KEGG   PATHWAY: hsa00970Help
Entry
hsa00970                    Pathway                                

Name
Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
Aminoacyl-tRNA biosynthesis
hsa00970

All organismsOrtholog table
Module
Aminoacyl-tRNA biosynthesis, eukaryotes [PATH:hsa00970]
Disease
H00264  
Charcot-Marie-Tooth disease (CMT)
H00810  
Progressive myoclonic epilepsy (PME/ EPM)
H00856  
Distal hereditary motor neuropathies (dHMN)
H00871  
Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
H00897  
Pontocerebellar hypoplasia
H00898  
Myopathy with lactic acidosis and sideroblastic anaemia (MLASA)
H01347  
MELAS Syndrome
H01351  
Spastic ataxia (SPAX)
H01356  
Myoclonic Epilepsy and Ragged-Red Fiber Disease
H01367  
Infantile liver failure
Organism
Homo sapiens (human) [GN:hsa]
Gene
4553  
K14218 tRNA Ala | (RefSeq) TRNA; tRNA-Ala [KO:K14218]
4573  
K14219 tRNA Arg | (RefSeq) TRNR; tRNA-Arg [KO:K14219]
4570  
K14220 tRNA Asn | (RefSeq) TRNN; tRNA-Asn [KO:K14220]
4555  
K14221 tRNA Asp | (RefSeq) TRND; tRNA-Asp [KO:K14221]
4511  
K14222 tRNA Cys | (RefSeq) TRNC; tRNA-Cys [KO:K14222]
4572  
K14223 tRNA Gln | (RefSeq) TRNQ; tRNA-Gln [KO:K14223]
4556  
K14224 tRNA Glu | (RefSeq) TRNE; tRNA-Glu [KO:K14224]
4563  
K14225 tRNA Gly | (RefSeq) TRNG; tRNA-Gly [KO:K14225]
4564  
K14226 tRNA His | (RefSeq) TRNH; tRNA-His [KO:K14226]
4565  
K14227 tRNA Ile | (RefSeq) TRNI; tRNA-Ile [KO:K14227]
4568  
K14228 tRNA Leu | (RefSeq) TRNL2; tRNA-Leu [KO:K14228]
4567  
K14228 tRNA Leu | (RefSeq) TRNL1; tRNA-Leu [KO:K14228]
4566  
K14229 tRNA Lys | (RefSeq) TRNK; tRNA-Lys [KO:K14229]
4569  
K14230 tRNA Met | (RefSeq) TRNM; tRNA-Met [KO:K14230]
4558  
K14231 tRNA Phe | (RefSeq) TRNF; tRNA-Phe [KO:K14231]
4571  
K14232 tRNA Pro | (RefSeq) TRNP; tRNA-Pro [KO:K14232]
4575  
K14233 tRNA Ser | (RefSeq) TRNS2; tRNA-Ser [KO:K14233]
4574  
K14233 tRNA Ser | (RefSeq) TRNS1; tRNA-Ser [KO:K14233]
4576  
K14234 tRNA Thr | (RefSeq) TRNT; tRNA-Thr [KO:K14234]
4578  
K14235 tRNA Trp | (RefSeq) TRNW; tRNA-Trp [KO:K14235]
4579  
K14236 tRNA Tyr | (RefSeq) TRNY; tRNA-Tyr [KO:K14236]
4577  
K14237 tRNA Val | (RefSeq) TRNV; tRNA-Val [KO:K14237]
124454  
K01885 glutamyl-tRNA synthetase [EC:6.1.1.17] | (RefSeq) EARS2; glutamyl-tRNA synthetase 2, mitochondrial [KO:K01885] [EC:6.1.1.17]
2058  
K14163 bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15] | (RefSeq) EPRS; glutamyl-prolyl-tRNA synthetase [KO:K14163] [EC:6.1.1.15 6.1.1.17]
55278  
K02433 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] | (RefSeq) QRSL1; glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 [KO:K02433] [EC:6.3.5.7 6.3.5.6]
5188  
K02434 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7] | (RefSeq) GATB; glutamyl-tRNA amidotransferase subunit B [KO:K02434] [EC:6.3.5.7 6.3.5.6]
283459  
K02435 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7] | (RefSeq) GATC; glutamyl-tRNA amidotransferase subunit C [KO:K02435] [EC:6.3.5.7 6.3.5.6]
5859  
K01886 glutaminyl-tRNA synthetase [EC:6.1.1.18] | (RefSeq) QARS; glutaminyl-tRNA synthetase [KO:K01886] [EC:6.1.1.18]
57505  
K01872 alanyl-tRNA synthetase [EC:6.1.1.7] | (RefSeq) AARS2; alanyl-tRNA synthetase 2, mitochondrial [KO:K01872] [EC:6.1.1.7]
16  
K01872 alanyl-tRNA synthetase [EC:6.1.1.7] | (RefSeq) AARS; alanyl-tRNA synthetase [KO:K01872] [EC:6.1.1.7]
55157  
K01876 aspartyl-tRNA synthetase [EC:6.1.1.12] | (RefSeq) DARS2; aspartyl-tRNA synthetase 2, mitochondrial [KO:K01876] [EC:6.1.1.12]
1615  
K01876 aspartyl-tRNA synthetase [EC:6.1.1.12] | (RefSeq) DARS; aspartyl-tRNA synthetase [KO:K01876] [EC:6.1.1.12]
79731  
K01893 asparaginyl-tRNA synthetase [EC:6.1.1.22] | (RefSeq) NARS2; asparaginyl-tRNA synthetase 2, mitochondrial (putative) [KO:K01893] [EC:6.1.1.22]
4677  
K01893 asparaginyl-tRNA synthetase [EC:6.1.1.22] | (RefSeq) NARS; asparaginyl-tRNA synthetase [KO:K01893] [EC:6.1.1.22]
2617  
K01880 glycyl-tRNA synthetase [EC:6.1.1.14] | (RefSeq) GARS; glycyl-tRNA synthetase [KO:K01880] [EC:6.1.1.14]
80222  
K01868 threonyl-tRNA synthetase [EC:6.1.1.3] | (RefSeq) TARS2; threonyl-tRNA synthetase 2, mitochondrial (putative) [KO:K01868] [EC:6.1.1.3]
6897  
K01868 threonyl-tRNA synthetase [EC:6.1.1.3] | (RefSeq) TARS; threonyl-tRNA synthetase [KO:K01868] [EC:6.1.1.3]
123283  
K01868 threonyl-tRNA synthetase [EC:6.1.1.3] | (RefSeq) TARSL2; threonyl-tRNA synthetase like 2 [KO:K01868] [EC:6.1.1.3]
54938  
K01875 seryl-tRNA synthetase [EC:6.1.1.11] | (RefSeq) SARS2; seryl-tRNA synthetase 2, mitochondrial [KO:K01875] [EC:6.1.1.11]
6301  
K01875 seryl-tRNA synthetase [EC:6.1.1.11] | (RefSeq) SARS; seryl-tRNA synthetase [KO:K01875] [EC:6.1.1.11]
118672  
K10837 O-phosphoseryl-tRNA(Sec) kinase [EC:2.7.1.164] | (RefSeq) PSTK; phosphoseryl-tRNA kinase [KO:K10837] [EC:2.7.1.164]
51091  
K03341 O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase [EC:2.9.1.2] | (RefSeq) SEPSECS; Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [KO:K03341] [EC:2.9.1.2]
833  
K01883 cysteinyl-tRNA synthetase [EC:6.1.1.16] | (RefSeq) CARS; cysteinyl-tRNA synthetase [KO:K01883] [EC:6.1.1.16]
79587  
K01883 cysteinyl-tRNA synthetase [EC:6.1.1.16] | (RefSeq) CARS2; cysteinyl-tRNA synthetase 2, mitochondrial (putative) [KO:K01883] [EC:6.1.1.16]
4141  
K01874 methionyl-tRNA synthetase [EC:6.1.1.10] | (RefSeq) MARS; methionyl-tRNA synthetase [KO:K01874] [EC:6.1.1.10]
92935  
K01874 methionyl-tRNA synthetase [EC:6.1.1.10] | (RefSeq) MARS2; methionyl-tRNA synthetase 2, mitochondrial [KO:K01874] [EC:6.1.1.10]
123263  
K00604 methionyl-tRNA formyltransferase [EC:2.1.2.9] | (RefSeq) MTFMT; mitochondrial methionyl-tRNA formyltransferase [KO:K00604] [EC:2.1.2.9]
57176  
K01873 valyl-tRNA synthetase [EC:6.1.1.9] | (RefSeq) VARS2; valyl-tRNA synthetase 2, mitochondrial [KO:K01873] [EC:6.1.1.9]
7407  
K01873 valyl-tRNA synthetase [EC:6.1.1.9] | (RefSeq) VARS; valyl-tRNA synthetase [KO:K01873] [EC:6.1.1.9]
51520  
K01869 leucyl-tRNA synthetase [EC:6.1.1.4] | (RefSeq) LARS; leucyl-tRNA synthetase [KO:K01869] [EC:6.1.1.4]
23395  
K01869 leucyl-tRNA synthetase [EC:6.1.1.4] | (RefSeq) LARS2; leucyl-tRNA synthetase 2, mitochondrial [KO:K01869] [EC:6.1.1.4]
3376  
K01870 isoleucyl-tRNA synthetase [EC:6.1.1.5] | (RefSeq) IARS; isoleucyl-tRNA synthetase [KO:K01870] [EC:6.1.1.5]
55699  
K01870 isoleucyl-tRNA synthetase [EC:6.1.1.5] | (RefSeq) IARS2; isoleucyl-tRNA synthetase 2, mitochondrial [KO:K01870] [EC:6.1.1.5]
3735  
K04567 lysyl-tRNA synthetase; lysyl-tRNA synthetase [KO:K04567] [EC:6.1.1.6]
57038  
K01887 arginyl-tRNA synthetase [EC:6.1.1.19] | (RefSeq) RARS2; arginyl-tRNA synthetase 2, mitochondrial [KO:K01887] [EC:6.1.1.19]
5917  
K01887 arginyl-tRNA synthetase [EC:6.1.1.19] | (RefSeq) RARS; arginyl-tRNA synthetase [KO:K01887] [EC:6.1.1.19]
25973  
K01881 prolyl-tRNA synthetase [EC:6.1.1.15] | (RefSeq) PARS2; prolyl-tRNA synthetase 2, mitochondrial (putative) [KO:K01881] [EC:6.1.1.15]
3035  
K01892 histidyl-tRNA synthetase [EC:6.1.1.21] | (RefSeq) HARS; histidyl-tRNA synthetase [KO:K01892] [EC:6.1.1.21]
23438  
K01892 histidyl-tRNA synthetase [EC:6.1.1.21] | (RefSeq) HARS2; histidyl-tRNA synthetase 2, mitochondrial [KO:K01892] [EC:6.1.1.21]
2193  
K01889 phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] | (RefSeq) FARSA; phenylalanyl-tRNA synthetase alpha subunit [KO:K01889] [EC:6.1.1.20]
10667  
K01889 phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] | (RefSeq) FARS2; phenylalanyl-tRNA synthetase 2, mitochondrial [KO:K01889] [EC:6.1.1.20]
10056  
K01890 phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] | (RefSeq) FARSB; phenylalanyl-tRNA synthetase beta subunit [KO:K01890] [EC:6.1.1.20]
8565  
K01866 tyrosyl-tRNA synthetase [EC:6.1.1.1] | (RefSeq) YARS; tyrosyl-tRNA synthetase [KO:K01866] [EC:6.1.1.1]
51067  
K01866 tyrosyl-tRNA synthetase [EC:6.1.1.1] | (RefSeq) YARS2; tyrosyl-tRNA synthetase 2 [KO:K01866] [EC:6.1.1.1]
10352  
K01867 tryptophanyl-tRNA synthetase [EC:6.1.1.2] | (RefSeq) WARS2; tryptophanyl tRNA synthetase 2, mitochondrial [KO:K01867] [EC:6.1.1.2]
7453  
K01867 tryptophanyl-tRNA synthetase [EC:6.1.1.2] | (RefSeq) WARS; tryptophanyl-tRNA synthetase [KO:K01867] [EC:6.1.1.2]
Compound
C00025  
L-Glutamate
C00037  
Glycine
C00041  
L-Alanine
C00047  
L-Lysine
C00049  
L-Aspartate
C00062  
L-Arginine
C00064  
L-Glutamine
C00065  
L-Serine
C00073  
L-Methionine
C00078  
L-Tryptophan
C00079  
L-Phenylalanine
C00082  
L-Tyrosine
C00097  
L-Cysteine
C00101  
Tetrahydrofolate
C00123  
L-Leucine
C00135  
L-Histidine
C00148  
L-Proline
C00152  
L-Asparagine
C00183  
L-Valine
C00188  
L-Threonine
C00234  
10-Formyltetrahydrofolate
C00407  
L-Isoleucine
C00886  
L-Alanyl-tRNA
C01005  
O-Phospho-L-serine
C01931  
L-Lysyl-tRNA
C02047  
L-Leucyl-tRNA
C02163  
L-Arginyl-tRNA(Arg)
C02282  
Glutaminyl-tRNA
C02412  
Glycyl-tRNA(Gly)
C02430  
L-Methionyl-tRNA
C02553  
L-Seryl-tRNA(Ser)
C02554  
L-Valyl-tRNA(Val)
C02702  
L-Prolyl-tRNA(Pro)
C02839  
L-Tyrosyl-tRNA(Tyr)
C02984  
L-Aspartyl-tRNA(Asp)
C02987  
L-Glutamyl-tRNA(Glu)
C02988  
L-Histidyl-tRNA(His)
C02992  
L-Threonyl-tRNA(Thr)
C03125  
L-Cysteinyl-tRNA(Cys)
C03127  
L-Isoleucyl-tRNA(Ile)
C03294  
N-Formylmethionyl-tRNA
C03402  
L-Asparaginyl-tRNA(Asn)
C03511  
L-Phenylalanyl-tRNA(Phe)
C03512  
L-Tryptophanyl-tRNA(Trp)
C06112  
L-Glutamyl-tRNA(Gln)
C06113  
L-Aspartyl-tRNA(Asn)
C06481  
L-Seryl-tRNA(Sec)
C06482  
L-Selenocysteinyl-tRNA(Sec)
C16138  
L-Pyrrolysine
C16638  
O-Phosphoseryl-tRNA(Sec)
C17022  
O-Phosphoseryl-tRNA(Cys)
C17027  
L-Pyrrolysyl-tRNA(Pyl)
Reference
  Authors
Sheppard K, Yuan J, Hohn MJ, Jester B, Devine KM, Soll D
  Title
From one amino acid to another: tRNA-dependent amino acid biosynthesis.
  Journal
Nucleic Acids Res 36:1813-25 (2008)
Reference
  Authors
Polycarpo C, Ambrogelly A, Berube A, Winbush SM, McCloskey JA, Crain PF, Wood JL, Soll D
  Title
An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
  Journal
Proc Natl Acad Sci U S A 101:12450-4 (2004)
KO pathway
 

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