KEGG   PATHWAY: kla03420
Entry
kla03420                    Pathway                                
Name
Nucleotide excision repair - Kluyveromyces lactis
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
kla03420  Nucleotide excision repair
kla03420

Other DBs
GO: 0006289
Organism
Kluyveromyces lactis [GN:kla]
Gene
KLLA0_F14234g  uncharacterized protein [KO:K03657] [EC:5.6.2.4]
KLLA0_F14256g  uncharacterized protein [KO:K03657] [EC:5.6.2.4]
KLLA0_E07151g  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
KLLA0_F14465g  uncharacterized protein [KO:K10838]
KLLA0_E22133g  uncharacterized protein [KO:K10839]
KLLA0_E22617g  uncharacterized protein [KO:K10841]
KLLA0_F05071g  uncharacterized protein [KO:K03006] [EC:2.7.7.6]
KLLA0_B05577g  uncharacterized protein [KO:K03010] [EC:2.7.7.6]
KLLA0_D16170g  uncharacterized protein [KO:K03011]
KLLA0_A05797g  uncharacterized protein [KO:K03012]
KLLA0_F21098g  uncharacterized protein [KO:K03013]
KLLA0_B03476g  uncharacterized protein [KO:K03014]
KLLA0_C06787g  uncharacterized protein [KO:K03015]
KLLA0_D07139g  uncharacterized protein [KO:K03016]
KLLA0_D03234g  uncharacterized protein [KO:K03017]
KLLA0_D06699g  uncharacterized protein [KO:K03007]
KLLA0_D08008g  uncharacterized protein [KO:K03009]
KLLA0_C06160g  uncharacterized protein [KO:K03008]
KLLA0_E14785g  uncharacterized protein [KO:K02202] [EC:2.7.11.22 2.7.11.23]
KLLA0_C14872g  uncharacterized protein [KO:K10842]
KLLA0_E06689g  uncharacterized protein [KO:K06634]
KLLA0_E13025g  uncharacterized protein [KO:K10843] [EC:5.6.2.4]
KLLA0_C17776g  uncharacterized protein [KO:K10844] [EC:5.6.2.3]
KLLA0_C11737g  uncharacterized protein [KO:K10845]
KLLA0_C14630g  uncharacterized protein [KO:K03141]
KLLA0_E09615g  uncharacterized protein [KO:K03142]
KLLA0_B08569g  uncharacterized protein [KO:K03143]
KLLA0_F01056g  uncharacterized protein [KO:K03144]
KLLA0_A09427g  uncharacterized protein [KO:K10846]
KLLA0_F06424g  uncharacterized protein [KO:K10847]
KLLA0_A08844g  uncharacterized protein [KO:K07466]
KLLA0_E07371g  uncharacterized protein [KO:K10739]
KLLA0_D12210g  uncharacterized protein [KO:K10848] [EC:3.1.-.-]
KLLA0_D10307g  uncharacterized protein [KO:K10849]
KLLA0_E01607g  uncharacterized protein [KO:K02327] [EC:2.7.7.7]
KLLA0_F14949g  uncharacterized protein [KO:K02328]
KLLA0_E22419g  uncharacterized protein [KO:K03504]
KLLA0_C02585g  uncharacterized protein [KO:K02324] [EC:2.7.7.7]
KLLA0_E04775g  uncharacterized protein [KO:K02325] [EC:2.7.7.7]
KLLA0_F19426g  uncharacterized protein [KO:K02326] [EC:2.7.7.7]
KLLA0_F01859g  uncharacterized protein [KO:K03506] [EC:2.7.7.7]
KLLA0_B12078g  uncharacterized protein [KO:K04802]
KLLA0_D06897g  uncharacterized protein [KO:K10754]
KLLA0_B13992g  uncharacterized protein [KO:K10755]
KLLA0_C03718g  uncharacterized protein [KO:K10755]
KLLA0_E13201g  uncharacterized protein [KO:K10756]
KLLA0_B12221g  uncharacterized protein [KO:K10756]
KLLA0_D12496g  uncharacterized protein [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
kla03020  RNA polymerase
kla04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (48)   
   KEGG GENES (48)   
All databases (49)   

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