KEGG   PATHWAY: hsa00970Help
Entry
hsa00970                    Pathway                                

Name
Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
hsa00970  Aminoacyl-tRNA biosynthesis
hsa00970

Ortholog table
Module
hsa_M00359  Aminoacyl-tRNA biosynthesis, eukaryotes [PATH:hsa00970]
Disease
H00264  Charcot-Marie-Tooth disease (CMT)
H00810  Progressive myoclonic epilepsy (PME/ EPM)
H00871  Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
H00897  Pontocerebellar hypoplasia
H00898  Myopathy with lactic acidosis and sideroblastic anaemia (MLASA)
H01347  MELAS Syndrome
H01351  Spastic ataxia (SPAX)
H01356  Myoclonic Epilepsy and Ragged-Red Fiber Disease
H01367  Infantile liver failure
Organism
Homo sapiens (human) [GN:hsa]
Gene
4553  TRNA; tRNA-Ala [KO:K14218]
4573  TRNR; tRNA-Arg [KO:K14219]
4570  TRNN; tRNA-Asn [KO:K14220]
4555  TRND; tRNA-Asp [KO:K14221]
4511  TRNC; tRNA-Cys [KO:K14222]
4572  TRNQ; tRNA-Gln [KO:K14223]
4556  TRNE; tRNA-Glu [KO:K14224]
4563  TRNG; tRNA-Gly [KO:K14225]
4564  TRNH; tRNA-His [KO:K14226]
4565  TRNI; tRNA-Ile [KO:K14227]
4568  TRNL2; tRNA-Leu [KO:K14228]
4567  TRNL1; tRNA-Leu [KO:K14228]
4566  TRNK; tRNA-Lys [KO:K14229]
4569  TRNM; tRNA-Met [KO:K14230]
4558  TRNF; tRNA-Phe [KO:K14231]
4571  TRNP; tRNA-Pro [KO:K14232]
4575  TRNS2; tRNA-Ser [KO:K14233]
4574  TRNS1; tRNA-Ser [KO:K14233]
4576  TRNT; tRNA-Thr [KO:K14234]
4578  TRNW; tRNA-Trp [KO:K14235]
4579  TRNY; tRNA-Tyr [KO:K14236]
4577  TRNV; tRNA-Val [KO:K14237]
124454  EARS2; glutamyl-tRNA synthetase 2, mitochondrial [KO:K01885] [EC:6.1.1.17]
2058  EPRS; glutamyl-prolyl-tRNA synthetase [KO:K14163] [EC:6.1.1.15 6.1.1.17]
55278  QRSL1; glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 [KO:K02433] [EC:6.3.5.7 6.3.5.6]
5188  GATB; glutamyl-tRNA amidotransferase subunit B [KO:K02434] [EC:6.3.5.7 6.3.5.6]
283459  GATC; glutamyl-tRNA amidotransferase subunit C [KO:K02435] [EC:6.3.5.7 6.3.5.6]
5859  QARS; glutaminyl-tRNA synthetase [KO:K01886] [EC:6.1.1.18]
57505  AARS2; alanyl-tRNA synthetase 2, mitochondrial [KO:K01872] [EC:6.1.1.7]
16  AARS; alanyl-tRNA synthetase [KO:K01872] [EC:6.1.1.7]
1615  DARS; aspartyl-tRNA synthetase [KO:K22503] [EC:6.1.1.12]
55157  DARS2; aspartyl-tRNA synthetase 2, mitochondrial [KO:K01876] [EC:6.1.1.12]
79731  NARS2; asparaginyl-tRNA synthetase 2, mitochondrial [KO:K01893] [EC:6.1.1.22]
4677  NARS; asparaginyl-tRNA synthetase [KO:K01893] [EC:6.1.1.22]
2617  GARS; glycyl-tRNA synthetase [KO:K01880] [EC:6.1.1.14]
80222  TARS2; threonyl-tRNA synthetase 2, mitochondrial [KO:K01868] [EC:6.1.1.3]
6897  TARS; threonyl-tRNA synthetase [KO:K01868] [EC:6.1.1.3]
123283  TARSL2; threonyl-tRNA synthetase like 2 [KO:K01868] [EC:6.1.1.3]
54938  SARS2; seryl-tRNA synthetase 2, mitochondrial [KO:K01875] [EC:6.1.1.11]
6301  SARS; seryl-tRNA synthetase [KO:K01875] [EC:6.1.1.11]
118672  PSTK; phosphoseryl-tRNA kinase [KO:K10837] [EC:2.7.1.164]
51091  SEPSECS; Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [KO:K03341] [EC:2.9.1.2]
833  CARS; cysteinyl-tRNA synthetase [KO:K01883] [EC:6.1.1.16]
79587  CARS2; cysteinyl-tRNA synthetase 2, mitochondrial [KO:K01883] [EC:6.1.1.16]
4141  MARS; methionyl-tRNA synthetase [KO:K01874] [EC:6.1.1.10]
92935  MARS2; methionyl-tRNA synthetase 2, mitochondrial [KO:K01874] [EC:6.1.1.10]
123263  MTFMT; mitochondrial methionyl-tRNA formyltransferase [KO:K00604] [EC:2.1.2.9]
57176  VARS2; valyl-tRNA synthetase 2, mitochondrial [KO:K01873] [EC:6.1.1.9]
7407  VARS; valyl-tRNA synthetase [KO:K01873] [EC:6.1.1.9]
51520  LARS; leucyl-tRNA synthetase [KO:K01869] [EC:6.1.1.4]
23395  LARS2; leucyl-tRNA synthetase 2, mitochondrial [KO:K01869] [EC:6.1.1.4]
3376  IARS; isoleucyl-tRNA synthetase [KO:K01870] [EC:6.1.1.5]
55699  IARS2; isoleucyl-tRNA synthetase 2, mitochondrial [KO:K01870] [EC:6.1.1.5]
3735  KARS; lysyl-tRNA synthetase [KO:K04567] [EC:6.1.1.6]
57038  RARS2; arginyl-tRNA synthetase 2, mitochondrial [KO:K01887] [EC:6.1.1.19]
5917  RARS; arginyl-tRNA synthetase [KO:K01887] [EC:6.1.1.19]
25973  PARS2; prolyl-tRNA synthetase 2, mitochondrial [KO:K01881] [EC:6.1.1.15]
3035  HARS; histidyl-tRNA synthetase [KO:K01892] [EC:6.1.1.21]
23438  HARS2; histidyl-tRNA synthetase 2, mitochondrial [KO:K01892] [EC:6.1.1.21]
2193  FARSA; phenylalanyl-tRNA synthetase alpha subunit [KO:K01889] [EC:6.1.1.20]
10667  FARS2; phenylalanyl-tRNA synthetase 2, mitochondrial [KO:K01889] [EC:6.1.1.20]
10056  FARSB; phenylalanyl-tRNA synthetase beta subunit [KO:K01890] [EC:6.1.1.20]
8565  YARS; tyrosyl-tRNA synthetase [KO:K01866] [EC:6.1.1.1]
51067  YARS2; tyrosyl-tRNA synthetase 2 [KO:K01866] [EC:6.1.1.1]
10352  WARS2; tryptophanyl tRNA synthetase 2, mitochondrial [KO:K01867] [EC:6.1.1.2]
7453  WARS; tryptophanyl-tRNA synthetase [KO:K01867] [EC:6.1.1.2]
Compound
C00025  L-Glutamate
C00037  Glycine
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00073  L-Methionine
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00123  L-Leucine
C00135  L-Histidine
C00148  L-Proline
C00152  L-Asparagine
C00183  L-Valine
C00188  L-Threonine
C00234  10-Formyltetrahydrofolate
C00407  L-Isoleucine
C00886  L-Alanyl-tRNA
C01005  O-Phospho-L-serine
C01931  L-Lysyl-tRNA
C02047  L-Leucyl-tRNA
C02163  L-Arginyl-tRNA(Arg)
C02282  Glutaminyl-tRNA
C02412  Glycyl-tRNA(Gly)
C02430  L-Methionyl-tRNA
C02553  L-Seryl-tRNA(Ser)
C02554  L-Valyl-tRNA(Val)
C02702  L-Prolyl-tRNA(Pro)
C02839  L-Tyrosyl-tRNA(Tyr)
C02984  L-Aspartyl-tRNA(Asp)
C02987  L-Glutamyl-tRNA(Glu)
C02988  L-Histidyl-tRNA(His)
C02992  L-Threonyl-tRNA(Thr)
C03125  L-Cysteinyl-tRNA(Cys)
C03127  L-Isoleucyl-tRNA(Ile)
C03294  N-Formylmethionyl-tRNA
C03402  L-Asparaginyl-tRNA(Asn)
C03511  L-Phenylalanyl-tRNA(Phe)
C03512  L-Tryptophanyl-tRNA(Trp)
C06112  L-Glutamyl-tRNA(Gln)
C06113  L-Aspartyl-tRNA(Asn)
C06481  L-Seryl-tRNA(Sec)
C06482  L-Selenocysteinyl-tRNA(Sec)
C16138  L-Pyrrolysine
C16638  O-Phosphoseryl-tRNA(Sec)
C17022  O-Phosphoseryl-tRNA(Cys)
C17027  L-Pyrrolysyl-tRNA(Pyl)
Reference
  Authors
Sheppard K, Yuan J, Hohn MJ, Jester B, Devine KM, Soll D
  Title
From one amino acid to another: tRNA-dependent amino acid biosynthesis.
  Journal
Nucleic Acids Res 36:1813-25 (2008)
DOI:10.1093/nar/gkn015
Reference
  Authors
Polycarpo C, Ambrogelly A, Berube A, Winbush SM, McCloskey JA, Crain PF, Wood JL, Soll D
  Title
An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
  Journal
Proc Natl Acad Sci U S A 101:12450-4 (2004)
DOI:10.1073/pnas.0405362101
KO pathway
ko00970   

DBGET integrated database retrieval system