Entry |
|
Name |
TGF-beta signaling pathway - Mus musculus (mouse)
|
Description |
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
|
Class |
Environmental Information Processing; Signal transduction
 |
Pathway map |

 |
Module |
|
Other DBs |
|
Organism |
Mus musculus (mouse) [GN: mmu]
|
Gene |
17965 | Nbl1; neuroblastoma, suppression of tumorigenicity 1 [KO:K19558] |
13590 | Lefty1; left right determination factor 1 [KO:K04668] |
320202 | Lefty2; left-right determination factor 2 [KO:K04668] |
14563 | Gdf5; growth differentiation factor 5 [KO:K04664] |
268977 | Ltbp1; latent transforming growth factor beta binding protein 1 [KO:K19559] |
21803 | Tgfb1; transforming growth factor, beta 1 [KO:K13375] |
21808 | Tgfb2; transforming growth factor, beta 2 [KO:K13376] |
21809 | Tgfb3; transforming growth factor, beta 3 [KO:K13377] |
12168 | Bmpr2; bone morphogenetic protein receptor, type II (serine/threonine kinase) [KO:K04671] [EC:2.7.11.30] |
68010 | Bambi; BMP and activin membrane-bound inhibitor [KO:K10162] |
218441 | Zfyve16; zinc finger, FYVE domain containing 16 [KO:K04679] |
230597 | Zfyve9; zinc finger, FYVE domain containing 9 [KO:K04679] |
19650 | Rbl1; RB transcriptional corepressor like 1 [KO:K04681] |
20683 | Sp1; trans-acting transcription factor 1 [KO:K04684] |
21815 | Tgif1; TGFB-induced factor homeobox 1 [KO:K19383] |
12579 | Cdkn2b; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [KO:K04685] |
18741 | Pitx2; paired-like homeodomain transcription factor 2 [KO:K04686] |
21402 | Skp1a; S-phase kinase-associated protein 1A [KO:K03094] |
67653 | 4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513] |
51792 | Ppp2r1a; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456] |
73699 | Ppp2r1b; protein phosphatase 2, regulatory subunit A, beta [KO:K03456] |
19052 | Ppp2ca; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [KO:K04382] [EC:3.1.3.16] |
19053 | Ppp2cb; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [KO:K04382] [EC:3.1.3.16] |
|
Reference |
|
Authors |
Shi Y, Massague J. |
Title |
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. |
Journal |
|
Reference |
|
Authors |
Derynck R, Zhang YE. |
Title |
Smad-dependent and Smad-independent pathways in TGF-beta family signalling. |
Journal |
|
Reference |
|
Authors |
Massague J. |
Title |
How cells read TGF-beta signals. |
Journal |
|
Reference |
|
Authors |
Siegel PM, Massague J. |
Title |
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. |
Journal |
|
Reference |
|
Authors |
Shimasaki S, Moore RK, Otsuka F, Erickson GF. |
Title |
The bone morphogenetic protein system in mammalian reproduction. |
Journal |
|
Reference |
|
Authors |
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O. |
Title |
The establishment of Spemann's organizer and patterning of the vertebrate embryo. |
Journal |
|
Reference |
|
Authors |
Gumienny TL, Padgett RW. |
Title |
The other side of TGF-beta superfamily signal regulation: thinking outside the cell. |
Journal |
|
Reference |
|
Authors |
Hamada H, Meno C, Watanabe D, Saijoh Y. |
Title |
Establishment of vertebrate left-right asymmetry. |
Journal |
|
Reference |
|
Authors |
Chang H, Brown CW, Matzuk MM. |
Title |
Genetic analysis of the mammalian transforming growth factor-beta superfamily. |
Journal |
|
Reference |
|
Authors |
Morita K, Chow KL, Ueno N. |
Title |
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family. |
Journal |
Development 126:1337-47 (1999) |
Reference |
|
Authors |
Krishna S, Maduzia LL, Padgett RW. |
Title |
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans. |
Journal |
Development 126:251-60 (1999) |
Reference |
|
Authors |
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF. |
Title |
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus. |
Journal |
|
Reference |
|
Authors |
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C |
Title |
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. |
Journal |
|
Reference |
|
Authors |
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG |
Title |
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. |
Journal |
|
KO pathway |
|