KEGG   PATHWAY: ecb05152Help
ecb05152                    Pathway                                

Tuberculosis - Equus caballus (horse)
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Human Diseases; Infectious diseases
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All organismsOrtholog table
Equus caballus (horse) [GN:ecb]
TNF; tumor necrosis factor [KO:K03156]
TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
TRADD; TNFRSF1A associated via death domain [KO:K03171]
FADD; Fas associated via death domain [KO:K02373]
CASP8; caspase 8 [KO:K04398] [EC:]
CASP10; caspase 10 [KO:K04400] [EC:]
CASP3; caspase 3 [KO:K02187] [EC:]
BID; BH3 interacting domain death agonist [KO:K04726]
BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
CYCS; cytochrome c, somatic [KO:K08738]
CASP9; caspase 9 [KO:K04399] [EC:]
APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:]
AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:]
AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:]
BAD; BCL2 associated agonist of cell death [KO:K02158]
BCL2; BCL2, apoptosis regulator [KO:K02161]
CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:]
CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:]
CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:]
CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:]
IFNG; interferon gamma [KO:K04687]
IFNGR1; interferon gamma receptor 1 [KO:K05132]
IFNGR2; interferon gamma receptor 2 [KO:K05133]
JAK1; Janus kinase 1 [KO:K11217] [EC:]
JAK2; Janus kinase 2 [KO:K04447] [EC:]
STAT1; signal transducer and activator of transcription 1 [KO:K11220]
CIITA; class II major histocompatibility complex transactivator [KO:K08060]
RFX5; regulatory factor X5 [KO:K08061]
RFXANK; regulatory factor X associated ankyrin containing protein [KO:K08062]
RFXAP; regulatory factor X associated protein [KO:K08063]
NFYA; nuclear transcription factor Y subunit alpha [KO:K08064]
NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
NFYC; nuclear transcription factor Y subunit gamma [KO:K08066]
CREB1; cAMP responsive element binding protein 1 [KO:K05870]
HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
DQA; MHC class II DQ-alpha [KO:K06752]
DRB; MHC class II DR-beta chain [KO:K06752]
DRB; MHC class II DR-beta chain [KO:K06752]
DRA; MHC class II DR alpha chain [KO:K06752]
DQB; MHC class II DQ-beta chain [KO:K06752]
HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
DRB; MHC class II DR-beta chain [KO:K06752]
DQA; MHC class II DQ-alpha chain [KO:K06752]
Eqca-DQB3; HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
DQA; MHC class II DQ-alpha chain [KO:K06752]
HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
DQB; MHC class II DQ-beta chain [KO:K06752]
CD74; CD74 molecule [KO:K06505]
EP300; E1A binding protein p300 [KO:K04498] [EC:]
CREBBP; CREB binding protein [KO:K04498] [EC:]
IL10; interleukin 10 [KO:K05443]
IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
CTSS; cathepsin S [KO:K01368] [EC:]
CLEC4E; C-type lectin domain family 4 member E [KO:K10059]
FCER1G; Fc fragment of IgE receptor Ig [KO:K07983]
high affinity immunoglobulin epsilon receptor subunit gamma-like [KO:K07983]
CLEC7A; C-type lectin domain family 7 member A [KO:K10074]
SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:]
SYK; spleen associated tyrosine kinase [KO:K05855] [EC:]
CARD9; caspase recruitment domain family member 9 [KO:K12794]
MALT1; MALT1 paracaspase [KO:K07369] [EC:3.4.22.-]
BCL10; B-cell CLL/lymphoma 10 [KO:K07368]
NOD2; nucleotide binding oligomerization domain containing 2 [KO:K10165]
RIPK2; receptor interacting serine/threonine kinase 2 [KO:K08846] [EC:]
HSPA9; heat shock protein family A (Hsp70) member 9 [KO:K04043]
HSPD1; heat shock protein family D (Hsp60) member 1 [KO:K04077]
LBP; lipopolysaccharide binding protein [KO:K05399]
lipopolysaccharide-binding protein-like [KO:K05399]
TLR2; toll like receptor 2 [KO:K10159]
TLR1; toll like receptor 1 [KO:K05398]
TLR6; toll like receptor 6 [KO:K10169]
TLR4; toll like receptor 4 [KO:K10160]
CD14; CD14 molecule [KO:K04391]
TIRAP; TIR domain containing adaptor protein [KO:K05403]
MYD88; myeloid differentiation primary response 88 [KO:K04729]
IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:]
IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:]
IRAK2; interleukin 1 receptor associated kinase 2 [KO:K04731] [EC:]
TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:]
NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:]
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:]
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:]
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:]
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:]
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:]
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:]
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:]
NOS2; nitric oxide synthase 2 [KO:K13241] [EC:]
IL6; interleukin 6 [KO:K05405]
IL12A; interleukin 12A [KO:K05406]
IL12B; interleukin 12B [KO:K05425]
IL18; interleukin 18 [KO:K05482]
IL23A; interleukin 23 subunit alpha [KO:K05426]
IL1A; interleukin 1 alpha [KO:K04383]
IL1B; interleukin 1, beta [KO:K04519]
IL1B; interleukin 1 beta [KO:K04519]
CEBPB; CCAAT/enhancer binding protein beta [KO:K10048]
CEBPG; CCAAT/enhancer binding protein gamma [KO:K10049]
TLR9; toll like receptor 9 [KO:K10161]
interferon alpha-2-like [KO:K05414]
interferon alpha-2-like [KO:K05414]
interferon-alpha-4 [KO:K05414]
IFN-ALPHA2; interferon-alpha-2 [KO:K05414]
IFNa1; interferon alpha-1 [KO:K05414]
interferon alpha-4-like [KO:K05414]
IFNA1; interferon, alpha 1 [KO:K05414]
interferon alpha-2-like [KO:K05414]
interferon alpha-2-like [KO:K05414]
IFND1; interferon delta 1 [KO:K05414]
IFND2; interferon-delta 2 [KO:K05414]
interferon alpha-2-like [KO:K05414]
IFNB1; interferon, beta 1, fibroblast [KO:K05415]
interferon beta-like [KO:K05415]
interferon beta-like [KO:K05415]
IFNB1; interferon beta 1 [KO:K05415]
CD209 antigen-like protein E [KO:K06563]
CD209 antigen-like protein 2 [KO:K06563]
ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
RHOA; ras homolog family member A [KO:K04513]
LSP1; lymphocyte-specific protein 1 [KO:K14957]
PLK3; polo like kinase 3 [KO:K08862] [EC:]
KSR1; kinase suppressor of ras 1 [KO:K14958]
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:]
TGFB1; transforming growth factor beta 1 [KO:K13375]
TGFB2; transforming growth factor beta 2 [KO:K13376]
TGFB3; transforming growth factor beta 3 [KO:K13377]
CYP27B1; cytochrome P450, family 27, subfamily B, polypeptide 1 [KO:K07438] [EC:]
VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor [KO:K08539]
ECATH-2; myeloid cathelicidin 2 [KO:K13916]
ECATH-3; myeloid cathelicidin 3 [KO:K13916]
protegrin-2-like [KO:K13916]
complement C3-like [KO:K03990]
complement C3-like [KO:K03990]
CR1; complement C3b/C4b receptor 1 (Knops blood group) [KO:K04011]
ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit) [KO:K06462]
ITGB2; integrin beta-2 [KO:K06464]
integrin beta-2-like [KO:K06464]
ITGAM; integrin subunit alpha M [KO:K06461]
MRC1; mannose receptor C-type 1 [KO:K06560]
MRC2; mannose receptor C type 2 [KO:K06560]
PLA2R1; phospholipase A2 receptor 1 [KO:K06560]
SPHK2; sphingosine kinase 2 [KO:K04718] [EC:]
SPHK1; sphingosine kinase 1 [KO:K04718] [EC:]
CALML5; calmodulin like 5 [KO:K02183]
CALM1; calmodulin 1 [KO:K02183]
CALML3; calmodulin like 3 [KO:K02183]
CALM3; calmodulin 3 [KO:K02183]
CALM2; calmodulin 2 [KO:K02183]
CALML6; calmodulin like 6 [KO:K02183]
CALML4; calmodulin like 4 [KO:K02183]
PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:]
RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
EEA1; early endosome antigen 1 [KO:K12478]
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
TCIRG1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
ATP6AP1; ATPase H+ transporting accessory protein 1 [KO:K03662]
ATP6V0C; ATPase H+ transporting V0 subunit c [KO:K02155]
ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:]
PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:]
PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:]
PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
CORO1A; coronin 1A [KO:K13882]
IGHC1; immunogobulin gamma 1 heavy chain constant region [KO:K06856]
uncharacterized LOC100060306 [KO:K06856]
IGH; putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b [KO:K12560]
CD16; low affinity immunoglobulin gamma Fc region receptor III-B [KO:K06463]
Calcium cation
alpha,alpha'-Trehalose 6,6'-bismycolate
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Sphingosine 1-phosphate
Saiga H, Shimada Y, Takeda K
Innate immune effectors in mycobacterial infection.
Clin Dev Immunol 2011:347594 (2011)
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
The immunology of tuberculosis: from bench to bedside.
Respirology 15:433-50 (2010)
van Crevel R, Ottenhoff TH, van der Meer JW
Innate immunity to Mycobacterium tuberculosis.
Clin Microbiol Rev 15:294-309 (2002)
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
Role of C-type lectins in mycobacterial infections.
Curr Drug Targets 9:102-12 (2008)
Jo EK, Yang CS, Choi CH, Harding CV
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
Cell Microbiol 9:1087-98 (2007)
Marakalala MJ, Graham LM, Brown GD
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
Clin Dev Immunol 2010:567571 (2010)
Koul A, Herget T, Klebl B, Ullrich A
Interplay between mycobacteria and host signalling pathways.
Nat Rev Microbiol 2:189-202 (2004)
Torrelles JB, Schlesinger LS
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
Tuberculosis (Edinb) 90:84-93 (2010)
Briken V, Porcelli SA, Besra GS, Kremer L
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
Mol Microbiol 53:391-403 (2004)
Baena A, Porcelli SA
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
Tissue Antigens 74:189-204 (2009)
Flannagan RS, Cosio G, Grinstein S
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
Nat Rev Microbiol 7:355-66 (2009)
Pieters J
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
Cell Host Microbe 3:399-407 (2008)
Scherr N, Jayachandran R, Mueller P, Pieters J
Interference of Mycobacterium tuberculosis with macrophage responses.
Indian J Exp Biol 47:401-6 (2009)
Reith W, LeibundGut-Landmann S, Waldburger JM.
Regulation of MHC class II gene expression by the class II transactivator.
Nat Rev Immunol 5:793-806 (2005)
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
J Immunol 179:3463-71 (2007)
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
Mycobacterium tuberculosis prevents inflammasome activation.
Cell Host Microbe 3:224-32 (2008)
Shtrichman R, Samuel CE
The role of gamma interferon in antimicrobial immunity.
Curr Opin Microbiol 4:251-9 (2001)
KO pathway

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