KEGG   PATHWAY: pif04145Help
pif04145                    Pathway                                

Phagosome - Phytophthora infestans
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
pif04145  Phagosome

Ortholog table
pif_M00401  Sec61 complex [PATH:pif04145]
Other DBs
BSID: 174214
GO: 0045335
Phytophthora infestans [GN:pif]
PITG_01139  hypothetical protein [KO:K13813]
PITG_15117  actin-like protein [KO:K05692]
PITG_15078  actin-like protein [KO:K05692]
PITG_08016  vesicle-trafficking protein SEC22b, putative [KO:K08517]
PITG_12326  phosphatidyl inositol kinase (PIK-A) [KO:K00914] [EC:]
PITG_13301  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02145] [EC:]
PITG_06118  V-type proton ATPase subunit B, putative [KO:K02147]
PITG_12141  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02148]
PITG_06615  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02149]
PITG_09796  V-type proton ATPase subunit E, putative [KO:K02150]
PITG_10219  V-type proton ATPase subunit E, putative [KO:K02150]
PITG_12289  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02151]
PITG_01698  small cysteine rich protein SCR76 [KO:K02153]
PITG_14362  vacuolar proton translocating ATPase A subunit, putative [KO:K02154]
PITG_17747  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02146]
PITG_00764  V-type proton ATPase subunit H, putative [KO:K02144]
PITG_02045  V-type proton ATPase 16 kDa proteolipid subunit, putative [KO:K02155]
PITG_02046  V-type proton ATPase 16 kDa proteolipid subunit, putative [KO:K02155]
PITG_03344  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K03661]
PITG_03148  Rab7 family GTPase, putative [KO:K07897]
PITG_17835  hypothetical protein [KO:K07897]
PITG_02526  dynein heavy chain [KO:K10413]
PITG_13968  dynein heavy chain [KO:K10414]
PITG_01997  dynein 1 light intermediate chain, putative [KO:K10416]
PITG_07996  alpha-tubulin [KO:K07374]
PITG_07999  alpha-tubulin, putative [KO:K07374]
PITG_07960  alpha-tubulin, putative [KO:K07374]
PITG_07961  cleavage induced tubulin alpha chain [KO:K07374]
PITG_07949  alpha-tubulin, putative [KO:K07374]
PITG_00156  beta-tubulin [KO:K07375]
PITG_05644  phosphatidylinositol-3-phosphate 5-kinase [KO:K00921] [EC:]
PITG_06917  Phosphatidylinositol-3-phosphate5- kinase (Fab-like; PIPK-A1) [KO:K00921] [EC:]
PITG_00330  phosphatidylinositol-4-phosphate-5-kinase (PI-PIPK-B) [KO:K00921] [EC:]
PITG_12916  cysteine protease family C01A, putative [KO:K01365] [EC:]
PITG_12041  cysteine protease family C01A, putative [KO:K01365] [EC:]
PITG_03414  cysteine protease family C01A, putative [KO:K01365] [EC:]
PITG_03415  cysteine protease family C01A, putative [KO:K01365] [EC:]
PITG_16276  cysteine protease family C01A, putative [KO:K01365] [EC:]
PITG_17314  cysteine protease family C01A, putative [KO:K01365] [EC:]
PITG_21621  cysteine protease family [KO:K01365] [EC:]
PITG_18089  protein transporter Sec61 subunit alpha, putative [KO:K10956]
PITG_09451  hypothetical protein [KO:K09481]
PITG_17637  Type II (General) Secretory Pathway (IISP) Family [KO:K07342]
PITG_18934  calreticulin precursor [KO:K08057]
PITG_15358  calreticulin precursor [KO:K08057]
PITG_19537  calnexin, putative [KO:K08054]
PITG_06691  cell division control protein 42 [KO:K04392]
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Stuart LM, Ezekowitz RA
Phagocytosis: elegant complexity.
Immunity 22:539-50 (2005)
Tjelle TE, Lovdal T, Berg T
Phagosome dynamics and function.
Dupuy AG, Caron E
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
J Cell Sci 121:1773-83 (2008)
Brumell JH, Grinstein S
Salmonella redirects phagosomal maturation.
Curr Opin Microbiol 7:78-84 (2004)
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
LAMP proteins are required for fusion of lysosomes with phagosomes.
EMBO J 26:313-24 (2007)
Luzio JP, Pryor PR, Bright NA
Lysosomes: fusion and function.
Nat Rev Mol Cell Biol 8:622-32 (2007)
Sumimoto H
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
FEBS J 275:3249-77 (2008)
KO pathway

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