KEGG   PATHWAY: paf03440
Entry
paf03440                    Pathway                                
Name
Homologous recombination - Pseudomonas aeruginosa M18
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
paf03440  Homologous recombination
paf03440

Other DBs
GO: 0000724
Organism
Pseudomonas aeruginosa M18 [GN:paf]
Gene
PAM18_1221  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
PAM18_0698  ssb; single-stranded DNA-binding protein [KO:K03111]
PAM18_0003  recF; recombination protein F [KO:K03629]
PAM18_4266  recO; DNA repair protein RecO [KO:K03584]
PAM18_3514  recR; recombination protein RecR [KO:K06187]
PAM18_1368  recA; recombinase A [KO:K03553]
PAM18_5614  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
PAM18_4071  ruvA; Holliday junction DNA helicase RuvA [KO:K03550]
PAM18_4070  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
PAM18_4072  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
PAM18_5465  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
PAM18_4373  recB; exodeoxyribonuclease V beta chain [KO:K03582] [EC:3.1.11.5]
PAM18_4374  recC; exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
PAM18_4372  recD; exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
PAM18_1306  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
PAM18_0002  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
PAM18_3516  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
PAM18_0950  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
PAM18_2000  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
PAM18_1739  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
PAM18_3228  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
PAM18_1106  holC; DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
PAM18_5165  priA; primosome assembly protein PriA [KO:K04066] [EC:5.6.2.4]
PAM18_2245  hypothetical protein [KO:K04067]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG GENES (24)   
All databases (25)   

Download RDF
DBGET integrated database retrieval system