KEGG   PATHWAY: hsa04514Help
Entry
hsa04514                    Pathway                                

Name
Cell adhesion molecules (CAMs) - Homo sapiens (human)
Description
Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Cell adhesion molecules (CAMs)
hsa04514

All organismsOrtholog table
Disease
H00577  
Syndromic X-linked mental retardation with epilepsy or seizures
H00586  
Epidermolysis bullosa, junctional
H00639  
Ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM syndrome)
H00742  
Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome
H00756  
Pitt-Hopkins syndrome
H00773  
Autosomal dominant mental retardation
H00785  
Congenital hypotrichosis with juvenile macular dystrophy
H00805  
Vitreoretinal degeneration
H00840  
Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG)
H01034  
L1 syndrome
H01155  
Roussy-Levy syndrome
H01210  
Hypomagnesemia
Drug
D02800  
Alefacept (USAN/INN)
D02811  
Alicaforsen sodium (USAN)
D02967  
Apolizumab (USAN/INN)
D03066  
Bectumomab (USAN/INN)
D03203  
Abatacept (USAN/INN)
D03222  
Belatacept (USAN/INN)
D03420  
Cedelizumab (USAN/INN)
D03497  
Cilengitide (USAN/INN)
D03959  
Efalizumab (USAN/INN)
D04000  
Enlimomab (USAN/INN)
D04036  
Epratuzumab (USAN/INN)
D04045  
Erlizumab (USAN/INN)
D04295  
Galiximab (USAN/INN)
D04603  
Ipilimumab (USAN/INN)
D05610  
Priliximab (USAN/INN)
D05777  
Ruplizumab (USAN/INN)
D05847  
Siplizumab (USAN/INN)
D06071  
Teneliximab (USAN/INN)
D06193  
Toralizumab (USAN/INN)
D06348  
Yttrium Y 90 epratuzumab (USAN)
D06349  
Yttrium Y 90 epratuzumab tetraxetan (USAN)
D06356  
Zanolimumab (USAN/INN)
D06590  
Firategrast (USAN)
D06657  
Tremelimumab (USAN/INN)
D06886  
Natalizumab (genetical recombination) (JAN)
D08083  
Vedolizumab (USAN)
D08896  
Dacetuzumab (USAN)
D08933  
Inotuzumab ozogamicin (USAN/INN)
D08942  
Lucatumumab (USAN)
D08993  
Rovelizumab (USAN/INN)
D09575  
Ibalizumab (USAN/INN)
D09631  
Intetumumab (USAN/INN)
D09901  
Etrolizumab (USAN/INN)
D09927  
Lorvotuzumab mertansine (USAN/INN)
D09929  
Maraciclatide (USAN/INN)
D09932  
Moxetumomab pasudotox (USAN/INN)
D10028  
Valategrast hydrochloride (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
965  
CD58; CD58 molecule [KO:K06492]
914  
CD2; CD2 molecule [KO:K06449]
941  
CD80; CD80 molecule [KO:K05412]
29126  
CD274; CD274 molecule [KO:K06745]
940  
CD28; CD28 molecule [KO:K06470]
942  
CD86; CD86 molecule [KO:K05413]
1493  
CTLA4; cytotoxic T-lymphocyte associated protein 4 [KO:K06538]
23308  
ICOSLG; inducible T-cell co-stimulator ligand [KO:K06710]
ICOS ligand; K06710 inducible T-cell co-stimulator ligand [KO:K06710]
29851  
ICOS; inducible T-cell co-stimulator [KO:K06713]
3108  
HLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
3109  
HLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
3111  
HLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
3112  
HLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
3113  
HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  
HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  
HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  
HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  
HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  
HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  
HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  
HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  
HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  
HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
HLA-DRB1; HLA class II histocompatibility antigen, DRB1-7 beta chain [KO:K06752]
920  
CD4; CD4 molecule [KO:K06454]
3105  
HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  
HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  
HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  
HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  
HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  
HLA-E; major histocompatibility complex, class I, E [KO:K06751]
925  
CD8A; CD8a molecule [KO:K06458]
926  
CD8B; CD8b molecule [KO:K06459]
80380  
PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
80381  
CD276; CD276 molecule [KO:K06746]
79679  
VTCN1; V-set domain containing T cell activation inhibitor 1 [KO:K06747]
5133  
PDCD1; programmed cell death 1 [KO:K06744]
958  
CD40; CD40 molecule [KO:K03160]
959  
CD40LG; CD40 ligand [KO:K03161]
214  
ALCAM; activated leukocyte cell adhesion molecule [KO:K06547]
923  
CD6; CD6 molecule [KO:K06456]
5817  
PVR; poliovirus receptor [KO:K06539]
10666  
CD226; CD226 molecule [KO:K06567]
5819  
NECTIN2; nectin cell adhesion molecule 2 [KO:K06531]
201633  
TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
3683  
ITGAL; integrin subunit alpha L [KO:K05718]
3689  
ITGB2; integrin subunit beta 2 [KO:K06464]
3383  
ICAM1; intercellular adhesion molecule 1 [KO:K06490]
3384  
ICAM2; intercellular adhesion molecule 2 [KO:K06523]
3385  
ICAM3; intercellular adhesion molecule 3 [KO:K06486]
933  
CD22; CD22 molecule [KO:K06467]
5788  
PTPRC; protein tyrosine phosphatase, receptor type C [KO:K06478] [EC:3.1.3.48]
6614  
SIGLEC1; sialic acid binding Ig like lectin 1 [KO:K06548]
6693  
SPN; sialophorin [KO:K06477]
leukosialin; K06477 sialophorin [KO:K06477]
25945  
NECTIN3; nectin cell adhesion molecule 3 [KO:K06592]
1364  
CLDN4; claudin 4 [KO:K06087]
1365  
CLDN3; claudin 3 [KO:K06087]
1366  
CLDN7; claudin 7 [KO:K06087]
149461  
CLDN19; claudin 19 [KO:K06087]
10686  
CLDN16; claudin 16 [KO:K06087]
23562  
CLDN14; claudin 14 [KO:K06087]
24146  
CLDN15; claudin 15 [KO:K06087]
26285  
CLDN17; claudin 17 [KO:K06087]
49861  
CLDN20; claudin 20 [KO:K06087]
5010  
CLDN11; claudin 11 [KO:K06087]
51208  
CLDN18; claudin 18 [KO:K06087]
53842  
CLDN22; claudin 22 [KO:K06087]
7122  
CLDN5; claudin 5 [KO:K06087]
9071  
CLDN10; claudin 10 [KO:K06087]
9073  
CLDN8; claudin 8 [KO:K06087]
9074  
CLDN6; claudin 6 [KO:K06087]
9075  
CLDN2; claudin 2 [KO:K06087]
9076  
CLDN1; claudin 1 [KO:K06087]
9080  
CLDN9; claudin 9 [KO:K06087]
137075  
CLDN23; claudin 23 [KO:K06087]
644672  
CLDN25; claudin 25 [KO:K06087]
CLDN24; claudin 24 [KO:K06087]
OCLN; occludin [KO:K06088]
50848  
F11R; F11 receptor [KO:K06089]
58494  
JAM2; junctional adhesion molecule 2 [KO:K06735]
83700  
JAM3; junctional adhesion molecule 3 [KO:K06785]
90952  
ESAM; endothelial cell adhesion molecule [KO:K06787]
1003  
CDH5; cadherin 5 [KO:K06533]
5175  
PECAM1; platelet and endothelial cell adhesion molecule 1 [KO:K06471]
4267  
CD99; CD99 molecule [KO:K06520]
3684  
ITGAM; integrin subunit alpha M [KO:K06461]
6404  
SELPLG; selectin P ligand [KO:K06544]
6403  
SELP; selectin P [KO:K06496]
3676  
ITGA4; integrin subunit alpha 4 [KO:K06483]
3688  
ITGB1; integrin subunit beta 1 [KO:K05719]
3680  
ITGA9; integrin subunit alpha 9 [KO:K06585]
7412  
VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
3695  
ITGB7; integrin subunit beta 7 [KO:K06590]
8174  
MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
6402  
SELL; selectin L [KO:K06495]
947  
CD34; CD34 molecule [KO:K06474]
2734  
GLG1; golgi glycoprotein 1 [KO:K06816]
6401  
SELE; selectin E [KO:K06494]
5818  
NECTIN1; nectin cell adhesion molecule 1 [KO:K06081]
1000  
CDH2; cadherin 2 [KO:K06736]
4684  
NCAM1; neural cell adhesion molecule 1 [KO:K06491]
4685  
NCAM2; neural cell adhesion molecule 2 [KO:K06491]
3897  
L1CAM; L1 cell adhesion molecule [KO:K06550]
23705  
CADM1; cell adhesion molecule 1 [KO:K06781]
257194  
NEGR1; neuronal growth regulator 1 [KO:K06775]
22854  
NTNG1; netrin G1 [KO:K07522]
57689  
LRRC4C; leucine rich repeat containing 4C [KO:K07523]
84628  
NTNG2; netrin G2 [KO:K16359]
64101  
LRRC4; leucine rich repeat containing 4 [KO:K16351]
5792  
PTPRF; protein tyrosine phosphatase, receptor type F [KO:K05695] [EC:3.1.3.48]
94030  
LRRC4B; leucine rich repeat containing 4B [KO:K16360]
6382  
SDC1; syndecan 1 [KO:K06257]
6383  
SDC2; syndecan 2 [KO:K16336]
9672  
SDC3; syndecan 3 [KO:K16337]
6385  
SDC4; syndecan 4 [KO:K16338]
3685  
ITGAV; integrin subunit alpha V [KO:K06487]
3696  
ITGB8; integrin subunit beta 8 [KO:K06591]
8516  
ITGA8; integrin subunit alpha 8 [KO:K06584]
9378  
NRXN1; neurexin 1 [KO:K07377]
9379  
NRXN2; neurexin 2 [KO:K07377]
9369  
NRXN3; neurexin 3 [KO:K07377]
22871  
NLGN1; neuroligin 1 [KO:K07378]
57555  
NLGN2; neuroligin 2 [KO:K07378]
54413  
NLGN3; neuroligin 3 [KO:K07378]
57502  
NLGN4X; neuroligin 4, X-linked [KO:K07378]
22829  
NLGN4Y; neuroligin 4, Y-linked [KO:K07378]
57863  
CADM3; cell adhesion molecule 3 [KO:K06780]
4897  
NRCAM; neuronal cell adhesion molecule [KO:K06756]
1272  
CNTN1; contactin 1 [KO:K06759]
5797  
PTPRM; protein tyrosine phosphatase, receptor type M [KO:K05693] [EC:3.1.3.48]
6900  
CNTN2; contactin 2 [KO:K06760]
23114  
NFASC; neurofascin [KO:K06757]
8506  
CNTNAP1; contactin associated protein 1 [KO:K07379]
26047  
CNTNAP2; contactin associated protein-like 2 [KO:K07380]
4359  
MPZ; myelin protein zero [KO:K06770]
9019  
MPZL1; myelin protein zero like 1 [KO:K06770]
4099  
MAG; myelin associated glycoprotein [KO:K06771]
999  
CDH1; cadherin 1 [KO:K05689]
1462  
VCAN; versican [KO:K06793]
3655  
ITGA6; integrin subunit alpha 6 [KO:K06485]
1001  
CDH3; cadherin 3 [KO:K06796]
1002  
CDH4; cadherin 4 [KO:K06797]
1013  
CDH15; cadherin 15 [KO:K06809]
4756  
NEO1; neogenin 1 [KO:K06766]
Reference
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
Reference
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
Reference
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
Reference
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
Reference
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
Reference
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
Reference
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
Reference
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
Reference
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
Reference
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
Reference
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
Reference
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
Reference
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
Reference
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
Reference
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
Reference
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
Reference
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
Reference
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
Reference
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
Reference
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
Reference
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
Reference
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
Reference
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
KO pathway
 

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