KEGG PATHWAY: mdo04664

PATHWAY: mdo04664

Entry

mdo04664 Pathway

Name

Fc epsilon RI signaling pathway - Monodelphis domestica (opossum)

Description

Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.

Class

Organismal Systems; Immune system

Pathway map

mdo04664

Fc epsilon RI signaling pathway

Other DBs

BSID:

87183

GO:

0045576

Organism

Monodelphis domestica (opossum) [GN:mdo]

Gene

103095080	FCER1A; Fc fragment of IgE receptor Ia [KO:K08089]
103096027	high affinity immunoglobulin epsilon receptor subunit beta-like [KO:K08090]
100032759	FCER1G; Fc fragment of IgE receptor Ig [KO:K07983]
100028356	tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
100616821	LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
100022891	BTK; Bruton tyrosine kinase [KO:K07370] [EC:2.7.10.2]
100021361	INPP5D; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
100032696	PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
100027579	PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
100024674	PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
100010412	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100017332	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100024769	PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100019317	PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100032726	PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100018830	PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100014564	AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100019947	AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100027373	AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100026992	RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100017517	RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
100029873	RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
100019828	MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100026752	MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
100016872	MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100029049	MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100028089	MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100618895	MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100010279	MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100010891	MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100026324	MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
100028821	MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103103487	IL13; interleukin 13 [KO:K05435]
100018747	IL5; interleukin 5 [KO:K05428]
103094208	CSF2; colony stimulating factor 2 [KO:K05427]
100023069	TNF; tumor necrosis factor [KO:K03156]
100026299	LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
100029844	VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
100015350	VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100020150	VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
100022459	FYN; FYN proto-oncogene, Src family tyrosine kinase [KO:K05703] [EC:2.7.10.2]
100017910	GAB2; GRB2 associated binding protein 2 [KO:K08091]
103104196	LAT; linker for activation of T-cells [KO:K07362]
100022894	GRB2; growth factor receptor bound protein 2 [KO:K04364]
100618058	SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100029256	SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100032921	HRAS; HRas proto-oncogene, GTPase [KO:K02833]
554186	KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197	NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
100015410	RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100018410	MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018044	MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100028096	MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100012916	MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100024859	PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
100009808	PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
100620032	PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
100029998	cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
100029983	PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
100013954	ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
100026200	ALOX5AP; arachidonate 5-lipoxygenase activating protein [KO:K20735]

Compound

C00076	Calcium cation
C00165	Diacylglycerol
C00219	Arachidonate
C00374	Heparin
C00388	Histamine
C00696	Prostaglandin D2
C01245	D-myo-Inositol 1,4,5-trisphosphate
C02166	Leukotriene C4
C05951	Leukotriene D4
C05952	Leukotriene E4
C05981	Phosphatidylinositol-3,4,5-trisphosphate

Reference

PMID:12360215

Authors

Kawakami T, Galli SJ.

Title

Regulation of mast-cell and basophil function and survival by IgE.

Journal

Nat Rev Immunol 2:773-86 (2002)
DOI:10.1038/nri914

Reference

PMID:14630197

Authors

Siraganian RP.

Title

Mast cell signal transduction from the high-affinity IgE receptor.

Journal

Curr Opin Immunol 15:639-46 (2003)
DOI:10.1016/j.coi.2003.09.010

Reference

Authors

Janeway CA, Travers P, Walport M, Shlomchik MJ.

Title

Immunobiology 6th edition

Journal

Garland Science Publishing (2005)

Reference

PMID:10586892

Authors

Turner H, Kinet JP.

Title

Signalling through the high-affinity IgE receptor Fc epsilonRI.

Journal

Nature 402:B24-30 (1999)

Reference

PMID:16470226

Authors

Gilfillan AM, Tkaczyk C.

Title

Integrated signalling pathways for mast-cell activation.

Journal

Nat Rev Immunol 6:218-30 (2006)
DOI:10.1038/nri1782

Reference

PMID:11079101

Authors

Nadler MJ, Matthews SA, Turner H, Kinet JP.

Title

Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.

Journal

Adv Immunol 76:325-55 (2000)
DOI:10.1016/S0065-2776(01)76022-1

Reference

PMID:11449275

Authors

Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.

Title

Essential role for Gab2 in the allergic response.

Journal

Nature 412:186-90 (2001)
DOI:10.1038/35084076

Reference

PMID:12145654

Authors

Nadler MJ, Kinet JP.

Title

Uncovering new complexities in mast cell signaling.

Journal

Nat Immunol 3:707-8 (2002)
DOI:10.1038/ni0802-707

KO pathway

ko04664

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (61)   
   KEGG GENES (61)   
All databases (63)   

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