO:K04515] [EC:2.7.11.17]
100071654  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100072618  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6 [KO:K04515] [EC:2.7.11.17]
100146368  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100073192  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100063339  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100069573  GUCY1A1; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
100069474  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
100054420  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
100069551  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
100034201  NPPA; natriuretic peptides A preproprotein [KO:K12334]
100061959  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
100055416  NPR2; atrial natriuretic peptide receptor 2 isoform X2 [KO:K12324] [EC:4.6.1.2]
100056559  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100070482  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
100053698  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100050092  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
100059367  MYL6B; myosin light chain 6B [KO:K12751]
100052035  MYL6; myosin light polypeptide 6 isoform X2 [KO:K12751]
100055199  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100050139  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100033878  ACTB; actin, cytoplasmic 1 [KO:K05692]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100034056  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100072339  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100071067  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100058160  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100059233  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100060501  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100063928  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X15 [KO:K12329]
100056464  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100050675  neuroendocrine secretory protein 55 [KO:K04632]
100065563  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100071337  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100055961  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100054305  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100070498  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100051295  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
100058891  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100057796  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100066046  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100052828  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100064302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
100055673  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100062085  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100058238  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100051282  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100050532  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
100062810  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X3 [KO:K21290]
100062779  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100058732  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
100060665  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
100058166  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
100064621  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100064022  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C13050  Cyclic ADP-ribose
Reference
  Authors
Devost D, Wrzal P, Zingg HH
  Title
Oxytocin receptor signalling.
  Journal
Prog Brain Res 170:167-76 (2008)
DOI:10.1016/S0079-6123(08)00415-9
Reference
  Authors
Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G
  Title
REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.
  Journal
CNS Neurosci Ther 16:e138-56 (2010)
DOI:10.1111/j.1755-5949.2010.00185.x
Reference
  Authors
Gutkowska J, Jankowski M
  Title
Oxytocin revisited: its role in cardiovascular regulation.
  Journal
J Neuroendocrinol 24:599-608 (2012)
DOI:10.1111/j.1365-2826.2011.02235.x
Reference
  Authors
Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z
  Title
The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.
  Journal
Int J Endocrinol 2011:350546 (2011)
DOI:10.1155/2011/350546
Reference
  Authors
Tom N, Assinder SJ
  Title
Oxytocin in health and disease.
  Journal
Int J Biochem Cell Biol 42:202-5 (2010)
DOI:10.1016/j.biocel.2009.10.008
Reference
PMID:9575824
  Authors
Strakova Z, Copland JA, Lolait SJ, Soloff MS
  Title
ERK2 mediates oxytocin-stimulated PGE2 synthesis.
  Journal
Am J Physiol 274:E634-41 (1998)
DOI:10.1152/ajpendo.1998.274.4.E634
Reference
  Authors
Slater DM, Zervou S, Thornton S
  Title
Prostaglandins and prostanoid receptors in human pregnancy and parturition.
  Journal
J Soc Gynecol Investig 9:118-24 (2002)
Reference
  Authors
Shmygol A, Gullam J, Blanks A, Thornton S
  Title
Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility.
  Journal
Acta Pharmacol Sin 27:827-32 (2006)
DOI:10.1111/j.1745-7254.2006.00393.x
Reference
  Authors
Tahara M, Morishige K, Sawada K, Ikebuchi Y, Kawagishi R, Tasaka K, Murata Y
  Title
RhoA/Rho-kinase cascade is involved in oxytocin-induced rat uterine contraction.
  Journal
Endocrinology 143:920-9 (2002)
DOI:10.1210/endo.143.3.8696
Reference
  Authors
Slattery MM, Morrison JJ
  Title
Preterm delivery.
  Journal
Lancet 360:1489-97 (2002)
DOI:10.1016/S0140-6736(02)11476-0
Reference
  Authors
Pont JN, McArdle CA, Lopez Bernal A
  Title
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
  Journal
Mol Endocrinol 26:1743-56 (2012)
DOI:10.1210/me.2012-1057
Reference
PMID:9326674
  Authors
Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg HH, McCann SM
  Title
Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart.
  Journal
Proc Natl Acad Sci U S A 94:11704-9 (1997)
DOI:10.1073/pnas.94.21.11704
Reference
  Authors
Antunes-Rodrigues J, de Castro M, Elias LL, Valenca MM, McCann SM
  Title
Neuroendocrine control of body fluid metabolism.
  Journal
Physiol Rev 84:169-208 (2004)
DOI:10.1152/physrev.00017.2003
Reference
  Authors
Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH
  Title
Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.
  Journal
Regul Pept 151:71-4 (2008)
DOI:10.1016/j.regpep.2008.05.001
Reference
PMID:9219843
  Authors
Cassoni P, Sapino A, Fortunati N, Munaron L, Chini B, Bussolati G
  Title
Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A.
  Journal
Reference
  Authors
Busnelli M, Peverelli E, Mantovani G, Spada A, Chini B
  Title
Deciphering the specific role of G(alphai/o) isoforms: functional selective oxytocin ligands and somatostatin SST5 receptor mutants.
  Journal
Biochem Soc Trans 41:166-71 (2013)
DOI:10.1042/BST20120306
Reference
  Authors
Reversi A, Rimoldi V, Brambillasca S, Chini B
  Title
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
  Journal
Am J Physiol Regul Integr Comp Physiol 291:R861-9 (2006)
DOI:10.1152/ajpregu.00333.2006
Reference
  Authors
Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H
  Title
CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour.
  Journal
J Neuroendocrinol 22:380-92 (2010)
DOI:10.1111/j.1365-2826.2010.01970.x
Reference
  Authors
Higashida H, Yokoyama S, Kikuchi M, Munesue T
  Title
CD38 and its role in oxytocin secretion and social behavior.
  Journal
Horm Behav 61:351-8 (2012)
DOI:10.1016/j.yhbeh.2011.12.011
Reference
  Authors
Lopatina O, Inzhutova A, Salmina AB, Higashida H
  Title
The roles of oxytocin and CD38 in social or parental behaviors.
  Journal
Front Neurosci 6:182 (2012)
DOI:10.3389/fnins.2012.00182
Reference
  Authors
Guse AH
  Title
Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).
  Journal
FEBS J 272:4590-7 (2005)
DOI:10.1111/j.1742-4658.2005.04863.x
Related
pathway
ecb00590  Arachidonic acid metabolism
ecb04010  MAPK signaling pathway
ecb04020  Calcium signaling pathway
ecb04110  Cell cycle
KO pathway
ko04921   

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