KEGG   PATHWAY: mmu04530
Entry
mmu04530                    Pathway                                
Name
Tight junction - Mus musculus (house mouse)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mmu04530  Tight junction
mmu04530

Other DBs
GO: 0005923
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
224912  Crb3; crumbs family member 3 [KO:K06090]
73934  Cldn34c4; claudin 34C4 [KO:K06087]
74987  Cldn34d; claudin 34D [KO:K06087]
114141  Cldn16; claudin 16 [KO:K06087]
12737  Cldn1; claudin 1 [KO:K06087]
12738  Cldn2; claudin 2 [KO:K06087]
12739  Cldn3; claudin 3 [KO:K06087]
12740  Cldn4; claudin 4 [KO:K06087]
12741  Cldn5; claudin 5 [KO:K06087]
18417  Cldn11; claudin 11 [KO:K06087]
239931  Cldn17; claudin 17 [KO:K06087]
242653  Cldn19; claudin 19 [KO:K06087]
53624  Cldn7; claudin 7 [KO:K06087]
54419  Cldn6; claudin 6 [KO:K06087]
54420  Cldn8; claudin 8 [KO:K06087]
56173  Cldn14; claudin 14 [KO:K06087]
56492  Cldn18; claudin 18 [KO:K06087]
56863  Cldn9; claudin 9 [KO:K06087]
57255  Cldn13; claudin 13 [KO:K06087]
58187  Cldn10; claudin 10 [KO:K06087]
60363  Cldn15; claudin 15 [KO:K06087]
71908  Cldn23; claudin 23 [KO:K06087]
621628  Cldn20; claudin 20 [KO:K06087]
75677  Cldn22; claudin 22 [KO:K06087]
628893  Cldn34-ps; claudin 34, pseudogene [KO:K06087]
100039801  Cldn24; claudin 24 [KO:K06087]
64945  Cldn12; claudin 12 [KO:K06087]
100042785  Cldn25; claudin 25 [KO:K06087]
18260  Ocln; occludin [KO:K06088]
16456  F11r; F11 receptor [KO:K06089]
67374  Jam2; junction adhesion molecule 2 [KO:K06735]
83964  Jam3; junction adhesion molecule 3 [KO:K06785]
23828  Bves; blood vessel epicardial substance [KO:K21108]
12540  Cdc42; cell division cycle 42 [KO:K04393]
56513  Pard6a; par-6 family cell polarity regulator alpha [KO:K06093]
58220  Pard6b; par-6 family cell polarity regulator beta [KO:K06093]
93737  Pard6g; par-6 family cell polarity regulator gamma [KO:K06093]
56217  Pals1; protein associated with LIN7 1, MAGUK family member [KO:K06091]
227157  Mpp4; membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) [KO:K21109]
27375  Tjp3; tight junction protein 3 [KO:K06097]
12695  Patj; PATJ, crumbs cell polarity complex component [KO:K06092]
17475  Mpdz; multiple PDZ domain crumbs cell polarity complex component [KO:K06095]
18762  Prkcz; protein kinase C, zeta [KO:K18952] [EC:2.7.11.13]
18759  Prkci; protein kinase C, iota [KO:K06069] [EC:2.7.11.13]
27494  Amot; angiomotin [KO:K16819]
75723  Amotl1; angiomotin-like 1 [KO:K06104]
56332  Amotl2; angiomotin-like 2 [KO:K06104]
70497  Arhgap17; Rho GTPase activating protein 17 [KO:K20638]
19353  Rac1; Rac family small GTPase 1 [KO:K04392]
18016  Nf2; neurofibromin 2 [KO:K16684]
16897  Llgl1; LLGL1 scribble cell polarity complex component [KO:K06094]
217325  Llgl2; LLGL2 scribble cell polarity complex component [KO:K06094]
13383  Dlg1; discs large MAGUK scaffold protein 1 [KO:K12076]
105782  Scrib; scribbled planar cell polarity [KO:K16175]
19052  Ppp2ca; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform [KO:K04382] [EC:3.1.3.16]
19053  Ppp2cb; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform [KO:K04382] [EC:3.1.3.16]
51792  Ppp2r1a; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456]
73699  Ppp2r1b; protein phosphatase 2, regulatory subunit A, beta [KO:K03456]
52432  Ppp2r2d; protein phosphatase 2, regulatory subunit B, delta [KO:K04354]
72930  Ppp2r2b; protein phosphatase 2, regulatory subunit B, beta [KO:K04354]
269643  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
71978  Ppp2r2a; protein phosphatase 2, regulatory subunit B, alpha [KO:K04354]
93742  Pard3; par-3 family cell polarity regulator [KO:K04237]
21844  Tiam1; T cell lymphoma invasion and metastasis 1 [KO:K05731]
21872  Tjp1; tight junction protein 1 [KO:K05701]
74094  Tjap1; tight junction associated protein 1 [KO:K06105]
23859  Dlg2; discs large MAGUK scaffold protein 2 [KO:K12075]
53310  Dlg3; discs large MAGUK scaffold protein 3 [KO:K21098]
17999  Nedd4; neural precursor cell expressed, developmentally down-regulated 4 [KO:K10591] [EC:2.3.2.26]
83814  Nedd4l; neural precursor cell expressed, developmentally down-regulated gene 4-like [KO:K13305] [EC:2.3.2.26]
70737  Cgn; cingulin [KO:K06102]
68178  Cgnl1; cingulin-like 1 [KO:K21110]
16800  Arhgef2; Rho/Rac guanine nucleotide exchange factor 2 [KO:K12791]
11848  Rhoa; ras homolog family member A [KO:K04513]
67653  4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513]
14463  Gata4; GATA binding protein 4 [KO:K09183]
73608  Marveld3; MARVEL (membrane-associating) domain containing 3 [KO:K21099]
26401  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
16476  Jun; jun proto-oncogene [KO:K04448]
12479  Cd1d1; CD1d1 antigen [KO:K06448]
12480  Cd1d2; CD1d2 antigen [KO:K06448]
12638  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
12567  Cdk4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
56449  Ybx3; Y box protein 3 [KO:K06099]
68188  Sympk; symplekin [KO:K06100]
18538  Pcna; proliferating cell nuclear antigen [KO:K04802]
12443  Ccnd1; cyclin D1 [KO:K04503]
13866  Erbb2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
12394  Runx1; runt related transcription factor 1 [KO:K08367]
15525  Hspa4; heat shock protein 4 [KO:K09489]
26941  Nherf1; NHERF family PDZ scaffold protein 1 [KO:K13365]
22350  Ezr; ezrin [KO:K08007]
19684  Rdx; radixin [KO:K05762]
17698  Msn; moesin [KO:K05763]
18754  Prkce; protein kinase C, epsilon [KO:K18050] [EC:2.7.11.13]
11465  Actg1; actin, gamma, cytoplasmic 1 [KO:K05692]
11461  Actb; actin, beta [KO:K05692]
12289  Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
26408  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
26400  Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
20779  Src; Rous sarcoma oncogene [KO:K05704] [EC:2.7.10.2]
13043  Cttn; cortactin [KO:K06106]
15163  Hcls1; hematopoietic cell specific Lyn substrate 1 [KO:K06106]
66713  Actr2; actin related protein 2 [KO:K17260]
242894  Actr3b; ARP3 actin-related protein 3B [KO:K18584]
74117  Actr3; ARP3 actin-related protein 3 [KO:K18584]
11867  Arpc1b; actin related protein 2/3 complex, subunit 1B [KO:K05757]
56443  Arpc1a; actin related protein 2/3 complex, subunit 1A [KO:K05757]
434782  Gm5637; predicted pseudogene 5637 [KO:K05757]
76709  Arpc2; actin related protein 2/3 complex, subunit 2 [KO:K05758]
56378  Arpc3; actin related protein 2/3 complex, subunit 3 [KO:K05756]
68089  Arpc4; actin related protein 2/3 complex, subunit 4 [KO:K05755]
67771  Arpc5; actin related protein 2/3 complex, subunit 5 [KO:K05754]
74192  Arpc5l; actin related protein 2/3 complex, subunit 5-like [KO:K05754]
434204  Whamm; WAS protein homolog associated with actin, golgi membranes and microtubules [KO:K20479]
22376  Was; Wiskott-Aldrich syndrome [KO:K05747]
22323  Vasp; vasodilator-stimulated phosphoprotein [KO:K06274]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
68328  Rab13; RAB13, member RAS oncogene family [KO:K06109]
102098  Arhgef18; Rho/Rac guanine nucleotide exchange factor 18 [KO:K21066]
19877  Rock1; Rho-associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
19878  Rock2; Rho-associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
17906  Myl2; myosin, light polypeptide 2, regulatory, cardiac, slow [KO:K10351]
54357  Epb41l4b; erythrocyte membrane protein band 4.1 like 4b [KO:K21111]
20869  Stk11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
105787  Prkaa1; protein kinase, AMP-activated, alpha 1 catalytic subunit [KO:K07198] [EC:2.7.11.31]
108079  Prkaa2; protein kinase, AMP-activated, alpha 2 catalytic subunit [KO:K07198] [EC:2.7.11.31]
19079  Prkab1; protein kinase, AMP-activated, beta 1 non-catalytic subunit [KO:K07199]
108097  Prkab2; protein kinase, AMP-activated, beta 2 non-catalytic subunit [KO:K07199]
19082  Prkag1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit [KO:K07200]
241113  Prkag3; protein kinase, AMP-activated, gamma 3 non-catalytic subunit [KO:K07200]
108099  Prkag2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit [KO:K07200]
17880  Myh11; myosin, heavy polypeptide 11, smooth muscle [KO:K10352]
17886  Myh9; myosin, heavy polypeptide 9, non-muscle [KO:K10352]
71960  Myh14; myosin, heavy polypeptide 14 [KO:K10352]
77579  Myh10; myosin, heavy polypeptide 10, non-muscle [KO:K10352]
17904  Myl6; myosin, light polypeptide 6, alkali, smooth muscle and non-muscle [KO:K12751]
216459  Myl6b; myosin, light polypeptide 6B [KO:K12751]
98932  Myl9; myosin, light polypeptide 9, regulatory [KO:K12755]
67938  Myl12b; myosin, light chain 12B, regulatory [KO:K12757]
67268  Myl12a; myosin, light chain 12A, regulatory, non-sarcomeric [KO:K12757]
72058  Igsf5; immunoglobulin superfamily, member 5 [KO:K06786]
14924  Magi1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
104027  Synpo; synaptopodin [KO:K21112]
60595  Actn4; actinin alpha 4 [KO:K05699]
109711  Actn1; actinin, alpha 1 [KO:K05699]
231830  Micall2; MICAL-like 2 [KO:K21068]
17274  Rab8a; RAB8A, member RAS oncogene family [KO:K07901]
235442  Rab8b; RAB8B, member RAS oncogene family [KO:K07902]
192786  Rapgef6; Rap guanine nucleotide exchange factor (GEF) 6 [KO:K08020]
109905  Rap1a; RAS-related protein 1a [KO:K04353]
16412  Itgb1; integrin beta 1 (fibronectin receptor beta) [KO:K05719]
17356  Afdn; afadin, adherens junction formation factor [KO:K05702]
21873  Tjp2; tight junction protein 2 [KO:K06098]
76089  Rapgef2; Rap guanine nucleotide exchange factor (GEF) 2 [KO:K08018]
72065  Rap2c; RAP2C, member of RAS oncogene family [KO:K07839]
218518  Marveld2; MARVEL (membrane-associating) domain containing 2 [KO:K17291]
22145  Tuba4a; tubulin, alpha 4A [KO:K07374]
22144  Tuba3a; tubulin, alpha 3A [KO:K07374]
22142  Tuba1a; tubulin, alpha 1A [KO:K07374]
22146  Tuba1c; tubulin, alpha 1C [KO:K07374]
22147  Tuba3b; tubulin, alpha 3B [KO:K07374]
22143  Tuba1b; tubulin, alpha 1B [KO:K07374]
53857  Tuba8; tubulin, alpha 8 [KO:K07374]
238463  Tubal3; tubulin, alpha-like 3 [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mmu04520  Adherens junction
mmu04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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Genome (1)   
   KEGG GENOME (1)   
Gene (169)   
   KEGG GENES (169)   
All databases (170)   

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