KEGG   PATHWAY: oaa04145Help
Entry
oaa04145                    Pathway                                

Name
Phagosome - Ornithorhynchus anatinus (platypus)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
oaa04145

All organismsOrtholog table
Other DBs
BSID: 
GO: 
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
STX12; syntaxin 12 [KO:K13813]
STX7; syntaxin 7 [KO:K08488]
actin-like; K05692 actin beta/gamma 1 [KO:K05692]
actin-3-like; K05692 actin beta/gamma 1 [KO:K05692]
actin-1-like; K05692 actin beta/gamma 1 [KO:K05692]
actin; K05692 actin beta/gamma 1 [KO:K05692]
actin-5-like; K05692 actin beta/gamma 1 [KO:K05692]
ACTB; actin, beta [KO:K05692]
coronin-1A-like; K13882 coronin-1A [KO:K13882]
STX18; syntaxin 18 [KO:K08492]
SEC22B; SEC22 vesicle trafficking protein homolog B (S. cerevisiae) [KO:K08517]
MHC class I-2 antigen; K06751 major histocompatibility complex, class I [KO:K06751]
RLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
BOLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
zinc-alpha-2-glycoprotein-like; K06751 major histocompatibility complex, class I [KO:K06751]
DLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
RLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
ORAN-DRA; MHC class II DR alpha [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
EEA1; early endosome antigen 1 [KO:K12478]
PIK3C3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
transferrin receptor protein 1-like; K06503 transferrin receptor [KO:K06503]
HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A [KO:K02145] [EC:3.6.3.14]
ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 [KO:K02147]
ATP6V1C1; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 [KO:K02148]
ATP6V1C2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 [KO:K02148]
ATP6V1D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D [KO:K02149]
V-type proton ATPase subunit E 1-like; K02150 V-type H+-transporting ATPase subunit E [KO:K02150]
ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F [KO:K02151]
ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 [KO:K02152]
V-type proton ATPase subunit G 2-like; K02152 V-type H+-transporting ATPase subunit G [KO:K02152]
ATP6V0E2; ATPase, H+ transporting V0 subunit e2 [KO:K02153]
ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 [KO:K02154]
ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a2 [KO:K02154]
ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4 [KO:K02154]
V-type proton ATPase subunit d 1-like; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
V-type proton ATPase subunit d 2-like; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
ATP6V1H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H [KO:K02144]
uncharacterized LOC100076983; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b [KO:K03661]
ATP6AP1; ATPase, H+ transporting, lysosomal accessory protein 1 [KO:K03662]
V-type proton ATPase subunit S1-like; K03662 V-type H+-transporting ATPase S1 subunit [KO:K03662]
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
RILP; Rab interacting lysosomal protein [KO:K13883]
DYNC1H1; dynein, cytoplasmic 1, heavy chain 1 [KO:K10413]
DYNC2H1; dynein, cytoplasmic 2, heavy chain 1 [KO:K10414]
DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2 [KO:K10415]
DYNC1LI1; dynein, cytoplasmic 1, light intermediate chain 1 [KO:K10416]
TUBA1B; tubulin, alpha 1b [KO:K07374]
TUBA8; tubulin, alpha 8 [KO:K07374]
TUBA1A; tubulin, alpha 1a [KO:K07374]
TUBB2A; tubulin, beta 2A class IIa [KO:K07375]
TUBB1; tubulin, beta 1 class VI [KO:K07375]
tubulin beta-5 chain; K07375 tubulin beta [KO:K07375]
TUBB3; tubulin, beta 3 class III [KO:K07375]
LAMP2; lysosomal-associated membrane protein 2 [KO:K06528]
LAMP1; lysosomal-associated membrane protein 1 [KO:K06528]
PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
cation-dependent mannose-6-phosphate receptor-like; K10089 cation-dependent mannose-6-phosphate receptor [KO:K10089]
cation-dependent mannose-6-phosphate receptor-like; K10089 cation-dependent mannose-6-phosphate receptor [KO:K10089]
NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
cathepsin L1-like; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
cathepsin L1-like; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
SEC61A1; Sec61 alpha 1 subunit (S. cerevisiae) [KO:K10956]
SEC61A2; Sec61 alpha 2 subunit (S. cerevisiae) [KO:K10956]
SEC61G; Sec61 gamma subunit [KO:K07342]
TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05654]
CALR; calreticulin [KO:K08057]
CANX; calnexin [KO:K08054]
high affinity immunoglobulin gamma Fc receptor I-like; K06498 high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
C1R; complement component 1, r subcomponent [KO:K01330] [EC:3.4.21.41]
ITGAM; integrin alpha-M [KO:K06461]
C3; complement component 3 [KO:K03990]
COLEC11; collectin sub-family member 11 [KO:K10066]
COLEC12; collectin sub-family member 12 [KO:K10062]
pulmonary surfactant-associated protein A-like; K10067 pulmonary surfactant-associated protein A [KO:K10067]
SFTPD; surfactant protein D [KO:K10068]
ITGAV; integrin, alpha V [KO:K06487]
ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
integrin beta-3-like; K06493 integrin beta 3 [KO:K06493]
THBS1; thrombospondin 1 [KO:K16857]
THBS2; thrombospondin 2 [KO:K04659]
TLR2; toll-like receptor 2 [KO:K10159]
TLR6; toll-like receptor 6 [KO:K10169]
TLR4; toll-like receptor 4 [KO:K10160]
CD14; CD14 molecule [KO:K04391]
PLA2R1; phospholipase A2 receptor 1, 180kDa [KO:K06560]
MRC1; mannose receptor, C type 1 [KO:K06560]
MSR1; macrophage scavenger receptor 1 [KO:K06558]
OLR1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763]
SCARB1; scavenger receptor class B, member 1 [KO:K13885]
CD36; CD36 molecule (thrombospondin receptor) [KO:K06259]
cytochrome b-245 light chain; K08009 cytochrome b-245, alpha polypeptide [KO:K08009]
cytochrome b-245 heavy chain; K08008 NADPH oxidase [KO:K08008]
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
neutrophil cytosol factor 1-like; K08011 neutrophil cytosolic factor 1 [KO:K08011]
NCF2; neutrophil cytosolic factor 2 [KO:K08010]
neutrophil cytosol factor 4-like; K08012 neutrophil cytosolic factor 4 [KO:K08012]
neutrophil cytosol factor 4-like; K08012 neutrophil cytosolic factor 4 [KO:K08012]
Compound
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
KO pathway
 

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