KEGG   PATHWAY: hsa00970Help
Entry
hsa00970                    Pathway                                

Name
Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Aminoacyl-tRNA biosynthesis
hsa00970

All organismsOrtholog table
Module
Aminoacyl-tRNA biosynthesis, eukaryotes [PATH:hsa00970]
Disease
H00264  
Charcot-Marie-Tooth disease (CMT)
H00810  
Progressive myoclonic epilepsy (PME/ EPM)
H00856  
Distal hereditary motor neuropathies (dHMN)
H00871  
Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
H00897  
Pontocerebellar hypoplasia
H00898  
Myopathy with lactic acidosis and sideroblastic anaemia (MLASA)
H01347  
MELAS Syndrome
H01351  
Spastic ataxia (SPAX)
H01356  
Myoclonic Epilepsy and Ragged-Red Fiber Disease
H01367  
Infantile liver failure
Organism
Homo sapiens (human) [GN:hsa]
Gene
4553  
TRNA; tRNA-Ala [KO:K14218]
4573  
TRNR; tRNA-Arg [KO:K14219]
4570  
TRNN; tRNA-Asn [KO:K14220]
4555  
TRND; tRNA-Asp [KO:K14221]
4511  
TRNC; tRNA-Cys [KO:K14222]
4572  
TRNQ; tRNA-Gln [KO:K14223]
4556  
TRNE; tRNA-Glu [KO:K14224]
4563  
TRNG; tRNA-Gly [KO:K14225]
4564  
TRNH; tRNA-His [KO:K14226]
4565  
TRNI; tRNA-Ile [KO:K14227]
4568  
TRNL2; tRNA-Leu [KO:K14228]
4567  
TRNL1; tRNA-Leu [KO:K14228]
4566  
TRNK; tRNA-Lys [KO:K14229]
4569  
TRNM; tRNA-Met [KO:K14230]
4558  
TRNF; tRNA-Phe [KO:K14231]
4571  
TRNP; tRNA-Pro [KO:K14232]
4575  
TRNS2; tRNA-Ser [KO:K14233]
4574  
TRNS1; tRNA-Ser [KO:K14233]
4576  
TRNT; tRNA-Thr [KO:K14234]
4578  
TRNW; tRNA-Trp [KO:K14235]
4579  
TRNY; tRNA-Tyr [KO:K14236]
4577  
TRNV; tRNA-Val [KO:K14237]
124454  
EARS2; glutamyl-tRNA synthetase 2, mitochondrial [KO:K01885] [EC:6.1.1.17]
2058  
EPRS; glutamyl-prolyl-tRNA synthetase [KO:K14163] [EC:6.1.1.15 6.1.1.17]
55278  
QRSL1; glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 [KO:K02433] [EC:6.3.5.7 6.3.5.6]
5188  
GATB; glutamyl-tRNA(Gln) amidotransferase, subunit B [KO:K02434] [EC:6.3.5.7 6.3.5.6]
283459  
GATC; glutamyl-tRNA(Gln) amidotransferase, subunit C [KO:K02435] [EC:6.3.5.7 6.3.5.6]
5859  
QARS; glutaminyl-tRNA synthetase [KO:K01886] [EC:6.1.1.18]
57505  
AARS2; alanyl-tRNA synthetase 2, mitochondrial [KO:K01872] [EC:6.1.1.7]
16  
AARS; alanyl-tRNA synthetase [KO:K01872] [EC:6.1.1.7]
55157  
DARS2; aspartyl-tRNA synthetase 2, mitochondrial [KO:K01876] [EC:6.1.1.12]
1615  
DARS; aspartyl-tRNA synthetase [KO:K01876] [EC:6.1.1.12]
79731  
NARS2; asparaginyl-tRNA synthetase 2, mitochondrial (putative) [KO:K01893] [EC:6.1.1.22]
4677  
NARS; asparaginyl-tRNA synthetase [KO:K01893] [EC:6.1.1.22]
2617  
GARS; glycyl-tRNA synthetase [KO:K01880] [EC:6.1.1.14]
80222  
TARS2; threonyl-tRNA synthetase 2, mitochondrial (putative) [KO:K01868] [EC:6.1.1.3]
6897  
TARS; threonyl-tRNA synthetase [KO:K01868] [EC:6.1.1.3]
123283  
TARSL2; threonyl-tRNA synthetase-like 2 [KO:K01868] [EC:6.1.1.3]
54938  
SARS2; seryl-tRNA synthetase 2, mitochondrial [KO:K01875] [EC:6.1.1.11]
6301  
SARS; seryl-tRNA synthetase [KO:K01875] [EC:6.1.1.11]
118672  
PSTK; phosphoseryl-tRNA kinase [KO:K10837] [EC:2.7.1.164]
51091  
SEPSECS; Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [KO:K03341] [EC:2.9.1.2]
833  
CARS; cysteinyl-tRNA synthetase [KO:K01883] [EC:6.1.1.16]
79587  
CARS2; cysteinyl-tRNA synthetase 2, mitochondrial (putative) [KO:K01883] [EC:6.1.1.16]
4141  
MARS; methionyl-tRNA synthetase [KO:K01874] [EC:6.1.1.10]
92935  
MARS2; methionyl-tRNA synthetase 2, mitochondrial [KO:K01874] [EC:6.1.1.10]
123263  
MTFMT; mitochondrial methionyl-tRNA formyltransferase [KO:K00604] [EC:2.1.2.9]
57176  
VARS2; valyl-tRNA synthetase 2, mitochondrial [KO:K01873] [EC:6.1.1.9]
7407  
VARS; valyl-tRNA synthetase [KO:K01873] [EC:6.1.1.9]
51520  
LARS; leucyl-tRNA synthetase [KO:K01869] [EC:6.1.1.4]
23395  
LARS2; leucyl-tRNA synthetase 2, mitochondrial [KO:K01869] [EC:6.1.1.4]
3376  
IARS; isoleucyl-tRNA synthetase [KO:K01870] [EC:6.1.1.5]
55699  
IARS2; isoleucyl-tRNA synthetase 2, mitochondrial [KO:K01870] [EC:6.1.1.5]
3735  
KARS; lysyl-tRNA synthetase [KO:K04567] [EC:6.1.1.6]
57038  
RARS2; arginyl-tRNA synthetase 2, mitochondrial [KO:K01887] [EC:6.1.1.19]
5917  
RARS; arginyl-tRNA synthetase [KO:K01887] [EC:6.1.1.19]
25973  
PARS2; prolyl-tRNA synthetase 2, mitochondrial (putative) [KO:K01881] [EC:6.1.1.15]
3035  
HARS; histidyl-tRNA synthetase [KO:K01892] [EC:6.1.1.21]
23438  
HARS2; histidyl-tRNA synthetase 2, mitochondrial [KO:K01892] [EC:6.1.1.21]
2193  
FARSA; phenylalanyl-tRNA synthetase alpha subunit [KO:K01889] [EC:6.1.1.20]
10667  
FARS2; phenylalanyl-tRNA synthetase 2, mitochondrial [KO:K01889] [EC:6.1.1.20]
10056  
FARSB; phenylalanyl-tRNA synthetase beta subunit [KO:K01890] [EC:6.1.1.20]
8565  
YARS; tyrosyl-tRNA synthetase [KO:K01866] [EC:6.1.1.1]
51067  
YARS2; tyrosyl-tRNA synthetase 2 [KO:K01866] [EC:6.1.1.1]
10352  
WARS2; tryptophanyl tRNA synthetase 2, mitochondrial [KO:K01867] [EC:6.1.1.2]
7453  
WARS; tryptophanyl-tRNA synthetase [KO:K01867] [EC:6.1.1.2]
Compound
C00025  
L-Glutamate
C00037  
Glycine
C00041  
L-Alanine
C00047  
L-Lysine
C00049  
L-Aspartate
C00062  
L-Arginine
C00064  
L-Glutamine
C00065  
L-Serine
C00073  
L-Methionine
C00078  
L-Tryptophan
C00079  
L-Phenylalanine
C00082  
L-Tyrosine
C00097  
L-Cysteine
C00101  
Tetrahydrofolate
C00123  
L-Leucine
C00135  
L-Histidine
C00148  
L-Proline
C00152  
L-Asparagine
C00183  
L-Valine
C00188  
L-Threonine
C00234  
10-Formyltetrahydrofolate
C00407  
L-Isoleucine
C00886  
L-Alanyl-tRNA
C01005  
O-Phospho-L-serine
C01931  
L-Lysyl-tRNA
C02047  
L-Leucyl-tRNA
C02163  
L-Arginyl-tRNA(Arg)
C02282  
Glutaminyl-tRNA
C02412  
Glycyl-tRNA(Gly)
C02430  
L-Methionyl-tRNA
C02553  
L-Seryl-tRNA(Ser)
C02554  
L-Valyl-tRNA(Val)
C02702  
L-Prolyl-tRNA(Pro)
C02839  
L-Tyrosyl-tRNA(Tyr)
C02984  
L-Aspartyl-tRNA(Asp)
C02987  
L-Glutamyl-tRNA(Glu)
C02988  
L-Histidyl-tRNA(His)
C02992  
L-Threonyl-tRNA(Thr)
C03125  
L-Cysteinyl-tRNA(Cys)
C03127  
L-Isoleucyl-tRNA(Ile)
C03294  
N-Formylmethionyl-tRNA
C03402  
L-Asparaginyl-tRNA(Asn)
C03511  
L-Phenylalanyl-tRNA(Phe)
C03512  
L-Tryptophanyl-tRNA(Trp)
C06112  
L-Glutamyl-tRNA(Gln)
C06113  
L-Aspartyl-tRNA(Asn)
C06481  
L-Seryl-tRNA(Sec)
C06482  
L-Selenocysteinyl-tRNA(Sec)
C16138  
L-Pyrrolysine
C16638  
O-Phosphoseryl-tRNA(Sec)
C17022  
O-Phosphoseryl-tRNA(Cys)
C17027  
L-Pyrrolysyl-tRNA(Pyl)
Reference
  Authors
Sheppard K, Yuan J, Hohn MJ, Jester B, Devine KM, Soll D
  Title
From one amino acid to another: tRNA-dependent amino acid biosynthesis.
  Journal
Nucleic Acids Res 36:1813-25 (2008)
Reference
  Authors
Polycarpo C, Ambrogelly A, Berube A, Winbush SM, McCloskey JA, Crain PF, Wood JL, Soll D
  Title
An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
  Journal
Proc Natl Acad Sci U S A 101:12450-4 (2004)
KO pathway
 

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