KEGG   PATHWAY: pps04622
Entry
pps04622                    Pathway                                
Name
RIG-I-like receptor signaling pathway - Pan paniscus (bonobo)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
pps04622  RIG-I-like receptor signaling pathway
pps04622

Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100967985  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
100981559  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
100983140  ZNFX1; NFX1-type zinc finger-containing protein 1 [KO:K27391]
100979730  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100985302  DHX58; probable ATP-dependent RNA helicase DHX58 isoform X1 [KO:K12649] [EC:5.6.2.6]
100980798  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100985915  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
100987620  AZI2; 5-azacytidine-induced protein 2 isoform X1 [KO:K12651]
100975838  TBKBP1; TANK-binding kinase 1-binding protein 1 isoform X1 [KO:K12652]
100987483  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117977645  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
100990211  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100992569  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100977114  IRF3; interferon regulatory factor 3 isoform X5 [KO:K05411]
100968579  interferon alpha-7 [KO:K05414]
100968923  interferon alpha-4-like [KO:K05414]
100969275  interferon alpha-10-like [KO:K05414]
100969624  interferon alpha-16 [KO:K05414]
100970300  interferon alpha-17-like [KO:K05414]
100970658  interferon alpha-14 [KO:K05414]
100971675  IFNA6; interferon alpha-6 [KO:K05414]
100972005  interferon alpha-1/13-like [KO:K05414]
100972354  interferon alpha-2 [KO:K05414]
100972691  IFNA8; interferon alpha-8 [KO:K05414]
100973049  interferon alpha-1/13 [KO:K05414]
100995734  interferon alpha-5 [KO:K05414]
100967539  interferon alpha-21 [KO:K05414]
117981650  interferon alpha-17 [KO:K05414]
117981651  interferon alpha-4-like [KO:K05414]
100968231  LOW QUALITY PROTEIN: interferon alpha-10 [KO:K05414]
117981652  interferon alpha-7-like [KO:K05414]
117981653  interferon alpha-7 [KO:K05414]
100995851  IFNB1; interferon beta [KO:K05415]
100996206  interferon omega-1 [KO:K05440]
112440856  IFNE; interferon epsilon [KO:K05442]
100982287  IFNK; interferon kappa [KO:K05441]
100989209  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100968673  FADD; FAS-associated death domain protein [KO:K02373]
100991521  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100978497  CASP8; caspase-8 isoform X4 [KO:K04398] [EC:3.4.22.61]
100972863  CASP10; caspase-10 isoform X1 [KO:K04400] [EC:3.4.22.63]
100995228  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100989390  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100980612  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100972867  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100979341  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100988429  RELA; transcription factor p65 isoform X1 [KO:K04735]
100982095  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
100974026  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100983960  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100994796  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
100984173  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
100982480  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100990080  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100982544  MAPK13; mitogen-activated protein kinase 13 isoform X5 [KO:K04441] [EC:2.7.11.24]
100983649  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100981268  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100980937  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100978369  CXCL8; interleukin-8 [KO:K10030]
100977674  TNF; tumor necrosis factor [KO:K03156]
100979574  IL12A; interleukin-12 subunit alpha [KO:K05406]
100989950  IL12B; interleukin-12 subunit beta [KO:K05425]
100992984  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100988581  ADAR; double-stranded RNA-specific adenosine deaminase isoform X3 [KO:K12968] [EC:3.5.4.37]
100971009  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
100986446  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X2 [KO:K08601] [EC:3.4.19.12]
100973859  RNF125; E3 ubiquitin-protein ligase RNF125 isoform X1 [KO:K12170] [EC:2.3.2.27]
100978850  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
100986285  ATG12; ubiquitin-like protein ATG12 isoform X2 [KO:K08336]
100990903  LOW QUALITY PROTEIN: ubiquitin-like protein ATG12 [KO:K08336]
100989144  NLRX1; NLR family member X1 [KO:K12653]
100981835  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
100983014  OTUD5; OTU domain-containing protein 5 isoform X2 [KO:K12655] [EC:3.4.19.12]
100970127  SIKE1; suppressor of IKBKE 1 isoform X2 [KO:K12656]
100970420  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
100970023  PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1 [KO:K09578] [EC:5.2.1.8]
100974411  TKFC; triokinase/FMN cyclase isoform X2 [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
pps04010  MAPK signaling pathway
pps04120  Ubiquitin mediated proteolysis
pps04210  Apoptosis
pps04630  JAK-STAT signaling pathway
KO pathway
ko04622   

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Genome (1)   
   KEGG GENOME (1)   
Gene (77)   
   KEGG GENES (77)   
All databases (78)   

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