Entry
Name
Cytokine-cytokine receptor interaction - Pan troglodytes (chimpanzee)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
ptr04060 Cytokine-cytokine receptor interaction
Organism
Pan troglodytes (chimpanzee) [GN:
ptr ]
Gene
100551503 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
100551504 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
100615583 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
100616505 IL11RA; interleukin-11 receptor subunit alpha isoform X2 [KO:K05056 ]
101059843 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
104003794 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X2 [KO:K05151 ]
107967131 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
107968771 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
107969654 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
449574 PL-D; LOW QUALITY PROTEIN: placental lactogen PL-D [KO:K05438 ]
450124 CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454 ]
450128 CCR5; C-C chemokine receptor type 5 isoform X1 [KO:K04180 ]
450884 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
451580 IL10RA; interleukin-10 receptor subunit alpha isoform X2 [KO:K05134 ]
451595 CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190 ]
451778 LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159 ]
452480 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X2 [KO:K05155 ]
453054 TGFB3; transforming growth factor beta-3 proprotein isoform X2 [KO:K13377 ]
454005 IL4R; interleukin-4 receptor subunit alpha isoform X5 [KO:K05071 ]
454006 IL21R; interleukin-21 receptor isoform X3 [KO:K05075 ]
454451 CXCL16; C-X-C motif chemokine 16 isoform X2 [KO:K10035 ]
454641 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
454654 CCR7; C-C chemokine receptor type 7 isoform X2 [KO:K04182 ]
455206 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
455851 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
456060 TGFB1; transforming growth factor beta-1 proprotein isoform X3 [KO:K13375 ]
456370 IL27RA; interleukin-27 receptor subunit alpha [KO:K19598 ]
456628 IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140 ]
456756 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
457127 CSF1; macrophage colony-stimulating factor 1 isoform X5 [KO:K05453 ]
457185 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
457221 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
457742 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
457960 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
457968 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X2 [KO:K05141 ]
458357 BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621 ]
458629 IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164 ]
458802 CSF2RB; cytokine receptor common subunit beta isoform X2 [KO:K04738 ]
459460 IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386 ]
459463 IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173 ]
459501 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
460122 ACKR3; atypical chemokine receptor 3 isoform X1 [KO:K04304 ]
460158 IL17RE; interleukin-17 receptor E isoform X1 [KO:K05168 ]
460159 IL17RC; interleukin-17 receptor C isoform X2 [KO:K05166 ]
460451 IL17RB; interleukin-17 receptor B isoform X1 [KO:K05165 ]
460816 IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406 ]
460852 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
460935 IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723 ]
461866 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
461908 OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057 ]
461922 IL7R; interleukin-7 receptor subunit alpha isoform X2 [KO:K05072 ]
462749 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
462787 BMP5; bone morphogenetic protein 5 isoform X2 [KO:K04663 ]
463026 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
464351 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
464686 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
466703 RELT; tumor necrosis factor receptor superfamily member 19L isoform X5 [KO:K05156 ]
466934 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
467323 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
467353 TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X2 [KO:K05473 ]
467905 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
468560 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X4 [KO:K05147 ]
468687 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
469224 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X2 [KO:K05138 ]
469348 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
469506 IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055 ]
469584 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
469586 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X3 [KO:K05469 ]
470077 IFNGR2; interferon gamma receptor 2 isoform X2 [KO:K05133 ]
470203 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
470455 IL1R2; interleukin-1 receptor type 2 isoform X5 [KO:K04387 ]
470456 IL1RL2; interleukin-1 receptor-like 2 isoform X1 [KO:K05172 ]
470605 MSTN; growth/differentiation factor 8 precursor [KO:K05497 ]
470644 CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050 ]
470645 CXCR1; C-X-C chemokine receptor type 1 isoform X1 [KO:K04175 ]
470795 CCR8; C-C chemokine receptor type 8 isoform X2 [KO:K04183 ]
470808 CCR9; C-C chemokine receptor type 9 isoform X2 [KO:K04184 ]
471545 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
471627 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
472713 TNFRSF10C; tumor necrosis factor receptor superfamily member 10C [KO:K22701 ]
472715 TNFRSF10D; tumor necrosis factor receptor superfamily member 10D [KO:K22702 ]
473218 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X2 [KO:K05059 ]
473468 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
473648 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
473965 IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131 ]
473966 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
735671 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X2 [KO:K05076 ]
735810 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
737135 EBI3; interleukin-27 subunit beta isoform X3 [KO:K24476 ]
737202 TSLP; thymic stromal lymphopoietin isoform X2 [KO:K05436 ]
737582 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
738190 TNFSF18; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
738192 IL15RA; interleukin-15 receptor subunit alpha isoform X4 [KO:K05074 ]
738331 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
738797 LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058 ]
739195 CXCL11; C-X-C motif chemokine 11 isoform X1 [KO:K12672 ]
739315 CSH1; chorionic somatomammotropin hormone 1 precursor [KO:K05438 ]
741172 IL36RN; interleukin-36 receptor antagonist protein [KO:K05483 ]
741567 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X3 [KO:K05154 ]
741624 CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031 ]
742595 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
742898 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X4 [KO:K04722 ]
743159 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722 ]
744045 IL23R; interleukin-23 receptor isoform X1 [KO:K05065 ]
744277 IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174 ]
744388 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
746029 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
747276 IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132 ]
749145 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X3 [KO:K05160 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway