KEGG PATHWAY: hsa03015

PATHWAY: hsa03015

Entry

hsa03015 Pathway

Name

mRNA surveillance pathway - Homo sapiens (human)

Description

The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.

Class

Genetic Information Processing; Translation

Pathway map

hsa03015

mRNA surveillance pathway

Module

hsa_M00399	Cap binding complex [PATH:hsa03015]
hsa_M00430	Exon junction complex (EJC) [PATH:hsa03015]

Disease

H00658	Syndromic X-linked mental retardation
H00704	Oculopharyngeal muscular dystrophy (OPMD)

Other DBs

BSID:

193328

GO:

0071028

Organism

Homo sapiens (human) [GN:hsa]

Gene

4686	NCBP1; nuclear cap binding protein subunit 1, 80kDa [KO:K12882]
22916	NCBP2; nuclear cap binding protein subunit 2, 20kDa [KO:K12883]
65109	UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
65110	UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
9939	RBM8A; RNA binding motif protein 8A [KO:K12876]
101060541	RNA-binding protein 8A-like; K12876 RNA-binding protein 8A [KO:K12876]
4116	MAGOH; mago-nashi homolog, proliferation-associated (Drosophila) [KO:K12877]
55110	MAGOHB; mago-nashi homolog B (Drosophila) [KO:K12877]
22794	CASC3; cancer susceptibility candidate 3 [KO:K14323]
9775	EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:3.6.4.13]
10284	SAP18; Sin3A-associated protein, 18kDa [KO:K14324]
5411	PNN; pinin, desmosome associated protein [KO:K13114]
22985	ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
10921	RNPS1; RNA binding protein S1, serine-rich domain [KO:K14325]
10189	ALYREF; Aly/REF export factor [KO:K12881]
10482	NXF1; nuclear RNA export factor 1 [KO:K14284]
56001	NXF2; nuclear RNA export factor 2 [KO:K14284]
728343	NXF2B; nuclear RNA export factor 2B [KO:K14284]
55998	NXF5; nuclear RNA export factor 5 [KO:K14284]
56000	NXF3; nuclear RNA export factor 3 [KO:K14284]
29107	NXT1; NTF2-like export factor 1 [KO:K14285]
55916	NXT2; nuclear transport factor 2-like export factor 2 [KO:K14285]
7919	DDX39B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B [KO:K12812] [EC:3.6.4.13]
84305	WIBG; within bgcn homolog (Drosophila) [KO:K14294]
10250	SRRM1; serine/arginine repetitive matrix 1 [KO:K13171]
8732	RNGTT; RNA guanylyltransferase and 5'-phosphatase [KO:K13917] [EC:3.1.3.33 2.7.7.50]
8731	RNMT; RNA (guanine-7-) methyltransferase [KO:K00565] [EC:2.1.1.56]
8106	PABPN1; poly(A) binding protein, nuclear 1 [KO:K14396]
390748	PABPN1L; poly(A) binding protein, nuclear 1-like (cytoplasmic) [KO:K14396]
100529063	BCL2L2-PABPN1; BCL2L2-PABPN1 readthrough [KO:K14396]
11051	NUDT21; nudix (nucleoside diphosphate linked moiety X)-type motif 21 [KO:K14397]
11052	CPSF6; cleavage and polyadenylation specific factor 6, 68kDa [KO:K14398]
79869	CPSF7; cleavage and polyadenylation specific factor 7, 59kDa [KO:K14398]
64895	PAPOLG; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
56903	PAPOLB; poly(A) polymerase beta (testis specific) [KO:K14376] [EC:2.7.7.19]
10914	PAPOLA; poly(A) polymerase alpha [KO:K14376] [EC:2.7.7.19]
10978	CLP1; cleavage and polyadenylation factor I subunit 1 [KO:K14399] [EC:2.7.1.78]
51585	PCF11; PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae) [KO:K14400]
29894	CPSF1; cleavage and polyadenylation specific factor 1, 160kDa [KO:K14401]
53981	CPSF2; cleavage and polyadenylation specific factor 2, 100kDa [KO:K14402]
51692	CPSF3; cleavage and polyadenylation specific factor 3, 73kDa [KO:K14403] [EC:3.1.27.-]
10898	CPSF4; cleavage and polyadenylation specific factor 4, 30kDa [KO:K14404]
81608	FIP1L1; FIP1 like 1 (S. cerevisiae) [KO:K14405]
55339	WDR33; WD repeat domain 33 [KO:K15542]
80335	WDR82; WD repeat domain 82 [KO:K14962]
5499	PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme [KO:K06269] [EC:3.1.3.16]
5500	PPP1CB; protein phosphatase 1, catalytic subunit, beta isozyme [KO:K06269] [EC:3.1.3.16]
5501	PPP1CC; protein phosphatase 1, catalytic subunit, gamma isozyme [KO:K06269] [EC:3.1.3.16]
29101	SSU72; SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) [KO:K15544] [EC:3.1.3.16]
1477	CSTF1; cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa [KO:K14406]
1478	CSTF2; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa [KO:K14407]
23283	CSTF2T; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant [KO:K14407]
1479	CSTF3; cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa [KO:K14408]
8189	SYMPK; symplekin [KO:K06100]
26528	DAZAP1; DAZ associated protein 1 [KO:K14411]
4440	MSI1; musashi RNA-binding protein 1 [KO:K14411]
124540	MSI2; musashi RNA-binding protein 2 [KO:K14411]
26986	PABPC1; poly(A) binding protein, cytoplasmic 1 [KO:K13126]
140886	PABPC5; poly(A) binding protein, cytoplasmic 5 [KO:K13126]
5042	PABPC3; poly(A) binding protein, cytoplasmic 3 [KO:K13126]
645974	PABPC1L2B; poly(A) binding protein, cytoplasmic 1-like 2B [KO:K13126]
80336	PABPC1L; poly(A) binding protein, cytoplasmic 1-like [KO:K13126]
340529	PABPC1L2A; poly(A) binding protein, cytoplasmic 1-like 2A [KO:K13126]
8761	PABPC4; poly(A) binding protein, cytoplasmic 4 (inducible form) [KO:K13126]
132430	PABPC4L; poly(A) binding protein, cytoplasmic 4-like [KO:K13126]
2107	ETF1; eukaryotic translation termination factor 1 [KO:K03265]
23708	GSPT2; G1 to S phase transition 2 [KO:K03267]
2935	GSPT1; G1 to S phase transition 1 [KO:K03267]
5976	UPF1; UPF1 regulator of nonsense transcripts homolog (yeast) [KO:K14326] [EC:3.6.4.-]
26019	UPF2; UPF2 regulator of nonsense transcripts homolog (yeast) [KO:K14327]
23049	SMG1; smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) [KO:K08873]
9887	SMG7; smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) [KO:K14409]
23381	SMG5; smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) [KO:K11125]
23293	SMG6; smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) [KO:K11124] [EC:3.1.-.-]
5515	PPP2CA; protein phosphatase 2, catalytic subunit, alpha isozyme [KO:K04382] [EC:3.1.3.16]
5516	PPP2CB; protein phosphatase 2, catalytic subunit, beta isozyme [KO:K04382] [EC:3.1.3.16]
5519	PPP2R1B; protein phosphatase 2, regulatory subunit A, beta [KO:K03456]
5518	PPP2R1A; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456]
5520	PPP2R2A; protein phosphatase 2, regulatory subunit B, alpha [KO:K04354]
5521	PPP2R2B; protein phosphatase 2, regulatory subunit B, beta [KO:K04354]
5522	PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
55844	PPP2R2D; protein phosphatase 2, regulatory subunit B, delta [KO:K04354]
28227	PPP2R3B; protein phosphatase 2, regulatory subunit B'', beta [KO:K11583]
55012	PPP2R3C; protein phosphatase 2, regulatory subunit B'', gamma [KO:K11583]
5523	PPP2R3A; protein phosphatase 2, regulatory subunit B'', alpha [KO:K11583]
5526	PPP2R5B; protein phosphatase 2, regulatory subunit B', beta [KO:K11584]
5527	PPP2R5C; protein phosphatase 2, regulatory subunit B', gamma [KO:K11584]
5528	PPP2R5D; protein phosphatase 2, regulatory subunit B', delta [KO:K11584]
5529	PPP2R5E; protein phosphatase 2, regulatory subunit B', epsilon isoform [KO:K11584]
5525	PPP2R5A; protein phosphatase 2, regulatory subunit B', alpha [KO:K11584]
10767	HBS1L; HBS1-like (S. cerevisiae) [KO:K14416]
53918	PELO; pelota homolog (Drosophila) [KO:K06965]

Reference

PMID:15040442

Authors

Maquat LE

Title

Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.

Journal

Nat Rev Mol Cell Biol 5:89-99 (2004)

Reference

PMID:16723977

Authors

Amrani N, Sachs MS, Jacobson A

Title

Early nonsense: mRNA decay solves a translational problem.

Journal

Nat Rev Mol Cell Biol 7:415-25 (2006)

Reference

PMID:17183357

Authors

Eulalio A, Behm-Ansmant I, Izaurralde E

Title

P bodies: at the crossroads of post-transcriptional pathways.

Journal

Nat Rev Mol Cell Biol 8:9-22 (2007)

Reference

PMID:18158581

Authors

Mandel CR, Bai Y, Tong L

Title

Protein factors in pre-mRNA 3'-end processing.

Journal

Cell Mol Life Sci 65:1099-122 (2008)

Reference

PMID:16715045

Authors

Clement SL, Lykke-Andersen J

Title

No mercy for messages that mess with the ribosome.

Journal

Nat Struct Mol Biol 13:299-301 (2006)

KO pathway

ko03015

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (3)   
   KEGG MODULE (2)   
   BioSystems (1)   
Disease (2)   
   KEGG DISEASE (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (92)   
   KEGG GENES (92)   
All databases (99)   

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