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gdi03440                    Pathway                                

Homologous recombination - Gluconacetobacter diazotrophicus PAl 5 (Brazil)
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
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Homologous recombination

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DNA polymerase III complex, bacteria [PATH:gdi03440]
Other DBs
Gluconacetobacter diazotrophicus PAl 5 (Brazil) [GN:gdi]
recJ; putative single-stranded-DNA-specific exonuclease recJ [KO:K07462] [EC:3.1.-.-]
ssb; Single-stranded DNA-binding protein [KO:K03111]
recF; putative DNA replication and repair protein recF [KO:K03629]
recO; putative DNA repair protein recO [KO:K03584]
recR; putative recombination protein recR [KO:K06187]
recA; Protein recA (Recombinase A) [KO:K03553]
polA; putative DNA polymerase I [KO:K02335] [EC:]
ruvA; putative holliday junction ATP-dependent DNA helicase ruvA [KO:K03550] [EC:]
ruvB; Holliday junction ATP-dependent DNA helicase ruvB [KO:K03551] [EC:]
ruvC; Crossover junction endodeoxyribonuclease ruvC [KO:K01159] [EC:]
recG; putative ATP-dependent DNA helicase recG [KO:K03655] [EC:]
recD; putative exodeoxyribonuclease V alpha chain [KO:K03581] [EC:]
recD; putative exodeoxyribonuclease [KO:K03581] [EC:]
dnaE; putative DNA polymerase III subunit alpha [KO:K02337] [EC:]
dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:]
dnaX; putative DNA polymerase III tau subunit [KO:K02343] [EC:]
holA; putative DNA polymerase III, delta subunit [KO:K02340] [EC:]
holB; putative DNA polymerase III delta' subunit [KO:K02341] [EC:]
dnaQ; putative DNA polymerase III epsilon subunit [KO:K02342] [EC:]
putative DNA polymerase III [KO:K02339] [EC:]
priA; putative primosomal protein N [KO:K04066] [EC:3.6.4.-]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators] Japanese
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
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