KEGG   PATHWAY: hsa00983Help
Entry
hsa00983                    Pathway                                

Name
Drug metabolism - other enzymes - Homo sapiens (human)
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
Drug metabolism - other enzymes
hsa00983

All organismsOrtholog table
Disease
H00193  
Dihydropyrimidine dehydrogenase deficiency
H00199  
Dihydropyrimidinase deficiency
H00200  
Beta-ureidopropionase deficiency
H00964  
Thiopurine S-methyltransferase deficiency (TPMT deficiency)
Drug
D00752  
Mycophenolate mofetil (JAN/USAN)
D01206  
Febuxostat (JAN/USAN/INN)
D01846  
Gimeracil (JAN/INN)
D02365  
Oxypurinol (USAN)
D03998  
Eniluracil (USAN/INN)
D04936  
Merimepodib (USAN/INN)
D05094  
Mycophenolate mofetil hydrochloride (USAN)
D05095  
Mycophenolate sodium (USAN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
3251  
HPRT1; hypoxanthine phosphoribosyltransferase 1 [KO:K00760] [EC:2.4.2.8]
3614  
IMPDH1; IMP (inosine 5'-monophosphate) dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
3615  
IMPDH2; IMP (inosine 5'-monophosphate) dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
8833  
GMPS; guanine monophosphate synthase [KO:K01951] [EC:6.3.5.2]
7172  
TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
7498  
XDH; xanthine dehydrogenase [KO:K00106] [EC:1.17.3.2 1.17.1.4]
3704  
ITPA; inosine triphosphatase [KO:K01519] [EC:3.6.1.19]
1066  
CES1; carboxylesterase 1 [KO:K01044] [EC:3.1.1.1]
8824  
CES2; carboxylesterase 2 [KO:K03927] [EC:3.1.1.56 3.1.1.84 3.1.1.1]
10941  
UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]
79799  
UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]
7367  
UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]
10720  
UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]
54490  
UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]
54578  
UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]
54657  
UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]
54658  
UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]
54659  
UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]
7365  
UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]
54600  
UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]
7364  
UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]
54575  
UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]
54576  
UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]
54579  
UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]
7366  
UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]
54577  
UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]
7363  
UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]
574537  
UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]
2990  
GUSB; glucuronidase beta [KO:K01195] [EC:3.2.1.31]
1576  
CYP3A4; cytochrome P450 family 3 subfamily A member 4 [KO:K17689] [EC:1.14.13.- 1.14.13.157 1.14.13.97 1.14.13.67 1.14.13.32]
978  
CDA; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
1890  
TYMP; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
1806  
DPYD; dihydropyrimidine dehydrogenase [KO:K00207] [EC:1.3.1.2]
1807  
DPYS; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
51733  
UPB1; beta-ureidopropionase 1 [KO:K01431] [EC:3.5.1.6]
1548  
CYP2A6; cytochrome P450 family 2 subfamily A member 6 [KO:K17683] [EC:1.14.13.-]
151531  
UPP2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
7378  
UPP1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
83549  
UCK1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
7371  
UCK2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
54963  
UCKL1; uridine-cytidine kinase 1 like 1 [KO:K00876] [EC:2.7.1.48]
7084  
TK2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
7083  
TK1; thymidine kinase 1 [KO:K00857] [EC:2.7.1.21]
7372  
UMPS; uridine monophosphate synthetase [KO:K13421] [EC:4.1.1.23 2.4.2.10]
10  
NAT2; N-acetyltransferase 2 (arylamine N-acetyltransferase) [KO:K00622] [EC:2.3.1.5]
9  
NAT1; N-acetyltransferase 1 (arylamine N-acetyltransferase) [KO:K00622] [EC:2.3.1.5]
Compound
C02380  
6-Mercaptopurine
C04242  
5-Fluorodeoxyuridine monophosphate
C04646  
6-Thioinosine-5'-monophosphate
C05361  
Hydrazine
C06837  
Azathioprine
C07054  
Isoniazid
C07446  
Isonicotinic acid
C07447  
Acetylhydrazine
C07585  
N-Acetylisoniazid
C07648  
Thioguanine
C07649  
5-FU
C11173  
SN-38
C11376  
SN38 glucuronide
C11736  
5-Fluorodeoxyuridine
C12650  
Capecitabine
C12673  
Tegafur
C12739  
5'-Deoxy-5-fluorouridine
C16542  
APC
C16543  
NPC
C16613  
6-Thiourate
C16614  
6-Methylmercaptopurine
C16615  
6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  
6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  
6-Mercaptopurine ribonucleoside triphosphate
C16618  
6-Thioxanthine 5'-monophosphate
C16619  
6-Thioguanosine monophosphate
C16620  
6-Methylthioguanosine monophosphate
C16621  
1-Methyl-4-nitroimidazole
C16622  
N,N'-Diacetylhydrazine
C16623  
Isonicotinylglycine
C16624  
Isoniazid pyruvate
C16625  
Isoniazid alpha-ketoglutaric acid
C16630  
5,6-Dihydro-5-fluorouracil
C16631  
alpha-Fluoro-beta-ureidopropionic acid
C16632  
alpha-Fluoro-beta-alanine
C16633  
5-Fluorouridine
C16634  
5-Fluorouridine monophosphate
C16635  
5'-Deoxy-5-fluorocytidine
C16641  
Irinotecan
D00238  
Azathioprine (JP17/USP/INN)
D00346  
Isoniazid (JP17/USP/INN)
D00584  
Fluorouracil (JP17/USP/INN)
D01223  
Capecitabine (JAN/USAN/INN)
D01244  
Tegafur (JP17/USAN/INN)
D01309  
Doxifluridine (JP17/INN)
D04197  
Floxuridine (USP/INN)
D04931  
Mercaptopurine (INN)
D08086  
Irinotecan (INN)
D08603  
Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
KO pathway
 

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