KEGG   PATHWAY: pif04145Help
Entry
pif04145                    Pathway                                

Name
Phagosome - Phytophthora infestans
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
pif04145  Phagosome
pif04145

Ortholog table
Module
pif_M00401  Sec61 complex [PATH:pif04145]
Other DBs
BSID: 174214
GO: 0045335
Organism
Phytophthora infestans [GN:pif]
Gene
PITG_01139  hypothetical protein [KO:K13813]
PITG_15117  actin-like protein [KO:K05692]
PITG_15078  actin-like protein [KO:K05692]
PITG_08016  vesicle-trafficking protein SEC22b, putative [KO:K08517]
PITG_12326  phosphatidyl inositol kinase (PIK-A) [KO:K00914] [EC:2.7.1.137]
PITG_13301  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02145] [EC:3.6.3.14]
PITG_06118  V-type proton ATPase subunit B, putative [KO:K02147]
PITG_12141  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02148]
PITG_06615  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02149]
PITG_09796  V-type proton ATPase subunit E, putative [KO:K02150]
PITG_10219  V-type proton ATPase subunit E, putative [KO:K02150]
PITG_12289  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02151]
PITG_01698  small cysteine rich protein SCR76 [KO:K02153]
PITG_14362  vacuolar proton translocating ATPase A subunit, putative [KO:K02154]
PITG_17747  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K02146]
PITG_00764  V-type proton ATPase subunit H, putative [KO:K02144]
PITG_02045  V-type proton ATPase 16 kDa proteolipid subunit, putative [KO:K02155]
PITG_02046  V-type proton ATPase 16 kDa proteolipid subunit, putative [KO:K02155]
PITG_03344  H - or Na -translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily [KO:K03661]
PITG_03148  Rab7 family GTPase, putative [KO:K07897]
PITG_17835  hypothetical protein [KO:K07897]
PITG_02526  dynein heavy chain [KO:K10413]
PITG_13968  dynein heavy chain [KO:K10414]
PITG_01997  dynein 1 light intermediate chain, putative [KO:K10416]
PITG_07996  alpha-tubulin [KO:K07374]
PITG_07999  alpha-tubulin, putative [KO:K07374]
PITG_07960  alpha-tubulin, putative [KO:K07374]
PITG_07961  cleavage induced tubulin alpha chain [KO:K07374]
PITG_07949  alpha-tubulin, putative [KO:K07374]
PITG_00156  beta-tubulin [KO:K07375]
PITG_05644  phosphatidylinositol-3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
PITG_06917  Phosphatidylinositol-3-phosphate5- kinase (Fab-like; PIPK-A1) [KO:K00921] [EC:2.7.1.150]
PITG_00330  phosphatidylinositol-4-phosphate-5-kinase (PI-PIPK-B) [KO:K00921] [EC:2.7.1.150]
PITG_12916  cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
PITG_12041  cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
PITG_03414  cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
PITG_03415  cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
PITG_16276  cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
PITG_17314  cysteine protease family C01A, putative [KO:K01365] [EC:3.4.22.15]
PITG_21621  cysteine protease family [KO:K01365] [EC:3.4.22.15]
PITG_18089  protein transporter Sec61 subunit alpha, putative [KO:K10956]
PITG_09451  hypothetical protein [KO:K09481]
PITG_17637  Type II (General) Secretory Pathway (IISP) Family [KO:K07342]
PITG_18934  calreticulin precursor [KO:K08057]
PITG_15358  calreticulin precursor [KO:K08057]
PITG_19537  calnexin, putative [KO:K08054]
PITG_06691  cell division control protein 42 [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
ko04145   

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