KEGG   PATHWAY: mbm00230
Entry
mbm00230                    Pathway                                
Name
Purine metabolism - Mycobacterium tuberculosis variant bovis BCG Mexico
Class
Metabolism; Nucleotide metabolism
Pathway map
mbm00230  Purine metabolism
mbm00230

Module
mbm_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mbm00230]
mbm_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mbm00230]
mbm_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mbm00230]
mbm_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mbm00230]
mbm_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mbm00230]
Other DBs
GO: 0006163 0042278
Organism
Mycobacterium tuberculosis variant bovis BCG Mexico [GN:mbm]
Gene
BCGMEX_0239  nrdB; Ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
BCGMEX_0365c  purA; Adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
BCGMEX_0396  purT; Phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
BCGMEX_0509  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
BCGMEX_0586  nrdZ; Ribonucleoside-diphosphate reductase [KO:K00525] [EC:1.17.4.1]
BCGMEX_0754  adk; Adenylate kinase [KO:K00939] [EC:2.7.4.3]
BCGMEX_0795  purD; Phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
BCGMEX_0800  purB; Putative adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
BCGMEX_0803  purC; Phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
BCGMEX_0811  [KO:K23264]
BCGMEX_0812  purQ; Phosphoribosylformylglycinamidine synthase subunit I [KO:K23265]
BCGMEX_0826  purL; Phosphoribosylformylglycinamidine synthase II [KO:K23269]
BCGMEX_0828  [KO:K03651] [EC:3.1.4.53]
BCGMEX_0831  purF; Amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
BCGMEX_0832  purM; Phosphoribosylformylglycinamidine cyclo-ligase [KO:K01933] [EC:6.3.3.1]
BCGMEX_0981  purN; Phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
BCGMEX_0982  purH; Phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
BCGMEX_1046c  prsA; Ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
BCGMEX_1050  [KO:K04765] [EC:3.6.1.9]
BCGMEX_1055  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
BCGMEX_1295  [KO:K01768] [EC:4.6.1.1]
BCGMEX_1316  cysD; putative sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
BCGMEX_1317  cysN; Sulfate adenylyltransferase subunit 1 / Adenylylsulfate kinase [KO:K00955] [EC:2.7.7.4 2.7.1.25]
BCGMEX_1375  [KO:K01519] [EC:3.6.1.66]
BCGMEX_1422  gmk; Guanylate kinase [KO:K00942] [EC:2.7.4.8]
BCGMEX_1635c  cya; Membrane-anchored Adenylyl cyclase [KO:K01768] [EC:4.6.1.1]
BCGMEX_1860c  guaB1; Inosine-5-monophosphate dehydrogenase [KO:K26110]
BCGMEX_1865  ureA; Urease subunit gamma [KO:K01430] [EC:3.5.1.5]
BCGMEX_1866  ureB; Urease subunit beta [KO:K01429] [EC:3.5.1.5]
BCGMEX_1867  ureC; Urease subunit alpha [KO:K01428] [EC:3.5.1.5]
BCGMEX_2153c  yfiH; Hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
BCGMEX_2205c  adoK; Adenosine kinase [KO:K00856] [EC:2.7.1.20]
BCGMEX_2356c  dgt; putative Deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
BCGMEX_2455c  ndkA; Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
BCGMEX_2599c  relA; Putative GTP pyrophosphokinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
BCGMEX_2600c  apt; Adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
BCGMEX_2631c  [KO:K19710] [EC:2.7.7.53]
BCGMEX_3069c  nrdF2; Ribonucleoside-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
BCGMEX_3072c  nrdE; Ribonucleoside-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
BCGMEX_3090c  pgmA; Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
BCGMEX_3302c  purE; Phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
BCGMEX_3303c  purK; Phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
BCGMEX_3369  deoD; Putative purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
BCGMEX_3377c  add; Adenosine deaminase [KO:K01488] [EC:3.5.4.4]
BCGMEX_3460  iunH; Putative nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
BCGMEX_3464c  guaA; GMP synthase (glutamine-hydrolyzing) [KO:K01951] [EC:6.3.5.2]
BCGMEX_3478c  guaB3; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
BCGMEX_3479c  guaB2; Inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
BCGMEX_3680c  hpt; Hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
BCGMEX_3701  [KO:K01768] [EC:4.6.1.1]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mbm00030  Pentose phosphate pathway
mbm00220  Arginine biosynthesis
mbm00250  Alanine, aspartate and glutamate metabolism
mbm00260  Glycine, serine and threonine metabolism
mbm00340  Histidine metabolism
mbm00630  Glyoxylate and dicarboxylate metabolism
mbm00730  Thiamine metabolism
mbm00740  Riboflavin metabolism
mbm00790  Folate biosynthesis
KO pathway
ko00230   

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