KEGG   PATHWAY: ppp04145Help
Entry
ppp04145                    Pathway                                

Name
Phagosome - Physcomitrella patens subsp. patens
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
ppp04145  Phagosome
ppp04145

Ortholog table
Module
ppp_M00401  Sec61 complex [PATH:ppp04145]
Other DBs
BSID: 153958
GO: 0045335
Organism
Physcomitrella patens subsp. patens [GN:ppp]
Gene
112289929  syntaxin-22-like [KO:K08488]
112283138  syntaxin-22-like [KO:K08488]
112283661  syntaxin-81-like [KO:K08492]
112279270  25.3 kDa vesicle transport protein-like isoform X1 [KO:K08517]
112290742  25.3 kDa vesicle transport protein-like [KO:K08517]
112283481  ras-related protein RABF1-like isoform X1 [KO:K07888]
112284713  ras-related protein RABF1-like isoform X1 [KO:K07888]
112282939  ras-related protein RHN1-like [KO:K07889]
112284058  ras-related protein RHN1-like [KO:K07889]
112288042  phosphatidylinositol 3-kinase, root isoform-like [KO:K00914] [EC:2.7.1.137]
112273461  V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:3.6.3.14]
112275512  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:3.6.3.14]
112285688  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:3.6.3.14]
112274087  V-type proton ATPase subunit B 2 [KO:K02147]
112275196  V-type proton ATPase subunit B3 [KO:K02147]
112295585  V-type proton ATPase subunit B 2 [KO:K02147]
112287086  V-type proton ATPase subunit C-like isoform X1 [KO:K02148]
112290179  V-type proton ATPase subunit C-like [KO:K02148]
112278278  V-type proton ATPase subunit D-like [KO:K02149]
112278289  mucin-5AC-like [KO:K02149]
112283595  V-type proton ATPase subunit D-like [KO:K02149]
112278631  V-type proton ATPase subunit E-like [KO:K02150]
112278632  V-type proton ATPase subunit E-like [KO:K02150]
112291357  V-type proton ATPase subunit E-like isoform X1 [KO:K02150]
112274775  V-type proton ATPase subunit E-like [KO:K02150]
112294396  V-type proton ATPase subunit E-like [KO:K02150]
112283129  V-type proton ATPase subunit F-like [KO:K02151]
112277194  V-type proton ATPase subunit F-like [KO:K02151]
112292277  uncharacterized protein LOC112292277 isoform X1 [KO:K02152]
112286351  V-type proton ATPase subunit G 1-like [KO:K02152]
112286109  V-type proton ATPase subunit e1-like [KO:K02153]
112288763  V-type proton ATPase subunit e1-like [KO:K02153]
112280509  V-type proton ATPase subunit a3-like isoform X1 [KO:K02154]
112280977  V-type proton ATPase subunit a3-like isoform X1 [KO:K02154]
112281677  V-type proton ATPase subunit a3-like isoform X1 [KO:K02154]
112290646  V-type proton ATPase subunit a3-like isoform X1 [KO:K02154]
112277881  V-type proton ATPase subunit a3-like [KO:K02154]
112272923  V-type proton ATPase subunit d2 [KO:K02146]
112287414  probable V-type proton ATPase subunit H [KO:K02144]
112291446  probable V-type proton ATPase subunit H isoform X1 [KO:K02144]
112286465  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
112279422  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
112282720  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
112284254  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
112292704  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
112280020  V-type proton ATPase subunit c''2-like [KO:K03661]
112289174  V-type proton ATPase subunit c''2-like [KO:K03661]
112281862  V-type proton ATPase subunit c''2-like [KO:K03661]
112285405  V-type proton ATPase subunit c''2-like [KO:K03661]
112288849  ras-related protein Rab7 [KO:K07897]
112283637  ras-related protein Rab7-like [KO:K07897]
112295384  ras-related protein Rab7-like [KO:K07897]
112277402  tubulin alpha-1 chain [KO:K07374]
112277403  tubulin alpha-1 chain [KO:K07374]
112279253  tubulin alpha-4 chain-like isoform X1 [KO:K07374]
112288231  tubulin alpha chain-like [KO:K07374]
112289159  tubulin alpha chain [KO:K07374]
112281110  tubulin alpha chain-like [KO:K07374]
112281111  tubulin alpha chain-like [KO:K07374]
112290284  tubulin alpha chain-like [KO:K07374]
112291159  tubulin alpha chain-like isoform X1 [KO:K07374]
112293488  tubulin alpha-6 chain [KO:K07374]
112276034  tubulin alpha chain-like [KO:K07374]
112293619  tubulin alpha-1 chain-like [KO:K07374]
112286729  tubulin beta-1/beta-2 chain isoform X1 [KO:K07375]
112278684  tubulin beta chain-like [KO:K07375]
112282642  tubulin beta chain-like [KO:K07375]
112282599  tubulin beta chain-like [KO:K07375]
112282495  tubulin beta chain-like [KO:K07375]
112283545  tubulin beta chain [KO:K07375]
112274189  tubulin beta chain-like [KO:K07375]
112274197  tubulin beta chain-like [KO:K07375]
112274203  tubulin beta chain-like [KO:K07375]
112283884  tubulin beta chain-like [KO:K07375]
112285519  tubulin beta-1/beta-2 chain-like [KO:K07375]
112291830  1-phosphatidylinositol-3-phosphate 5-kinase FAB1A-like [KO:K00921] [EC:2.7.1.150]
112291923  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like isoform X1 [KO:K00921] [EC:2.7.1.150]
112294466  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like [KO:K00921] [EC:2.7.1.150]
112294710  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like isoform X1 [KO:K00921] [EC:2.7.1.150]
112285909  protein transport protein Sec61 subunit alpha-like [KO:K10956]
112276941  protein transport protein Sec61 subunit alpha-like [KO:K10956]
112296050  protein transport protein Sec61 subunit beta-like [KO:K09481]
112273939  protein transport protein Sec61 subunit beta-like [KO:K09481]
112295087  protein transport protein Sec61 subunit beta-like isoform X1 [KO:K09481]
112280074  protein transport protein Sec61 subunit gamma-1 [KO:K07342]
112290754  protein transport protein Sec61 subunit gamma-1-like [KO:K07342]
112295043  protein transport protein Sec61 subunit gamma [KO:K07342]
112295789  protein transport protein Sec61 subunit gamma [KO:K07342]
112291264  calreticulin-like [KO:K08057]
112294652  calreticulin-like isoform X1 [KO:K08057]
112279925  calnexin homolog 1-like [KO:K08054]
112279926  calnexin homolog 1-like [KO:K08054]
112290628  calnexin homolog 1-like [KO:K08054]
112290630  calnexin homolog 1-like [KO:K08054]
112291317  calnexin homolog 1-like [KO:K08054]
112279094  rac-like GTP-binding protein 5 [KO:K04392]
112288090  rac-like GTP-binding protein 5 [KO:K04392]
112289166  rac-like GTP-binding protein 5 isoform X1 [KO:K04392]
112291224  rac-like GTP-binding protein 5 [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
KO pathway
ko04145   

DBGET integrated database retrieval system