KEGG   PATHWAY: pcs04145Help
Entry
pcs04145                    Pathway                                

Name
Phagosome - Penicillium rubens
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
pcs04145  Phagosome
pcs04145

Ortholog table
Module
pcs_M00401  Sec61 complex [PATH:pcs04145]
Other DBs
BSID: 153990
GO: 0045335
Organism
Penicillium rubens [GN:pcs]
Gene
Pc20g11630  act; gamma-actin act-Penicillium chrysogenum [KO:K05692]
Pc20g12620  Pc20g12620 [KO:K08517]
Pc13g07680  Pc13g07680 [KO:K07889]
Pc18g00620  Pc18g00620 [KO:K07889]
Pc21g00590  Pc21g00590 [KO:K00914] [EC:2.7.1.137]
Pc12g10850  Pc12g10850 [KO:K12182]
Pc21g15100  Pc21g15100 [KO:K02145] [EC:3.6.3.14]
Pc22g13480  Pc22g13480 [KO:K02147]
Pc13g08280  Pc13g08280 [KO:K02148]
Pc21g07030  Pc21g07030 [KO:K02149]
Pc22g24360  Pc22g24360 [KO:K02150]
Pc15g00440  hypothetical protein [KO:K02151]
Pc21g12120  Pc21g12120 [KO:K02152]
Pc22g05740  Pc22g05740 [KO:K02154]
Pc13g14670  Pc13g14670 [KO:K02146]
Pc16g04460  hypothetical protein [KO:K02144]
Pc18g01630  hypothetical protein [KO:K02155]
Pc21g02930  Pc21g02930 [KO:K03661]
Pc21g07250  Pc21g07250 [KO:K07897]
Pc21g06900  Pc21g06900 [KO:K10413]
Pc21g05210  Pc21g05210 [KO:K10415]
Pc22g16440  Pc22g16440 [KO:K10416]
Pc16g14970  Pc16g14970 [KO:K07374]
Pc22g21650  Pc22g21650 [KO:K07374]
Pc12g00070  Pc12g00070 [KO:K07374]
Pc13g13470  Pc13g13470 [KO:K07375]
Pc18g06030  Pc18g06030 [KO:K00921] [EC:2.7.1.150]
Pc18g01990  Pc18g01990 [KO:K10089]
Pc22g15970  Pc22g15970 [KO:K10956]
Pc16g09660  Pc16g09660 [KO:K09481]
Pc20g02810  Pc20g02810 [KO:K07342]
Pc22g02800  Pc22g02800 [KO:K08054]
Pc20g07530  Pc20g07530 [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
ko04145   

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