KEGG   PATHWAY: oaa04145
Entry
oaa04145                    Pathway                                
Name
Phagosome - Ornithorhynchus anatinus (platypus)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
oaa04145  Phagosome
oaa04145

Other DBs
GO: 0045335
Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100073474  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
100073476  CANX; calnexin isoform X1 [KO:K08054]
100073571  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
100073772  STX7; syntaxin-7 [KO:K08488]
100073807  CD36; platelet glycoprotein 4 [KO:K06259]
100073907  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100073959  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100074235  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100074275  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
100074341  [KO:K03990]
100074389  [KO:K03990]
100074575  RAB7A; ras-related protein Rab-7a [KO:K07897]
100074966  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
100075168  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
100075232  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
100075272  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
100075816  [KO:K07374]
100075818  [KO:K10067]
100075895  MBL2; mannose-binding protein C [KO:K03991]
100075971  SFTPD; pulmonary surfactant-associated protein D isoform X1 [KO:K10068]
100076077  [KO:K01365] [EC:3.4.22.15]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100076253  ATP6V0A2; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
100076268  [KO:K03662]
100076306  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100076348  ITGA2; integrin alpha-2 [KO:K06481]
100076756  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
100076879  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
100076907  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
100076995  RAB5A; ras-related protein Rab-5A [KO:K07887]
100077010  COLEC11; collectin-11 isoform X2 [KO:K10066]
100077158  COLEC12; collectin-12 isoform X2 [KO:K10062]
100077354  TUBB4B; tubulin beta-4B chain [KO:K07375]
100077627  [KO:K07374]
100077771  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
100078069  MPO; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
100078241  MRC1; macrophage mannose receptor 1 [KO:K06560]
100078249  [KO:K06751]
100078376  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100078585  [KO:K06751]
100078752  DYNC2H1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
100078865  ACTB; actin, cytoplasmic 1 [KO:K05692]
100079040  [KO:K07375]
100079111  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
100079322  ORAN-DRA; MHC class II DR alpha precursor [KO:K06752]
100079549  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100079562  [KO:K07375]
100079644  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
100079742  TUBA1B; tubulin alpha-1B chain [KO:K07374]
100079918  TUBA1A; tubulin alpha-1A chain [KO:K07374]
100080031  TUBB3; tubulin beta-3 chain [KO:K07375]
100080473  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100080932  [KO:K06751]
100081070  STX18; syntaxin-18 [KO:K08492]
100081248  TLR2; toll-like receptor 2 [KO:K10159]
100081508  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
100081912  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
100082089  THBS2; thrombospondin-2 [KO:K04659]
100082182  MSR1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
100082295  [KO:K10169]
100082836  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
100082910  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
100082988  [KO:K21421] [EC:1.-.-.-]
100083529  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100083913  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
100084201  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
100084242  [KO:K08009]
100084551  ATP6AP1; LOW QUALITY PROTEIN: V-type proton ATPase subunit S1 [KO:K03662]
100084759  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
100084840  [KO:K01365] [EC:3.4.22.15]
100085024  [KO:K06751]
100085078  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100085356  ACTL8; actin-like protein 8 [KO:K05692]
100085428  SEC61A2; protein transport protein Sec61 subunit alpha [KO:K10956]
100085462  [KO:K06461]
100085562  [KO:K13883]
100085661  ITGAV; integrin alpha-V [KO:K06487]
100085817  NCF2; neutrophil cytosol factor 2 [KO:K08010]
100085869  RAB5C; ras-related protein Rab-5C [KO:K07889]
100085942  [KO:K07374]
100086060  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
100086183  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
100086501  [KO:K06751]
100086559  TFRC; transferrin receptor protein 1 [KO:K06503]
100086751  [KO:K06751]
100086969  TUBB4A; tubulin beta-4A chain [KO:K07375]
100087119  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100087962  THBS4; LOW QUALITY PROTEIN: thrombospondin-4 [KO:K04659]
100088053  [KO:K06752]
100088072  [KO:K06752]
100088116  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100088270  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
100088320  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100088515  [KO:K07374]
100088532  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
100088825  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100089091  TUBB6; tubulin beta-6 chain [KO:K07375]
100089429  STX12; syntaxin-12 [KO:K13813]
100089934  [KO:K06751]
100090507  ITGA5; integrin alpha-5 [KO:K06484]
100090546  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
100090998  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
100091110  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
100091425  [KO:K06751]
100091501  [KO:K06463]
100091528  [KO:K08057]
100091892  ATP6V0A4; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a [KO:K02154]
100092394  ITGB2; integrin beta-2 [KO:K06464]
100092493  [KO:K05692]
100092611  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
100092744  [KO:K04659]
100092966  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
100092988  THBS1; thrombospondin-1 [KO:K16857]
100093242  [KO:K06751]
100093248  [KO:K06751]
100093259  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100093360  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
100093369  [KO:K01365] [EC:3.4.22.15]
100093395  [KO:K06498]
100093403  [KO:K01365] [EC:3.4.22.15]
100529066  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100529072  [KO:K06751]
100681949  [KO:K02153]
100682230  CD14; monocyte differentiation antigen CD14 [KO:K04391]
103164820  MRC2; LOW QUALITY PROTEIN: C-type mannose receptor 2 [KO:K06560]
103166389  [KO:K06752]
103166539  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
103166556  [KO:K06751]
103166634  [KO:K06856]
103166980  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
103167150  MARCO; macrophage receptor MARCO [KO:K13884]
103167834  [KO:K06751]
103168165  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
103168706  CLEC7A; C-type lectin domain family 7 member A [KO:K10074]
103169025  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
103169177  [KO:K06751]
103169489  [KO:K02153]
103169645  [KO:K06463]
103170674  [KO:K07897]
107546818  TUBB; tubulin beta chain [KO:K07375]
107546926  THBS3; thrombospondin-3 [KO:K04659]
114805389  [KO:K07375]
114805411  [KO:K07375]
114805429  [KO:K06751]
114806121  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
114807636  [KO:K06752]
114807664  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
114807666  [KO:K06752]
114809048  CORO1A; coronin-1A [KO:K13882]
114811053  TLR4; toll-like receptor 4 [KO:K10160]
114811288  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
114811984  TUBA4A; tubulin alpha-4A chain [KO:K07374]
114814513  RAB5B; ras-related protein Rab-5B [KO:K07888]
114818227  [KO:K06751]
120638088  CALR; calreticulin [KO:K08057]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
oaa04142  Lysosome
oaa04144  Endocytosis
oaa04610  Complement and coagulation cascades
oaa04612  Antigen processing and presentation
oaa04620  Toll-like receptor signaling pathway
oaa04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   

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