KEGG   PATHWAY: mmu04120Help
Entry
mmu04120                    Pathway                                

Name
Ubiquitin mediated proteolysis - Mus musculus (mouse)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Ubiquitin mediated proteolysis
mmu04120

All organismsOrtholog table
Module
SCF-BTRC complex [PATH:mmu04120]
SCF-SKP2 complex [PATH:mmu04120]
SCF-FBS complex [PATH:mmu04120]
ECV complex [PATH:mmu04120]
Cul3-SPOP complex [PATH:mmu04120]
Cul4-DDB1-DDB2 complex [PATH:mmu04120]
Cul4-DDB1-CSA complex [PATH:mmu04120]
SCF-FBW7 complex [PATH:mmu04120]
ECS complex [PATH:mmu04120]
APC/C complex [PATH:mmu04120]
Other DBs
BSID: 
GO: 
Organism
Mus musculus (mouse) [GN:mmu]
Gene
22202  
Uba1y; ubiquitin-activating enzyme, Chr Y [KO:K03178] [EC:6.2.1.45]
22201  
Uba1; ubiquitin-like modifier activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
56459  
Sae1; SUMO1 activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
50995  
Uba2; ubiquitin-like modifier activating enzyme 2 [KO:K10685] [EC:6.2.1.45]
22200  
Uba3; ubiquitin-like modifier activating enzyme 3 [KO:K10686] [EC:6.2.1.45]
74153  
Uba7; ubiquitin-like modifier activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
231380  
Uba6; ubiquitin-like modifier activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
22209  
Ube2a; ubiquitin-conjugating enzyme E2A [KO:K10573] [EC:2.3.2.23]
22210  
Ube2b; ubiquitin-conjugating enzyme E2B [KO:K10574] [EC:2.3.2.23]
68612  
Ube2c; ubiquitin-conjugating enzyme E2C [KO:K06688] [EC:2.3.2.23]
216080  
Ube2d1; ubiquitin-conjugating enzyme E2D 1 [KO:K06689] [EC:2.3.2.23]
56550  
Ube2d2a; ubiquitin-conjugating enzyme E2D 2A [KO:K06689] [EC:2.3.2.23]
66105  
Ube2d3; ubiquitin-conjugating enzyme E2D 3 [KO:K06689] [EC:2.3.2.23]
73318  
Ube2d2b; ubiquitin-conjugating enzyme E2D 2B [KO:K06689] [EC:2.3.2.23]
218793  
Ube2e2; ubiquitin-conjugating enzyme E2E 2 [KO:K20217] [EC:2.3.2.23]
22193  
Ube2e3; ubiquitin-conjugating enzyme E2E 3 [KO:K20217] [EC:2.3.2.23]
22194  
Ube2e1; ubiquitin-conjugating enzyme E2E 1 [KO:K20217] [EC:2.3.2.23]
67921  
Ube2f; ubiquitin-conjugating enzyme E2F (putative) [KO:K10687] [EC:2.3.2.23]
67128  
Ube2g1; ubiquitin-conjugating enzyme E2G 1 [KO:K10575] [EC:2.3.2.23]
22213  
Ube2g2; ubiquitin-conjugating enzyme E2G 2 [KO:K04555] [EC:2.3.2.23]
22214  
Ube2h; ubiquitin-conjugating enzyme E2H [KO:K10576] [EC:2.3.2.23]
22196  
Ube2i; ubiquitin-conjugating enzyme E2I [KO:K10577]
56228  
Ube2j1; ubiquitin-conjugating enzyme E2J 1 [KO:K10578] [EC:2.3.2.23]
140499  
Ube2j2; ubiquitin-conjugating enzyme E2J 2 [KO:K04554] [EC:2.3.2.23]
22195  
Ube2l3; ubiquitin-conjugating enzyme E2L 3 [KO:K04552] [EC:2.3.2.23]
Gm10705; predicted gene 10705 [KO:K04552] [EC:2.3.2.23]
56791  
Ube2l6; ubiquitin-conjugating enzyme E2L 6 [KO:K04553] [EC:2.3.2.23]
22192  
Ube2m; ubiquitin-conjugating enzyme E2M [KO:K10579]
93765  
Ube2n; ubiquitin-conjugating enzyme E2N [KO:K10580] [EC:2.3.2.23]
217342  
Ube2o; ubiquitin-conjugating enzyme E2O [KO:K10581] [EC:2.3.2.24]
70093  
Ube2q1; ubiquitin-conjugating enzyme E2Q family member 1 [KO:K10582] [EC:2.3.2.23]
109161  
Ube2q2; ubiquitin-conjugating enzyme E2Q family member 2 [KO:K10582] [EC:2.3.2.23]
76980  
Ube2ql1; ubiquitin-conjugating enzyme E2Q family-like 1 [KO:K10582] [EC:2.3.2.23]
245350  
OTTMUSG00000017000; expressed sequence AA414768 [KO:K10582] [EC:2.3.2.23]
67615  
Ube2r2; ubiquitin-conjugating enzyme E2R 2 [KO:K02207] [EC:2.3.2.23]
216150  
Cdc34; cell division cycle 34 [KO:K02207] [EC:2.3.2.23]
77891  
Ube2s; ubiquitin-conjugating enzyme E2S [KO:K10583] [EC:2.3.2.23]
381534  
Ube2u; ubiquitin-conjugating enzyme E2U (putative) [KO:K10584] [EC:2.3.2.23]
66799  
Ube2w; ubiquitin-conjugating enzyme E2W (putative) [KO:K10688] [EC:2.3.2.25]
268470  
Ube2z; ubiquitin-conjugating enzyme E2Z [KO:K10585] [EC:2.3.2.23]
53323  
Ube2k; ubiquitin-conjugating enzyme E2K [KO:K04649] [EC:2.3.2.23]
12211  
Birc6; baculoviral IAP repeat-containing 6 [KO:K10586] [EC:2.3.2.23]
22215  
Ube3a; ubiquitin protein ligase E3A [KO:K10587] [EC:2.3.2.26]
117146  
Ube3b; ubiquitin protein ligase E3B [KO:K10588] [EC:2.3.2.26]
100763  
Ube3c; ubiquitin protein ligase E3C [KO:K10589] [EC:2.3.2.26]
66313  
Smurf2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:2.3.2.26]
75788  
Smurf1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:2.3.2.26]
16396  
Itch; itchy, E3 ubiquitin protein ligase [KO:K05632] [EC:2.3.2.26]
107568  
Wwp1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:2.3.2.26]
66894  
Wwp2; WW domain containing E3 ubiquitin protein ligase 2 [KO:K05630] [EC:2.3.2.26]
14897  
Trip12; thyroid hormone receptor interactor 12 [KO:K10590] [EC:2.3.2.26]
17999  
Nedd4; neural precursor cell expressed, developmentally down-regulated 4 [KO:K10591] [EC:2.3.2.26]
83814  
Nedd4l; neural precursor cell expressed, developmentally down-regulated gene 4-like [KO:K13305] [EC:2.3.2.26]
59026  
Huwe1; HECT, UBA and WWE domain containing 1 [KO:K10592] [EC:2.3.2.26]
70790  
Ubr5; ubiquitin protein ligase E3 component n-recognin 5 [KO:K10593] [EC:2.3.2.26]
235439  
Herc1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [KO:K10594] [EC:2.3.2.26]
15204  
Herc2; HECT and RLD domain containing E3 ubiquitin protein ligase 2 [KO:K10595] [EC:2.3.2.26]
73998  
Herc3; hect domain and RLD 3 [KO:K10614] [EC:2.3.2.26]
67345  
Herc4; hect domain and RLD 4 [KO:K10615] [EC:2.3.2.26]
140630  
Ube4a; ubiquitination factor E4A [KO:K10596] [EC:2.3.2.27]
63958  
Ube4b; ubiquitination factor E4B [KO:K10597] [EC:2.3.2.27]
56424  
Stub1; STIP1 homology and U-Box containing protein 1 [KO:K09561] [EC:2.3.2.27]
66053  
Ppil2; peptidylprolyl isomerase (cyclophilin)-like 2 [KO:K10598] [EC:5.2.1.8]
28000  
Prpf19; pre-mRNA processing factor 19 [KO:K10599] [EC:2.3.2.27]
140629  
Ubox5; U box domain containing 5 [KO:K10600]
17246  
Mdm2; transformed mouse 3T3 cell double minute 2 [KO:K06643] [EC:2.3.2.27]
12402  
Cbl; Casitas B-lineage lymphoma [KO:K04707] [EC:2.3.2.27]
208650  
Cblb; Casitas B-lineage lymphoma b [KO:K04707] [EC:2.3.2.27]
80794  
Cblc; Casitas B-lineage lymphoma c [KO:K04707] [EC:2.3.2.27]
50873  
Park2; Parkinson disease (autosomal recessive, juvenile) 2, parkin [KO:K04556] [EC:2.3.2.27]
20437  
Siah1a; seven in absentia 1A [KO:K04506] [EC:2.3.2.27]
20438  
Siah1b; seven in absentia 1B [KO:K04506] [EC:2.3.2.27]
18854  
Pml; promyelocytic leukemia [KO:K10054]
22034  
Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
26401  
Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
26374  
Rfwd2; ring finger and WD repeat domain 2 [KO:K10143] [EC:2.3.2.27]
68098  
Rchy1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:2.3.2.27]
11797  
Birc2; baculoviral IAP repeat-containing 2 [KO:K16060]
11796  
Birc3; baculoviral IAP repeat-containing 3 [KO:K16060]
11798  
Xiap; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27]
329581  
Birc7; baculoviral IAP repeat-containing 7 (livin) [KO:K16061]
56469  
Pias1; protein inhibitor of activated STAT 1 [KO:K04706]
17344  
Pias2; protein inhibitor of activated STAT 2 [KO:K16063]
229615  
Pias3; protein inhibitor of activated STAT 3 [KO:K16064]
59004  
Pias4; protein inhibitor of activated STAT 4 [KO:K16065]
74126  
Syvn1; synovial apoptosis inhibitor 1, synoviolin [KO:K10601] [EC:2.3.2.27]
105193  
Nhlrc1; NHL repeat containing 1 [KO:K10602] [EC:2.3.2.27]
11634  
Aire; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) [KO:K10603]
17237  
Mgrn1; mahogunin, ring finger 1 [KO:K10604] [EC:2.3.2.27]
12189  
Brca1; breast cancer 1, early onset [KO:K10605] [EC:2.3.2.27]
67030  
Fancl; Fanconi anemia, complementation group L [KO:K10606] [EC:2.3.2.27]
17318  
Mid1; midline 1 [KO:K08285] [EC:2.3.2.27]
69807  
Trim32; tripartite motif-containing 32 [KO:K10607] [EC:2.3.2.27]
68729  
Trim37; tripartite motif-containing 37 [KO:K10608] [EC:2.3.2.27]
56438  
Rbx1; ring-box 1 [KO:K03868]
Gm9840; predicted gene 9840 [KO:K03868]
26965  
Cul1; cullin 1 [KO:K03347]
21402  
Skp1a; S-phase kinase-associated protein 1A [KO:K03094]
103583  
Fbxw11; F-box and WD-40 domain protein 11 [KO:K03362]
12234  
Btrc; beta-transducin repeat containing protein [KO:K03362]
27401  
Skp2; S-phase kinase-associated protein 2 (p45) [KO:K03875]
50754  
Fbxw7; F-box and WD-40 domain protein 7 [KO:K10260]
230904  
Fbxo2; F-box protein 2 [KO:K10099]
106052  
Fbxo4; F-box protein 4 [KO:K10291]
71745  
Cul2; cullin 2 [KO:K03870]
67923  
Tceb1; transcription elongation factor B (SIII), polypeptide 1 [KO:K03872]
67673  
Tceb2; transcription elongation factor B (SIII), polypeptide 2 [KO:K03873]
22346  
Vhl; von Hippel-Lindau tumor suppressor [KO:K03871]
26554  
Cul3; cullin 3 [KO:K03869]
50868  
Keap1; kelch-like ECH-associated protein 1 [KO:K10456]
242521  
Klhl9; kelch-like 9 [KO:K10447]
67455  
Klhl13; kelch-like 13 [KO:K10447]
246710  
Rhobtb2; Rho-related BTB domain containing 2 [KO:K07868]
69288  
Rhobtb1; Rho-related BTB domain containing 1 [KO:K07868]
72584  
Cul4b; cullin 4B [KO:K10609]
99375  
Cul4a; cullin 4A [KO:K10609]
13194  
Ddb1; damage specific DNA binding protein 1 [KO:K10610]
107986  
Ddb2; damage specific DNA binding protein 2 [KO:K10140]
71991  
Ercc8; excision repaiross-complementing rodent repair deficiency, complementation group 8 [KO:K10570]
76375  
Det1; de-etiolated homolog 1 (Arabidopsis) [KO:K10571]
19823  
Rnf7; ring finger protein 7 [KO:K10611]
75717  
Cul5; cullin 5 [KO:K10612]
12703  
Socs1; suppressor of cytokine signaling 1 [KO:K04694]
12702  
Socs3; suppressor of cytokine signaling 3 [KO:K04696]
66515  
Cul7; cullin 7 [KO:K10613]
231672  
Fbxw8; F-box and WD-40 domain protein 8 [KO:K10264]
66156  
Anapc11; anaphase promoting complex subunit 11 [KO:K03358]
99152  
Anapc2; anaphase promoting complex subunit 2 [KO:K03349]
107995  
Cdc20; cell division cycle 20 [KO:K03363]
56371  
Fzr1; fizzy/cell division cycle 20 related 1 (Drosophila) [KO:K03364]
17222  
Anapc1; anaphase promoting complex subunit 1 [KO:K03348]
217232  
Cdc27; cell division cycle 27 [KO:K03350]
52206  
Anapc4; anaphase promoting complex subunit 4 [KO:K03351]
59008  
Anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
69957  
Cdc16; CDC16 cell division cycle 16 [KO:K03353]
56317  
Anapc7; anaphase promoting complex subunit 7 [KO:K03354]
52563  
Cdc23; CDC23 cell division cycle 23 [KO:K03355]
68999  
Anapc10; anaphase promoting complex subunit 10 [KO:K03357]
66440  
Cdc26; cell division cycle 26 [KO:K03359]
69010  
Anapc13; anaphase promoting complex subunit 13 [KO:K12456]
 
 
 
 
433742  
 
Reference
PMID:16922370 (Japanese)
  Authors
Kamura T.
  Title
[Cullin-based E3 family] Japanese
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408 (Japanese)
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367 (Japanese)
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
Reference
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
Reference
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
KO pathway
 

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