KEGG   PATHWAY: fca04510
Entry
fca04510                    Pathway                                
Name
Focal adhesion - Felis catus (domestic cat)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
fca04510  Focal adhesion
fca04510

Other DBs
GO: 0005925
Organism
Felis catus (domestic cat) [GN:fca]
Gene
101092216  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101089428  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101087493  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
101089498  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
101093002  COL4A5; collagen alpha-5(IV) chain isoform X4 [KO:K06237]
101096282  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101096030  COL4A1; collagen alpha-1(IV) chain isoform X2 [KO:K06237]
101087512  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
101091469  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
101092138  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
101096163  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
101081156  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101095676  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
101081323  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
101100658  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
101086148  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101090632  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
111559739  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101083299  LAMA1; laminin subunit alpha-1 isoform X3 [KO:K05637]
101092612  LAMA2; laminin subunit alpha-2 isoform X7 [KO:K05637]
101100161  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
101083923  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
101086907  LAMA4; laminin subunit alpha-4 isoform X2 [KO:K06241]
101080367  LAMB1; laminin subunit beta-1 [KO:K05636]
101082047  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
101088641  LAMB3; laminin subunit beta-3 [KO:K06244]
101101552  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
101090321  LAMC1; laminin subunit gamma-1 [KO:K05635]
101089571  LAMC2; laminin subunit gamma-2 [KO:K06246]
101098499  LAMC3; laminin subunit gamma-3 [KO:K06247]
111557728  CHAD; chondroadherin [KO:K06248]
101085703  RELN; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
101092689  THBS1; thrombospondin-1 [KO:K16857]
101087199  THBS4; thrombospondin-4 [KO:K04659]
101088820  COMP; cartilage oligomeric matrix protein [KO:K04659]
101100567  THBS2; thrombospondin-2 [KO:K04659]
101093580  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101081746  FN1; fibronectin isoform X1 [KO:K05717]
101094264  SPP1; osteopontin isoform X1 [KO:K06250]
101100765  VTN; vitronectin [KO:K06251]
101096629  TNR; tenascin-R [KO:K06252]
101083629  TNC; tenascin isoform X2 [KO:K06252]
101097863  TNN; tenascin-N isoform X1 [KO:K06252]
101101563  TNXB; tenascin-X isoform X1 [KO:K06252]
493760  VWF; von Willebrand factor precursor [KO:K03900]
101095252  IBSP; bone sialoprotein 2 [KO:K06253]
101089743  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
101090237  ITGA2; integrin alpha-2 [KO:K06481]
101100930  ITGA2B; integrin alpha-IIb [KO:K06476]
101093156  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101081745  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
101093870  ITGA5; integrin alpha-5 [KO:K06484]
101092454  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101089783  ITGA7; integrin alpha-7 isoform X4 [KO:K06583]
101100222  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
101090796  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
101097997  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
101093524  ITGA11; integrin alpha-11 [KO:K06587]
101085820  ITGAV; integrin alpha-V [KO:K06487]
751821  ITGB1; integrin beta-1 precursor [KO:K05719]
101092159  ITGB3; integrin beta-3 [KO:K06493]
101080415  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
101101247  ITGB5; integrin beta-5 [KO:K06588]
101094363  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101099982  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
101087724  ITGB8; integrin beta-8 [KO:K06591]
101085593  EMP2; epithelial membrane protein 2 [KO:K26256]
101087287  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
100135774  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
101088742  PDGFC; platelet-derived growth factor C [KO:K05450]
101084984  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
493978  EGF; pro-epidermal growth factor precursor [KO:K04357]
101101237  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
493845  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
101092465  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101095904  PGF; placenta growth factor isoform X8 [KO:K16859]
493703  VEGFD; vascular endothelial growth factor D [KO:K05449]
101085368  VEGFC; vascular endothelial growth factor C [KO:K05449]
493705  HGF; hepatocyte growth factor precursor [KO:K05460]
101090765  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101084600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100500937  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101090260  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101088292  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
101094727  FLT4; vascular endothelial growth factor receptor 3 isoform X3 [KO:K05097] [EC:2.7.10.1]
493669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
751824  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
101094110  EMP1; epithelial membrane protein 1 [KO:K26255]
101100378  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101089912  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101088248  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
101084011  RHOA; transforming protein RhoA [KO:K04513]
101101441  DIAPH1; protein diaphanous homolog 1 isoform X4 [KO:K05740]
101092552  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101094501  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101101169  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
493974  MYL5; myosin light chain 5 [KO:K12753]
101095326  MYL7; myosin regulatory light chain 2, atrial isoform isoform X2 [KO:K12754]
101097882  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101082365  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
101085247  myosin regulatory light chain 12B [KO:K12757]
101085837  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
101094812  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101100922  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101092932  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109492306  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101089624  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
101098766  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X6 [KO:K12329]
101092809  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
101088408  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
101091744  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101095813  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101098154  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
101081420  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X5 [KO:K00889] [EC:2.7.1.68]
101097791  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5 [KO:K00889] [EC:2.7.1.68]
100144392  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101098507  ACTB; actin, cytoplasmic 1 [KO:K05692]
101092941  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
101083231  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
101093978  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101097986  ACTN1; alpha-actinin-1 isoform X6 [KO:K05699]
101092367  TLN2; talin-2 isoform X2 [KO:K06271]
101093057  TLN1; talin-1 isoform X3 [KO:K06271]
101082637  FLNA; filamin-A isoform X1 [KO:K04437]
101098612  FLNB; filamin-B isoform X4 [KO:K27392]
101080922  PXN; paxillin isoform X2 [KO:K05760]
101092790  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
101099953  ZYX; zyxin [KO:K06273]
101094805  VASP; vasodilator-stimulated phosphoprotein isoform X3 [KO:K06274]
101089215  VCL; vinculin isoform X2 [KO:K05700]
101087850  PARVB; beta-parvin isoform X2 [KO:K06275]
101091474  PARVA; alpha-parvin [KO:K06275]
101088092  PARVG; gamma-parvin isoform X1 [KO:K06275]
101101686  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101081660  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101097342  CTNNB1; catenin beta-1 [KO:K02105]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101088970  PRKCB; protein kinase C beta type isoform X3 [KO:K19662] [EC:2.7.11.13]
101082196  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101095952  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101093286  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101091813  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101097212  VAV1; proto-oncogene vav isoform X3 [KO:K05730]
101087417  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101086264  VAV2; guanine nucleotide exchange factor VAV2 isoform X7 [KO:K05730]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101096744  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101080496  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101087171  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101082845  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101092248  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101098348  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
101091011  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101091201  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101094772  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101082454  cell division control protein 42 homolog [KO:K04393]
101096625  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
101084908  CRKL; crk-like protein isoform X1 [KO:K04438]
101086100  CRK; adapter molecule crk isoform X1 [KO:K04438]
101084320  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
101099507  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
101094942  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101095993  RAP1B; ras-related protein Rap-1b [KO:K07836]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101097261  JUN; transcription factor AP-1 [KO:K04448]
101092346  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
493668  CAV1; caveolin-1 [KO:K06278]
493667  CAV2; caveolin-2 [KO:K12958]
101081453  CAV3; caveolin-3 [KO:K12959]
101085720  FYN; LOW QUALITY PROTEIN: tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
101092911  SHC1; SHC-transforming protein 1 isoform X3 [KO:K06279]
101083489  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
101095865  SHC3; SHC-transforming protein 3 [KO:K17448]
101099050  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
101099916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101098862  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101088847  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101095156  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
100037407  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101090950  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101101311  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101083444  baculoviral IAP repeat-containing protein 3 [KO:K16060]
101101663  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
101090594  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
493934  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
fca04010  MAPK signaling pathway
fca04060  Cytokine-cytokine receptor interaction
fca04070  Phosphatidylinositol signaling system
fca04110  Cell cycle
fca04151  PI3K-Akt signaling pathway
fca04310  Wnt signaling pathway
fca04512  ECM-receptor interaction
fca04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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Genome (1)   
   KEGG GENOME (1)   
Gene (201)   
   KEGG GENES (201)   
All databases (202)   

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