KEGG   PATHWAY: pif04145Help
Entry
pif04145                    Pathway                                

Name
Phagosome - Phytophthora infestans
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
pif04145

All organismsOrtholog table
Module
Sec61 complex [PATH:pif04145]
Other DBs
BSID: 
GO: 
Organism
Phytophthora infestans [GN:pif]
Gene
hypothetical protein [KO:K13813]
actin-like protein [KO:K05692]
actin-like protein [KO:K05692]
vesicle-trafficking protein SEC22b, putative [KO:K08517]
phosphatidyl inositol kinase (PIK-A) [KO:K00914] [EC:2.7.1.137]
H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02145] [EC:3.6.3.14]
V-type proton ATPase subunit B, putative [KO:K02147]
H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02148]
H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02149]
V-type proton ATPase subunit E, putative [KO:K02150]
V-type proton ATPase subunit E, putative [KO:K02150]
H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02151]
small cysteine rich protein SCR76 [KO:K02153]
vacuolar proton translocating ATPase A subunit, putative [KO:K02154]
H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02146]
V-type proton ATPase subunit H, putative [KO:K02144]
V-type proton ATPase 16 kDa proteolipid subunit, putative [KO:K02155]
V-type proton ATPase 16 kDa proteolipid subunit, putative [KO:K02155]
H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K03661]
Rab7 family GTPase, putative [KO:K07897]
hypothetical protein [KO:K07897]
dynein heavy chain [KO:K10413]
dynein heavy chain [KO:K10414]
dynein 1 light intermediate chain, putative [KO:K10416]
alpha-tubulin [KO:K07374]
alpha-tubulin, putative [KO:K07374]
alpha-tubulin, putative [KO:K07374]
cleavage induced tubulin alpha chain [KO:K07374]
alpha-tubulin, putative [KO:K07374]
beta-tubulin [KO:K07375]
phosphatidylinositol-3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
Phosphatidylinositol-3-phosphate5- kinase (Fab-like; PIPK-A1) [KO:K00921] [EC:2.7.1.150]
phosphatidylinositol-4-phosphate-5-kinase (PI-PIPK-B) [KO:K00921] [EC:2.7.1.150]
cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
protein transporter Sec61 subunit alpha, putative [KO:K10956]
hypothetical protein [KO:K09481]
Type II (General) Secretory Pathway (IISP) Family [KO:K07342]
calreticulin precursor [KO:K08057]
calreticulin precursor [KO:K08057]
calnexin, putative [KO:K08054]
cell division control protein 42 [KO:K04392]
Compound
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
 

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