KEGG   PATHWAY: mdo04664Help
Entry
mdo04664                    Pathway                                

Name
Fc epsilon RI signaling pathway - Monodelphis domestica (opossum)
Description
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Fc epsilon RI signaling pathway
mdo04664

All organismsOrtholog table
Other DBs
BSID: 
GO: 
Organism
Monodelphis domestica (opossum) [GN:mdo]
Gene
ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
high affinity immunoglobulin epsilon receptor subunit gamma-like; K07983 Fc receptor, IgE, high affinity I, gamma polypeptide [KO:K07983]
tyrosine-protein kinase SYK-like; K05855 spleen tyrosine kinase [EC:2.7.10.2] [KO:K05855] [EC:2.7.10.2]
tyrosine-protein kinase Lyn-like; K05854 tyrosine-protein kinase Lyn [EC:2.7.10.2] [KO:K05854] [EC:2.7.10.2]
tyrosine-protein kinase BTK-like; K07370 Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] [KO:K07370] [EC:2.7.10.2]
INPP5D; inositol polyphosphate-5-phosphatase, 145kDa [KO:K03084] [EC:3.1.3.86]
PLCG1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
PLCG2; phospholipase C, gamma 2 (phosphatidylinositol-specific) [KO:K05859] [EC:3.1.4.11]
phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
phosphatidylinositol 3-kinase regulatory subunit beta-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
3-phosphoinositide-dependent protein kinase 1-like; K06276 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1] [KO:K06276] [EC:2.7.11.1]
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
RAC-alpha serine/threonine-protein kinase-like; K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04456] [EC:2.7.11.1]
AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
ras-related C3 botulinum toxin substrate 1-like; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
ras-related C3 botulinum toxin substrate 2-like; K07860 Ras-related C3 botulinum toxin substrate 2 [KO:K07860]
ras-related C3 botulinum toxin substrate 3-like; K07861 Ras-related C3 botulinum toxin substrate 3 [KO:K07861]
MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
dual specificity mitogen-activated protein kinase kinase 7-like; K04431 mitogen-activated protein kinase kinase 7 [EC:2.7.12.2] [KO:K04431] [EC:2.7.12.2]
dual specificity mitogen-activated protein kinase kinase 3-like; K04432 mitogen-activated protein kinase kinase 3 [EC:2.7.12.2] [KO:K04432] [EC:2.7.12.2]
MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
mitogen-activated protein kinase 12-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
mitogen-activated protein kinase 11-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
mitogen-activated protein kinase 13-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
interleukin-4-like; K05430 interleukin 4 [KO:K05430]
interleukin-5-like; K05428 interleukin 5 [KO:K05428]
tumor necrosis factor-like; K03156 tumor necrosis factor superfamily, member 2 [KO:K03156]
LCP2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) [KO:K07361]
VAV3; vav 3 guanine nucleotide exchange factor [KO:K05730]
VAV2; vav 2 guanine nucleotide exchange factor [KO:K05730]
VAV1; vav 1 guanine nucleotide exchange factor [KO:K05730]
FYN; FYN oncogene related to SRC, FGR, YES [KO:K05703] [EC:2.7.10.2]
GAB2; GRB2-associated binding protein 2 [KO:K08091]
growth factor receptor-bound protein 2-like; K04364 growth factor receptor-binding protein 2 [KO:K04364]
son of sevenless homolog 1-like; K03099 son of sevenless [KO:K03099]
SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
GTPase HRas-like; K02833 GTPase HRas [KO:K02833]
GTPase KRas-like; K07827 GTPase KRas [KO:K07827]
554186  
KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
554197  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
RAF proto-oncogene serine/threonine-protein kinase-like; K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04366] [EC:2.7.11.1]
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
dual specificity mitogen-activated protein kinase kinase 2-like; K04369 mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] [KO:K04369] [EC:2.7.12.2]
mitogen-activated protein kinase 1-like; K04371 mitogen-activated protein kinase 1/3 [EC:2.7.11.24] [KO:K04371] [EC:2.7.11.24]
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
PLA2G4E; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
cytosolic phospholipase A2 delta-like; K16342 cytosolic phospholipase A2 [EC:3.1.1.4] [KO:K16342] [EC:3.1.1.4]
cytosolic phospholipase A2 gamma-like; K16342 cytosolic phospholipase A2 [EC:3.1.1.4] [KO:K16342] [EC:3.1.1.4]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00219  
Arachidonate
C00374  
Heparin
C00388  
Histamine
C00696  
Prostaglandin D2
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C02166  
Leukotriene C4
C05951  
Leukotriene D4
C05952  
Leukotriene E4
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kawakami T, Galli SJ.
  Title
Regulation of mast-cell and basophil function and survival by IgE.
  Journal
Nat Rev Immunol 2:773-86 (2002)
Reference
  Authors
Siraganian RP.
  Title
Mast cell signal transduction from the high-affinity IgE receptor.
  Journal
Curr Opin Immunol 15:639-46 (2003)
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
  Authors
Turner H, Kinet JP.
  Title
Signalling through the high-affinity IgE receptor Fc epsilonRI.
  Journal
Nature 402:B24-30 (1999)
Reference
  Authors
Gilfillan AM, Tkaczyk C.
  Title
Integrated signalling pathways for mast-cell activation.
  Journal
Nat Rev Immunol 6:218-30 (2006)
Reference
  Authors
Nadler MJ, Matthews SA, Turner H, Kinet JP.
  Title
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
  Journal
Adv Immunol 76:325-55 (2000)
Reference
  Authors
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
  Title
Essential role for Gab2 in the allergic response.
  Journal
Nature 412:186-90 (2001)
Reference
  Authors
Nadler MJ, Kinet JP.
  Title
Uncovering new complexities in mast cell signaling.
  Journal
Nat Immunol 3:707-8 (2002)
KO pathway
 

DBGET integrated database retrieval system