KEGG   PATHWAY: hsa00565Help
Entry
hsa00565                    Pathway                                

Name
Ether lipid metabolism - Homo sapiens (human)
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
hsa00565  Ether lipid metabolism
hsa00565

Ortholog table
Module
hsa_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:hsa00565]
Disease
H00207  Rhizomelic chondrodysplasia punctata
Drug
D03650  Darapladib (JAN/USAN)
D04368  Goxalapladib (USAN)
D05728  Rilapladib (USAN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
8540  AGPS; alkylglycerone phosphate synthase [KO:K00803] [EC:2.5.1.26]
8611  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
8613  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
8612  PLPP2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
85465  SELENOI; selenoprotein I [KO:K00993] [EC:2.7.8.1]
56994  CHPT1; choline phosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
10390  CEPT1; choline/ethanolamine phosphotransferase 1 [KO:K13644] [EC:2.7.8.2 2.7.8.1]
8399  PLA2G10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
26279  PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
30814  PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
50487  PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
64600  PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
81579  PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
84647  PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
5319  PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
5322  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
5320  PLA2G2A; phospholipase A2 group IIA [KO:K01047] [EC:3.1.1.4]
391013  PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
123745  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
5321  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
8681  JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
100137049  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
8605  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
283748  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
255189  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
8398  PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
151056  PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.5 3.1.1.4]
11145  PLA2G16; phospholipase A2 group XVI [KO:K16817] [EC:3.1.1.4 3.1.1.32]
254531  LPCAT4; lysophosphatidylcholine acyltransferase 4 [KO:K13512] [EC:2.3.1.- 2.3.1.23]
133121  ENPP6; ectonucleotide pyrophosphatase/phosphodiesterase 6 [KO:K08743] [EC:3.1.4.-]
5168  ENPP2; ectonucleotide pyrophosphatase/phosphodiesterase 2 [KO:K01122] [EC:3.1.4.39]
79153  GDPD3; glycerophosphodiester phosphodiesterase domain containing 3 [KO:K22387] [EC:3.1.4.39]
284161  GDPD1; glycerophosphodiester phosphodiesterase domain containing 1 [KO:K22387] [EC:3.1.4.39]
255043  TMEM86B; transmembrane protein 86B [KO:K18575] [EC:3.3.2.2]
5337  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
5338  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
23646  PLD3; phospholipase D family member 3 [KO:K16860] [EC:3.1.4.4]
122618  PLD4; phospholipase D family member 4 [KO:K16860] [EC:3.1.4.4]
7368  UGT8; UDP glycosyltransferase 8 [KO:K04628] [EC:2.4.1.47]
9514  GAL3ST1; galactose-3-O-sulfotransferase 1 [KO:K01019] [EC:2.8.2.11]
54947  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.67 2.3.1.23]
79888  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.67 2.3.1.23]
5048  PAFAH1B1; platelet activating factor acetylhydrolase 1b regulatory subunit 1 [KO:K16794]
5049  PAFAH1B2; platelet activating factor acetylhydrolase 1b catalytic subunit 2 [KO:K16795] [EC:3.1.1.47]
5050  PAFAH1B3; platelet activating factor acetylhydrolase 1b catalytic subunit 3 [KO:K16795] [EC:3.1.1.47]
7941  PLA2G7; phospholipase A2 group VII [KO:K01062] [EC:3.1.1.47]
5051  PAFAH2; platelet activating factor acetylhydrolase 2 [KO:K01062] [EC:3.1.1.47]
Compound
C00670  sn-Glycero-3-phosphocholine
C00958  Plasmenylcholine
C01233  sn-Glycero-3-phosphoethanolamine
C01264  2-Acetyl-1-alkyl-sn-glycero-3-phosphate
C02773  1-Alkyl-sn-glycerol
C03201  1-Alkyl-2-acylglycerol
C03372  Acylglycerone phosphate
C03454  1-Alkenyl-2-acylglycerol
C03715  O-Alkylglycerone phosphate
C03820  1-Alkyl-2-acetyl-sn-glycerol
C03968  1-Alkyl-sn-glycero-3-phosphate
C04317  1-Organyl-2-lyso-sn-glycero-3-phosphocholine
C04361  1-O-Alkyl-2-acetyl-3-acyl-sn-glycerol
C04475  1-Alkyl-2-acylglycerophosphoethanolamine
C04517  1-(1-Alkenyl)-sn-glycero-3-phosphocholine
C04598  2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
C04635  1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine
C04756  O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine
C05212  1-Radyl-2-acyl-sn-glycero-3-phosphocholine
C05977  2-Acyl-1-alkyl-sn-glycero-3-phosphate
C15645  1-(1-Alkenyl)-sn-glycerol
C15646  1-(1-Alkenyl)-sn-glycero-3-phosphate
C15647  2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate
C20825  Seminolipid
C20859  Galactosyl-1-alkyl-2-acylglycerol
Reference
  Authors
Nagan N, Zoeller RA.
  Title
Plasmalogens: biosynthesis and functions.
  Journal
Prog Lipid Res 40:199-229 (2001)
DOI:10.1016/S0163-7827(01)00003-0
Reference
  Authors
Montrucchio G, Alloatti G, Camussi G.
  Title
Role of platelet-activating factor in cardiovascular pathophysiology.
  Journal
Physiol Rev 80:1669-99 (2000)
Reference
  Authors
Sakagami H, Aoki J, Natori Y, Nishikawa K, Kakehi Y, Natori Y, Arai H.
  Title
Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
  Journal
J Biol Chem 280:23084-93 (2005)
DOI:10.1074/jbc.M413438200
KO pathway
ko00565   

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