KEGG   PATHWAY: hsa03015Help
Entry
hsa03015                    Pathway                                

Name
mRNA surveillance pathway - Homo sapiens (human)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These  pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
mRNA surveillance pathway
hsa03015

All organismsOrtholog table
Module
Cap binding complex [PATH:hsa03015]
Exon junction complex (EJC) [PATH:hsa03015]
Disease
H00658  
Syndromic X-linked mental retardation
H00704  
Oculopharyngeal muscular dystrophy (OPMD)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
4686  
NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
22916  
NCBP2; nuclear cap binding protein subunit 2 [KO:K12883]
65109  
UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
65110  
UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
9939  
RBM8A; RNA binding motif protein 8A [KO:K12876]
4116  
MAGOH; mago homolog, exon junction complex core component [KO:K12877]
55110  
MAGOHB; mago homolog B, exon junction complex core component [KO:K12877]
22794  
CASC3; cancer susceptibility candidate 3 [KO:K14323]
9775  
EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:3.6.4.13]
10284  
SAP18; Sin3A associated protein 18kDa [KO:K14324]
5411  
PNN; pinin, desmosome associated protein [KO:K13114]
22985  
ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
10921  
RNPS1; RNA binding protein with serine rich domain 1 [KO:K14325]
10189  
ALYREF; Aly/REF export factor [KO:K12881]
10482  
NXF1; nuclear RNA export factor 1 [KO:K14284]
56001  
NXF2; nuclear RNA export factor 2 [KO:K14284]
728343  
NXF2B; nuclear RNA export factor 2B [KO:K14284]
55998  
NXF5; nuclear RNA export factor 5 [KO:K14284]
56000  
NXF3; nuclear RNA export factor 3 [KO:K14284]
29107  
NXT1; nuclear transport factor 2 like export factor 1 [KO:K14285]
55916  
NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
7919  
DDX39B; DEAD-box helicase 39B [KO:K12812] [EC:3.6.4.13]
84305  
PYM1; PYM homolog 1, exon junction complex associated factor [KO:K14294]
10250  
SRRM1; serine and arginine repetitive matrix 1 [KO:K13171]
8732  
RNGTT; RNA guanylyltransferase and 5'-phosphatase [KO:K13917] [EC:3.6.1.- 2.7.7.50]
8731  
RNMT; RNA guanine-7 methyltransferase [KO:K00565] [EC:2.1.1.56]
8106  
PABPN1; poly(A) binding protein nuclear 1 [KO:K14396]
390748  
PABPN1L; poly(A) binding protein nuclear 1 like (cytoplasmic) [KO:K14396]
BCL2L2-PABPN1; BCL2L2-PABPN1 readthrough [KO:K14396]
11051  
NUDT21; nudix hydrolase 21 [KO:K14397]
11052  
CPSF6; cleavage and polyadenylation specific factor 6 [KO:K14398]
79869  
CPSF7; cleavage and polyadenylation specific factor 7 [KO:K14398]
64895  
PAPOLG; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
56903  
PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
10914  
PAPOLA; poly(A) polymerase alpha [KO:K14376] [EC:2.7.7.19]
10978  
CLP1; cleavage and polyadenylation factor I subunit 1 [KO:K14399] [EC:2.7.1.78]
51585  
PCF11; PCF11 cleavage and polyadenylation factor subunit [KO:K14400]
29894  
CPSF1; cleavage and polyadenylation specific factor 1 [KO:K14401]
53981  
CPSF2; cleavage and polyadenylation specific factor 2 [KO:K14402]
51692  
CPSF3; cleavage and polyadenylation specific factor 3 [KO:K14403] [EC:3.1.27.-]
10898  
CPSF4; cleavage and polyadenylation specific factor 4 [KO:K14404]
81608  
FIP1L1; factor interacting with PAPOLA and CPSF1 [KO:K14405]
55339  
WDR33; WD repeat domain 33 [KO:K15542]
80335  
WDR82; WD repeat domain 82 [KO:K14962]
5499  
PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
5500  
PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
5501  
PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
29101  
SSU72; SSU72 homolog, RNA polymerase II CTD phosphatase [KO:K15544] [EC:3.1.3.16]
1477  
CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
1478  
CSTF2; cleavage stimulation factor subunit 2 [KO:K14407]
23283  
CSTF2T; cleavage stimulation factor subunit 2, tau variant [KO:K14407]
1479  
CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
8189  
SYMPK; symplekin [KO:K06100]
26528  
DAZAP1; DAZ associated protein 1 [KO:K14411]
4440  
MSI1; musashi RNA binding protein 1 [KO:K14411]
124540  
MSI2; musashi RNA binding protein 2 [KO:K14411]
26986  
PABPC1; poly(A) binding protein cytoplasmic 1 [KO:K13126]
140886  
PABPC5; poly(A) binding protein cytoplasmic 5 [KO:K13126]
5042  
PABPC3; poly(A) binding protein cytoplasmic 3 [KO:K13126]
645974  
PABPC1L2B; poly(A) binding protein cytoplasmic 1 like 2B [KO:K13126]
80336  
PABPC1L; poly(A) binding protein cytoplasmic 1 like [KO:K13126]
340529  
PABPC1L2A; poly(A) binding protein cytoplasmic 1 like 2A [KO:K13126]
8761  
PABPC4; poly(A) binding protein cytoplasmic 4 [KO:K13126]
132430  
PABPC4L; poly(A) binding protein cytoplasmic 4 like [KO:K13126]
2107  
ETF1; eukaryotic translation termination factor 1 [KO:K03265]
23708  
GSPT2; G1 to S phase transition 2 [KO:K03267]
2935  
GSPT1; G1 to S phase transition 1 [KO:K03267]
5976  
UPF1; UPF1, RNA helicase and ATPase [KO:K14326] [EC:3.6.4.-]
26019  
UPF2; UPF2 regulator of nonsense transcripts homolog (yeast) [KO:K14327]
23049  
SMG1; SMG1, nonsense mediated mRNA decay associated PI3K related kinase [KO:K08873] [EC:2.7.11.1]
9887  
SMG7; SMG7, nonsense mediated mRNA decay factor [KO:K14409]
23381  
SMG5; SMG5, nonsense mediated mRNA decay factor [KO:K11125]
23293  
SMG6; SMG6, nonsense mediated mRNA decay factor [KO:K11124] [EC:3.1.-.-]
5515  
PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
5516  
PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
5519  
PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
5518  
PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
5520  
PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
5521  
PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
5522  
PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
55844  
PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
28227  
PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
55012  
PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
5523  
PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1; K11583 serine/threonine-protein phosphatase 2A regulatory subunit B'' [KO:K11583]
5526  
PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
5527  
PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
5528  
PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
5529  
PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
5525  
PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
10767  
HBS1L; HBS1 like translational GTPase [KO:K14416]
53918  
PELO; pelota homolog (Drosophila) [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
KO pathway
 

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