Entry
Name
Nucleotide excision repair - Gallus gallus (chicken)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Gallus gallus (chicken) [GN:
gga ]
Gene
416039 XPC; DNA repair protein complementing XP-C cells isoform X2 [KO:K10838 ]
431623 RAD23B; UV excision repair protein RAD23 homolog B isoform X4 [KO:K10839 ]
100859241 RAD23A; UV excision repair protein RAD23 homolog A isoform X2 [KO:K10839 ]
427153 ERCC8; DNA excision repair protein ERCC-8 isoform X2 [KO:K10570 ]
423785 ERCC6; DNA excision repair protein ERCC-6 isoform X1 [KO:K10841 ]
415635 POLR2C; DNA-directed RNA polymerase II subunit RPB3 [KO:K03011 ]
424754 POLR2D; DNA-directed RNA polymerase II subunit RPB4 [KO:K03012 ]
420103 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013 ]
395486 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014 ]
424954 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1 [KO:K03016 ]
426289 POLR2I; DNA-directed RNA polymerase II subunit RPB9 isoform X1 [KO:K03017 ]
770704 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007 ]
112529926 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009 ]
107049063 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008 ]
423521 MNAT1; CDK-activating kinase assembly factor MAT1 [KO:K10842 ]
424226 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843 ] [EC:5.6.2.4 ]
769754 GTF2H5; general transcription factor IIH subunit 5 [KO:K10845 ]
423081 GTF2H1; general transcription factor IIH subunit 1 [KO:K03141 ]
100858972 GTF2H2; general transcription factor IIH subunit 2 isoform X1 [KO:K03142 ]
771837 GTF2H3; general transcription factor IIH subunit 3 [KO:K03143 ]
428019 ERCC5; DNA repair protein complementing XP-G cells [KO:K10846 ]
395659 XPA; DNA repair protein complementing XP-A cells homolog [KO:K10847 ]
417563 RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466 ]
419566 RPA4; replication protein A 32 kDa subunit [KO:K10739 ]
420578 RPA3; replication protein A 14 kDa subunit [KO:K10740 ]
416420 ERCC4; DNA repair endonuclease XPF [KO:K10848 ] [EC:3.1.-.-]
Reference
Authors
Sugasawa K.
Title
[Molecular mechanism of mammalian nucleotide excision repair]
Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
Authors
Nakatsu Y.
Title
[Transcription-coupled repair and Cockayne syndrome]
Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
Authors
Nakagawa N, Masui R, Kuramitsu S.
Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Journal
Reference
Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Journal
Reference
Authors
Sugasawa K.
Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
Authors
Ito S, Ando D, Tanaka K.
Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related pathway
KO pathway