Entry
Name
Lysosome - Macaca mulatta (rhesus monkey)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene
677865 ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X4 [KO:K02154 ]
710162 ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154 ]
715492 ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154 ]
710650 TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
693838 ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146 ]
698345 ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146 ]
693323 ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144 ]
100425716 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155 ]
702243 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661 ]
695302 WDR7; WD repeat-containing protein 7 isoform X4 [KO:K24738 ]
712861 NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442 ]
715505 CTSW; cathepsin W isoform X1 [KO:K08569 ] [EC:3.4.22.-]
718912 ARSG; arylsulfatase G isoform X1 [KO:K12381 ] [EC:3.1.6.-]
697331 LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528 ]
695379 LAMP2; lysosome-associated membrane glycoprotein 2 precursor [KO:K06528 ]
574213 LAMP3; lysosome-associated membrane glycoprotein 3 precursor [KO:K06562 ]
700835 NPC1; NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385 ]
699881 NPC2; epididymal secretory protein E1 precursor [KO:K13443 ]
701025 SLC11A1; natural resistance-associated macrophage protein 1 isoform X4 [KO:K12347 ]
693986 SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398 ]
701298 LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387 ]
704041 LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387 ]
702648 LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387 ]
721631 ABCA2; ATP-binding cassette sub-family A member 2 isoform X3 [KO:K05642 ]
707709 ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656 ]
699242 CD164; sialomucin core protein 24 precursor [KO:K06546 ]
696352 CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390 ]
713336 MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307 ]
697307 GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239 ] [EC:2.7.8.17 ]
722441 GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma precursor [KO:K10087 ]
707352 NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125 ] [EC:3.1.4.45 ]
703220 IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564 ]
716696 M6PR; cation-dependent mannose-6-phosphate receptor isoform X2 [KO:K10089 ]
719087 CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646 ]
710171 AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391 ]
714638 AP1B1; AP-1 complex subunit beta-1 isoform X7 [KO:K12392 ]
720531 AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393 ]
710257 AP1S3; AP-1 complex subunit sigma-3 isoform X2 [KO:K12395 ]
694091 AP3B2; AP-3 complex subunit beta-2 isoform X2 [KO:K12397 ]
708754 AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397 ]
705729 AP3M1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398 ]
696644 AP3S1; AP-3 complex subunit sigma-1 isoform X3 [KO:K12399 ]
693444 AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400 ]
707634 AP4B1; AP-4 complex subunit beta-1 isoform X2 [KO:K12401 ]
710944 AP4M1; AP-4 complex subunit mu-1 isoform X2 [KO:K12402 ]
717146 AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403 ]
697929 GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404 ]
705751 GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404 ]
700421 GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404 ]
711743 LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363 ]
Compound
Reference
Authors
Eskelinen EL, Tanaka Y, Saftig P
Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
Journal
Reference
Authors
Neufeld EF
Title
Lysosomal storage diseases.
Journal
Reference
Authors
von Figura K, Hasilik A
Title
Lysosomal enzymes and their receptors.
Journal
Reference
Authors
Janvier K, Bonifacino JS
Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Journal
Reference
Authors
Vergarajauregui S, Puertollano R
Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
Journal
Reference
Authors
Jaskolka MC, Winkley SR, Kane PM
Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
Journal
Reference
Authors
Majdoul S, Compton AA
Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
Journal
Related pathway
mcc04130 SNARE interactions in vesicular transport
KO pathway