KEGG PATHWAY: mdo04664

PATHWAY: mdo04664

Entry

mdo04664 Pathway

Name

Fc epsilon RI signaling pathway - Monodelphis domestica (opossum)

Description

Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.

Class

Organismal Systems; Immune system

Pathway map

mdo04664

Fc epsilon RI signaling pathway

Other DBs

BSID:

87183

GO:

0045576

Organism

Monodelphis domestica (opossum) [GN:mdo]

Gene

100618912	ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
100618709	ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
100618872	ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
100619427	ig heavy chain V-III region VH26-like; K06856 immunoglobulin heavy chain [KO:K06856]
100032759	high affinity immunoglobulin epsilon receptor subunit gamma-like; K07983 Fc receptor, IgE, high affinity I, gamma polypeptide [KO:K07983]
100028356	tyrosine-protein kinase SYK-like; K05855 spleen tyrosine kinase [EC:2.7.10.2] [KO:K05855] [EC:2.7.10.2]
100616821	tyrosine-protein kinase Lyn-like; K05854 tyrosine-protein kinase Lyn [EC:2.7.10.2] [KO:K05854] [EC:2.7.10.2]
100022891	tyrosine-protein kinase BTK-like; K07370 Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] [KO:K07370] [EC:2.7.10.2]
100021361	INPP5D; inositol polyphosphate-5-phosphatase, 145kDa [KO:K03084] [EC:3.1.3.86]
100032696	PLCG1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
100027579	PLCG2; phospholipase C, gamma 2 (phosphatidylinositol-specific) [KO:K05859] [EC:3.1.4.11]
100009879	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100010412	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100017332	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100019317	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
100012464	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
100032726	phosphatidylinositol 3-kinase regulatory subunit beta-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
100023778	3-phosphoinositide-dependent protein kinase 1-like; K06276 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1] [KO:K06276] [EC:2.7.11.1]
100014564	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
100019947	RAC-alpha serine/threonine-protein kinase-like; K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04456] [EC:2.7.11.1]
100027373	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
100026992	ras-related C3 botulinum toxin substrate 1-like; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100017517	ras-related C3 botulinum toxin substrate 2-like; K07860 Ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100029873	ras-related C3 botulinum toxin substrate 3-like; K07861 Ras-related C3 botulinum toxin substrate 3 [KO:K07861]
100019828	MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100026752	dual specificity mitogen-activated protein kinase kinase 7-like; K04431 mitogen-activated protein kinase kinase 7 [EC:2.7.12.2] [KO:K04431] [EC:2.7.12.2]
100016872	dual specificity mitogen-activated protein kinase kinase 3-like; K04432 mitogen-activated protein kinase kinase 3 [EC:2.7.12.2] [KO:K04432] [EC:2.7.12.2]
100029049	MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100014343	MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
100028089	MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100618895	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100010279	mitogen-activated protein kinase 12-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
100010891	mitogen-activated protein kinase 11-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
100026324	MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
100028821	mitogen-activated protein kinase 13-like; K04441 p38 MAP kinase [EC:2.7.11.24] [KO:K04441] [EC:2.7.11.24]
100617451	interleukin-4-like; K05430 interleukin 4 [KO:K05430]
100018747	interleukin-5-like; K05428 interleukin 5 [KO:K05428]
100023069	tumor necrosis factor-like; K03156 tumor necrosis factor superfamily, member 2 [KO:K03156]
100026299	LCP2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) [KO:K07361]
100029844	VAV3; vav 3 guanine nucleotide exchange factor [KO:K05730]
100015350	VAV2; vav 2 guanine nucleotide exchange factor [KO:K05730]
100020150	VAV1; vav 1 guanine nucleotide exchange factor [KO:K05730]
100022459	FYN; FYN oncogene related to SRC, FGR, YES [KO:K05703] [EC:2.7.10.2]
100017910	GAB2; GRB2-associated binding protein 2 [KO:K08091]
100022894	growth factor receptor-bound protein 2-like; K04364 growth factor receptor-binding protein 2 [KO:K04364]
100618058	son of sevenless homolog 1-like; K03099 son of sevenless [KO:K03099]
100029256	SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
100032921	GTPase HRas-like; K02833 GTPase HRas [KO:K02833]
100009992	GTPase KRas-like; K07827 GTPase KRas [KO:K07827]
554186	KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
554197	NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
100015410	RAF proto-oncogene serine/threonine-protein kinase-like; K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04366] [EC:2.7.11.1]
100018410	MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018044	dual specificity mitogen-activated protein kinase kinase 2-like; K04369 mitogen-activated protein kinase kinase 2 [EC:2.7.12.2] [KO:K04369] [EC:2.7.12.2]
100028096	mitogen-activated protein kinase 1-like; K04371 mitogen-activated protein kinase 1/3 [EC:2.7.11.24] [KO:K04371] [EC:2.7.11.24]
100012916	MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100009808	PLA2G4E; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
100620032	cytosolic phospholipase A2 delta-like; K16342 cytosolic phospholipase A2 [EC:3.1.1.4] [KO:K16342] [EC:3.1.1.4]
100029998	cytosolic phospholipase A2 gamma-like; K16342 cytosolic phospholipase A2 [EC:3.1.1.4] [KO:K16342] [EC:3.1.1.4]

Compound

C00076	Calcium cation
C00165	Diacylglycerol
C00219	Arachidonate
C00374	Heparin
C00388	Histamine
C00696	Prostaglandin D2
C01245	D-myo-Inositol 1,4,5-trisphosphate
C02166	Leukotriene C4
C05951	Leukotriene D4
C05952	Leukotriene E4
C05981	Phosphatidylinositol-3,4,5-trisphosphate

Reference

PMID:12360215

Authors

Kawakami T, Galli SJ.

Title

Regulation of mast-cell and basophil function and survival by IgE.

Journal

Nat Rev Immunol 2:773-86 (2002)

Reference

PMID:14630197

Authors

Siraganian RP.

Title

Mast cell signal transduction from the high-affinity IgE receptor.

Journal

Curr Opin Immunol 15:639-46 (2003)

Reference

Authors

Janeway CA, Travers P, Walport M, Shlomchik MJ.

Title

Immunobiology 6th edition

Journal

Garland Science Publishing (2005)

Reference

PMID:10586892

Authors

Turner H, Kinet JP.

Title

Signalling through the high-affinity IgE receptor Fc epsilonRI.

Journal

Nature 402:B24-30 (1999)

Reference

PMID:16470226

Authors

Gilfillan AM, Tkaczyk C.

Title

Integrated signalling pathways for mast-cell activation.

Journal

Nat Rev Immunol 6:218-30 (2006)

Reference

PMID:11079101

Authors

Nadler MJ, Matthews SA, Turner H, Kinet JP.

Title

Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.

Journal

Adv Immunol 76:325-55 (2000)

Reference

PMID:11449275

Authors

Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.

Title

Essential role for Gab2 in the allergic response.

Journal

Nature 412:186-90 (2001)

Reference

PMID:12145654

Authors

Nadler MJ, Kinet JP.

Title

Uncovering new complexities in mast cell signaling.

Journal

Nat Immunol 3:707-8 (2002)

KO pathway

ko04664

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (59)   
   KEGG GENES (59)   
All databases (61)   

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