KEGG   PATHWAY: mmu05146
Entry
mmu05146                    Pathway                                
Name
Amoebiasis - Mus musculus (house mouse)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
mmu05146  Amoebiasis
mmu05146

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
16176  Il1b; interleukin 1 beta [KO:K04519]
16177  Il1r1; interleukin 1 receptor, type I [KO:K04386]
16178  Il1r2; interleukin 1 receptor, type II [KO:K04387]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
15507  Hspb1; heat shock protein 1 [KO:K04455]
17831  Muc2; mucin 2 [KO:K10955]
12842  Col1a1; collagen, type I, alpha 1 [KO:K06236]
12843  Col1a2; collagen, type I, alpha 2 [KO:K06236]
12826  Col4a1; collagen, type IV, alpha 1 [KO:K06237]
12827  Col4a2; collagen, type IV, alpha 2 [KO:K06237]
12829  Col4a4; collagen, type IV, alpha 4 [KO:K06237]
94216  Col4a6; collagen, type IV, alpha 6 [KO:K06237]
12830  Col4a5; collagen, type IV, alpha 5 [KO:K06237]
12828  Col4a3; collagen, type IV, alpha 3 [KO:K06237]
14268  Fn1; fibronectin 1 [KO:K05717]
16772  Lama1; laminin, alpha 1 [KO:K05637]
16773  Lama2; laminin, alpha 2 [KO:K05637]
16774  Lama3; laminin, alpha 3 [KO:K06240]
16776  Lama5; laminin, alpha 5 [KO:K06240]
16775  Lama4; laminin, alpha 4 [KO:K06241]
16777  Lamb1; laminin B1 [KO:K05636]
16779  Lamb2; laminin, beta 2 [KO:K06243]
16780  Lamb3; laminin, beta 3 [KO:K06244]
226519  Lamc1; laminin, gamma 1 [KO:K05635]
16782  Lamc2; laminin, gamma 2 [KO:K06246]
23928  Lamc3; laminin gamma 3 [KO:K06247]
12367  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
14682  Gnaq; guanine nucleotide binding protein, alpha q polypeptide [KO:K04634]
14672  Gna11; guanine nucleotide binding protein, alpha 11 [KO:K04635]
14675  Gna14; guanine nucleotide binding protein, alpha 14 [KO:K04636]
14676  Gna15; guanine nucleotide binding protein, alpha 15 [KO:K04637]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
18750  Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18751  Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
18752  Prkcg; protein kinase C, gamma [KO:K19663] [EC:2.7.11.13]
14683  Gnas; GNAS complex locus [KO:K04632]
14680  Gnal; guanine nucleotide binding protein, alpha stimulating, olfactory type [KO:K04633]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
271457  Rab5a; RAB5A, member RAS oncogene family [KO:K07887]
19344  Rab5b; RAB5B, member RAS oncogene family [KO:K07888]
19345  Rab5c; RAB5C, member RAS oncogene family [KO:K07889]
19349  Rab7; RAB7, member RAS oncogene family [KO:K07897]
226421  Rab7b; RAB7B, member RAS oncogene family [KO:K07898]
24088  Tlr2; toll-like receptor 2 [KO:K10159]
21898  Tlr4; toll-like receptor 4 [KO:K10160]
12475  Cd14; CD14 antigen [KO:K04391]
16193  Il6; interleukin 6 [KO:K05405]
14825  Cxcl1; C-X-C motif chemokine ligand 1 [KO:K05505]
20310  Cxcl2; C-X-C motif chemokine ligand 2 [KO:K05505]
330122  Cxcl3; C-X-C motif chemokine ligand 3 [KO:K05505]
12981  Csf2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
21926  Tnf; tumor necrosis factor [KO:K03156]
16159  Il12a; interleukin 12a [KO:K05406]
16160  Il12b; interleukin 12b [KO:K05425]
12479  Cd1d1; CD1d1 antigen [KO:K06448]
12480  Cd1d2; CD1d2 antigen [KO:K06448]
15978  Ifng; interferon gamma [KO:K04687]
12825  Col3a1; collagen, type III, alpha 1 [KO:K19720]
14083  Ptk2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
22330  Vcl; vinculin [KO:K05700]
60595  Actn4; actinin alpha 4 [KO:K05699]
109711  Actn1; actinin, alpha 1 [KO:K05699]
11846  Arg1; arginase, liver [KO:K01476] [EC:3.5.3.1]
11847  Arg2; arginase type II [KO:K01476] [EC:3.5.3.1]
18126  Nos2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
16414  Itgb2; integrin beta 2 [KO:K06464]
16415  Itgb2l; integrin beta 2-like [KO:K06464]
16409  Itgam; integrin alpha M [KO:K06461]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
18477  Prdx1; peroxiredoxin 1 [KO:K13279] [EC:1.11.1.24]
20248  Serpinb3a; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A [KO:K13963]
20719  Serpinb6a; serine (or cysteine) peptidase inhibitor, clade B, member 6a [KO:K13963]
20723  Serpinb9; serine (or cysteine) peptidase inhibitor, clade B, member 9 [KO:K13963]
241197  Serpinb10; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 [KO:K13963]
241196  Serpinb13; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13 [KO:K13963]
20710  Serpinb9e; serine (or cysteine) peptidase inhibitor, clade B, member 9e [KO:K13963]
20706  Serpinb9b; serine (or cysteine) peptidase inhibitor, clade B, member 9b [KO:K13963]
544923  Serpinb9h; serine (or cysteine) peptidase inhibitor, clade B, member 9h [KO:K13963]
93806  Serpinb9g; serine (or cysteine) peptidase inhibitor, clade B, member 9g [KO:K13963]
20709  Serpinb9f; serine (or cysteine) peptidase inhibitor, clade B, member 9f [KO:K13963]
20707  Serpinb9c; serine (or cysteine) peptidase inhibitor, clade B, member 9c [KO:K13963]
20726  Serpinb9d; serine (or cysteine) peptidase inhibitor, clade B, member 9d [KO:K13963]
394252  Serpinb3d; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D [KO:K13963]
97848  Serpinb6c; serine (or cysteine) peptidase inhibitor, clade B, member 6c [KO:K13963]
20708  Serpinb6b; serine (or cysteine) peptidase inhibitor, clade B, member 6b [KO:K13963]
381286  Serpinb3c; serine (or cysteine) peptidase inhibitor, clade B, member 3C [KO:K13963]
383548  Serpinb3b; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B [KO:K13963]
435350  Serpinb6e; serine (or cysteine) peptidase inhibitor, clade B, member 6e [KO:K13963]
13035  Ctsg; cathepsin G [KO:K01319] [EC:3.4.21.20]
16153  Il10; interleukin 10 [KO:K05443]
21803  Tgfb1; transforming growth factor, beta 1 [KO:K13375]
21808  Tgfb2; transforming growth factor, beta 2 [KO:K13376]
21809  Tgfb3; transforming growth factor, beta 3 [KO:K13377]
230558  C8a; complement component 8, alpha polypeptide [KO:K03997]
110382  C8b; complement component 8, beta polypeptide [KO:K03998]
69379  C8g; complement component 8, gamma polypeptide [KO:K03999]
12279  C9; complement component 9 [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
mmu00330  Arginine and proline metabolism
mmu00590  Arachidonic acid metabolism
mmu04144  Endocytosis
mmu04210  Apoptosis
mmu04510  Focal adhesion
mmu04610  Complement and coagulation cascades
mmu04612  Antigen processing and presentation
mmu04620  Toll-like receptor signaling pathway
mmu04672  Intestinal immune network for IgA production
mmu04810  Regulation of actin cytoskeleton
KO pathway
ko05146   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (108)   
   KEGG GENES (108)   
All databases (109)   

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