KEGG   PATHWAY: pif04145Help
Entry
pif04145                    Pathway                                
Name
Phagosome - Phytophthora infestans
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
pif04145

All organismsOrtholog table
Module
Sec61 complex [PATH:pif04145]
Other DBs
BSID: 
GO: 
Organism
Phytophthora infestans [GN:pif]
Gene
syntaxin 7-like protein; K13813 syntaxin 12/13 [KO:K13813]
hypothetical protein; K08488 syntaxin 7 [KO:K08488]
actin-like protein; K05692 actin beta/gamma 1 [KO:K05692]
vesicle-trafficking protein SEC22b; K08517 vesicle transport protein SEC22 [KO:K08517]
Rab5 family GTPase; K07889 Ras-related protein Rab-5C [KO:K07889]
phosphatidyl inositol kinase (PIK-A); K00914 phosphatidylinositol 3-kinase [EC:2.7.1.137] [KO:K00914] [EC:2.7.1.137]
H - or Na -translocating F-type; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
V-type proton ATPase subunit B; K02147 V-type H+-transporting ATPase subunit B [EC:3.6.3.14] [KO:K02147] [EC:3.6.3.14]
H - or Na -translocating F-type; K02148 V-type H+-transporting ATPase subunit C [EC:3.6.3.14] [KO:K02148] [EC:3.6.3.14]
H - or Na -translocating F-type; K02149 V-type H+-transporting ATPase subunit D [EC:3.6.3.14] [KO:K02149] [EC:3.6.3.14]
V-type proton ATPase subunit E; K02150 V-type H+-transporting ATPase subunit E [EC:3.6.3.14] [KO:K02150] [EC:3.6.3.14]
V-type proton ATPase subunit E; K02150 V-type H+-transporting ATPase subunit E [EC:3.6.3.14] [KO:K02150] [EC:3.6.3.14]
H - or Na -translocating F-type; K02151 V-type H+-transporting ATPase subunit F [EC:3.6.3.14] [KO:K02151] [EC:3.6.3.14]
small cysteine rich protein SCR76; K02153 V-type H+-transporting ATPase subunit H [EC:3.6.3.14] [KO:K02153] [EC:3.6.3.14]
vacuolar proton translocating ATPase A subunit; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
H - or Na -translocating F-type; K02146 V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14] [KO:K02146] [EC:3.6.3.14]
V-type proton ATPase subunit H; K02144 V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14] [KO:K02144] [EC:3.6.3.14]
V-type proton ATPase 16 kDa proteolipid subunit; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
V-type proton ATPase 16 kDa proteolipid subunit; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
H - or Na -translocating F-type; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14] [KO:K03661] [EC:3.6.3.14]
Rab7 family GTPase; K07897 Ras-related protein Rab-7A [KO:K07897]
dynein heavy chain; K10413 dynein heavy chain 1, cytosolic [KO:K10413]
dynein heavy chain; K10414 dynein heavy chain 2, cytosolic [KO:K10414]
dynein 1 light intermediate chain; K10416 dynein light intermediate chain 1, cytosolic [KO:K10416]
alpha-tubulin; K07374 tubulin alpha [KO:K07374]
alpha-tubulin; K07374 tubulin alpha [KO:K07374]
beta-tubulin; K07375 tubulin beta [KO:K07375]
phosphatidylinositol-3-phosphate 5-kinase; K00921 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150] [KO:K00921] [EC:2.7.1.150]
Phosphatidylinositol-3-phosphate5- kinase (Fab-like; PIPK-A1) [KO:K00921] [EC:2.7.1.150]
protein transporter Sec61 subunit alpha; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
Type II (General) Secretory Pathway (IISP) Family; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
calreticulin precursor; K08057 calreticulin [KO:K08057]
calreticulin precursor; K08057 calreticulin [KO:K08057]
calnexin; K08054 calnexin [KO:K08054]
cell division control protein 42; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
Compound
C00007  
Oxygen
C00027  
Hydrogen peroxide
C00533  
Nitric oxide
C00704  
O2.-
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
KO pathway
 
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