KEGG   PATHWAY: epr03440
Entry
epr03440                    Pathway                                
Name
Homologous recombination - Erwinia pyrifoliae DSM 12163
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
epr03440  Homologous recombination
epr03440

Other DBs
GO: 0000724
Organism
Erwinia pyrifoliae DSM 12163 [GN:epr]
Gene
EPYR_03166  recJ; Single-stranded-DNA-specific exonuclease recJ [KO:K07462] [EC:3.1.-.-]
EPYR_03545  ssb; Single-stranded DNA-binding protein (Helix-destabilizing protein) [KO:K03111]
EPYR_03285  ssb; Single-stranded DNA-binding protein (Helix-destabilizing protein) [KO:K03111]
EPYR_03953  recF; DNA replication and repair protein recF [KO:K03629]
EPYR_01066  recO; DNA repair protein recO (Recombination protein O) [KO:K03584]
EPYR_02806  recR; Recombination protein recR [KO:K06187]
EPYR_03033  recA; Recombinase A [KO:K03553]
EPYR_00024  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
EPYR_01685  ruvA; Holliday junction ATP-dependent DNA helicase ruvA [KO:K03550]
EPYR_01686  ruvB; Holliday junction ATP-dependent DNA helicase ruvB [KO:K03551] [EC:5.6.2.4]
EPYR_01684  ruvC; Holliday junction nuclease [KO:K01159] [EC:3.1.21.10]
EPYR_00040  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
EPYR_03100  recB; DNA helicase, ATP-dependent dsDNA/ssDNA exonuclease V subunit, ssDNA endonuclease [KO:K03582] [EC:3.1.11.5]
EPYR_03102  recC; Exodeoxyribonuclease V gamma chain (Exodeoxyribonuclease V 125 kDa polypeptide) [KO:K03583] [EC:3.1.11.5]
EPYR_03099  recD; exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
EPYR_00933  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
EPYR_03954  dnaN; DNA polymerase III, beta-subunit [KO:K02338] [EC:2.7.7.7]
EPYR_02808  dnaX; DNA polymerase III, tau and gamma subunits [KO:K02343] [EC:2.7.7.7]
EPYR_02688  holA; holA [KO:K02340] [EC:2.7.7.7]
EPYR_02305  holB; DNA polymerase III, delta' subunit [KO:K02341] [EC:2.7.7.7]
EPYR_02996  dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
EPYR_01702  holE; DNA polymerase III, theta subunit [KO:K02345] [EC:2.7.7.7]
EPYR_00400  holC; DNA polymerase III chi subunit, HolC [KO:K02339] [EC:2.7.7.7]
EPYR_00146  priA; Primosomal protein N' [KO:K04066] [EC:5.6.2.4]
EPYR_00535  priB; Nucleic acid-binding, OB-fold, Single-strand binding protein family [KO:K02686]
EPYR_02811  priC; Primosomal replication protein priC [KO:K04067]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG GENES (26)   
All databases (27)   

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