KEGG   PATHWAY: ppa04146
Entry
ppa04146                    Pathway                                
Name
Peroxisome - Komagataella phaffii
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
ppa04146  Peroxisome
ppa04146

Other DBs
GO: 0005777
Organism
Komagataella phaffii [GN:ppa]
Gene
PAS_chr3_1073  Peroxisomal membrane protein (PMP) [KO:K13336]
PAS_chr2-1_0715  PEX19; peroxisomal biogenesis protein [KO:K13337]
PAS_chr3_1045  Peroxisome biosynthesis protein PAS1 [KO:K13338]
PAS_chr1-4_0133  AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p [KO:K13339]
PAS_chr1-4_0433  Peroxisomal signal receptor for the N-terminal nonapeptide signal of peroxisomal matrix proteins [KO:K13341]
PAS_chr2-2_0186  Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) [KO:K13342]
PAS_chr4_0794  Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery [KO:K13343]
PAS_chr2-2_0207  Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins [KO:K13344]
PAS_chr4_0759  C3HC4-type RING-finger peroxisomal membrane peroxin [KO:K13345]
PAS_chr3_0043  peroxisomal integral membrane protein [KO:K06664]
PAS_chr2-2_0273  Protein required for ethanol metabolism [KO:K13348]
PAS_chr1-1_0352  hypothetical protein [KO:K13350]
PAS_chr2-1_0504  Peroxisomal membrane protein [KO:K13352]
PAS_chr3_0099  Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YE [KO:K13354]
PAS_chr1-1_0394  hypothetical protein with low sequence identity to Pdc1p [KO:K12261] [EC:4.1.2.63]
PAS_FragB_0025  Phytanoyl-CoA dioxygenase domain-containing protein [KO:K00477] [EC:1.14.11.18]
PAS_chr1-4_0538  Fatty-acyl coenzyme A oxidase [KO:K00232] [EC:1.3.3.6]
PAS_chr2-2_0267  3-ketoacyl-CoA thiolase with broad chain length specificity [KO:K07513] [EC:2.3.1.16]
PAS_chr3_0975  Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation [KO:K13237] [EC:1.3.1.124]
PAS_FragB_0022  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial [KO:K12663] [EC:5.3.3.21]
PAS_chr3_0822  Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p) [KO:K15628] [EC:7.6.2.4]
PAS_chr2-2_0272  Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p) [KO:K15628] [EC:7.6.2.4]
PAS_chr2-1_0785  Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids [KO:K01897] [EC:6.2.1.3]
PAS_chr4_0352  Long chain fatty acyl-CoA synthetase [KO:K01897] [EC:6.2.1.3]
PAS_chr1-4_0663  hypothetical protein [KO:K13239] [EC:5.3.3.8]
PAS_chr3_0069  Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated A [KO:K00624] [EC:2.3.1.7]
PAS_chr1-4_0074  Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme [KO:K00624] [EC:2.3.1.7]
PAS_chr3_0761  Carnitine acetyltransferase [KO:K00624] [EC:2.3.1.7]
PAS_chr1-3_0187  Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol [KO:K00869] [EC:2.7.1.36]
PAS_chr4_0416  Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
PAS_chr3_1033  hypothetical protein [KO:K00273] [EC:1.4.3.3]
PAS_chr3_0406  D-aspartate oxidase [KO:K00272] [EC:1.4.3.1]
PAS_chr1-1_0233  Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate [KO:K00031] [EC:1.1.1.42]
PAS_chr2-1_0580  Cytosolic NADP-specific isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
PAS_chr2-2_0131  Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1 [KO:K03781] [EC:1.11.1.6]
PAS_chr2-1_0502  Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage [KO:K11187] [EC:1.11.1.24]
PAS_chr4_0786  Cytosolic superoxide dismutase [KO:K04565] [EC:1.15.1.1]
PAS_chr2-1_0230  Mitochondrial ribosomal protein of the small subunit [KO:K04564] [EC:1.15.1.1]
PAS_chr4_0788  Mitochondrial ribosomal protein of the small subunit [KO:K04564] [EC:1.15.1.1]
PAS_chr1-4_0071  Mitochondrial superoxide dismutase, protects cells against oxygen toxicity [KO:K04564] [EC:1.15.1.1]
PAS_chr2-2_0112  hypothetical protein [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Reference
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
ppa00071  Fatty acid degradation
ppa00230  Purine metabolism
ppa00564  Glycerophospholipid metabolism
ppa00565  Ether lipid metabolism
ppa00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   

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