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oaa04145                    Pathway                                

Phagosome - Ornithorhynchus anatinus (platypus)
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Cellular Processes; Transport and catabolism
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Ornithorhynchus anatinus (platypus) [GN:oaa]
STX12; syntaxin 12 [KO:K13813]
STX7; syntaxin 7 [KO:K08488]
actin-like [KO:K05692]
ACTC1; actin, alpha, cardiac muscle 1 [KO:K05692]
actin-85C-like [KO:K05692]
actin, cytoplasmic type 5 [KO:K05692]
actin-5-like [KO:K05692]
ACTB; actin beta [KO:K05692]
STX18; syntaxin 18 [KO:K08492]
SEC22B; SEC22 homolog B, vesicle trafficking protein [KO:K08517]
MHC class I-2 antigen [KO:K06751]
RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751]
BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
zinc-alpha-2-glycoprotein-like [KO:K06751]
DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751]
ORAN-DRA; MHC class II DR alpha [KO:K06752]
HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
EEA1; early endosome antigen 1 [KO:K12478]
PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:]
TFRC; transferrin receptor [KO:K06503]
HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:]
ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
V-type proton ATPase subunit G 2-like [KO:K02152]
ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
ATP6V0A1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
ATP6V0A2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
ATP6V0A4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
V-type proton ATPase subunit d 1-like [KO:K02146]
V-type proton ATPase subunit d 2-like [KO:K02146]
ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
ATP6V0B; ATPase H+ transporting V0 subunit b [KO:K03661]
ATP6AP1; ATPase H+ transporting accessory protein 1 [KO:K03662]
V-type proton ATPase subunit S1-like [KO:K03662]
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
RILP; Rab interacting lysosomal protein [KO:K13883]
DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
TUBA1B; tubulin alpha-1B chain [KO:K07374]
TUBA8; tubulin alpha-8 chain [KO:K07374]
TUBA1A; tubulin alpha 1a [KO:K07374]
TUBB2A; tubulin beta-2A chain [KO:K07375]
TUBB1; tubulin beta 1 class VI [KO:K07375]
TUBB6; tubulin beta 6 class V [KO:K07375]
TUBB3; tubulin beta 3 class III [KO:K07375]
LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:]
cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
NOS1; nitric oxide synthase, brain [KO:K13240] [EC:]
cathepsin L1-like [KO:K01365] [EC:]
cathepsin L1-like [KO:K01365] [EC:]
CTSS; cathepsin S [KO:K01368] [EC:]
SEC61A1; Sec61 translocon alpha 1 subunit [KO:K10956]
SEC61A2; Sec61 translocon alpha 2 subunit [KO:K10956]
SEC61G; Sec61 translocon gamma subunit [KO:K07342]
TAP2; transporter 2, ATP binding cassette subfamily B member [KO:K05654]
CALR; calreticulin [KO:K08057]
CANX; calnexin [KO:K08054]
high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560]
Ig heavy chain Mem5-like [KO:K06856]
putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
C1R; complement C1r-A subcomponent [KO:K01330] [EC:]
ITGAM; integrin alpha-M [KO:K06461]
C3; complement C3 [KO:K03990]
COLEC11; collectin subfamily member 11 [KO:K10066]
COLEC12; collectin subfamily member 12 [KO:K10062]
MBL2; mannose binding lectin 2 [KO:K03991]
pulmonary surfactant-associated protein A-like [KO:K10067]
SFTPD; surfactant protein D [KO:K10068]
ITGAV; integrin subunit alpha V [KO:K06487]
ITGB1; integrin subunit beta 1 [KO:K05719]
integrin beta-3-like [KO:K06493]
THBS1; thrombospondin 1 [KO:K16857]
THBS2; thrombospondin 2 [KO:K04659]
TLR2; toll like receptor 2 [KO:K10159]
TLR6; toll like receptor 6 [KO:K10169]
TLR4; toll like receptor 4 [KO:K10160]
CD14; CD14 molecule [KO:K04391]
PLA2R1; phospholipase A2 receptor 1 [KO:K06560]
MRC1; mannose receptor C-type 1 [KO:K06560]
C-type lectin domain family 7 member A-like [KO:K10074]
MSR1; macrophage scavenger receptor 1 [KO:K06558]
OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
SCARB1; scavenger receptor class B member 1 [KO:K13885]
CD36; CD36 molecule [KO:K06259]
cytochrome b-245 light chain [KO:K08009]
cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
neutrophil cytosol factor 1-like [KO:K08011]
NCF2; neutrophil cytosolic factor 2 [KO:K08010]
neutrophil cytosol factor 4-like [KO:K08012]
neutrophil cytosol factor 4-like [KO:K08012]
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Stuart LM, Ezekowitz RA
Phagocytosis: elegant complexity.
Immunity 22:539-50 (2005)
Tjelle TE, Lovdal T, Berg T
Phagosome dynamics and function.
Dupuy AG, Caron E
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
J Cell Sci 121:1773-83 (2008)
Brumell JH, Grinstein S
Salmonella redirects phagosomal maturation.
Curr Opin Microbiol 7:78-84 (2004)
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
LAMP proteins are required for fusion of lysosomes with phagosomes.
EMBO J 26:313-24 (2007)
Luzio JP, Pryor PR, Bright NA
Lysosomes: fusion and function.
Nat Rev Mol Cell Biol 8:622-32 (2007)
Sumimoto H
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
FEBS J 275:3249-77 (2008)
KO pathway

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