KEGG   PATHWAY: fli03440
Entry
fli03440                    Pathway                                
Name
Homologous recombination - Bernardetia litoralis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
fli03440  Homologous recombination
fli03440

Other DBs
GO: 0000724
Organism
Bernardetia litoralis [GN:fli]
Gene
Fleli_1292  exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Fleli_2089  single stranded DNA-binding protein [KO:K03111]
Fleli_0253  single stranded DNA-binding protein [KO:K03111]
Fleli_2327  single stranded DNA-binding protein [KO:K03111]
Fleli_0469  DNA replication and repair protein RecF [KO:K03629]
Fleli_3768  DNA replication and repair protein RecO [KO:K03584]
Fleli_2085  DNA replication and repair protein RecR [KO:K06187]
Fleli_1089  protein RecA [KO:K03553]
Fleli_2405  Holliday junction DNA helicase subunit RuvA [KO:K03550]
Fleli_2839  Holliday junction DNA helicase subunit RuvB [KO:K03551] [EC:5.6.2.4]
Fleli_0085  Holliday junction endonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Fleli_3135  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Fleli_1691  DNA-directed DNA polymerase III PolC [KO:K02337] [EC:2.7.7.7]
Fleli_2921  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Fleli_3859  DNA polymerase III, subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
Fleli_3685  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Fleli_2533  DNA polymerase III, gamma/tau subunit [KO:K02341] [EC:2.7.7.7]
Fleli_0168  DNA polymerase III epsilon subunit-like 3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
Fleli_1762  DNA polymerase III epsilon subunit-like 3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
Fleli_3592  DNA polymerase III epsilon subunit-like 3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
Fleli_1489  replication restart DNA helicase PriA [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG GENES (21)   
All databases (22)   

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