KEGG   PATHWAY: pcs04145Help
Entry
pcs04145                    Pathway                                

Name
Phagosome - Penicillium chrysogenum
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
pcs04145

All organismsOrtholog table
Module
Sec61 complex [PATH:pcs04145]
Other DBs
BSID: 
GO: 
Organism
Penicillium chrysogenum [GN:pcs]
Gene
Pc22g18300; K08488 syntaxin 7 [KO:K08488]
act; gamma-actin act-Penicillium chrysogenum [KO:K05692]
Pc20g12620; K08517 vesicle transport protein SEC22 [KO:K08517]
Pc13g07680; K07889 Ras-related protein Rab-5C [KO:K07889]
Pc21g00590; K00914 phosphatidylinositol 3-kinase [EC:2.7.1.137] [KO:K00914] [EC:2.7.1.137]
Pc12g10850; K12182 hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
Pc21g15100; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
Pc22g13480; K02147 V-type H+-transporting ATPase subunit B [KO:K02147]
Pc13g08280; K02148 V-type H+-transporting ATPase subunit C [KO:K02148]
Pc21g07030; K02149 V-type H+-transporting ATPase subunit D [KO:K02149]
Pc22g24360; K02150 V-type H+-transporting ATPase subunit E [KO:K02150]
hypothetical protein; K02151 V-type H+-transporting ATPase subunit F [KO:K02151]
Pc21g12120; K02152 V-type H+-transporting ATPase subunit G [KO:K02152]
Pc22g05740; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
Pc13g14670; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
hypothetical protein; K02144 V-type H+-transporting ATPase subunit H [KO:K02144]
hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
Pc21g02930; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [KO:K03661]
Pc21g07250; K07897 Ras-related protein Rab-7A [KO:K07897]
Pc21g06900; K10413 dynein heavy chain 1, cytosolic [KO:K10413]
Pc21g05210; K10415 dynein intermediate chain, cytosolic [KO:K10415]
Pc22g16440; K10416 dynein light intermediate chain 1, cytosolic [KO:K10416]
Pc16g14970; K07374 tubulin alpha [KO:K07374]
Pc22g21650; K07374 tubulin alpha [KO:K07374]
Pc12g00070; K07374 tubulin alpha [KO:K07374]
Pc13g13470; K07375 tubulin beta [KO:K07375]
Pc18g06030; K00921 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150] [KO:K00921] [EC:2.7.1.150]
Pc18g01990; K10089 cation-dependent mannose-6-phosphate receptor [KO:K10089]
Pc22g15970; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
Pc16g09660; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
Pc20g02810; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
Pc22g02800; K08054 calnexin [KO:K08054]
Pc22g01190; K08008 NADPH oxidase [KO:K08008]
Pc20g07530; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
Compound
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
KO pathway
 

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