KEGG   PATHWAY: ecc00260
Entry
ecc00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Escherichia coli O6:K2:H1 CFT073 (UPEC)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ecc00260  Glycine, serine and threonine metabolism
ecc00260

Module
ecc_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ecc00260]
ecc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ecc00260]
ecc_M00555  Betaine biosynthesis, choline => betaine [PATH:ecc00260]
ecc_M00621  Glycine cleavage system [PATH:ecc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Escherichia coli O6:K2:H1 CFT073 (UPEC) [GN:ecc]
Gene
c4990  lysC; Lysine-sensitive aspartokinase III [KO:K00928] [EC:2.7.2.4]
c0003  thrA; Aspartokinase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
c4893  metL; AKII-HDII protein [KO:K12525] [EC:2.7.2.4 1.1.1.3]
c4220  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
c0004  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
c0005  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
c1003  ybjU; Low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
c3073  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
c1295  ycdW; Putative 2-hydroxyacid dehydrogenase ycdW [KO:K12972] [EC:1.1.1.79 1.1.1.81]
c4372  yiaE; 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
c3879  yhaD; Glycerate kinase 2 [KO:K00865] [EC:2.7.1.165]
c0628  ybbZ; Glycerate kinase 1 [KO:K00865] [EC:2.7.1.165]
c0831  gpmA; Phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
c5482  gpmB; Probable phosphoglycerate mutase 2 [KO:K15634] [EC:5.4.2.11]
c4438  yibO; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
c3405  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
c3494  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
c1045  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
c5473  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
c1965  ydfG; Probable oxidoreductase ydfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
c4444  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
c4443  tdh; Threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
c3483  gcvP; Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
c3485  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
c5035  Putative 2-oxoglutarate dehydrogenase [KO:K00382] [EC:1.8.1.4]
c0145  lpdA; Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
c3484  gcvH; Glycine cleavage system H protein [KO:K02437]
c3110  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
c0431  betA; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
c0432  betB; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
c3365  sdaB; L-serine dehydratase 2 [KO:K01752] [EC:4.3.1.17]
c3870  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
c2219  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
c3875  tdcB; Threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
c4694  ilvA; Threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
c2901  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
c3437  ygeA; Hypothetical protein ygeA [KO:K25316] [EC:5.1.1.10]
c1725  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
c1726  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ecc00010  Glycolysis / Gluconeogenesis
ecc00020  Citrate cycle (TCA cycle)
ecc00230  Purine metabolism
ecc00250  Alanine, aspartate and glutamate metabolism
ecc00270  Cysteine and methionine metabolism
ecc00290  Valine, leucine and isoleucine biosynthesis
ecc00300  Lysine biosynthesis
ecc00330  Arginine and proline metabolism
ecc00460  Cyanoamino acid metabolism
ecc00470  D-Amino acid metabolism
ecc00564  Glycerophospholipid metabolism
ecc00600  Sphingolipid metabolism
ecc00620  Pyruvate metabolism
ecc00630  Glyoxylate and dicarboxylate metabolism
ecc00640  Propanoate metabolism
ecc00680  Methane metabolism
ecc00860  Porphyrin metabolism
ecc00920  Sulfur metabolism
KO pathway
ko00260   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (39)   
   KEGG GENES (39)   
All databases (40)   

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