KEGG   PATHWAY: pcs04145Help
pcs04145                    Pathway                                

Phagosome - Penicillium rubens
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Cellular Processes; Transport and catabolism
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All organismsOrtholog table
Sec61 complex [PATH:pcs04145]
Other DBs
Penicillium rubens [GN:pcs]
Pc22g18300; K08488 syntaxin 7 [KO:K08488]
act; gamma-actin act-Penicillium chrysogenum [KO:K05692]
Pc20g12620; K08517 vesicle transport protein SEC22 [KO:K08517]
Pc13g07680; K07889 Ras-related protein Rab-5C [KO:K07889]
Pc18g00620; K07889 Ras-related protein Rab-5C [KO:K07889]
Pc21g00590; K00914 phosphatidylinositol 3-kinase [EC:] [KO:K00914] [EC:]
Pc12g10850; K12182 hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
Pc21g15100; K02145 V-type H+-transporting ATPase subunit A [EC:] [KO:K02145] [EC:]
Pc22g13480; K02147 V-type H+-transporting ATPase subunit B [KO:K02147]
Pc13g08280; K02148 V-type H+-transporting ATPase subunit C [KO:K02148]
Pc21g07030; K02149 V-type H+-transporting ATPase subunit D [KO:K02149]
Pc22g24360; K02150 V-type H+-transporting ATPase subunit E [KO:K02150]
hypothetical protein; K02151 V-type H+-transporting ATPase subunit F [KO:K02151]
Pc21g12120; K02152 V-type H+-transporting ATPase subunit G [KO:K02152]
Pc22g05740; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
Pc13g14670; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
hypothetical protein; K02144 V-type H+-transporting ATPase subunit H [KO:K02144]
hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
Pc21g02930; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [KO:K03661]
Pc21g07250; K07897 Ras-related protein Rab-7A [KO:K07897]
Pc21g06900; K10413 dynein heavy chain 1, cytosolic [KO:K10413]
Pc21g05210; K10415 dynein intermediate chain, cytosolic [KO:K10415]
Pc22g16440; K10416 dynein light intermediate chain 1, cytosolic [KO:K10416]
Pc16g14970; K07374 tubulin alpha [KO:K07374]
Pc22g21650; K07374 tubulin alpha [KO:K07374]
Pc12g00070; K07374 tubulin alpha [KO:K07374]
Pc13g13470; K07375 tubulin beta [KO:K07375]
Pc18g06030; K00921 1-phosphatidylinositol-3-phosphate 5-kinase [EC:] [KO:K00921] [EC:]
Pc18g01990; K10089 cation-dependent mannose-6-phosphate receptor [KO:K10089]
Pc22g15970; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
Pc16g09660; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
Pc20g02810; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
Pc22g02800; K08054 calnexin [KO:K08054]
Pc22g01190; K08008 NADPH oxidase [KO:K08008]
Pc20g07530; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Stuart LM, Ezekowitz RA
Phagocytosis: elegant complexity.
Immunity 22:539-50 (2005)
Tjelle TE, Lovdal T, Berg T
Phagosome dynamics and function.
Bioessays 22:255-63 (2000)
Dupuy AG, Caron E
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
J Cell Sci 121:1773-83 (2008)
Brumell JH, Grinstein S
Salmonella redirects phagosomal maturation.
Curr Opin Microbiol 7:78-84 (2004)
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
LAMP proteins are required for fusion of lysosomes with phagosomes.
EMBO J 26:313-24 (2007)
Luzio JP, Pryor PR, Bright NA
Lysosomes: fusion and function.
Nat Rev Mol Cell Biol 8:622-32 (2007)
Sumimoto H
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
FEBS J 275:3249-77 (2008)
KO pathway

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