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mgp03440                    Pathway                                

Homologous recombination - Meleagris gallopavo (turkey)
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
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Homologous recombination

All organismsOrtholog table
RPA complex [PATH:mgp03440]
MRN complex [PATH:mgp03440]
BRCA1-associated genome surveillance complex (BASC) [PATH:mgp03440]
Other DBs
Meleagris gallopavo (turkey) [GN:mgp]
SSBP1; single stranded DNA binding protein 1 [KO:K03111]
RAD50; RAD50 double strand break repair protein [KO:K10866] [EC:3.6.-.-]
MRE11; MRE11 homolog, double strand break repair nuclease [KO:K10865]
NBN; nibrin [KO:K10867]
ATM; serine-protein kinase ATM [KO:K04728] [EC:]
breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:]
BARD1; BRCA1 associated RING domain 1 [KO:K10683]
RBBP8; RB binding protein 8, endonuclease [KO:K20773] [EC:3.1.-.-]
BRIP1; BRCA1 interacting protein C-terminal helicase 1 [KO:K15362] [EC:]
TOPBP1; topoisomerase (DNA) II binding protein 1 [KO:K10728]
FAM175A; family with sequence similarity 175 member A [KO:K20774]
UIMC1; ubiquitin interaction motif containing 1 [KO:K20775]
BABAM1; BRISC and BRCA1 A complex member 1 [KO:K20776]
BRE; brain and reproductive organ-expressed (TNFRSF1A modulator) [KO:K12173]
BRCC3; BRCA1/BRCA2-containing complex subunit 3 [KO:K11864] [EC:3.4.19.-]
PALB2; partner and localizer of BRCA2 [KO:K10897]
BRCA2; BRCA2, DNA repair associated [KO:K08775]
SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
SYCP3; synaptonemal complex protein 3 [KO:K19528]
RPA1; replication protein A1 [KO:K07466]
RPA2; replication protein A2 [KO:K10739]
RPA3; replication protein A3 [KO:K10740]
RAD51; RAD51 recombinase [KO:K04482]
RAD52; RAD52 homolog, DNA repair protein [KO:K10873]
RAD51B; RAD51 paralog B [KO:K10869]
RAD51C; RAD51 paralog C [KO:K10870]
RAD51D; RAD51 paralog D [KO:K10871]
XRCC2; X-ray repair cross complementing 2 [KO:K10879]
XRCC3; X-ray repair cross complementing 3 [KO:K10880]
RAD54L; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:3.6.4.-]
RAD54B; RAD54 homolog B (S. cerevisiae) [KO:K10877] [EC:3.6.4.-]
POLD2; DNA polymerase delta 2, accessory subunit [KO:K02328]
POLD3; DNA polymerase delta 3, accessory subunit [KO:K03504]
DNA polymerase delta subunit 3-like [KO:K03504]
BLM; Bloom syndrome RecQ like helicase [KO:K10901] [EC:]
TOP3A; topoisomerase (DNA) III alpha [KO:K03165] [EC:]
TOP3B; topoisomerase (DNA) III beta [KO:K03165] [EC:]
EME1; essential meiotic structure-specific endonuclease 1 [KO:K10882] [EC:3.1.22.-]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators] Japanese
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
KO pathway

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