KEGG   PATHWAY: nko03440
Entry
nko03440                    Pathway                                
Name
Homologous recombination - Niastella koreensis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
nko03440  Homologous recombination
nko03440

Other DBs
GO: 0000724
Organism
Niastella koreensis [GN:nko]
Gene
Niako_5115  exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Niako_3883  single-strand binding protein/Primosomal replication protein n [KO:K03111]
Niako_5049  single-strand binding protein [KO:K03111]
Niako_5789  single-strand binding protein [KO:K03111]
Niako_1586  single-strand binding protein [KO:K03111]
Niako_2024  DNA replication and repair protein RecF [KO:K03629]
Niako_5742  DNA replication and repair protein RecO [KO:K03584]
Niako_6017  DNA replication and repair protein RecR [KO:K06187]
Niako_6285  Protein recA [KO:K03553]
Niako_6289  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Niako_5087  Holliday junction DNA helicase subunit RuvA [KO:K03550]
Niako_6946  Holliday junction DNA helicase subunit RuvB [KO:K03551] [EC:5.6.2.4]
Niako_6930  Holliday junction endonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Niako_4786  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Niako_7307  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Niako_1024  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Niako_6359  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Niako_5521  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Niako_0902  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Niako_5801  DNA polymerase III gamma/tau subunits-like protein [KO:K02341] [EC:2.7.7.7]
Niako_4422  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Niako_4801  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Niako_2995  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Niako_2926  replication restart DNA helicase PriA [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG GENES (24)   
All databases (25)   

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