KEGG   PATHWAY: lma03440
Entry
lma03440                    Pathway                                
Name
Homologous recombination - Leishmania major
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
lma03440  Homologous recombination
lma03440

Other DBs
GO: 0000724
Organism
Leishmania major [GN:lma]
Gene
LMJF_28_0530  RAD50 DNA repair-like protein [KO:K10866] [EC:3.6.-.-]
LMJF_27_1890  putative endo/exonuclease Mre11 [KO:K10865]
LMJF_29_1790  hypothetical protein [KO:K10728]
LMJF_26_2430  putative metallopeptidase [KO:K11864] [EC:3.4.19.-]
LMJF_28_1820  RPA1; putative replication factor A, 51kDa subunit [KO:K07466]
LMJF_15_0270  putative replication Factor A 28 kDa subunit [KO:K10739]
LMJF_28_0550  RAD51; putative RAD51 protein [KO:K04482]
LMJF_24_0760  putative DNA repair and recombination protein RAD54 [KO:K10877] [EC:5.6.2.-]
LMJF_33_1690  putative DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
LMJF_25_1410  putative DNA polymerase delta subunit 2 [KO:K02328]
LMJF_24_1530  putative ATP-dependent DEAD/H DNA helicase RecQ [KO:K10901] [EC:5.6.2.4]
LMJF_28_1780  putative DNA topoisomerase III [KO:K03165] [EC:5.6.2.1]
LMJF_36_3200  putative DNA topoisomerase III [KO:K03165] [EC:5.6.2.1]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG GENES (13)   
All databases (14)   

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