KEGG PATHWAY: oaa04145

PATHWAY: oaa04145

Entry

oaa04145 Pathway

Name

Phagosome - Ornithorhynchus anatinus (platypus)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

oaa04145

Phagosome

Other DBs

BSID:

153929

GO:

0045335

Organism

Ornithorhynchus anatinus (platypus) [GN:oaa]

Gene

100089429	STX12; syntaxin 12 [KO:K13813]
100073772	STX7; syntaxin 7 [KO:K08488]
100085078	actin-like; K05692 actin beta/gamma 1 [KO:K05692]
100085356	actin-3-like; K05692 actin beta/gamma 1 [KO:K05692]
100076703	actin-1-like; K05692 actin beta/gamma 1 [KO:K05692]
100092493	actin; K05692 actin beta/gamma 1 [KO:K05692]
100076341	actin-5-like; K05692 actin beta/gamma 1 [KO:K05692]
100078865	ACTB; actin, beta [KO:K05692]
100081070	STX18; syntaxin 18 [KO:K08492]
100088532	SEC22B; SEC22 vesicle trafficking protein homolog B (S. cerevisiae) [KO:K08517]
100078585	MHC class I-2 antigen; K06751 major histocompatibility complex, class I [KO:K06751]
100075931	RLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
100078249	BOLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
100085024	class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
100086501	zinc-alpha-2-glycoprotein-like; K06751 major histocompatibility complex, class I [KO:K06751]
100086751	DLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
100091425	H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
100093248	RLA class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
100079322	ORAN-DRA; MHC class II DR alpha [KO:K06752]
100088072	HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
100076995	RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
100079644	EEA1; early endosome antigen 1 [KO:K12478]
100086559	transferrin receptor protein 1-like; K06503 transferrin receptor [KO:K06503]
100088320	ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A [KO:K02145] [EC:3.6.3.14]
100073907	ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 [KO:K02147]
100074966	ATP6V1C1; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 [KO:K02148]
100073474	ATP6V1C2; ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 [KO:K02148]
100074235	ATP6V1D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D [KO:K02149]
100093209	V-type proton ATPase subunit E 1-like; K02150 V-type H+-transporting ATPase subunit E [KO:K02150]
100078376	ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F [KO:K02151]
100076907	ATP6V1G1; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 [KO:K02152]
100086060	V-type proton ATPase subunit G 2-like; K02152 V-type H+-transporting ATPase subunit G [KO:K02152]
100082910	ATP6V0E2; ATPase, H+ transporting V0 subunit e2 [KO:K02153]
100092966	ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1 [KO:K02154]
100076253	ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a2 [KO:K02154]
100081508	V-type proton ATPase subunit d 1-like; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
100079549	ATP6V1H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H [KO:K02144]
100076983	uncharacterized LOC100076983; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
100090546	ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b [KO:K03661]
100084551	ATP6AP1; ATPase, H+ transporting, lysosomal accessory protein 1 [KO:K03662]
100076268	V-type proton ATPase subunit S1-like; K03662 V-type H+-transporting ATPase S1 subunit [KO:K03662]
100075232	RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
100085562	RILP; Rab interacting lysosomal protein [KO:K13883]
100082836	DYNC1H1; dynein, cytoplasmic 1, heavy chain 1 [KO:K10413]
100078752	DYNC2H1; dynein, cytoplasmic 2, heavy chain 1 [KO:K10414]
100083913	DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2 [KO:K10415]
100077771	DYNC1LI1; dynein, cytoplasmic 1, light intermediate chain 1 [KO:K10416]
100079742	TUBA1B; tubulin, alpha 1b [KO:K07374]
100075816	TUBA8; tubulin, alpha 8 [KO:K07374]
100079918	TUBA1A; tubulin, alpha 1a [KO:K07374]
100079040	TUBB2A; tubulin, beta 2A class IIa [KO:K07375]
100080473	TUBB1; tubulin, beta 1 class VI [KO:K07375]
100089091	tubulin beta-5 chain; K07375 tubulin beta [KO:K07375]
100080031	TUBB3; tubulin, beta 3 class III [KO:K07375]
100079111	LAMP2; lysosomal-associated membrane protein 2 [KO:K06528]
100084759	LAMP1; lysosomal-associated membrane protein 1 [KO:K06528]
100076756	PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
100084201	cation-dependent mannose-6-phosphate receptor-like; K10089 cation-dependent mannose-6-phosphate receptor [KO:K10089]
100078520	cation-dependent mannose-6-phosphate receptor-like; K10089 cation-dependent mannose-6-phosphate receptor [KO:K10089]
100079842	NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100093403	cathepsin L1-like; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
100093369	cathepsin L1-like; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
100075168	SEC61A1; Sec61 alpha 1 subunit (S. cerevisiae) [KO:K10956]
100085428	SEC61A2; Sec61 alpha 2 subunit (S. cerevisiae) [KO:K10956]
100075272	SEC61G; Sec61 gamma subunit [KO:K07342]
100529066	TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) [KO:K05654]
100073476	CANX; calnexin [KO:K08054]
100093395	high affinity immunoglobulin gamma Fc receptor I-like; K06498 high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
100090998	C1R; complement component 1, r subcomponent [KO:K01330] [EC:3.4.21.41]
100085462	ITGAM; integrin alpha-M [KO:K06461]
100074341	C3; complement component 3 [KO:K03990]
100077010	COLEC11; collectin sub-family member 11 [KO:K10066]
100077158	COLEC12; collectin sub-family member 12 [KO:K10062]
100075818	pulmonary surfactant-associated protein A-like; K10067 pulmonary surfactant-associated protein A [KO:K10067]
100075971	SFTPD; surfactant protein D [KO:K10068]
100085661	ITGAV; integrin, alpha V [KO:K06487]
100073959	ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
100087119	integrin beta-3-like; K06493 integrin beta 3 [KO:K06493]
100092988	THBS1; thrombospondin 1 [KO:K16857]
100082089	THBS2; thrombospondin 2 [KO:K04659]
100081248	TLR2; toll-like receptor 2 [KO:K10159]
100082295	TLR6; toll-like receptor 6 [KO:K10169]
100682230	CD14; CD14 molecule [KO:K04391]
100081912	PLA2R1; phospholipase A2 receptor 1, 180kDa [KO:K06560]
100078241	MRC1; mannose receptor, C type 1 [KO:K06560]
100082182	MSR1; macrophage scavenger receptor 1 [KO:K06558]
100092611	OLR1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763]
100076879	SCARB1; scavenger receptor class B, member 1 [KO:K13885]
100073807	CD36; CD36 molecule (thrombospondin receptor) [KO:K06259]
100084242	cytochrome b-245 light chain; K08009 cytochrome b-245, alpha polypeptide [KO:K08009]
100082988	cytochrome b-245 heavy chain; K08008 NADPH oxidase [KO:K08008]
100076220	RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100088825	neutrophil cytosol factor 1-like; K08011 neutrophil cytosolic factor 1 [KO:K08011]
100085817	NCF2; neutrophil cytosolic factor 2 [KO:K08010]
100086183	neutrophil cytosol factor 4-like; K08012 neutrophil cytosolic factor 4 [KO:K08012]
100090637	neutrophil cytosol factor 4-like; K08012 neutrophil cytosolic factor 4 [KO:K08012]

Compound

C04549

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

PMID:15894272

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)

Reference

PMID:10684585

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)

Reference

PMID:18492791

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)

Reference

PMID:15036145

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)

Reference

PMID:17245426

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)

Reference

PMID:17637737

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)

Reference

PMID:18513324

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)

KO pathway

ko04145

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (96)   
   KEGG GENES (96)   
All databases (98)   

Download RDF

DBGET integrated database retrieval system