KEGG   PATHWAY: hsa04270Help
Entry
hsa04270                    Pathway                                

Name
Vascular smooth muscle contraction - Homo sapiens (human)
Description
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration ([Ca2+]c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase [Ca2+]c in VSMCs. The increase in [Ca2+]c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement.
The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs.
Class
Organismal Systems; Circulatory system
BRITE hierarchy
Pathway map
Vascular smooth muscle contraction
hsa04270

All organismsOrtholog table
Disease
H00728  
Brugada syndrome (BRS)
H00731  
Atrial fibrillation
H00746  
Hypokalemic periodic paralysis (HypoPP)
H00801  
Familial thoracic aortic aneurysm and dissection (TAAD)
H01258  
Generalized epilepsy and paroxysmal dyskinesia (GEPD)
H01396  
Moyamoya Disease
Drug
D00045  
Adenosine (JAN/USP)
D00076  
Noradrenaline (JP17)
D00095  
Epinephrine (USP/INN)
D00101  
Vasopressin (JP17/USP)
D00106  
Epoprostenol (USAN/INN)
D00124  
Ephedrine (USP)
D00150  
Angiotensin II (INN)
D00227  
Aminophylline (USP/INN)
D00255  
Carvedilol (JAN/USAN/INN)
D00283  
Clozapine (JAN/USP/INN)
D00291  
Desmopressin (INN)
D00319  
Felodipine (JAN/USP/INN)
D00349  
Isradipine (USP/INN)
D00357  
Losartan potassium (JP17/USAN)
D00366  
Lypressin (USP/INN)
D00371  
Theophylline (JP17)
D00400  
Valsartan (JP17/USAN/INN)
D00426  
Risperidone (JP17/USAN/INN)
D00437  
Nifedipine (JP17/USP/INN)
D00438  
Nimodipine (USAN/INN)
D00454  
Olanzapine (JAN/USAN/INN)
D00458  
Quetiapine fumarate (JP17/USAN)
D00485  
Pseudoephedrine hydrochloride (USP)
D00507  
Phenoxybenzamine hydrochloride (USP)
D00509  
Phentolamine mesylate (USP)
D00511  
Phenylephrine hydrochloride (JP17/USP)
D00522  
Candesartan (USAN/INN)
D00523  
Irbesartan (JP17/USAN/INN)
D00528  
Caffeine (USP)
D00600  
Labetalol hydrochloride (JP17/USP)
D00607  
Guanadrel sulfate (USP)
D00608  
Doxazosin mesylate (USAN)
D00609  
Prazosin hydrochloride (JP17/USP)
D00610  
Terazosin hydrochloride (USAN)
D00615  
Amlodipine besylate (USAN)
D00616  
Diltiazem hydrochloride (JP17/USP)
D00617  
Nicardipine hydrochloride (JP17/USAN)
D00618  
Nisoldipine (JAN/USAN/INN)
D00619  
Verapamil hydrochloride (JP17/USP)
D00626  
Candesartan cilexetil (JP17/USAN)
D00627  
Telmisartan (JP17/USAN/INN)
D00629  
Nitrendipine (JP17/USAN/INN)
D00631  
Bepridil hydrochloride (USAN)
D00636  
Amiodarone hydrochloride (JP17/USAN)
D00679  
Ergotamine tartrate (JP17/USP)
D00680  
Methylergonovine maleate (USP)
D00743  
Naphazoline hydrochloride (JP17/USP)
D00756  
Tetrahydrozoline nitrate (JAN)
D00757  
Xylometazoline hydrochloride (USP)
D00996  
Epinephrine hydrochloride (JAN)
D00997  
Tolazoline hydrochloride (JAN/USP)
D01017  
Dipivefrin hydrochloride (JAN/USP)
D01019  
Metaraminol bitartrate (JAN/USP)
D01020  
Methoxamine hydrochloride (JAN)
D01021  
Naphazoline nitrate (JP17)
D01022  
Oxymetazoline hydrochloride (JAN/USP)
D01023  
Tetrahydrozoline hydrochloride (JAN/USP)
D01024  
Tamsulosin hydrochloride (JP17/USAN)
D01104  
Barnidipine hydrochloride (JAN)
D01145  
Azelnidipine (JP17/INN)
D01163  
Ergonovine maleate (USP)
D01173  
Cilnidipine (JP17/INN)
D01188  
Pimilprost (JAN/INN)
D01204  
Olmesartan medoxomil (JP17/USAN)
D01227  
Bosentan (USAN)
D01236  
Conivaptan hydrochloride (JAN/USAN)
D01290  
Nicergoline (JP17/USAN/INN)
D01307  
Midodrine hydrochloride (JAN/USAN)
D01333  
Urapidil (JP17/INN)
D01337  
Epoprostenol sodium (JAN/USAN)
D01347  
Tramazoline hydrochloride (JAN/USAN)
D01358  
Mianserin hydrochloride (JAN/USAN)
D01385  
Ibudilast (JP17/INN)
D01386  
Ephedrine hydrochloride (JP17/USP)
D01405  
Norfenefrine hydrochloride (JAN)
D01444  
Bunitrolol hydrochloride (JAN)
D01445  
Ifenprodil tartrate (JP17)
D01453  
Caffeine hydrate (JP17)
D01469  
Amosulalol hydrochloride (JP17)
D01520  
Levomepromazine hydrochloride (JAN/USAN)
D01551  
Beraprost sodium (JP17/USAN)
D01553  
Manidipine hydrochloride (JP17)
D01562  
Aranidipine (JAN/INN)
D01571  
Moxisylyte hydrochloride (JAN)
D01573  
Etilefrine hydrochloride (JP17)
D01604  
Efonidipine hydrochloride ethanolate (JAN)
D01674  
Naftopidil (JP17/INN)
D01692  
Alfuzosin hydrochloride (JAN/USAN)
D01712  
Theophylline sodium acetate (JAN)
D01771  
Proxyphylline (JAN/INN)
D01830  
Arotinolol hydrochloride (JP17)
D01849  
Lercanidipine hydrochloride (JAN/USAN)
D01887  
Bunazosin hydrochloride (JP17)
D01908  
Nilvadipine (JP17/USAN/INN)
D01922  
Pratosartan (JAN/INN)
D01952  
L-Methylephedrine hydrochloride (JAN)
D01965  
Silodosin (JP17/INN)
D01969  
Gallopamil hydrochloride (JAN)
D02014  
Angiotensin II (human type) (JAN)
D02017  
Oxtriphylline (USP)
D02034  
Setiptiline maleate (JAN)
D02045  
Benidipine hydrochloride (JP17)
D02048  
Clinprost (JAN/INN)
D02082  
Eprosartan mesylate (USAN)
D02109  
dl-Methylephedrine hydrochloride (JP17)
D02149  
Epinephrine bitartrate (JAN/USP)
D02211  
Dihydroergotamine mesylate (USP)
D02235  
Desmopressin acetate (USAN)
D02248  
Levomepromazine maleate (JP17/USAN)
D02349  
Dipivefrin (USAN)
D02356  
Verapamil (USAN/INN)
D02363  
Ketanserin (USAN/INN)
D02537  
Dronedarone (INN)
D02720  
Beraprost (USAN)
D02721  
Iloprost (USAN/INN)
D02910  
Amiodarone (USAN/INN)
D02914  
Amlodipine maleate (USAN)
D02939  
Angiotensin amide (USAN)
D02976  
Arbutamine hydrochloride (USAN)
D02983  
Argipressin tannate (USAN)
D02995  
Asenapine maleate (JAN/USAN)
D03009  
Atrasentan hydrochloride (USAN)
D03120  
Binodenoson (USAN/INN)
D03212  
Apadenoson (USAN)
D03415  
Carvedilol phosphate (USAN)
D03648  
Dapiprazole hydrochloride (USAN)
D03655  
Darodipine (USAN/INN)
D03830  
Diltiazem malate (USAN)
D03914  
Dronedarone hydrochloride (USAN)
D03953  
Edonentan (USAN)
D04006  
Enprofylline (USAN/INN)
D04018  
Ephedrine sulfate (USP)
D04040  
Eprosartan (USAN/INN)
D04126  
Saralasin acetate (USAN)
D04137  
Felypressin (USAN/INN)
D04184  
Fiduxosin hydrochloride (USAN)
D04243  
Forasartan (USAN/INN)
D04531  
Indoramin (USAN/INN)
D04532  
Indoramin hydrochloride (USAN)
D04641  
Istradefylline (JAN/USAN/INN)
D04657  
Lacidipine (USAN/INN)
D04888  
Medroxalol (USAN/INN)
D04889  
Medroxalol hydrochloride (USAN)
D05147  
Nesiritide (USAN/INN)
D05148  
Nesiritide citrate (USAN)
D05206  
Norepinephrine bitartrate (USP)
D05246  
Olmesartan (USAN/INN)
D05395  
Pelanserin hydrochloride (USAN)
D05429  
Aminophylline hydrate (JP17)
D05648  
Pseudoephedrine polistirex (USAN)
D05649  
Pseudoephedrine sulfate (USP)
D05711  
Regadenoson (USAN/INN)
D06103  
Theophylline (USP)
D06104  
Theophylline sodium glycinate (USP)
D06213  
Treprostinil (JAN/USAN/INN)
D06234  
Trimazosin hydrochloride (USAN)
D06394  
Dabuzalgron hydrochloride (USAN)
D06623  
Olanzapine pamoate (USAN)
D06672  
Terlipressin (USAN/INN)
D07077  
Ambrisentan (JAN/INN)
D07124  
Alfuzosin (INN)
D07148  
Oxedrine (BAN)
D07171  
Sitaxentan (USAN/INN)
D07185  
Fendiline (INN)
D07227  
Ornipressin (INN)
D07450  
Amlodipine (USAN/INN)
D07451  
Amosulalol (INN)
D07465  
Arotinolol (INN)
D07494  
Barnidipine (INN)
D07509  
Benidipine (INN)
D07520  
Bepridil (INN)
D07538  
Bosentan (INN)
D07550  
Bunazosin (INN)
D07577  
Cinaciguat (JAN/INN)
D07603  
Caffeine citrate (USP)
D07682  
Clazosentan sodium (JAN)
D07741  
Zibotentan (JAN/USAN/INN)
D07748  
Conivaptan (INN)
D07837  
Dihydroergotamine (INN)
D07838  
Dihydroergotamine tartrate
D07845  
Diltiazem (INN)
D07874  
Doxazosin (INN)
D07886  
Efonidipine (INN)
D07905  
Ergometrine (INN)
D07906  
Ergotamine (INN)
D07931  
Etilefrine (INN)
D08009  
Gallopamil (INN)
D08064  
Ifenprodil (INN)
D08065  
Iloprost tromethamine
D08067  
Azilsartan medoxomil (USAN)
D08099  
Ketanserin tartrate
D08106  
Labetalol (INN)
D08111  
Lercanidipine (INN)
D08146  
Losartan (INN)
D08155  
Manidipine (INN)
D08192  
Metaraminol (INN)
D08201  
Methoxamine (BAN)
D08206  
Methylephedrine (BAN)
D08207  
Methylergometrine (INN)
D08212  
Trimazosin (INN)
D08216  
Mianserin (INN)
D08220  
Midodrine (INN)
D08239  
Moxisylyte (INN)
D08253  
Naphazoline (INN)
D08270  
Nicardipine (INN)
D08271  
Nicergoline tartrate
D08284  
Norepinephrine hydrochoride
D08286  
Norfenefrine (INN)
D08308  
Oxedrine tartrate
D08309  
Oxedrine hydrochloride
D08322  
Oxymetazoline (INN)
D08340  
Perhexiline (INN)
D08358  
Phenoxybenzamine (INN)
D08362  
Phentolamine (INN)
D08365  
Phenylephrine (INN)
D08366  
Phenylephrine tartrate
D08411  
Prazosin (INN)
D08449  
Pseudoephedrine (INN)
D08456  
Quetiapine (INN)
D08511  
Setiptiline (INN)
D08517  
Sitaxentan sodium (USAN)
D08560  
Tamsulosin (INN)
D08569  
Terazosin (INN)
D08571  
Terlipressin acetate (JAN)
D08578  
Tetryzoline (INN)
D08614  
Tolazoline (INN)
D08624  
Tramazoline (INN)
D08628  
Treprostinil monosodium salt
D08662  
Urapidil hydrochloride
D08684  
Xylometazoline (INN)
D08864  
Azilsartan (JAN/USAN/INN)
D08865  
Azilsartan kamedoxomil (USAN)
D08892  
Clevidipine (USAN/INN)
D08966  
Phenylephrine bitartrate (USP)
D09003  
Sonedenoson (USAN)
D09391  
Telcagepant (USAN)
D09392  
Telcagepant potassium (USAN)
D09572  
Riociguat (JAN/INN)
D09671  
Sotrastaurin (USAN/INN)
D09718  
Sotrastaurin acetate (USAN)
D09789  
Kirenidipine hydrochloride (JAN)
D09794  
Norepinephrine hydrochloride (JAN)
D09820  
Vasopressin tannate (JAN)
D09842  
dl-Methylephedrine saccharinate (JAN)
D09991  
Vipadenant (USAN/INN)
D09994  
Selexipag (JAN/USAN/INN)
D10063  
Cenderitide (USAN)
D10135  
Macitentan (JAN/USAN)
D10430  
Treprostinil diolamine (USAN)
D10628  
Esuberaprost (USAN/INN)
D10703  
Esuberaprost sodium (USAN)
D10725  
Ralinepag (USAN/INN)
D10737  
Verosudil (USAN/INN)
D10738  
Verosudil hydrochloride (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
148  
ADRA1A; adrenoceptor alpha 1A [KO:K04135]
147  
ADRA1B; adrenoceptor alpha 1B [KO:K04136]
146  
ADRA1D; adrenoceptor alpha 1D [KO:K04137]
185  
AGTR1; angiotensin II receptor type 1 [KO:K04166]
1909  
EDNRA; endothelin receptor type A [KO:K04197]
552  
AVPR1A; arginine vasopressin receptor 1A [KO:K04226]
553  
AVPR1B; arginine vasopressin receptor 1B [KO:K04227]
2776  
GNAQ; G protein subunit alpha q [KO:K04634]
2767  
GNA11; G protein subunit alpha 11 [KO:K04635]
8399  
PLA2G10; phospholipase A2 group X [KO:K01047] [EC:3.1.1.4]
26279  
PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
30814  
PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
50487  
PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
64600  
PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
81579  
PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
84647  
PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
5319  
PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
5322  
PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
5320  
PLA2G2A; phospholipase A2 group IIA [KO:K01047] [EC:3.1.1.4]
391013  
PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
123745  
PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
5321  
PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
8681  
JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
8605  
PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
283748  
PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
255189  
PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
8398  
PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
1579  
CYP4A11; cytochrome P450 family 4 subfamily A member 11 [KO:K17687] [EC:1.14.15.3]
284541  
CYP4A22; cytochrome P450 family 4 subfamily A member 22 [KO:K17688] [EC:1.14.15.3]
3778  
KCNMA1; potassium calcium-activated channel subfamily M alpha 1 [KO:K04936]
157855  
KCNU1; potassium calcium-activated channel subfamily U member 1 [KO:K05274]
3779  
KCNMB1; potassium calcium-activated channel subfamily M regulatory beta subunit 1 [KO:K04937]
10242  
KCNMB2; potassium calcium-activated channel subfamily M regulatory beta subunit 2 [KO:K04938]
27094  
KCNMB3; potassium calcium-activated channel subfamily M regulatory beta subunit 3 [KO:K04939]
27345  
KCNMB4; potassium calcium-activated channel subfamily M regulatory beta subunit 4 [KO:K04941]
775  
CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
776  
CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
778  
CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
779  
CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
810  
CALML3; calmodulin like 3 [KO:K02183]
805  
CALM2; calmodulin 2 (phosphorylase kinase, delta) [KO:K02183]
808  
CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
801  
CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
163688  
CALML6; calmodulin like 6 [KO:K02183]
51806  
CALML5; calmodulin like 5 [KO:K02183]
4638  
MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
85366  
MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
91807  
MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
340156  
MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
140465  
MYL6B; myosin light chain 6B [KO:K12751]
4637  
MYL6; myosin light chain 6 [KO:K12751]
10398  
MYL9; myosin light chain 9 [KO:K12755]
23236  
PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
5330  
PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
5331  
PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
5332  
PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
3708  
ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
3709  
ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
3710  
ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
5578  
PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
5579  
PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
5582  
PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
5580  
PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
5581  
PRKCE; protein kinase C epsilon [KO:K18050] [EC:2.7.11.13]
5583  
PRKCH; protein kinase C eta [KO:K18051] [EC:2.7.11.13]
5588  
PRKCQ; protein kinase C theta [KO:K18052] [EC:2.7.11.13]
369  
ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
673  
BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
5894  
RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
5604  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  
MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
800  
CALD1; caldesmon 1 [KO:K12327]
59  
ACTA2; actin, alpha 2, smooth muscle, aorta [KO:K12313]
72  
ACTG2; actin, gamma 2, smooth muscle, enteric [KO:K12315]
94274  
PPP1R14A; protein phosphatase 1 regulatory inhibitor subunit 14A [KO:K12328]
5499  
PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
5500  
PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
5501  
PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
4659  
PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
4660  
PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
54776  
PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
2768  
GNA12; G protein subunit alpha 12 [KO:K04346]
10672  
GNA13; G protein subunit alpha 13 [KO:K04639]
23365  
ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
9138  
ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
9826  
ARHGEF11; Rho guanine nucleotide exchange factor 11 [KO:K12331]
387  
RHOA; ras homolog family member A [KO:K04513]
6093  
ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
9475  
ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
135  
ADORA2A; adenosine A2a receptor [KO:K04266]
136  
ADORA2B; adenosine A2b receptor [KO:K04267]
5739  
PTGIR; prostaglandin I2 (prostacyclin) receptor (IP) [KO:K04263]
10203  
CALCRL; calcitonin receptor like receptor [KO:K04577]
10267  
RAMP1; receptor activity modifying protein 1 [KO:K08447]
10266  
RAMP2; receptor activity modifying protein 2 [KO:K08448]
10268  
RAMP3; receptor (G protein-coupled) activity modifying protein 3 [KO:K08449]
2778  
GNAS; GNAS complex locus [KO:K04632]
107  
ADCY1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
108  
ADCY2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
109  
ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
196883  
ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
111  
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
112  
ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
113  
ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
114  
ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
115  
ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
5566  
PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
5567  
PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
5568  
PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
4881  
NPR1; natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
4882  
NPR2; natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
5592  
PRKG1; protein kinase, cGMP-dependent, type I [KO:K07376] [EC:2.7.11.12]
10335  
MRVI1; murine retrovirus integration site 1 homolog [KO:K12337]
2977  
GUCY1A2; guanylate cyclase 1, soluble, alpha 2 [KO:K12318] [EC:4.6.1.2]
2982  
GUCY1A3; guanylate cyclase 1, soluble, alpha 3 [KO:K12318] [EC:4.6.1.2]
2983  
GUCY1B3; guanylate cyclase 1, soluble, beta 3 [KO:K12319] [EC:4.6.1.2]
4629  
MYH11; myosin, heavy chain 11, smooth muscle [KO:K10352]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00212  
Adenosine
C00219  
Arachidonate
C00238  
Potassium cation
C00533  
Nitric oxide
C00547  
L-Noradrenaline
C00575  
3',5'-Cyclic AMP
C00942  
3',5'-Cyclic GMP
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C01312  
Prostaglandin I2
C02135  
Angiotensin II
C13662  
Arg-vasopressin
C14748  
20-HETE
C14768  
5,6-EET
C14769  
8,9-EET
C14770  
11,12-EET
C14771  
14,15-EET
C16003  
Atrial natriuretic peptide
C16004  
Brain natriuretic peptide
C16005  
C-Type natriuretic peptide
C16010  
Endothelin-1
C16012  
Endothelin-2
C16013  
Endothelin-3
C16125  
Calcitonin gene-related peptide 1
C16127  
Adrenomedullin
Reference
  Authors
Akata T
  Title
Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.
  Journal
J Anesth 21:232-42 (2007)
Reference
  Authors
Ogut O, Brozovich FV
  Title
Regulation of force in vascular smooth muscle.
  Journal
J Mol Cell Cardiol 35:347-55 (2003)
Reference
  Authors
Hilgers RH, Webb RC
  Title
Molecular aspects of arterial smooth muscle contraction: focus on Rho.
  Journal
Exp Biol Med (Maywood) 230:829-35 (2005)
Reference
  Authors
Schlossmann J, Feil R, Hofmann F
  Title
Signaling through NO and cGMP-dependent protein kinases.
  Journal
Ann Med 35:21-7 (2003)
Reference
  Authors
Mehta PK, Griendling KK
  Title
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
  Journal
Am J Physiol Cell Physiol 292:C82-97 (2007)
Reference
  Authors
Kim HR, Appel S, Vetterkind S, Gangopadhyay SS, Morgan KG
  Title
Smooth muscle signalling pathways in health and disease.
  Journal
J Cell Mol Med 12:2165-80 (2008)
Reference
  Authors
Fukata Y, Amano M, Kaibuchi K
  Title
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
  Journal
Trends Pharmacol Sci 22:32-9 (2001)
Reference
  Authors
Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T
  Title
Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle.
  Journal
Circ Res 100:121-9 (2007)
Reference
  Authors
Hynynen MM, Khalil RA
  Title
The vascular endothelin system in hypertension--recent patents and discoveries.
  Journal
Recent Pat Cardiovasc Drug Discov 1:95-108 (2006)
Reference
  Authors
Brain SD, Grant AD
  Title
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
  Journal
Physiol Rev 84:903-34 (2004)
Reference
  Authors
Roman RJ
  Title
P-450 metabolites of arachidonic acid in the control of cardiovascular function.
  Journal
Physiol Rev 82:131-85 (2002)
Reference
  Authors
Surks HK
  Title
cGMP-dependent protein kinase I and smooth muscle relaxation: a tale of two isoforms.
  Journal
Circ Res 101:1078-80 (2007)
Reference
  Authors
Vanhoutte PM
  Title
Endothelium-dependent hyperpolarizations: the history.
  Journal
Pharmacol Res 49:503-8 (2004)
Reference
  Authors
Davis MJ, Hill MA
  Title
Signaling mechanisms underlying the vascular myogenic response.
  Journal
Physiol Rev 79:387-423 (1999)
Reference
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
Reference
  Authors
Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP
  Title
Molecular mechanism of cGMP-mediated smooth muscle relaxation.
  Journal
J Cell Physiol 184:409-20 (2000)
Reference
  Authors
Ko EA, Han J, Jung ID, Park WS
  Title
Physiological roles of K+ channels in vascular smooth muscle cells.
  Journal
J Smooth Muscle Res 44:65-81 (2008)
Reference
  Authors
Woodard GE, Rosado JA
  Title
Natriuretic peptides in vascular physiology and pathology.
  Journal
Int Rev Cell Mol Biol 268:59-93 (2008)
Reference
  Authors
Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG
  Title
Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.
  Journal
Am J Physiol Heart Circ Physiol 281:H2337-65 (2001)
Reference
  Authors
Hirano K, Hirano M, Kanaide H
  Title
Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.
  Journal
J Smooth Muscle Res 40:219-36 (2004)
Reference
PMID:9458738
  Authors
Freeman EJ, Ruehr ML, Dorman RV
  Title
ANG II-induced translocation of cytosolic PLA2 to the nucleus in vascular smooth muscle cells.
  Journal
Am J Physiol 274:C282-8 (1998)
Reference
  Authors
Murphy TV, Spurrell BE, Hill MA
  Title
Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways.
  Journal
Clin Exp Pharmacol Physiol 29:612-9 (2002)
KO pathway
 

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