KEGG   PATHWAY: mgp03440
Entry
mgp03440                    Pathway                                
Name
Homologous recombination - Meleagris gallopavo (turkey)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
mgp03440  Homologous recombination
mgp03440

Other DBs
GO: 0000724
Organism
Meleagris gallopavo (turkey) [GN:mgp]
Gene
100538376  BARD1; BRCA1-associated RING domain protein 1 [KO:K10683]
100538396  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
100538889  XRCC3; DNA repair protein XRCC3 [KO:K10880]
100538985  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
100540056  [KO:K04728] [EC:2.7.11.1]
100540070  RAD51B; DNA repair protein RAD51 homolog 2 isoform X1 [KO:K10869]
100540316  RAD52; DNA repair protein RAD52 homolog isoform X2 [KO:K10873]
100540368  [KO:K04728] [EC:2.7.11.1]
100540611  BRIP1; Fanconi anemia group J protein isoform X2 [KO:K15362] [EC:5.6.2.3]
100541292  RBBP8; LOW QUALITY PROTEIN: DNA endonuclease RBBP8 [KO:K20773] [EC:3.1.-.-]
100541552  NBN; nibrin [KO:K10867]
100541664  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
100542097  RPA2; replication protein A 32 kDa subunit [KO:K10739]
100542278  TOPBP1; DNA topoisomerase 2-binding protein 1 [KO:K10728]
100542527  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
100542730  BRCA2; LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein [KO:K08775]
100543187  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
100543843  TOP3A; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
100544281  RAD54B; DNA repair and recombination protein RAD54B isoform X2 [KO:K10877] [EC:5.6.2.-]
100544744  SYCP3; synaptonemal complex protein 3 [KO:K19528]
100545211  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774]
100545231  TOP3B; DNA topoisomerase 3-beta-1 isoform X1 [KO:K03165] [EC:5.6.2.1]
100545326  XRCC2; LOW QUALITY PROTEIN: DNA repair protein XRCC2 [KO:K10879]
100546696  BABAM2; BRISC and BRCA1-A complex member 2 [KO:K12173]
100547823  MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
100548521  [KO:K10605] [EC:2.3.2.27]
100549133  RAD51D; DNA repair protein RAD51 homolog 4 [KO:K10871]
100549297  BABAM1; LOW QUALITY PROTEIN: BRISC and BRCA1-A complex member 1 [KO:K20776]
100549534  RAD50; DNA repair protein RAD50 isoform X2 [KO:K10866] [EC:3.6.-.-]
100549794  RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
100550195  [KO:K10875] [EC:5.6.2.-]
100550883  SSBP1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
100550982  BLM; Bloom syndrome protein [KO:K10901] [EC:5.6.2.4]
100551403  [KO:K03504]
104909450  [KO:K03504]
104912460  [KO:K10875] [EC:5.6.2.-]
104913273  UIMC1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
104913485  PALB2; partner and localizer of BRCA2 [KO:K10897]
104913828  EME1; LOW QUALITY PROTEIN: crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
104915636  RPA3; replication protein A 14 kDa subunit [KO:K10740]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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