KEGG PATHWAY: hsa00620

PATHWAY: hsa00620

Entry

hsa00620 Pathway

Name

Pyruvate metabolism - Homo sapiens (human)

Class

Metabolism; Carbohydrate metabolism

Pathway map

hsa00620

Pyruvate metabolism

Module

hsa_M00307	Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:hsa00620]
hsa_M00310	Pyruvate:ferredoxin oxidoreductase [PATH:hsa00620]

Disease

H00072	Pyruvate dehydrogenase complex deficiency
H00073	Pyruvate carboxylase deficiency
H01096	Pyruvate kinase (PK) deficiency

Drug

D00123	Cyanamide (JP16)
D00131	Disulfiram (JP16/USP/INN)

Other DBs

BSID:

82998

GO:

0006090

Organism

Homo sapiens (human) [GN:hsa]

Gene

84532	ACSS1; acyl-CoA synthetase short-chain family member 1 [KO:K01895] [EC:6.2.1.1]
55902	ACSS2; acyl-CoA synthetase short-chain family member 2 [KO:K01895] [EC:6.2.1.1]
5161	PDHA2; pyruvate dehydrogenase (lipoamide) alpha 2 [KO:K00161] [EC:1.2.4.1]
5160	PDHA1; pyruvate dehydrogenase (lipoamide) alpha 1 [KO:K00161] [EC:1.2.4.1]
5162	PDHB; pyruvate dehydrogenase (lipoamide) beta [KO:K00162] [EC:1.2.4.1]
1737	DLAT; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:2.3.1.12]
1738	DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
5315	PKM; pyruvate kinase, muscle [KO:K00873] [EC:2.7.1.40]
5313	PKLR; pyruvate kinase, liver and RBC [KO:K12406] [EC:2.7.1.40]
31	ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.3.4.14 6.4.1.2]
32	ACACB; acetyl-CoA carboxylase beta [KO:K11262] [EC:6.3.4.14 6.4.1.2]
98	ACYP2; acylphosphatase 2, muscle type [KO:K01512] [EC:3.6.1.7]
97	ACYP1; acylphosphatase 1, erythrocyte (common) type [KO:K01512] [EC:3.6.1.7]
217	ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
224	ALDH3A2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]
219	ALDH1B1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
501	ALDH7A1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223	ALDH9A1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
134526	ACOT12; acyl-CoA thioesterase 12 [KO:K01067] [EC:3.1.2.1]
160287	LDHAL6A; lactate dehydrogenase A-like 6A [KO:K00016] [EC:1.1.1.27]
92483	LDHAL6B; lactate dehydrogenase A-like 6B [KO:K00016] [EC:1.1.1.27]
3939	LDHA; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
3945	LDHB; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
3948	LDHC; lactate dehydrogenase C [KO:K00016] [EC:1.1.1.27]
197257	LDHD; lactate dehydrogenase D [KO:K00102] [EC:1.1.2.4]
2739	GLO1; glyoxalase I [KO:K01759] [EC:4.4.1.5]
84264	HAGHL; hydroxyacylglutathione hydrolase-like [KO:K01069] [EC:3.1.2.6]
3029	HAGH; hydroxyacylglutathione hydrolase [KO:K01069] [EC:3.1.2.6]
9380	GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.81 1.1.1.79]
231	AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase) [KO:K00011] [EC:1.1.1.21]
57016	AKR1B10; aldo-keto reductase family 1, member B10 (aldose reductase) [KO:K00011] [EC:1.1.1.21]
4200	ME2; malic enzyme 2, NAD(+)-dependent, mitochondrial [KO:K00027] [EC:1.1.1.38]
10873	ME3; malic enzyme 3, NADP(+)-dependent, mitochondrial [KO:K00029] [EC:1.1.1.40]
4199	ME1; malic enzyme 1, NADP(+)-dependent, cytosolic [KO:K00029] [EC:1.1.1.40]
5091	PC; pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
4190	MDH1; malate dehydrogenase 1, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
4191	MDH2; malate dehydrogenase 2, NAD (mitochondrial) [KO:K00026] [EC:1.1.1.37]
5105	PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) [KO:K01596] [EC:4.1.1.32]
5106	PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:4.1.1.32]
39	ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38	ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]

Compound

C00022	Pyruvate
C00024	Acetyl-CoA
C00033	Acetate
C00036	Oxaloacetate
C00058	Formate
C00068	Thiamin diphosphate
C00074	Phosphoenolpyruvate
C00083	Malonyl-CoA
C00084	Acetaldehyde
C00111	Glycerone phosphate
C00149	(S)-Malate
C00186	(S)-Lactate
C00227	Acetyl phosphate
C00256	(R)-Lactate
C00332	Acetoacetyl-CoA
C00424	(S)-Lactaldehyde
C00546	Methylglyoxal
C00583	Propane-1,2-diol
C00937	(R)-Lactaldehyde
C01251	(R)-2-Hydroxybutane-1,2,4-tricarboxylate
C02488	(R)-2-Ethylmalate
C02504	alpha-Isopropylmalate
C03248	Acetylenedicarboxylate
C03451	(R)-S-Lactoylglutathione
C03981	2-Hydroxyethylenedicarboxylate
C05125	2-(alpha-Hydroxyethyl)thiamine diphosphate
C05993	Acetyl adenylate
C05994	2-Propylmalate
C05999	Lactaldehyde
C15972	Enzyme N6-(lipoyl)lysine
C15973	Enzyme N6-(dihydrolipoyl)lysine
C16255	[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine

KO pathway

ko00620

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Disease (3)   
   KEGG DISEASE (3)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG GENES (42)   
All databases (51)   

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