KEGG   PATHWAY: ecb05152Help
Entry
ecb05152                    Pathway                                

Name
Tuberculosis - Equus caballus (horse)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Tuberculosis
ecb05152

All organismsOrtholog table
Organism
Equus caballus (horse) [GN:ecb]
Gene
TNF; tumor necrosis factor [KO:K03156]
TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
TRADD; TNFRSF1A associated via death domain [KO:K03171]
FADD; Fas associated via death domain [KO:K02373]
CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
CASP10; caspase 10 [KO:K04400] [EC:3.4.22.63]
CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
BID; BH3 interacting domain death agonist [KO:K04726]
BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
CYCS; cytochrome c, somatic [KO:K08738]
CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
BAD; BCL2 associated agonist of cell death [KO:K02158]
BCL2; BCL2, apoptosis regulator [KO:K02161]
CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
IFNG; interferon gamma [KO:K04687]
IFNGR1; interferon gamma receptor 1 [KO:K05132]
IFNGR2; interferon gamma receptor 2 [KO:K05133]
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
STAT1; signal transducer and activator of transcription 1 [KO:K11220]
CIITA; class II major histocompatibility complex transactivator [KO:K08060]
RFX5; regulatory factor X5 [KO:K08061]
RFXANK; regulatory factor X associated ankyrin containing protein [KO:K08062]
RFXAP; regulatory factor X associated protein [KO:K08063]
NFYA; nuclear transcription factor Y subunit alpha [KO:K08064]
NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
NFYC; nuclear transcription factor Y subunit gamma [KO:K08066]
CREB1; cAMP responsive element binding protein 1 [KO:K05870]
HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
DQA; MHC class II DQ-alpha [KO:K06752]
DRB; MHC class II DR-beta chain [KO:K06752]
DRB; MHC class II DR-beta chain [KO:K06752]
DRA; MHC class II DR alpha chain [KO:K06752]
DQB; MHC class II DQ-beta chain [KO:K06752]
HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
DRB; MHC class II DR-beta chain [KO:K06752]
DQA; MHC class II DQ-alpha chain [KO:K06752]
Eqca-DQB3; HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
DQA; MHC class II DQ-alpha chain [KO:K06752]
HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
DQB; MHC class II DQ-beta chain [KO:K06752]
CD74; CD74 molecule [KO:K06505]
EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
IL10; interleukin 10 [KO:K05443]
IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
CLEC4E; C-type lectin domain family 4 member E [KO:K10059]
FCER1G; Fc fragment of IgE receptor Ig [KO:K07983]
high affinity immunoglobulin epsilon receptor subunit gamma-like [KO:K07983]
CLEC7A; C-type lectin domain family 7 member A [KO:K10074]
SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
CARD9; caspase recruitment domain family member 9 [KO:K12794]
MALT1; MALT1 paracaspase [KO:K07369] [EC:3.4.22.-]
BCL10; B-cell CLL/lymphoma 10 [KO:K07368]
NOD2; nucleotide binding oligomerization domain containing 2 [KO:K10165]
RIPK2; receptor interacting serine/threonine kinase 2 [KO:K08846] [EC:2.7.11.1]
HSPA9; heat shock protein family A (Hsp70) member 9 [KO:K04043]
HSPD1; heat shock protein family D (Hsp60) member 1 [KO:K04077]
LBP; lipopolysaccharide binding protein [KO:K05399]
lipopolysaccharide-binding protein-like [KO:K05399]
TLR2; toll like receptor 2 [KO:K10159]
TLR1; toll like receptor 1 [KO:K05398]
TLR6; toll like receptor 6 [KO:K10169]
TLR4; toll like receptor 4 [KO:K10160]
CD14; CD14 molecule [KO:K04391]
TIRAP; TIR domain containing adaptor protein [KO:K05403]
MYD88; myeloid differentiation primary response 88 [KO:K04729]
IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
IRAK2; interleukin 1 receptor associated kinase 2 [KO:K04731] [EC:2.7.11.1]
TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
791246  
NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
IL6; interleukin 6 [KO:K05405]
IL12A; interleukin 12A [KO:K05406]
IL12B; interleukin 12B [KO:K05425]
IL18; interleukin 18 [KO:K05482]
IL23A; interleukin 23 subunit alpha [KO:K05426]
IL1A; interleukin 1 alpha [KO:K04383]
IL1B; interleukin 1, beta [KO:K04519]
IL1B; interleukin 1 beta [KO:K04519]
CEBPB; CCAAT/enhancer binding protein beta [KO:K10048]
CEBPG; CCAAT/enhancer binding protein gamma [KO:K10049]
TLR9; toll like receptor 9 [KO:K10161]
interferon alpha-2-like [KO:K05414]
interferon alpha-2-like [KO:K05414]
interferon-alpha-4 [KO:K05414]
IFN-ALPHA2; interferon-alpha-2 [KO:K05414]
IFNa1; interferon alpha-1 [KO:K05414]
interferon alpha-4-like [KO:K05414]
IFNA1; interferon, alpha 1 [KO:K05414]
interferon alpha-2-like [KO:K05414]
interferon alpha-2-like [KO:K05414]
IFND1; interferon delta 1 [KO:K05414]
IFND2; interferon-delta 2 [KO:K05414]
interferon alpha-2-like [KO:K05414]
IFNB1; interferon, beta 1, fibroblast [KO:K05415]
interferon beta-like [KO:K05415]
interferon beta-like [KO:K05415]
IFNB1; interferon beta 1 [KO:K05415]
CD209 antigen-like protein E [KO:K06563]
CD209 antigen-like protein 2 [KO:K06563]
ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
RHOA; ras homolog family member A [KO:K04513]
LSP1; lymphocyte-specific protein 1 [KO:K14957]
PLK3; polo like kinase 3 [KO:K08862] [EC:2.7.11.21]
KSR1; kinase suppressor of ras 1 [KO:K14958]
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
TGFB1; transforming growth factor beta 1 [KO:K13375]
TGFB2; transforming growth factor beta 2 [KO:K13376]
TGFB3; transforming growth factor beta 3 [KO:K13377]
CYP27B1; cytochrome P450, family 27, subfamily B, polypeptide 1 [KO:K07438] [EC:1.14.15.18]
VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor [KO:K08539]
ECATH-2; myeloid cathelicidin 2 [KO:K13916]
ECATH-3; myeloid cathelicidin 3 [KO:K13916]
protegrin-2-like [KO:K13916]
complement C3-like [KO:K03990]
complement C3-like [KO:K03990]
CR1; complement C3b/C4b receptor 1 (Knops blood group) [KO:K04011]
ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit) [KO:K06462]
ITGB2; integrin beta-2 [KO:K06464]
integrin beta-2-like [KO:K06464]
ITGAM; integrin subunit alpha M [KO:K06461]
MRC1; mannose receptor C-type 1 [KO:K06560]
MRC2; mannose receptor C type 2 [KO:K06560]
PLA2R1; phospholipase A2 receptor 1 [KO:K06560]
SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
CALML5; calmodulin like 5 [KO:K02183]
CALM1; calmodulin 1 [KO:K02183]
CALML3; calmodulin like 3 [KO:K02183]
CALM3; calmodulin 3 [KO:K02183]
CALM2; calmodulin 2 [KO:K02183]
CALML6; calmodulin like 6 [KO:K02183]
CALML4; calmodulin like 4 [KO:K02183]
PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
RAB5B; RAB5B, member RAS oncogene family [KO:K07888]
RAB5C; RAB5C, member RAS oncogene family [KO:K07889]
EEA1; early endosome antigen 1 [KO:K12478]
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
TCIRG1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
ATP6AP1; ATPase H+ transporting accessory protein 1 [KO:K03662]
ATP6V0C; ATPase H+ transporting V0 subunit c [KO:K02155]
ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
CORO1A; coronin 1A [KO:K13882]
IGHC1; immunogobulin gamma 1 heavy chain constant region [KO:K06856]
uncharacterized LOC100060306 [KO:K06856]
IGH; putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b [KO:K12560]
CD16; low affinity immunoglobulin gamma Fc region receptor III-B [KO:K06463]
Compound
C00076  
Calcium cation
C00338  
Lipopolysaccharide
C01194  
1-Phosphatidyl-D-myo-inositol
C01561  
Calcidiol
C01673  
Calcitriol
C04465  
alpha,alpha'-Trehalose 6,6'-bismycolate
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  
Sphingosine 1-phosphate
C19190  
Trehalose-6,6'-dibehenate
Reference
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
KO pathway
 
DBGET integrated database retrieval system