Entry
Name
Homologous recombination - Meleagris gallopavo (turkey)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Other DBs
Organism
Meleagris gallopavo (turkey) [GN:
mgp ]
Gene
100538396 RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466 ]
100538985 BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864 ] [EC:3.4.19.-]
100540070 RAD51B; DNA repair protein RAD51 homolog 2 isoform X1 [KO:K10869 ]
100541292 RBBP8; LOW QUALITY PROTEIN: DNA endonuclease RBBP8 [KO:K20773 ] [EC:3.1.-.-]
100542730 BRCA2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein [KO:K08775 ]
100544281 RAD54B; DNA repair and recombination protein RAD54B isoform X2 [KO:K10877 ] [EC:5.6.2.-]
100545211 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774 ]
100547823 MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865 ]
100549297 BABAM1; LOW QUALITY PROTEIN: BRISC and BRCA1-A complex member 1 [KO:K20776 ]
100549534 RAD50; DNA repair protein RAD50 isoform X2 [KO:K10866 ] [EC:3.6.-.-]
100549794 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870 ]
100550883 SSBP1; single-stranded DNA-binding protein, mitochondrial [KO:K03111 ]
104913828 EME1; LOW QUALITY PROTEIN: crossover junction endonuclease EME1 [KO:K10882 ] [EC:3.1.22.-]
Reference
Authors
Maloisel L, Fabre F, Gangloff S.
Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Journal
Reference
Authors
Haruta-Takahashi N, Iwasaki H.
Title
[Recombination mediators]
Journal
Seikagaku 79:449-53 (2007)
Reference
Authors
Ouyang KJ, Woo LL, Ellis NA.
Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Journal
Reference
Authors
Kawabata M, Kawabata T, Nishibori M.
Title
Role of recA/RAD51 family proteins in mammals.
Journal
Reference
Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Title
Mitotic recombination in Saccharomyces cerevisiae.
Journal
Reference
Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Title
Rad54: the Swiss Army knife of homologous recombination?
Journal
Reference
Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Title
Recombination proteins and rescue of arrested replication forks.
Journal
KO pathway