KEGG   PATHWAY: pbl03420
Entry
pbl03420                    Pathway                                
Name
Nucleotide excision repair - Paracoccidioides lutzii Pb01
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
pbl03420  Nucleotide excision repair
pbl03420

Other DBs
GO: 0006289
Organism
Paracoccidioides lutzii Pb01 [GN:pbl]
Gene
PAAG_07371  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
PAAG_03979  DNA damage-binding protein 1a [KO:K10610]
PAAG_11735  PAAG_03742; hypothetical protein [KO:K10838]
PAAG_01296  DNA repair protein rhp41 [KO:K10838]
PAAG_04949  hypothetical protein [KO:K10839]
PAAG_06445  DNA excision repair protein ERCC-8 [KO:K10570]
PAAG_06491  DNA repair and recombination protein RAD26 [KO:K10841]
PAAG_05397  DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]
PAAG_06854  DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
PAAG_06261  DNA-directed RNA polymerase II subunit RPB3 [KO:K03011]
PAAG_01710  polymerase II polypeptide D [KO:K03012]
PAAG_02185  DNA-directed RNA polymerases I [KO:K03013]
PAAG_00809  DNA-directed RNA polymerases I [KO:K03014]
PAAG_04818  DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]
PAAG_02337  DNA-directed RNA polymerases I [KO:K03016]
PAAG_07510  hypothetical protein [KO:K03017]
PAAG_03303  DNA-directed RNA polymerases N/8 kDa subunit superfamily [KO:K03007]
PAAG_02763  metallothionein-I gene transcription activator [KO:K03009]
PAAG_06694  DNA-directed RNA polymerase II 13.3 kDa polypeptide [KO:K03008]
PAAG_00829  serine/threonine-protein kinase crk1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
PAAG_03256  RNA polymerase II transcription factor B subunit 3 [KO:K10842]
PAAG_04902  hypothetical protein [KO:K06634]
PAAG_04336  DNA repair helicase RAD25 [KO:K10843] [EC:5.6.2.4]
PAAG_02196  DNA repair helicase RAD3 [KO:K10844] [EC:5.6.2.3]
PAAG_03431  RNA polymerase II transcription factor B subunit 5 [KO:K10845]
PAAG_02736  RNA polymerase II transcription factor B subunit 1 [KO:K03141]
PAAG_09006  suppressor of stem-loop protein [KO:K03142]
PAAG_02398  RNA polymerase II transcription factor B subunit 4 [KO:K03143]
PAAG_06332  RNA polymerase II transcription factor B subunit 2 [KO:K03144]
PAAG_06371  DNA-repair protein rad13 [KO:K10846]
PAAG_01009  DNA repair protein RAD14 [KO:K10847]
PAAG_00294  replication factor-A protein [KO:K07466]
PAAG_03970  replication factor-A protein [KO:K10739]
PAAG_06139  DNA repair protein rad16 [KO:K10848] [EC:3.1.-.-]
PAAG_04389  mating-type switching protein swi10 [KO:K10849]
PAAG_06601  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
PAAG_00711  DNA polymerase subunit delta-2 [KO:K02328]
PAAG_05160  hypothetical protein [KO:K03505]
PAAG_07398  DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]
PAAG_00984  DNA polymerase epsilon subunit B [KO:K02325] [EC:2.7.7.7]
PAAG_02892  hypothetical protein [KO:K02326] [EC:2.7.7.7]
PAAG_00923  proliferating cell nuclear antigen [KO:K04802]
PAAG_00191  replication factor C subunit 1 [KO:K10754]
PAAG_03621  replication factor C subunit 2 [KO:K10755]
PAAG_00660  replication factor C subunit 2 [KO:K10755]
PAAG_08450  replication factor C subunit 3 [KO:K10756]
PAAG_00193  replication factor C subunit 3 [KO:K10756]
PAAG_02226  DNA ligase [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
pbl03020  RNA polymerase
pbl04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (48)   
   KEGG GENES (48)   
All databases (49)   

Download RDF
DBGET integrated database retrieval system