KEGG   PATHWAY: pif03420
Entry
pif03420                    Pathway                                
Name
Nucleotide excision repair - Phytophthora infestans
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
pif03420  Nucleotide excision repair
pif03420

Other DBs
GO: 0006289
Organism
Phytophthora infestans [GN:pif]
Gene
PITG_03056  DNA polymerase I, putative [KO:K02335] [EC:2.7.7.7]
PITG_01524  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
PITG_06199  Cullin family protein, putative [KO:K10609]
PITG_01737  DNA damage-binding protein, putative [KO:K10610]
PITG_10602  DNA repair protein, putative [KO:K10838]
PITG_02211  UV excision repair protein RAD23 [KO:K10839]
PITG_12943  DNA excision repair ERCC-8-like protein [KO:K10570]
PITG_05259  DNA excision repair protein ERCC-6 [KO:K10841]
PITG_21077  DNA-directed RNA polymerase II largest subunit [KO:K03006] [EC:2.7.7.6]
PITG_13404  DNA-directed RNA polymerase II 135 kDa polypeptide [KO:K03010] [EC:2.7.7.6]
PITG_18113  DNA-directed RNA polymerase II 36 kDa polypeptide A [KO:K03011]
PITG_03793  hypothetical protein [KO:K03012]
PITG_03795  hypothetical protein [KO:K03012]
PITG_10445  DNA-directed RNA polymerase I, II, and III subunit RPABC1, putative [KO:K03013]
PITG_12877  DNA-directed RNA polymerase I, II, and III subunit RPABC2, putative [KO:K03014]
PITG_14885  DNA-directed RNA polymerase II 19 kDa polypeptide [KO:K03015]
PITG_09712  DNA-directed RNA polymerase I, II, and III subunit rpabc3, putative [KO:K03016]
PITG_04645  hypothetical protein [KO:K03017]
PITG_18727  DNA-directed RNA polymerase II subunit J [KO:K03008]
PITG_07995  cyclin-dependent kinase, putative [KO:K02202] [EC:2.7.11.22 2.7.11.23]
PITG_21504  cyclin-dependent kinase, putative [KO:K02202] [EC:2.7.11.22 2.7.11.23]
PITG_07745  hypothetical protein [KO:K10842]
PITG_00236  cyclin-H, putative [KO:K06634]
PITG_17617  TFIIH basal transcription factor complex helicase XPB subunit [KO:K10843] [EC:5.6.2.4]
PITG_15696  TFIIH basal transcription factor complex helicase subunit [KO:K10844] [EC:5.6.2.3]
PITG_03523  general transcription factor IIH subunit, putative [KO:K03141]
PITG_00220  general transcription factor IIH subunit, putative [KO:K03143]
PITG_15486  general transcription factor IIH subunit, putative [KO:K03144]
PITG_01812  hypothetical protein [KO:K10847]
PITG_05679  replication protein A 70 kDa DNA-binding subunit, putative [KO:K07466]
PITG_07546  replication protein A 32 kDa subunit, putative [KO:K10739]
PITG_06111  hypothetical protein [KO:K10740]
PITG_12229  DNA repair endonuclease XPF, putative [KO:K10848] [EC:3.1.-.-]
PITG_13719  DNA excision repair protein ERCC-1 [KO:K10849]
PITG_20527  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
PITG_16691  DNA polymerase alpha/epsilon subunit B, putative [KO:K02328]
PITG_16698  DNA polymerase alpha/epsilon subunit B, putative [KO:K02328]
PITG_15505  DNA polymerase epsilon catalytic subunit, putative [KO:K02324] [EC:2.7.7.7]
PITG_05369  DNA polymerase epsilon subunit, putative [KO:K02325] [EC:2.7.7.7]
PITG_07175  hypothetical protein [KO:K02326] [EC:2.7.7.7]
PITG_14397  proliferating cell nuclear antigen [KO:K04802]
PITG_07644  replication factor C subunit 1 [KO:K10754]
PITG_18696  replication factor C subunit, putative [KO:K10754]
PITG_03389  replication factor C subunit 4 [KO:K10755]
PITG_18237  replication factor C subunit 2 [KO:K10755]
PITG_19314  replication factor C subunit 3 [KO:K10756]
PITG_05302  replication factor C subunit 5 [KO:K10756]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
pif03020  RNA polymerase
pif04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (47)   
   KEGG GENES (47)   
All databases (48)   

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