KEGG   PATHWAY: hsa00620Help
Entry
hsa00620                    Pathway                                

Name
Pyruvate metabolism - Homo sapiens (human)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Pyruvate metabolism
hsa00620

All organismsOrtholog table
Module
Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:hsa00620]
Disease
H00072  
Pyruvate dehydrogenase complex deficiency
H00073  
Pyruvate carboxylase deficiency
H01096  
Pyruvate kinase (PK) deficiency
H01354  
Leigh syndrome
Drug
D00123  
Cyanamide (JP16)
D00131  
Disulfiram (JP16/USP/INN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
84532  
ACSS1; acyl-CoA synthetase short-chain family member 1 [KO:K01895] [EC:6.2.1.1]
55902  
ACSS2; acyl-CoA synthetase short-chain family member 2 [KO:K01895] [EC:6.2.1.1]
5161  
PDHA2; pyruvate dehydrogenase (lipoamide) alpha 2 [KO:K00161] [EC:1.2.4.1]
5160  
PDHA1; pyruvate dehydrogenase (lipoamide) alpha 1 [KO:K00161] [EC:1.2.4.1]
5162  
PDHB; pyruvate dehydrogenase (lipoamide) beta [KO:K00162] [EC:1.2.4.1]
1737  
DLAT; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:2.3.1.12]
1738  
DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
5315  
PKM; pyruvate kinase, muscle [KO:K00873] [EC:2.7.1.40]
5313  
PKLR; pyruvate kinase, liver and RBC [KO:K12406] [EC:2.7.1.40]
31  
ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.3.4.14 6.4.1.2]
32  
ACACB; acetyl-CoA carboxylase beta [KO:K11262] [EC:6.3.4.14 6.4.1.2]
98  
ACYP2; acylphosphatase 2, muscle type [KO:K01512] [EC:3.6.1.7]
97  
ACYP1; acylphosphatase 1, erythrocyte (common) type [KO:K01512] [EC:3.6.1.7]
217  
ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
224  
ALDH3A2; aldehyde dehydrogenase 3 family, member A2 [KO:K00128] [EC:1.2.1.3]
219  
ALDH1B1; aldehyde dehydrogenase 1 family, member B1 [KO:K00128] [EC:1.2.1.3]
501  
ALDH7A1; aldehyde dehydrogenase 7 family, member A1 [KO:K14085] [EC:1.2.1.3 1.2.1.8 1.2.1.31]
223  
ALDH9A1; aldehyde dehydrogenase 9 family, member A1 [KO:K00149] [EC:1.2.1.3 1.2.1.47]
134526  
ACOT12; acyl-CoA thioesterase 12 [KO:K01067] [EC:3.1.2.1]
160287  
LDHAL6A; lactate dehydrogenase A-like 6A [KO:K00016] [EC:1.1.1.27]
92483  
LDHAL6B; lactate dehydrogenase A-like 6B [KO:K00016] [EC:1.1.1.27]
3939  
LDHA; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
3945  
LDHB; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
3948  
LDHC; lactate dehydrogenase C [KO:K00016] [EC:1.1.1.27]
197257  
LDHD; lactate dehydrogenase D [KO:K00102] [EC:1.1.2.4]
2739  
GLO1; glyoxalase I [KO:K01759] [EC:4.4.1.5]
84264  
HAGHL; hydroxyacylglutathione hydrolase-like [KO:K01069] [EC:3.1.2.6]
3029  
HAGH; hydroxyacylglutathione hydrolase [KO:K01069] [EC:3.1.2.6]
9380  
GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.81 1.1.1.79]
231  
AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase) [KO:K00011] [EC:1.1.1.21]
57016  
AKR1B10; aldo-keto reductase family 1, member B10 (aldose reductase) [KO:K00011] [EC:1.1.1.21]
4200  
ME2; malic enzyme 2, NAD(+)-dependent, mitochondrial [KO:K00027] [EC:1.1.1.38]
10873  
ME3; malic enzyme 3, NADP(+)-dependent, mitochondrial [KO:K00029] [EC:1.1.1.40]
4199  
ME1; malic enzyme 1, NADP(+)-dependent, cytosolic [KO:K00029] [EC:1.1.1.40]
5091  
PC; pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
4190  
MDH1; malate dehydrogenase 1, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
4191  
MDH2; malate dehydrogenase 2, NAD (mitochondrial) [KO:K00026] [EC:1.1.1.37]
2271  
FH; fumarate hydratase [KO:K01679] [EC:4.2.1.2]
5105  
PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) [KO:K01596] [EC:4.1.1.32]
5106  
PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:4.1.1.32]
39  
ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]
38  
ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]
Compound
C00022  
Pyruvate
C00024  
Acetyl-CoA
C00033  
Acetate
C00036  
Oxaloacetate
C00042  
Succinate
C00058  
Formate
C00068  
Thiamin diphosphate
C00074  
Phosphoenolpyruvate
C00083  
Malonyl-CoA
C00084  
Acetaldehyde
C00111  
Glycerone phosphate
C00122  
Fumarate
C00149  
(S)-Malate
C00186  
(S)-Lactate
C00227  
Acetyl phosphate
C00256  
(R)-Lactate
C00332  
Acetoacetyl-CoA
C00424  
(S)-Lactaldehyde
C00546  
Methylglyoxal
C00583  
Propane-1,2-diol
C00937  
(R)-Lactaldehyde
C01251  
(R)-2-Hydroxybutane-1,2,4-tricarboxylate
C02488  
(R)-2-Ethylmalate
C02504  
alpha-Isopropylmalate
C03248  
Acetylenedicarboxylate
C03451  
(R)-S-Lactoylglutathione
C03981  
2-Hydroxyethylenedicarboxylate
C05125  
2-(alpha-Hydroxyethyl)thiamine diphosphate
C05993  
Acetyl adenylate
C05994  
2-Propylmalate
C05999  
Lactaldehyde
C15972  
Enzyme N6-(lipoyl)lysine
C15973  
Enzyme N6-(dihydrolipoyl)lysine
C16255  
[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
KO pathway
 

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