KEGG   PATHWAY: ecb05152Help
Entry
ecb05152                    Pathway                                
Name
Tuberculosis - Equus caballus (horse)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Tuberculosis
ecb05152

All organismsOrtholog table
Organism
Equus caballus (horse) [GN:ecb]
Gene
TNF; tumor necrosis factor [KO:K03156]
TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
tumor necrosis factor receptor type 1-associated DEATH domain protein-like; K03171 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
protein FADD-like; K02373 FAS-associated death domain protein [KO:K02373]
CASP8; caspase 8, apoptosis-related cysteine peptidase [KO:K04398] [EC:3.4.22.61]
CASP10; caspase 10, apoptosis-related cysteine peptidase [KO:K04400] [EC:3.4.22.63]
CASP3; caspase 3, apoptosis-related cysteine peptidase [KO:K02187] [EC:3.4.22.56]
BH3-interacting domain death agonist-like; K04726 BH3 interacting domain death agonist [KO:K04726]
apoptosis regulator BAX-like; K02159 apoptosis regulator BAX [KO:K02159]
CYCS; cytochrome c, somatic [KO:K08738]
cytochrome c; K08738 cytochrome c [KO:K08738]
CASP9; caspase 9, apoptosis-related cysteine peptidase [KO:K04399] [EC:3.4.22.62]
APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
RAC-alpha serine/threonine-protein kinase-like; K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04456] [EC:2.7.11.1]
bcl2 antagonist of cell death-like; K02158 BCL2-antagonist of cell death [KO:K02158]
apoptosis regulator Bcl-2-like; K02161 apoptosis regulator BCL-2 [KO:K02161]
CAMK2G; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
CAMK2A; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
CAMK2D; calcium/calmodulin-dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
CAMK2B; calcium/calmodulin-dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
IFNG; interferon, gamma [KO:K04687]
IFNR1; interferon gamma receptor 1 [KO:K05132]
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
tyrosine-protein kinase JAK2-like; K04447 Janus kinase 2 [EC:2.7.10.2] [KO:K04447] [EC:2.7.10.2]
signal transducer and activator of transcription 1-like; K11220 signal transducer and activator of transcription 1 [KO:K11220]
CIITA; class II, major histocompatibility complex, transactivator [KO:K08060]
RFX5; regulatory factor X, 5 (influences HLA class II expression) [KO:K08061]
DNA-binding protein RFXANK-like; K08062 regulatory factor X-associated ankyrin-containing protein [KO:K08062]
NFYA; nuclear transcription factor Y, alpha [KO:K08064]
NFYB; nuclear transcription factor Y, beta [KO:K08065]
NFYC; nuclear transcription factor Y, gamma [KO:K08066]
CREB1; cAMP responsive element binding protein 1 [KO:K05870]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
DQA; MHC class II DQ-alpha [KO:K06752]
DRB; MHC class II DR-beta chain [KO:K06752]
DRB; MHC class II DR-beta chain [KO:K06752]
DRA; MHC class II DR alpha chain [KO:K06752]
DQB; MHC class II DQ-beta chain [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
DRB; MHC class II DR-beta chain [KO:K06752]
DQA; MHC class II DQ-alpha chain [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
MHC class II associated invariant chain; K06505 CD74 antigen [KO:K06505]
EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
IL10; interleukin 10 [KO:K05443]
interleukin-10 receptor subunit alpha-like; K05134 interleukin 10 receptor alpha [KO:K05134]
interleukin-10 receptor subunit beta-like; K05135 interleukin 10 receptor beta [KO:K05135]
cathepsin S-like; K01368 cathepsin S [EC:3.4.22.27] [KO:K01368] [EC:3.4.22.27]
c-type lectin domain family 4 member E-like; K10059 C-type lectin domain family 4, member E [KO:K10059]
FCER1G; Fc fragment of IgE, high affinity I, receptor for [KO:K07983]
c-type lectin domain family 7 member A-like; K10074 C-type lectin domain family 7, member A [KO:K10074]
SYK; spleen tyrosine kinase [KO:K05855] [EC:2.7.10.2]
CARD9; caspase recruitment domain family, member 9 [KO:K12794]
MALT1; mucosa associated lymphoid tissue lymphoma translocation gene 1 [KO:K07369] [EC:3.4.22.-]
b-cell lymphoma/leukemia 10-like; K07368 B-cell CLL/lymphoma 10 [KO:K07368]
nucleotide-binding oligomerization domain-containing protein 2-like; K10165 nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
RIPK2; receptor-interacting serine-threonine kinase 2 [KO:K08846] [EC:2.7.11.1]
HSPA9; heat shock 70kDa protein 9 (mortalin) [KO:K04043]
HSPD1; heat shock 60kDa protein 1 (chaperonin) [KO:K04077]
LBP; lipopolysaccharide binding protein [KO:K05399]
TLR2; toll-like receptor 2 [KO:K10159]
TLR1; toll-like receptor 1 [KO:K05398]
TLR6; toll-like receptor 6 [KO:K10169]
TLR4; toll-like receptor 4 [KO:K10160]
CD14; CD14 molecule [KO:K04391]
toll/interleukin-1 receptor domain-containing adapter protein-like; K05403 toll-interleukin 1 receptor (TIR) domain-containing adaptor protein [KO:K05403]
myeloid differentiation primary response protein MyD88-like; K04729 myeloid differentiation primary response protein MyD88 [KO:K04729]
IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
interleukin-1 receptor-associated kinase-like 2-like; K04731 interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1] [KO:K04731] [EC:2.7.11.1]
TNF receptor-associated factor 6-like; K03175 TNF receptor-associated factor 6 [KO:K03175]
nuclear factor NF-kappa-B p105 subunit-like; K02580 nuclear factor NF-kappa-B p105 subunit [KO:K02580]
transcription factor p65-like; K04735 transcription factor p65 [KO:K04735]
mitogen-activated protein kinase 11-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
mitogen-activated protein kinase 12-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
mitogen-activated protein kinase 1-like; K04371 extracellular signal-regulated kinase 1/2 [EC:2.7.11.24] [KO:K04371] [EC:2.7.11.24]
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
791246  
INOS; inducible nitric oxide synthase [KO:K13241] [EC:1.14.13.39]
IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [KO:K05406]
IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [KO:K05425]
IL18; interleukin 18 (interferon-gamma-inducing factor) [KO:K05482]
IL23A; interleukin 23, alpha subunit p19 [KO:K05426]
IL1A; interleukin 1, alpha [KO:K04383]
IL1B; interleukin 1, beta [KO:K04519]
interleukin-1 beta-like; K04519 interleukin 1 beta [KO:K04519]
interleukin-1 beta-like; K04519 interleukin 1 beta [KO:K04519]
CCAAT/enhancer-binding protein beta-like; K10048 CCAAT/enhancer binding protein (C/EBP), beta [KO:K10048]
CCAAT/enhancer-binding protein gamma-like; K10049 CCAAT/enhancer binding protein (C/EBP), gamma [KO:K10049]
TLR9; toll-like receptor 9 [KO:K10161]
interferon alpha-2-like; K05414 interferon alpha [KO:K05414]
interferon alpha-2-like; K05414 interferon alpha [KO:K05414]
interferon-alpha-4; K05414 interferon alpha [KO:K05414]
IFN-ALPHA2; interferon-alpha-2 [KO:K05414]
interferon alpha-1-like; K05414 interferon alpha [KO:K05414]
IFNB1; interferon, beta 1, fibroblast [KO:K05415]
interferon beta-like; K05415 interferon beta [KO:K05415]
interferon beta-like; K05415 interferon beta [KO:K05415]
CD209 antigen-like protein 2-like; K06563 CD209 antigen [KO:K06563]
CD209 antigen-like protein 2-like; K06563 CD209 antigen [KO:K06563]
rho guanine nucleotide exchange factor 12-like; K07532 Rho guanine nucleotide exchange factor 12 [KO:K07532]
transforming protein RhoA-like; K04513 Ras homolog gene family, member A [KO:K04513]
lymphocyte-specific protein 1-like; K14957 lymphocyte-specific protein 1 [KO:K14957]
PLK3; polo-like kinase 3 [KO:K08862] [EC:2.7.11.21]
KSR1; kinase suppressor of ras 1 [KO:K14958]
RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [KO:K04366] [EC:2.7.11.1]
RAF proto-oncogene serine/threonine-protein kinase-like; K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04366] [EC:2.7.11.1]
TGFB1; transforming growth factor, beta 1 [KO:K13375]
transforming growth factor beta-2-like; K13376 transforming growth factor beta-2 [KO:K13376]
TGFB3; transforming growth factor, beta 3 [KO:K13377]
CYP27B1; cytochrome P450, family 27, subfamily B, polypeptide 1 [KO:K07438] [EC:1.14.13.13]
VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor [KO:K08539]
ECATH-2; myeloid cathelicidin 2 [KO:K13916]
complement C3-like; K03990 complement component 3 [KO:K03990]
complement receptor type 1-like; K04011 complement component (3b/4b) receptor 1 [KO:K04011]
ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit) [KO:K06462]
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) [KO:K06461]
MRC1; mannose receptor, C type 1 [KO:K06560]
c-type mannose receptor 2-like; K06560 mannose receptor, C type [KO:K06560]
SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
calmodulin-like protein 5-like; K02183 calmodulin [KO:K02183]
calmodulin-like; K02183 calmodulin [KO:K02183]
calmodulin-like protein 3-like; K02183 calmodulin [KO:K02183]
calmodulin-like; K02183 calmodulin [KO:K02183]
calmodulin-like; K02183 calmodulin [KO:K02183]
PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
ras-related protein Rab-5A-like; K07887 Ras-related protein Rab-5A [KO:K07887]
ras-related protein Rab-5B-like; K07888 Ras-related protein Rab-5B [KO:K07888]
ras-related protein Rab-5C-like; K07889 Ras-related protein Rab-5C [KO:K07889]
EEA1; early endosome antigen 1 [KO:K12478]
ras-related protein Rab-7a-like; K07897 Ras-related protein Rab-7A [KO:K07897]
ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 [KO:K02154] [EC:3.6.3.14]
v-type proton ATPase 116 kDa subunit a isoform 3-like; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4 [KO:K02154] [EC:3.6.3.14]
ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a2 [KO:K02154] [EC:3.6.3.14]
ATP6V0D2; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 [KO:K02146] [EC:3.6.3.14]
ATP6V0D1; ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 [KO:K02146] [EC:3.6.3.14]
v-type proton ATPase subunit H-like; K02144 V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14] [KO:K02144] [EC:3.6.3.14]
ATP6AP1; ATPase, H+ transporting, lysosomal accessory protein 1 [KO:K03662] [EC:3.6.3.14]
v-type proton ATPase 16 kDa proteolipid subunit-like; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
v-type proton ATPase 21 kDa proteolipid subunit-like; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14] [KO:K03661] [EC:3.6.3.14]
LAMP2; lysosomal-associated membrane protein 2 [KO:K06528]
lysosome-associated membrane glycoprotein 1-like; K06528 lysosomal-associated membrane protein 1/2 [KO:K06528]
serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like; K04348 protein phosphatase 3, catalytic subunit [EC:3.1.3.16] [KO:K04348] [EC:3.1.3.16]
PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
calcineurin B homologous protein 2-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
calcineurin subunit B type 1-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
calcium-binding protein p22-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
CORO1A; coronin, actin binding protein, 1A [KO:K13882]
IGHC1; immunogobulin gamma 1 heavy chain constant region [KO:K06856]
uncharacterized LOC100060306; K06856 immunoglobulin heavy chain [KO:K06856]
ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
uncharacterized LOC100059796; K06498 high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
Compound
C00076  
Calcium cation
C00338  
Lipopolysaccharide
C01194  
1-Phosphatidyl-D-myo-inositol
C01561  
Calcidiol
C01673  
Calcitriol
C04465  
alpha,alpha'-Trehalose 6,6'-bismycolate
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  
Sphingosine 1-phosphate
C19190  
Trehalose-6,6'-dibehenate
Reference
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
Reference
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
Reference
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
Reference
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
Reference
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
Reference
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
Reference
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
Reference
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
Reference
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
Reference
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
Reference
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
Reference
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
Reference
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
Reference
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
Reference
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
Reference
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
KO pathway
 
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