KEGG PATHWAY: ko05168

PATHWAY: ko05168

Entry

ko05168                     Pathway

Name

Herpes simplex virus 1 infection

Description

Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.

Class

Human Diseases; Infectious disease: viral

Pathway map

ko05168

Herpes simplex virus 1 infection

Disease

H00365

Herpes simplex virus infection

Orthology

K05468

lymphotoxin alpha (TNF superfamily, member 1)

K05477

tumor necrosis factor ligand superfamily member 14

K05152

tumor necrosis factor receptor superfamily member 14

K03173

TNF receptor-associated factor 2 [EC:2.3.2.27]

K09849

TNF receptor-associated factor 5

K07209

inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]

K04467

inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]

K07210

inhibitor of nuclear factor kappa-B kinase subunit gamma

K04734

NF-kappa-B inhibitor alpha

K02580

nuclear factor NF-kappa-B p105 subunit

K04735

transcription factor p65

K16060

baculoviral IAP repeat-containing protein 2/3

K14624

C-C motif chemokine 2

K19264

Simplexvirus envelope glycoprotein D

K06081

poliovirus receptor-related protein 1

K06531

poliovirus receptor-related protein 2

K19255

Herpesviridae envelope glycoprotein B

K19256

Simplexvirus envelope glycoprotein C

K15411

paired immunoglobulin-like type 2 receptor

K07293

tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]

K19434

Simplexvirus envelope glycoprotein H

K19435

Simplexvirus envelope glycoprotein L

K06484

integrin alpha 5

K06493

integrin beta 3

K05704

tyrosine-protein kinase Src [EC:2.7.10.2]

K05855

spleen tyrosine kinase [EC:2.7.10.2]

K12794

caspase recruitment domain-containing protein 9

K05411

interferon regulatory factor 3

K05415

interferon beta

K19436

Simplexvirus E3 ubiquitin-protein ligase ICP0

K04451

tumor protein p53

K03990

complement component 3

K03994

complement component 5

K15412

complement factor properdin

K10159

toll-like receptor 2

K10161

toll-like receptor 9

K04729

myeloid differentiation primary response protein MyD88

K09447

interferon regulatory factor 7

K05401

toll-like receptor 3

K19439

Simplexvirus serine/threonine-protein kinase US3 [EC:2.7.11.1]

K05842

toll-like receptor adapter molecule 1

K04733

interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]

K04730

interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]

K03175

TNF receptor-associated factor 6 [EC:2.3.2.27]

K04427

mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]

K04403

TAK1-binding protein 1

K04404

TAK1-binding protein 2

K04519

interleukin 1 beta

K12499

C-C motif chemokine 5

K05405

interleukin 6

K03156

tumor necrosis factor superfamily, member 2

K05406

interleukin 12A

K05425

interleukin 12B

K19438

Simplexvirus RNA-binding protein

K12646

ATP-dependent RNA helicase DDX58 [EC:5.6.2.6]

K12647

interferon-induced helicase C domain-containing protein 1 [EC:5.6.2.6]

K12648

mitochondrial antiviral-signaling protein

K21075

Herpesviridae large tegument protein deneddylase [EC:3.4.19.12 3.4.22.-]

K03174

TNF receptor-associated factor 3

K07211

inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10]

K05410

TANK-binding kinase 1 [EC:2.7.11.10]

K19437

Simplexvirus neurovirulence factor ICP34.5

K05414

interferon alpha

K17834

cyclic GMP-AMP synthase [EC:2.7.7.86]

K19447

Simplexvirus virion host shutoff protein [EC:3.1.27.-]

K12654

stimulator of interferon genes protein

K06269

serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]

K16194

eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]

K16195

eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]

K08860

eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]

K16196

eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]

K03237

translation initiation factor 2 subunit 1

K03239

translation initiation factor eIF-2B subunit alpha

K03754

translation initiation factor eIF-2B subunit beta

K03241

translation initiation factor eIF-2B subunit gamma

K03680

translation initiation factor eIF-2B subunit delta

K03240

translation initiation factor eIF-2B subunit epsilon

K14216

2'-5'-oligoadenylate synthetase [EC:2.7.7.84]

K01165

ribonuclease L

K19444

Simplexvirus tegument protein VP16

K14966

host cell factor 1

K27390

host cell factor 2

K09364

POU domain transcription factor, class 2

K19445

Simplexvirus major viral transcription factor ICP4

K19441

Simplexvirus transcriptional regulator ICP22

K19443

Simplexvirus mRNA export factor

K19446

Simplexvirus ICP47 protein

K05130

interferon receptor 1

K05131

interferon receptor 2

K19440

Simplexvirus serine/threonine-protein kinase UL13 [EC:2.7.11.1]

K04696

suppressor of cytokine signaling 3

K11217

Janus kinase 1 [EC:2.7.10.2]

K11219

non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]

K11220

signal transducer and activator of transcription 1

K11221

signal transducer and activator of transcription 2

K04693

interferon regulatory factor 9

K09228

KRAB domain-containing zinc finger protein

K06731

bone marrow stromal cell antigen 2

K04687

interferon gamma

K05132

interferon gamma receptor 1

K05133

interferon gamma receptor 2

K04447

Janus kinase 2 [EC:2.7.10.2]

K02308

death-associated protein 6

K15413

nuclear body protein Sp100

K10054

E3 SUMO-protein ligase PML [EC:2.3.2.-]

K05653

ATP-binding cassette, subfamily B (MDR/TAP), member 2 [EC:7.4.2.14]

K05654

ATP-binding cassette, subfamily B (MDR/TAP), member 3 [EC:7.4.2.14]

K08058

TAP binding protein (tapasin)

K08056

protein disulfide-isomerase A3 [EC:5.3.4.1]

K08057

calreticulin

K06751

MHC class I antigen

K08055

beta-2-microglobulin

K06752

MHC class II antigen

K06505

CD74 antigen

K23212

Simplexvirus tegument protein VP11/12

K00922

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]

K02649

phosphoinositide-3-kinase regulatory subunit alpha/beta/delta

K04456

RAC serine/threonine-protein kinase [EC:2.7.11.1]

K07206

tuberous sclerosis 1

K07207

tuberous sclerosis 2

K07208

Ras homolog enriched in brain

K07203

serine/threonine-protein kinase mTOR [EC:2.7.11.1]

K07205

eukaryotic translation initiation factor 4E binding protein 1

K15409

serine/threonine-protein kinase SRPK1 [EC:2.7.11.1]

K12890

serine/arginine-rich splicing factor 1

K12891

serine/arginine-rich splicing factor 2/8

K12892

serine/arginine-rich splicing factor 3

K12893

serine/arginine-rich splicing factor 4/5/6

K12896

serine/arginine-rich splicing factor 7

K21123

serine/arginine-rich splicing factor 9

K14284

nuclear RNA export factor

K12881

THO complex subunit 4

K04389

tumor necrosis factor ligand superfamily member 6

K04390

tumor necrosis factor receptor superfamily member 6

K03158

tumor necrosis factor receptor superfamily member 1A

K03171

tumor necrosis factor receptor type 1-associated DEATH domain protein

K02373

FAS-associated death domain protein

K19448

Simplexvirus ribonucleoside-diphosphate reductase large subunit [EC:1.17.4.1]

K04398

caspase 8 [EC:3.4.22.61]

K04726

BH3 interacting domain death agonist

K02159

apoptosis regulator BAX

K14021

Bcl-2 homologous antagonist/killer

K02158

Bcl-2-antagonist of cell death

K02161

apoptosis regulator Bcl-2

K04570

Bcl-2-like 1 (apoptosis regulator Bcl-X)

K08738

cytochrome c

K02084

apoptotic protease-activating factor

K04399

caspase 9 [EC:3.4.22.62]

K02187

caspase 3 [EC:3.4.22.56]

Compound

C05981

Phosphatidylinositol-3,4,5-trisphosphate

C20640

Cyclic GMP-AMP

C20935

2-5A

Reference

PMID:12787566

Authors

Granger SW, Rickert S

Title

LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.

Journal

Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5

Reference

PMID:19495760

Authors

Steinberg MW, Shui JW, Ware CF, Kronenberg M

Title

Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.

Journal

Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4

Reference

PMID:20221426

Authors

MacLeod IJ, Minson T

Title

Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.

Journal

PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560

Reference

PMID:23150579

Authors

Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G

Title

alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.

Journal

Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109

Reference

PMID:25375272

Authors

Gianni T, Campadelli-Fiume G

Title

The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.

Journal

PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477

Reference

PMID:15056211

Authors

Spear PG

Title

Herpes simplex virus: receptors and ligands for cell entry.

Journal

Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x

Reference

PMID:12855695

Authors

Boutell C, Everett RD

Title

The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.

Journal

J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200

Reference

PMID:24262390

Authors

Ma Y, He B

Title

Recognition of herpes simplex viruses: toll-like receptors and beyond.

Journal

J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012

Reference

PMID:26952111

Authors

Su C, Zhan G, Zheng C

Title

Evasion of host antiviral innate immunity by HSV-1, an update.

Journal

Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5

Reference

PMID:21994567

Authors

Melchjorsen J, Matikainen S, Paludan SR

Title

Activation and evasion of innate antiviral immunity by herpes simplex virus.

Journal

Viruses 1:737-59 (2009)
DOI:10.3390/v1030737

Reference

PMID:15276609

Authors

Morrison LA

Title

The Toll of herpes simplex virus infection.

Journal

Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001

Reference

PMID:29298887

Authors

Zheng C

Title

Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.

Journal

J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17

Reference

PMID:19344302

Authors

Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC

Title

Design and application of oncolytic HSV vectors for glioblastoma therapy.

Journal

Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9

Reference

PMID:23115300

Authors

Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A

Title

The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.

Journal

J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12

Reference

PMID:17229694

Authors

Sanchez R, Mohr I

Title

Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.

Journal

J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06

Reference

PMID:12826401

Authors

Wysocka J, Herr W

Title

The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.

Journal

Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4

Reference

PMID:27367734

Authors

Fleming SB

Title

Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.

Journal

Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023

Reference

PMID:15163721

Authors

Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N

Title

Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.

Journal

J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004

Reference

PMID:23864622

Authors

Gu H, Zheng Y, Roizman B

Title

Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.

Journal

J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13

Reference

PMID:21994592

Authors

Tavalai N, Stamminger T

Title

Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.

Journal

Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240

Reference

PMID:21146386

Authors

Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ

Title

Viral evasion of T cell immunity: ancient mechanisms offering new applications.

Journal

Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005

Reference

PMID:12960333

Authors

Neumann J, Eis-Hubinger AM, Koch N

Title

Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.

Journal

J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075

Reference

PMID:25798530

Authors

Liu X, Cohen JI

Title

The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.

Journal

Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040

Reference

PMID:28468873

Authors

Vink EI, Smiley JR, Mohr I

Title

Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.

Journal

J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17

Reference

PMID:18508584

Authors

Sandri-Goldin RM

Title

The many roles of the regulatory protein ICP27 during herpes simplex virus infection.

Journal

Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078

Reference

PMID:15078920

Authors

Sandri-Goldin RM

Title

Viral regulation of mRNA export.

Journal

J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004

Reference

PMID:27154074

Authors

Yu X, He S

Title

The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.

Journal

Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0

Related
pathway

ko03040

Spliceosome

ko03050

Proteasome

ko04115

p53 signaling pathway

ko04151

PI3K-Akt signaling pathway

ko04210

Apoptosis

ko04610

Complement and coagulation cascades

ko04612

Antigen processing and presentation

ko04620

Toll-like receptor signaling pathway

ko04622

RIG-I-like receptor signaling pathway

ko04630

JAK-STAT signaling pathway

All links

Gene (149)   
   KEGG ORTHOLOGY (149)   
All databases (149)   

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