KEGG   PATHWAY: ptr04060Help
Entry
ptr04060                    Pathway                                

Name
Cytokine-cytokine receptor interaction - Pan troglodytes (chimpanzee)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Cytokine-cytokine receptor interaction
ptr04060

All organismsOrtholog table
Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
739778  
PPBPL1; pro-platelet basic protein-like 1 [KO:K10029]
740420  
PPBP; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) [KO:K10029]
471205  
IL8; interleukin 8 [KO:K10030]
471200  
CXCL9; chemokine (C-X-C motif) ligand 9 [KO:K05416]
461242  
CXCL10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
739195  
CXCL11; chemokine (C-X-C motif) ligand 11 [KO:K12672]
741624  
uncharacterized LOC741624; K10031 C-X-C motif chemokine 12 [KO:K10031]
738275  
CXCL13; chemokine (C-X-C motif) ligand 13 [KO:K10032]
454451  
CXCL16; chemokine (C-X-C motif) ligand 16 [KO:K10035]
740477  
PF4; platelet factor 4 [KO:K05407]
740621  
PF4V1; platelet factor 4 variant 1 [KO:K05407]
471640  
CXCL14; chemokine (C-X-C motif) ligand 14 [KO:K10033]
454115  
CX3CL1; chemokine (C-X3-C motif) ligand 1 [KO:K05508]
459991  
CCL20; chemokine (C-C motif) ligand 20 [KO:K14625]
743059  
CCL25; chemokine (C-C motif) ligand 25 [KO:K13072]
473220  
CCL19; chemokine (C-C motif) ligand 19 [KO:K05512]
746205  
CCL21; chemokine (C-C motif) ligand 21 [KO:K16062]
748205  
CCL2; chemokine (C-C motif) ligand 2 [KO:K14624]
454593  
CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
455004  
CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
749913  
c-C motif chemokine 3-like 1-like; K05408 C-C motif chemokine 3 [KO:K05408]
454592  
CCL3; chemokine (C-C motif) ligand 3 [KO:K05408]
748142  
CCL13; chemokine (C-C motif) ligand 13 [KO:K16595]
454579  
CCL7; chemokine (C-C motif) ligand 7 [KO:K05509]
747004  
CCL5; chemokine (C-C motif) ligand 5 [KO:K12499]
468209  
CCL8; chemokine (C-C motif) ligand 8 [KO:K16596]
468208  
CCL11; chemokine (C-C motif) ligand 11 [KO:K16597]
735978  
CCL28; chemokine (C-C motif) ligand 28 [KO:K05513]
CCL27; chemokine (C-C motif) ligand 27 [KO:K16598]
463288  
IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
736204  
IL11; interleukin 11 [KO:K05417]
736338  
OSM; oncostatin M [KO:K05418]
736309  
LIF; leukemia inhibitory factor [KO:K05419]
CNTF; ciliary neurotrophic factor [KO:K05420]
467955  
CTF1; cardiotrophin 1 [KO:K05422]
454641  
CSF3; colony stimulating factor 3 (granulocyte) [KO:K05423]
449638  
LEP; leptin [KO:K05424]
449565  
IL4; interleukin 4 [KO:K05430]
449564  
IL13; interleukin 13 [KO:K05435]
460816  
IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [KO:K05406]
471723  
IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [KO:K05425]
467036  
IL23A; interleukin 23, alpha subunit p19 [KO:K05426]
471627  
CSF2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
471626  
IL3; interleukin 3 (colony-stimulating factor, multiple) [KO:K04736]
743963  
IL5; interleukin 5 (colony-stimulating factor, eosinophil) [KO:K05428]
461472  
IL2; interleukin 2 [KO:K05429]
464245  
IL7; interleukin 7 [KO:K05431]
745517  
IL9; interleukin 9 [KO:K05432]
737808  
IL15; interleukin 15 [KO:K05433]
471295  
IL21; interleukin 21 [KO:K05434]
737202  
TSLP; thymic stromal lymphopoietin [KO:K05436]
463609  
EPO; erythropoietin [KO:K05437]
462468  
PRL; prolactin [KO:K05439]
470287  
TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
740202  
PDGFA; platelet-derived growth factor alpha polypeptide [KO:K04359]
458844  
PDGFB; platelet-derived growth factor beta polypeptide [KO:K17386]
741897  
VEGFB; vascular endothelial growth factor B [KO:K16858]
471358  
VEGFC; vascular endothelial growth factor C [KO:K05449]
465508  
FIGF; c-fos induced growth factor (vascular endothelial growth factor D) [KO:K05449]
463503  
HGF; hepatocyte growth factor (hepapoietin A [KO:K05460]
461435  
EGF; epidermal growth factor [KO:K04357]
457127  
CSF1; colony stimulating factor 1 (macrophage) [KO:K05453]
452114  
KITLG; KIT ligand [KO:K05461]
FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
473185  
IFNA21; interferon, alpha 21 [KO:K05414]
473193  
IFNA14; interferon, alpha 14 [KO:K05414]
473196  
IFNA6; interferon, alpha 6 [KO:K05414]
473198  
IFNA2; interferon, alpha 2 [KO:K05414]
473199  
IFNA8; interferon, alpha 8 [KO:K05414]
741890  
IFNA4; interferon, alpha 4 [KO:K05414]
741660  
IFNA17; interferon, alpha 17 [KO:K05414]
473195  
IFNA5; interferon, alpha 5 [KO:K05414]
741747  
IFNA7; interferon, alpha 7 [KO:K05414]
742651  
IFNA13; interferon, alpha 13 [KO:K05414]
741978  
IFNA16; interferon, alpha 16 [KO:K05414]
744748  
IFNA4; interferon, alpha 4 [KO:K05414]
473191  
interferon alpha-17-like; K05414 interferon alpha [KO:K05414]
473183  
IFNB1; interferon, beta 1, fibroblast [KO:K05415]
473184  
IFNW1; interferon, omega 1 [KO:K05440]
473120  
IFNK; interferon, kappa [KO:K05441]
473203  
IFNE; interferon, epsilon [KO:K05442]
449517  
IFNG; interferon, gamma [KO:K04687]
469657  
IL10; interleukin 10 [KO:K05443]
741423  
IL22; interleukin 22 [KO:K05445]
741377  
IL26; interleukin 26 [KO:K05446]
473468  
TNFSF15; tumor necrosis factor (ligand) superfamily, member 15 [KO:K05478]
460852  
TNFSF10; tumor necrosis factor (ligand) superfamily, member 10 [KO:K04721]
467353  
TNFSF11; tumor necrosis factor (ligand) superfamily, member 11 [KO:K05473]
TNFSF12; tumor necrosis factor (ligand) superfamily, member 12 [KO:K05474]
494186  
TNF; tumor necrosis factor [KO:K03156]
494185  
LTA; lymphotoxin alpha (TNF superfamily, member 1) [KO:K05468]
744486  
LTB; lymphotoxin beta (TNF superfamily, member 3) [KO:K03157]
468687  
TNFSF14; tumor necrosis factor (ligand) superfamily, member 14 [KO:K05477]
469584  
FASLG; Fas ligand (TNF superfamily, member 6) [KO:K04389]
473802  
CD40LG; CD40 ligand [KO:K03161]
464686  
TNFSF8; tumor necrosis factor (ligand) superfamily, member 8 [KO:K05471]
469586  
TNFSF4; tumor necrosis factor (ligand) superfamily, member 4 [KO:K05469]
738190  
TNFSF18; tumor necrosis factor (ligand) superfamily, member 18 [KO:K05479]
TNFSF13; tumor necrosis factor (ligand) superfamily, member 13 [KO:K05475]
467323  
TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b [KO:K05476]
473652  
EDA; ectodysplasin A [KO:K05480]
ectodysplasin-A-like; K05480 ectodysplasin-A [KO:K05480]
456060  
TGFB1; transforming growth factor, beta 1 [KO:K13375]
457742  
TGFB2; transforming growth factor, beta 2 [KO:K13376]
453054  
TGFB3; transforming growth factor, beta 3 [KO:K13377]
AMH; anti-Mullerian hormone [KO:K04665]
458357  
BMP7; bone morphogenetic protein 7 [KO:K16621]
472029  
IL17A; interleukin 17A [KO:K05489]
741839  
IL17B; interleukin 17B [KO:K05490]
467404  
IL25; interleukin 25 [KO:K05493]
470485  
IL1A; interleukin 1, alpha [KO:K04383]
450200  
IL1B; interleukin 1, beta [KO:K04519]
739011  
IL18; interleukin 18 (interferon-gamma-inducing factor) [KO:K05482]
470644  
CXCR2; chemokine (C-X-C motif) receptor 2 [KO:K05050]
470645  
CXCR1; chemokine (C-X-C motif) receptor 1 [KO:K04175]
465704  
CXCR3; chemokine (C-X-C motif) receptor 3 [KO:K04188]
450130  
CXCR4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
451595  
CXCR5; chemokine (C-X-C motif) receptor 5 [KO:K04190]
450138  
CXCR6; chemokine (C-X-C motif) receptor 6 [KO:K04191]
460122  
CXCR7; chemokine (C-X-C motif) receptor 7 [KO:K04304]
460321  
XCR1; chemokine (C motif) receptor 1 [KO:K04193]
460281  
CX3CR1; chemokine (C-X3-C motif) receptor 1 [KO:K04192]
470795  
CCR8; chemokine (C-C motif) receptor 8 [KO:K04183]
CCR6; chemokine (C-C motif) receptor 6 [KO:K04181]
470808  
CCR9; chemokine (C-C motif) receptor 9 [KO:K04184]
470781  
CCR4; chemokine (C-C motif) receptor 4 [KO:K04179]
454654  
CCR7; chemokine (C-C motif) receptor 7 [KO:K04182]
740071  
CCR2; chemokine (C-C motif) receptor 2 [KO:K04177]
450128  
CCR5; chemokine (C-C motif) receptor 5 [KO:K04180]
460323  
CCR1; chemokine (C-C motif) receptor 1 [KO:K04176]
470810  
CCR3; chemokine (C-C motif) receptor 3 [KO:K04178]
741917  
CCR10; chemokine (C-C motif) receptor 10 [KO:K04185]
469506  
IL6R; interleukin 6 receptor [KO:K05055]
461866  
IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor) [KO:K05060]
IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
738797  
LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
461908  
OSMR; oncostatin M receptor [KO:K05057]
473218  
CNTFR; ciliary neurotrophic factor receptor [KO:K05059]
456756  
CSF3R; colony stimulating factor 3 receptor (granulocyte) [KO:K05061]
456919  
LEPR; leptin receptor [KO:K05062]
454005  
IL4R; interleukin 4 receptor [KO:K05071]
735671  
IL13RA1; interleukin 13 receptor, alpha 1 [KO:K05076]
455851  
IL12RB1; interleukin 12 receptor, beta 1 [KO:K05063]
469348  
IL12RB2; interleukin 12 receptor, beta 2 [KO:K05064]
744045  
IL23R; interleukin 23 receptor [KO:K05065]
746936  
CSF2RA; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [KO:K05066]
458802  
CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [KO:K04738]
751052  
IL3RA; interleukin 3 receptor, alpha (low affinity) [KO:K04737]
737582  
IL5RA; interleukin 5 receptor, alpha [KO:K05067]
450884  
IL2RA; interleukin 2 receptor, alpha [KO:K05068]
470203  
IL2RB; interleukin 2 receptor, beta [KO:K05069]
465692  
CXHXorf65; interleukin 2 receptor, gamma [KO:K05070]
cytokine receptor common subunit gamma-like; K05070 interleukin 2 receptor gamma [KO:K05070]
461922  
IL7R; interleukin 7 receptor [KO:K05072]
741980  
IL9R; interleukin 9 receptor [KO:K05073]
738192  
IL15RA; interleukin 15 receptor, alpha [KO:K05074]
454006  
IL21R; interleukin 21 receptor [KO:K05075]
749701  
cytokine receptor-like factor 2-like; K05078 thymic stromal-derived lymphopoietin receptor [KO:K05078]
749758  
CRLF2; cytokine receptor-like factor 2 [KO:K05078]
455728  
EPOR; erythropoietin receptor [KO:K05079]
471560  
GHR; growth hormone receptor [KO:K05080]
461925  
PRLR; prolactin receptor [KO:K05081]
747522  
MPL; myeloproliferative leukemia virus oncogene [KO:K05082]
461318  
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
462188  
PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
452512  
FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) [KO:K05096] [EC:2.7.10.1]
461315  
KDR; kinase insert domain receptor (a type III receptor tyrosine kinase) [KO:K05098] [EC:2.7.10.1]
462339  
FLT4; fms-related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
463671  
MET; met proto-oncogene (hepatocyte growth factor receptor) [KO:K05099] [EC:2.7.10.1]
463415  
EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
462187  
CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
461316  
KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [KO:K05091] [EC:2.7.10.1]
452508  
FLT3; fms-related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
458516  
IFNAR1; interferon (alpha, beta and omega) receptor 1 [KO:K05130]
473965  
IFNAR2; interferon (alpha, beta and omega) receptor 2 [KO:K05131]
747276  
IFNGR1; interferon gamma receptor 1 [KO:K05132]
470077  
IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1) [KO:K05133]
451580  
IL10RA; interleukin 10 receptor, alpha [KO:K05134]
473966  
IL10RB; interleukin 10 receptor, beta [KO:K05135]
463026  
IL20RA; interleukin 20 receptor, alpha [KO:K05136]
742595  
IL20RB; interleukin 20 receptor beta [KO:K05137]
469224  
IL22RA1; interleukin 22 receptor, alpha 1 [KO:K05138]
472133  
IL22RA2; interleukin 22 receptor, alpha 2 [KO:K05139]
456628  
IL28RA; interleukin 28 receptor, alpha (interferon, lambda receptor) [KO:K05140]
464351  
TNFRSF11B; tumor necrosis factor receptor superfamily, member 11b [KO:K05148]
468560  
TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator [KO:K05147]
749145  
TNFRSF25; tumor necrosis factor receptor superfamily, member 25 [KO:K05160]
747558  
TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A [KO:K05149]
462749  
TNFRSF21; tumor necrosis factor receptor superfamily, member 21 [KO:K05157]
455206  
NGFR; nerve growth factor receptor [KO:K02583]
457968  
TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B [KO:K05141]
466934  
TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
451778  
LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3) [KO:K03159]
457221  
TNFRSF14; tumor necrosis factor receptor superfamily, member 14 [KO:K05152]
746784  
TNFRSF6B; tumor necrosis factor receptor superfamily, member 6b, decoy [KO:K05143]
738331  
FAS; Fas (TNF receptor superfamily, member 6) [KO:K04390]
CD40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
451780  
CD27; CD27 molecule [KO:K05144]
457960  
TNFRSF8; tumor necrosis factor receptor superfamily, member 8 [KO:K05145]
746029  
TNFRSF9; tumor necrosis factor receptor superfamily, member 9 [KO:K05146]
457185  
TNFRSF4; tumor necrosis factor receptor superfamily, member 4 [KO:K05142]
741567  
TNFRSF18; tumor necrosis factor receptor superfamily, member 18 [KO:K05154]
467905  
TNFRSF17; tumor necrosis factor receptor superfamily, member 17 [KO:K05153]
744388  
TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B [KO:K05150]
746611  
TNFRSF13C; tumor necrosis factor receptor superfamily, member 13C [KO:K05151]
735810  
EDAR; ectodysplasin A receptor [KO:K05162]
473648  
EDA2R; ectodysplasin A2 receptor [KO:K05163]
452480  
TNFRSF19; tumor necrosis factor receptor superfamily, member 19 [KO:K05155]
466703  
RELT; RELT tumor necrosis factor receptor [KO:K05156]
460243  
TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
472992  
TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
459646  
ACVR2A; activin A receptor, type IIA [KO:K04670] [EC:2.7.11.30]
460271  
ACVR2B; activin A receptor, type IIB [KO:K13596] [EC:2.7.11.30]
470565  
ACVR1; activin A receptor, type I [KO:K04675] [EC:2.7.11.30]
451911  
ACVR1B; activin A receptor, type IB [KO:K13567] [EC:2.7.11.30]
467005  
AMHR2; anti-Mullerian hormone receptor, type II [KO:K04672] [EC:2.7.11.30]
459885  
BMPR2; bone morphogenetic protein receptor, type II (serine/threonine kinase) [KO:K04671] [EC:2.7.11.30]
450572  
BMPR1A; bone morphogenetic protein receptor, type IA [KO:K04673] [EC:2.7.11.30]
461683  
BMPR1B; bone morphogenetic protein receptor, type IB [KO:K13578] [EC:2.7.11.30]
458629  
IL17RA; interleukin 17 receptor A [KO:K05164]
460451  
IL17RB; interleukin 17 receptor B [KO:K05165]
459460  
IL1R1; interleukin 1 receptor, type I [KO:K04386]
460935  
IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
470455  
IL1R2; interleukin 1 receptor, type II [KO:K04387]
459463  
IL18R1; interleukin 18 receptor 1 [KO:K05173]
744277  
IL18RAP; interleukin 18 receptor accessory protein [KO:K05174]
Reference
  Authors
Oppenheim JJ, Feldman M (ed).
  Title
Cytokine Reference
  Journal
Academic Press (2001)
Reference
  Authors
Thomson AW, Lotze MT (ed).
  Title
The Cytokine Handbook (Fourth edition)
  Journal
Academic Press (2003)
Reference
  Authors
Zlotnik A, Yoshie O.
  Title
Chemokines: a new classification system and their role in immunity.
  Journal
Immunity 12:121-7 (2000)
Reference
  Authors
Ozaki K, Leonard WJ.
  Title
Cytokine and cytokine receptor pleiotropy and redundancy.
  Journal
J Biol Chem 277:29355-8 (2002)
Reference
  Authors
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW.
  Title
Signaling through the JAK/STAT pathway, recent advances and future challenges.
  Journal
Gene 285:1-24 (2002)
Reference
  Authors
Li X, Eriksson U.
  Title
Novel PDGF family members: PDGF-C and PDGF-D.
  Journal
Cytokine Growth Factor Rev 14:91-8 (2003)
Reference
  Authors
Li X, Eriksson U.
  Title
Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D.
  Journal
Int J Biochem Cell Biol 33:421-6 (2001)
Reference
  Authors
Zachary I, Gliki G.
  Title
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.
  Journal
Cardiovasc Res 49:568-81 (2001)
Reference
  Authors
Dey A, She H, Kim L, Boruch A, Guris DL, Carlberg K, Sebti SM, Woodley DT, Imamoto A, Li W.
  Title
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.
  Journal
Mol Biol Cell 11:3835-48 (2000)
Reference
  Authors
Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB.
  Title
Interleukin-10 and related cytokines and receptors.
  Journal
Annu Rev Immunol 22:929-79 (2004)
Reference
  Authors
Bodmer JL, Schneider P, Tschopp J.
  Title
The molecular architecture of the TNF superfamily.
  Journal
Trends Biochem Sci 27:19-26 (2002)
Reference
PMID:9395284
  Authors
Derynck R, Feng XH.
  Title
TGF-beta receptor signaling.
  Journal
Biochim Biophys Acta 1333:F105-50 (1997)
Reference
PMID:7791754
  Authors
Liu F, Ventura F, Doody J, Massague J.
  Title
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
  Journal
Mol Cell Biol 15:3479-86 (1995)
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)
Reference
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
Reference
  Authors
Moseley TA, Haudenschild DR, Rose L, Reddi AH.
  Title
Interleukin-17 family and IL-17 receptors.
  Journal
Cytokine Growth Factor Rev 14:155-74 (2003)
Reference
  Authors
Martin MU, Wesche H.
  Title
Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family.
  Journal
Biochim Biophys Acta 1592:265-80 (2002)
Reference
PMID:9862719
  Authors
Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU.
  Title
The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.
  Journal
J Immunol 161:6871-7 (1998)
KO pathway
 

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