Entry
Name
Cytosolic DNA-sensing pathway - Mus musculus (house mouse)
Description
Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Ortholog table
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
74414 Polr3c; polymerase (RNA) III (DNA directed) polypeptide C [KO:K03023 ]
67065 Polr3d; polymerase (RNA) III (DNA directed) polypeptide D [KO:K03026 ]
26939 Polr3e; polymerase (RNA) III (DNA directed) polypeptide E [KO:K14721 ]
20016 Polr1c; polymerase (RNA) I polypeptide C [KO:K03027 ]
67005 Polr3k; polymerase (RNA) III (DNA directed) polypeptide K [KO:K03019 ]
20018 Polr1d; polymerase (RNA) I polypeptide D [KO:K03020 ]
78929 Polr3h; polymerase (RNA) III (DNA directed) polypeptide H [KO:K03022 ]
67486 Polr3g; polymerase (RNA) III (DNA directed) polypeptide G [KO:K03024 ]
69870 Polr3gl; polymerase (RNA) III (DNA directed) polypeptide G like [KO:K03024 ]
70408 Polr3f; polymerase (RNA) III (DNA directed) polypeptide F [KO:K03025 ]
66420 Polr2e; polymerase (RNA) II (DNA directed) polypeptide E [KO:K03013 ]
69833 Polr2f; polymerase (RNA) II (DNA directed) polypeptide F [KO:K03014 ]
245841 Polr2h; polymerase (RNA) II (DNA directed) polypeptide H [KO:K03016 ]
17749 Polr2k; polymerase (RNA) II (DNA directed) polypeptide K [KO:K03009 ]
66491 Polr2l; polymerase (RNA) II (DNA directed) polypeptide L [KO:K03007 ]
228607 Mavs; mitochondrial antiviral signaling protein [KO:K12648 ]
18033 Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580 ]
19697 Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735 ]
67917 Zcchc3; zinc finger, CCHC domain containing 3 [KO:K27162 ]
72512 Sting1; stimulator of interferon response cGAMP interactor 1 [KO:K12654 ]
15951 Ifi204; interferon activated gene 204 [KO:K20914 ]
16151 Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210 ]
18036 Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581 ]
18035 Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734 ]
15945 Cxcl10; C-X-C motif chemokine ligand 10 [KO:K12671 ]
216799 Nlrp3; NLR family, pyrin domain containing 3 [KO:K12800 ]
14082 Fadd; Fas associated via death domain [KO:K02373 ]
66824 Pycard; PYD and CARD domain containing [KO:K12799 ]
56045 Samhd1; SAM domain and HD domain, 1 [KO:K22544 ] [EC:3.1.5.-]
26388 Ifi202b; interferon activated gene 202B [KO:K12971 ]
Compound
Reference
Authors
Yanai H, Savitsky D, Tamura T, Taniguchi T
Title
Regulation of the cytosolic DNA-sensing system in innate immunity: a current view.
Journal
Reference
Authors
Vilaysane A, Muruve DA
Title
The innate immune response to DNA.
Journal
Reference
Authors
Takeshita F, Ishii KJ
Title
Intracellular DNA sensors in immunity.
Journal
Reference
Authors
Takaoka A, Shinohara S
Title
DNA sensors in innate immune system.
Journal
Reference
Authors
Takaoka A, Taniguchi T
Title
Cytosolic DNA recognition for triggering innate immune responses.
Journal
Reference
Authors
Kaiser WJ, Upton JW, Mocarski ES
Title
Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors.
Journal
Reference
Authors
Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J
Title
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
Journal
Reference
Authors
Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T
Title
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.
Journal
Reference
Authors
Stetson DB, Ko JS, Heidmann T, Medzhitov R
Title
Trex1 prevents cell-intrinsic initiation of autoimmunity.
Journal
Reference
Authors
Schroder K, Muruve DA, Tschopp J
Title
Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.
Journal
Reference
Authors
Krieg AM
Title
AIMing 2 detect foreign DNA.
Journal
Reference
Authors
O'Neill LA
Title
DNA makes RNA makes innate immunity.
Journal
Reference
Authors
Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S
Title
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Journal
Reference
Authors
Cao X
Title
New DNA-sensing pathway feeds RIG-I with RNA.
Journal
Reference
Authors
Sun L, Wu J, Du F, Chen X, Chen ZJ
Title
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Journal
Reference
Authors
Gao M, He Y, Tang H, Chen X, Liu S, Tao Y
Title
cGAS/STING: novel perspectives of the classic pathway.
Journal
Reference
Authors
Benjamin P, Sudhakar S, D'Arco F, Lobel U, Carney O, Roux CJ, Boddaert N, Hemingway C, Eleftheriou D, Mankad K
Title
Spectrum of Neuroradiologic Findings Associated with Monogenic Interferonopathies.
Journal
Reference
Authors
Place DE, Lee S, Kanneganti TD
Title
PANoptosis in microbial infection.
Journal
Reference
Authors
Jiang W, Deng Z, Dai X, Zhao W
Title
PANoptosis: A New Insight Into Oral Infectious Diseases.
Journal
Reference
Authors
Wang Y, Kanneganti TD
Title
From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways.
Journal
Related pathway
mmu04621 NOD-like receptor signaling pathway
mmu04622 RIG-I-like receptor signaling pathway
KO pathway