KEGG PATHWAY: ppp04145

PATHWAY: ppp04145

Entry

ppp04145 Pathway

Name

Phagosome - Physcomitrella patens subsp. patens

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

ppp04145

Phagosome

Module

ppp_M00401

Sec61 complex [PATH:ppp04145]

Other DBs

BSID:

153958

GO:

0045335

Organism

Physcomitrella patens subsp. patens [GN:ppp]

Gene

PHYPADRAFT_105891	SYP2B1; Qa-SNARE, SYP2/Pep12p/Syntaxin 7-type [KO:K08488]
PHYPADRAFT_181911	SYP8; Qa-SNARE, SYP8/Ufe1p/Syntaxin 18-type [KO:K08492]
PHYPADRAFT_209168	SEC22; R-SNARE, SEC22-family [KO:K08517]
PHYPADRAFT_228618	SEC22A2-2; R-SNARE, SEC22-family [KO:K08517]
PHYPADRAFT_179911	RabF1; Rab5/RabF-family small GTPase [KO:K07888]
PHYPADRAFT_182554	hypothetical protein; K00914 phosphatidylinositol 3-kinase [EC:2.7.1.137] [KO:K00914] [EC:2.7.1.137]
PHYPADRAFT_114420	hypothetical protein; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
PHYPADRAFT_202293	hypothetical protein; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
PHYPADRAFT_208090	hypothetical protein; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
PHYPADRAFT_214369	hypothetical protein; K02147 V-type H+-transporting ATPase subunit B [EC:3.6.3.14] [KO:K02147] [EC:3.6.3.14]
PHYPADRAFT_106587	hypothetical protein; K02147 V-type H+-transporting ATPase subunit B [EC:3.6.3.14] [KO:K02147] [EC:3.6.3.14]
PHYPADRAFT_173198	hypothetical protein; K02147 V-type H+-transporting ATPase subunit B [EC:3.6.3.14] [KO:K02147] [EC:3.6.3.14]
PHYPADRAFT_139628	hypothetical protein; K02148 V-type H+-transporting ATPase subunit C [EC:3.6.3.14] [KO:K02148] [EC:3.6.3.14]
PHYPADRAFT_170976	hypothetical protein; K02149 V-type H+-transporting ATPase subunit D [EC:3.6.3.14] [KO:K02149] [EC:3.6.3.14]
PHYPADRAFT_224180	hypothetical protein; K02149 V-type H+-transporting ATPase subunit D [EC:3.6.3.14] [KO:K02149] [EC:3.6.3.14]
PHYPADRAFT_148600	hypothetical protein; K02149 V-type H+-transporting ATPase subunit D [EC:3.6.3.14] [KO:K02149] [EC:3.6.3.14]
PHYPADRAFT_77945	hypothetical protein; K02150 V-type H+-transporting ATPase subunit E [EC:3.6.3.14] [KO:K02150] [EC:3.6.3.14]
PHYPADRAFT_223748	hypothetical protein; K02150 V-type H+-transporting ATPase subunit E [EC:3.6.3.14] [KO:K02150] [EC:3.6.3.14]
PHYPADRAFT_196540	hypothetical protein; K02150 V-type H+-transporting ATPase subunit E [EC:3.6.3.14] [KO:K02150] [EC:3.6.3.14]
PHYPADRAFT_208972	hypothetical protein; K02151 V-type H+-transporting ATPase subunit F [EC:3.6.3.14] [KO:K02151] [EC:3.6.3.14]
PHYPADRAFT_203227	hypothetical protein; K02151 V-type H+-transporting ATPase subunit F [EC:3.6.3.14] [KO:K02151] [EC:3.6.3.14]
PHYPADRAFT_177548	hypothetical protein; K02152 V-type H+-transporting ATPase subunit G [EC:3.6.3.14] [KO:K02152] [EC:3.6.3.14]
PHYPADRAFT_212771	hypothetical protein; K02152 V-type H+-transporting ATPase subunit G [EC:3.6.3.14] [KO:K02152] [EC:3.6.3.14]
PHYPADRAFT_29621	hypothetical protein; K02153 V-type H+-transporting ATPase subunit H [EC:3.6.3.14] [KO:K02153] [EC:3.6.3.14]
PHYPADRAFT_19874	hypothetical protein; K02153 V-type H+-transporting ATPase subunit H [EC:3.6.3.14] [KO:K02153] [EC:3.6.3.14]
PHYPADRAFT_126569	hypothetical protein; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
PHYPADRAFT_113417	hypothetical protein; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
PHYPADRAFT_214893	hypothetical protein; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
PHYPADRAFT_197495	hypothetical protein; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
PHYPADRAFT_134945	hypothetical protein; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
PHYPADRAFT_110623	hypothetical protein; K02146 V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14] [KO:K02146] [EC:3.6.3.14]
PHYPADRAFT_160330	hypothetical protein; K02144 V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14] [KO:K02144] [EC:3.6.3.14]
PHYPADRAFT_209130	hypothetical protein; K02144 V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14] [KO:K02144] [EC:3.6.3.14]
PHYPADRAFT_180835	hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
PHYPADRAFT_111402	hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
PHYPADRAFT_180833	hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
PHYPADRAFT_220835	hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
PHYPADRAFT_62159	hypothetical protein; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
PHYPADRAFT_161729	hypothetical protein; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14] [KO:K03661] [EC:3.6.3.14]
PHYPADRAFT_190230	hypothetical protein; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14] [KO:K03661] [EC:3.6.3.14]
PHYPADRAFT_188359	hypothetical protein; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14] [KO:K03661] [EC:3.6.3.14]
PHYPADRAFT_132378	hypothetical protein; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14] [KO:K03661] [EC:3.6.3.14]
PHYPADRAFT_110619	RabG11; Rab7/RabG-family small GTPase [KO:K07897]
PHYPADRAFT_210411	RabG13; Rab7/RabG-family small GTPase [KO:K07897]
PHYPADRAFT_81163	inner dynein arm 1 heavy chain 1-ALPHa; K10413 dynein heavy chain 1, cytosolic [KO:K10413]
PHYPADRAFT_211478	hypothetical protein; K07374 tubulin alpha [KO:K07374]
PHYPADRAFT_108007	hypothetical protein; K07374 tubulin alpha [KO:K07374]
PHYPADRAFT_136749	hypothetical protein; K07374 tubulin alpha [KO:K07374]
PHYPADRAFT_121199	hypothetical protein; K07375 tubulin beta [KO:K07375]
PHYPADRAFT_117822	hypothetical protein; K07375 tubulin beta [KO:K07375]
PHYPADRAFT_232451	hypothetical protein; K07375 tubulin beta [KO:K07375]
PHYPADRAFT_223212	hypothetical protein; K07375 tubulin beta [KO:K07375]
PHYPADRAFT_210788	hypothetical protein; K00921 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150] [KO:K00921] [EC:2.7.1.150]
PHYPADRAFT_40158	hypothetical protein; K00921 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150] [KO:K00921] [EC:2.7.1.150]
PHYPADRAFT_121474	hypothetical protein; K00921 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150] [KO:K00921] [EC:2.7.1.150]
PHYPADRAFT_225537	hypothetical protein; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
PHYPADRAFT_215299	hypothetical protein; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
PHYPADRAFT_29562	hypothetical protein; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
PHYPADRAFT_9591	hypothetical protein; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
PHYPADRAFT_9587	hypothetical protein; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
PHYPADRAFT_111919	hypothetical protein; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
PHYPADRAFT_226751	hypothetical protein; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
PHYPADRAFT_187710	hypothetical protein; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
PHYPADRAFT_164102	hypothetical protein; K08057 calreticulin [KO:K08057]
PHYPADRAFT_118597	hypothetical protein; K08054 calnexin [KO:K08054]
PHYPADRAFT_59289	hypothetical protein; K08054 calnexin [KO:K08054]
PHYPADRAFT_181629	Rop4; rop-family small GTPase [KO:K04392]
PHYPADRAFT_191636	ROP2; rop-family small GTPase [KO:K04392]
PHYPADRAFT_188969	hypothetical protein; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]

Compound

C00007	Oxygen
C00027	Hydrogen peroxide
C00533	Nitric oxide
C00704	O2.-
C04549	1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

PMID:15894272

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)

Reference

PMID:10684585

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)

Reference

PMID:18492791

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)

Reference

PMID:15036145

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)

Reference

PMID:17245426

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)

Reference

PMID:17637737

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)

Reference

PMID:18513324

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)

KO pathway

ko04145

All links

Pathway (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (69)   
   KEGG GENES (69)   
All databases (72)   

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