KEGG   PATHWAY: pol03440
Entry
pol03440                    Pathway                                
Name
Homologous recombination - Polaromonas sp. JS666
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
pol03440  Homologous recombination
pol03440

Other DBs
GO: 0000724
Organism
Polaromonas sp. JS666 [GN:pol]
Gene
Bpro_1012  exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Bpro_4565  single-strand binding protein [KO:K03111]
Bpro_3633  DNA repair protein RecO [KO:K03584]
Bpro_2270  DNA replication and repair protein RecR [KO:K06187]
Bpro_4685  RecA protein [KO:K03553]
Bpro_1729  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Bpro_4094  Holliday junction DNA helicase RuvA [KO:K03550]
Bpro_4093  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Bpro_1083  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Bpro_0468  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Bpro_1706  putative ATP-dependent exoDNAse (exonuclease V), alpha subunit [KO:K03581] [EC:3.1.11.5]
Bpro_2893  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Bpro_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Bpro_2268  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Bpro_4600  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Bpro_2518  DNA-directed DNA polymerase [KO:K02341] [EC:2.7.7.7]
Bpro_0009  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Bpro_2184  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Bpro_4151  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Bpro_2409  DNA polymerase III chi subunit, HolC [KO:K02339] [EC:2.7.7.7]
Bpro_4265  primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Bpro_3036  putative primosomal replication protein [KO:K02686]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG GENES (22)   
All databases (23)   

Download RDF
DBGET integrated database retrieval system