KEGG PATHWAY: ptr04060

PATHWAY: ptr04060

Entry

ptr04060 Pathway

Name

Cytokine-cytokine receptor interaction - Pan troglodytes (chimpanzee)

Description

Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.

Class

Environmental Information Processing; Signaling molecules and interaction

Pathway map

ptr04060

Cytokine-cytokine receptor interaction

Organism

Pan troglodytes (chimpanzee) [GN:ptr]

Gene

739778	PPBPL1; pro-platelet basic protein-like 1 [KO:K10029]
740420	PPBP; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) [KO:K10029]
471205	IL8; interleukin 8 [KO:K10030]
471200	CXCL9; chemokine (C-X-C motif) ligand 9 [KO:K05416]
461242	CXCL10; chemokine (C-X-C motif) ligand 10 [KO:K12671]
739195	CXCL11; chemokine (C-X-C motif) ligand 11 [KO:K12672]
741624	uncharacterized LOC741624; K10031 C-X-C motif chemokine 12 [KO:K10031]
738275	CXCL13; chemokine (C-X-C motif) ligand 13 [KO:K10032]
454451	CXCL16; chemokine (C-X-C motif) ligand 16 [KO:K10035]
740477	PF4; platelet factor 4 [KO:K05407]
740621	PF4V1; platelet factor 4 variant 1 [KO:K05407]
471640	CXCL14; chemokine (C-X-C motif) ligand 14 [KO:K10033]
454115	CX3CL1; chemokine (C-X3-C motif) ligand 1 [KO:K05508]
459991	CCL20; chemokine (C-C motif) ligand 20 [KO:K14625]
743059	CCL25; chemokine (C-C motif) ligand 25 [KO:K13072]
473220	CCL19; chemokine (C-C motif) ligand 19 [KO:K05512]
746205	CCL21; chemokine (C-C motif) ligand 21 [KO:K16062]
748205	CCL2; chemokine (C-C motif) ligand 2 [KO:K14624]
454593	CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
455004	CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
749913	c-C motif chemokine 3-like 1-like; K05408 C-C motif chemokine 3 [KO:K05408]
454592	CCL3; chemokine (C-C motif) ligand 3 [KO:K05408]
748142	CCL13; chemokine (C-C motif) ligand 13 [KO:K16595]
454579	CCL7; chemokine (C-C motif) ligand 7 [KO:K05509]
747004	CCL5; chemokine (C-C motif) ligand 5 [KO:K12499]
468209	CCL8; chemokine (C-C motif) ligand 8 [KO:K16596]
468208	CCL11; chemokine (C-C motif) ligand 11 [KO:K16597]
735978	CCL28; chemokine (C-C motif) ligand 28 [KO:K05513]
100610389	CCL27; chemokine (C-C motif) ligand 27 [KO:K16598]
463288	IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
736204	IL11; interleukin 11 [KO:K05417]
736338	OSM; oncostatin M [KO:K05418]
736309	LIF; leukemia inhibitory factor [KO:K05419]
100610090	CNTF; ciliary neurotrophic factor [KO:K05420]
467955	CTF1; cardiotrophin 1 [KO:K05422]
454641	CSF3; colony stimulating factor 3 (granulocyte) [KO:K05423]
449638	LEP; leptin [KO:K05424]
449565	IL4; interleukin 4 [KO:K05430]
449564	IL13; interleukin 13 [KO:K05435]
460816	IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [KO:K05406]
471723	IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [KO:K05425]
467036	IL23A; interleukin 23, alpha subunit p19 [KO:K05426]
471627	CSF2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
471626	IL3; interleukin 3 (colony-stimulating factor, multiple) [KO:K04736]
743963	IL5; interleukin 5 (colony-stimulating factor, eosinophil) [KO:K05428]
461472	IL2; interleukin 2 [KO:K05429]
464245	IL7; interleukin 7 [KO:K05431]
745517	IL9; interleukin 9 [KO:K05432]
737808	IL15; interleukin 15 [KO:K05433]
471295	IL21; interleukin 21 [KO:K05434]
737202	TSLP; thymic stromal lymphopoietin [KO:K05436]
463609	EPO; erythropoietin [KO:K05437]
462468	PRL; prolactin [KO:K05439]
470287	TPO; thyroid peroxidase [KO:K00431] [EC:1.11.1.8]
741897	VEGFB; vascular endothelial growth factor B [KO:K16858]
471358	VEGFC; vascular endothelial growth factor C [KO:K05449]
465508	FIGF; c-fos induced growth factor (vascular endothelial growth factor D) [KO:K05449]
463503	HGF; hepatocyte growth factor (hepapoietin A [KO:K05460]
461435	EGF; epidermal growth factor [KO:K04357]
457127	CSF1; colony stimulating factor 1 (macrophage) [KO:K05453]
452114	KITLG; KIT ligand [KO:K05461]
100610021	FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
473185	IFNA21; interferon, alpha 21 [KO:K05414]
473193	IFNA14; interferon, alpha 14 [KO:K05414]
473196	IFNA6; interferon, alpha 6 [KO:K05414]
473198	IFNA2; interferon, alpha 2 [KO:K05414]
473199	IFNA8; interferon, alpha 8 [KO:K05414]
741890	IFNA4; interferon, alpha 4 [KO:K05414]
741660	IFNA17; interferon, alpha 17 [KO:K05414]
473195	IFNA5; interferon, alpha 5 [KO:K05414]
741747	IFNA7; interferon, alpha 7 [KO:K05414]
742651	IFNA13; interferon, alpha 13 [KO:K05414]
741978	IFNA16; interferon, alpha 16 [KO:K05414]
744748	IFNA4; interferon, alpha 4 [KO:K05414]
473191	interferon alpha-17-like; K05414 interferon alpha [KO:K05414]
473183	IFNB1; interferon, beta 1, fibroblast [KO:K05415]
473184	IFNW1; interferon, omega 1 [KO:K05440]
473120	IFNK; interferon, kappa [KO:K05441]
473203	IFNE; interferon, epsilon [KO:K05442]
449517	IFNG; interferon, gamma [KO:K04687]
469657	IL10; interleukin 10 [KO:K05443]
741423	IL22; interleukin 22 [KO:K05445]
741377	IL26; interleukin 26 [KO:K05446]
473468	TNFSF15; tumor necrosis factor (ligand) superfamily, member 15 [KO:K05478]
460852	TNFSF10; tumor necrosis factor (ligand) superfamily, member 10 [KO:K04721]
467353	TNFSF11; tumor necrosis factor (ligand) superfamily, member 11 [KO:K05473]
100551503	TNFSF12; tumor necrosis factor (ligand) superfamily, member 12 [KO:K05474]
494186	TNF; tumor necrosis factor [KO:K03156]
494185	LTA; lymphotoxin alpha (TNF superfamily, member 1) [KO:K05468]
744486	LTB; lymphotoxin beta (TNF superfamily, member 3) [KO:K03157]
468687	TNFSF14; tumor necrosis factor (ligand) superfamily, member 14 [KO:K05477]
469584	FASLG; Fas ligand (TNF superfamily, member 6) [KO:K04389]
473802	CD40LG; CD40 ligand [KO:K03161]
464686	TNFSF8; tumor necrosis factor (ligand) superfamily, member 8 [KO:K05471]
469586	TNFSF4; tumor necrosis factor (ligand) superfamily, member 4 [KO:K05469]
738190	TNFSF18; tumor necrosis factor (ligand) superfamily, member 18 [KO:K05479]
100551504	TNFSF13; tumor necrosis factor (ligand) superfamily, member 13 [KO:K05475]
467323	TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b [KO:K05476]
473652	EDA; ectodysplasin A [KO:K05480]
101058344	ectodysplasin-A-like; K05480 ectodysplasin-A [KO:K05480]
456060	TGFB1; transforming growth factor, beta 1 [KO:K13375]
457742	TGFB2; transforming growth factor, beta 2 [KO:K13376]
453054	TGFB3; transforming growth factor, beta 3 [KO:K13377]
100608039	AMH; anti-Mullerian hormone [KO:K04665]
458357	BMP7; bone morphogenetic protein 7 [KO:K16621]
472029	IL17A; interleukin 17A [KO:K05489]
741839	IL17B; interleukin 17B [KO:K05490]
467404	IL25; interleukin 25 [KO:K05493]
470485	IL1A; interleukin 1, alpha [KO:K04383]
450200	IL1B; interleukin 1, beta [KO:K04519]
739011	IL18; interleukin 18 (interferon-gamma-inducing factor) [KO:K05482]
470644	CXCR2; chemokine (C-X-C motif) receptor 2 [KO:K05050]
470645	CXCR1; chemokine (C-X-C motif) receptor 1 [KO:K04175]
465704	CXCR3; chemokine (C-X-C motif) receptor 3 [KO:K04188]
450130	CXCR4; chemokine (C-X-C motif) receptor 4 [KO:K04189]
451595	CXCR5; chemokine (C-X-C motif) receptor 5 [KO:K04190]
450138	CXCR6; chemokine (C-X-C motif) receptor 6 [KO:K04191]
460122	CXCR7; chemokine (C-X-C motif) receptor 7 [KO:K04304]
460321	XCR1; chemokine (C motif) receptor 1 [KO:K04193]
460281	CX3CR1; chemokine (C-X3-C motif) receptor 1 [KO:K04192]
470795	CCR8; chemokine (C-C motif) receptor 8 [KO:K04183]
100612069	CCR6; chemokine (C-C motif) receptor 6 [KO:K04181]
470808	CCR9; chemokine (C-C motif) receptor 9 [KO:K04184]
470781	CCR4; chemokine (C-C motif) receptor 4 [KO:K04179]
454654	CCR7; chemokine (C-C motif) receptor 7 [KO:K04182]
740071	CCR2; chemokine (C-C motif) receptor 2 [KO:K04177]
450128	CCR5; chemokine (C-C motif) receptor 5 [KO:K04180]
460323	CCR1; chemokine (C-C motif) receptor 1 [KO:K04176]
470810	CCR3; chemokine (C-C motif) receptor 3 [KO:K04178]
741917	CCR10; chemokine (C-C motif) receptor 10 [KO:K04185]
469506	IL6R; interleukin 6 receptor [KO:K05055]
461866	IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor) [KO:K05060]
100616505	IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
738797	LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
461908	OSMR; oncostatin M receptor [KO:K05057]
473218	CNTFR; ciliary neurotrophic factor receptor [KO:K05059]
456756	CSF3R; colony stimulating factor 3 receptor (granulocyte) [KO:K05061]
456919	LEPR; leptin receptor [KO:K05062]
454005	IL4R; interleukin 4 receptor [KO:K05071]
735671	IL13RA1; interleukin 13 receptor, alpha 1 [KO:K05076]
455851	IL12RB1; interleukin 12 receptor, beta 1 [KO:K05063]
469348	IL12RB2; interleukin 12 receptor, beta 2 [KO:K05064]
744045	IL23R; interleukin 23 receptor [KO:K05065]
746936	CSF2RA; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [KO:K05066]
458802	CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [KO:K04738]
751052	IL3RA; interleukin 3 receptor, alpha (low affinity) [KO:K04737]
737582	IL5RA; interleukin 5 receptor, alpha [KO:K05067]
450884	IL2RA; interleukin 2 receptor, alpha [KO:K05068]
470203	IL2RB; interleukin 2 receptor, beta [KO:K05069]
465692	CXHXorf65; interleukin 2 receptor, gamma [KO:K05070]
101059843	cytokine receptor common subunit gamma-like; K05070 interleukin 2 receptor gamma [KO:K05070]
461922	IL7R; interleukin 7 receptor [KO:K05072]
741980	IL9R; interleukin 9 receptor [KO:K05073]
738192	IL15RA; interleukin 15 receptor, alpha [KO:K05074]
454006	IL21R; interleukin 21 receptor [KO:K05075]
749701	cytokine receptor-like factor 2-like; K05078 thymic stromal-derived lymphopoietin receptor [KO:K05078]
749758	CRLF2; cytokine receptor-like factor 2 [KO:K05078]
455728	EPOR; erythropoietin receptor [KO:K05079]
471560	GHR; growth hormone receptor [KO:K05080]
461925	PRLR; prolactin receptor [KO:K05081]
747522	MPL; myeloproliferative leukemia virus oncogene [KO:K05082]
461318	PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
462188	PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
452512	FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) [KO:K05096] [EC:2.7.10.1]
461315	KDR; kinase insert domain receptor (a type III receptor tyrosine kinase) [KO:K05098] [EC:2.7.10.1]
462339	FLT4; fms-related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
463671	MET; met proto-oncogene (hepatocyte growth factor receptor) [KO:K05099] [EC:2.7.10.1]
463415	EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
462187	CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
461316	KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [KO:K05091] [EC:2.7.10.1]
452508	FLT3; fms-related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
458516	IFNAR1; interferon (alpha, beta and omega) receptor 1 [KO:K05130]
473965	IFNAR2; interferon (alpha, beta and omega) receptor 2 [KO:K05131]
747276	IFNGR1; interferon gamma receptor 1 [KO:K05132]
470077	IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1) [KO:K05133]
451580	IL10RA; interleukin 10 receptor, alpha [KO:K05134]
473966	IL10RB; interleukin 10 receptor, beta [KO:K05135]
463026	IL20RA; interleukin 20 receptor, alpha [KO:K05136]
742595	IL20RB; interleukin 20 receptor beta [KO:K05137]
469224	IL22RA1; interleukin 22 receptor, alpha 1 [KO:K05138]
472133	IL22RA2; interleukin 22 receptor, alpha 2 [KO:K05139]
456628	IL28RA; interleukin 28 receptor, alpha (interferon, lambda receptor) [KO:K05140]
464351	TNFRSF11B; tumor necrosis factor receptor superfamily, member 11b [KO:K05148]
468560	TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator [KO:K05147]
749145	TNFRSF25; tumor necrosis factor receptor superfamily, member 25 [KO:K05160]
747558	TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A [KO:K05149]
462749	TNFRSF21; tumor necrosis factor receptor superfamily, member 21 [KO:K05157]
455206	NGFR; nerve growth factor receptor [KO:K02583]
457968	TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B [KO:K05141]
466934	TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
451778	LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3) [KO:K03159]
457221	TNFRSF14; tumor necrosis factor receptor superfamily, member 14 [KO:K05152]
746784	TNFRSF6B; tumor necrosis factor receptor superfamily, member 6b, decoy [KO:K05143]
738331	FAS; Fas (TNF receptor superfamily, member 6) [KO:K04390]
100615583	CD40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
451780	CD27; CD27 molecule [KO:K05144]
457960	TNFRSF8; tumor necrosis factor receptor superfamily, member 8 [KO:K05145]
746029	TNFRSF9; tumor necrosis factor receptor superfamily, member 9 [KO:K05146]
457185	TNFRSF4; tumor necrosis factor receptor superfamily, member 4 [KO:K05142]
741567	TNFRSF18; tumor necrosis factor receptor superfamily, member 18 [KO:K05154]
467905	TNFRSF17; tumor necrosis factor receptor superfamily, member 17 [KO:K05153]
744388	TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B [KO:K05150]
746611	TNFRSF13C; tumor necrosis factor receptor superfamily, member 13C [KO:K05151]
735810	EDAR; ectodysplasin A receptor [KO:K05162]
473648	EDA2R; ectodysplasin A2 receptor [KO:K05163]
452480	TNFRSF19; tumor necrosis factor receptor superfamily, member 19 [KO:K05155]
466703	RELT; RELT tumor necrosis factor receptor [KO:K05156]
460243	TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
472992	TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
459646	ACVR2A; activin A receptor, type IIA [KO:K04670] [EC:2.7.11.30]
460271	ACVR2B; activin A receptor, type IIB [KO:K13596] [EC:2.7.11.30]
470565	ACVR1; activin A receptor, type I [KO:K04675] [EC:2.7.11.30]
451911	ACVR1B; activin A receptor, type IB [KO:K13567] [EC:2.7.11.30]
467005	AMHR2; anti-Mullerian hormone receptor, type II [KO:K04672] [EC:2.7.11.30]
459885	BMPR2; bone morphogenetic protein receptor, type II (serine/threonine kinase) [KO:K04671] [EC:2.7.11.30]
450572	BMPR1A; bone morphogenetic protein receptor, type IA [KO:K04673] [EC:2.7.11.30]
461683	BMPR1B; bone morphogenetic protein receptor, type IB [KO:K13578] [EC:2.7.11.30]
458629	IL17RA; interleukin 17 receptor A [KO:K05164]
460451	IL17RB; interleukin 17 receptor B [KO:K05165]
459460	IL1R1; interleukin 1 receptor, type I [KO:K04386]
460935	IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
470455	IL1R2; interleukin 1 receptor, type II [KO:K04387]
459463	IL18R1; interleukin 18 receptor 1 [KO:K05173]
744277	IL18RAP; interleukin 18 receptor accessory protein [KO:K05174]

Reference

Authors

Oppenheim JJ, Feldman M (ed).

Title

Cytokine Reference

Journal

Academic Press (2001)

Reference

Authors

Thomson AW, Lotze MT (ed).

Title

The Cytokine Handbook (Fourth edition)

Journal

Academic Press (2003)

Reference

PMID:10714678

Authors

Zlotnik A, Yoshie O.

Title

Chemokines: a new classification system and their role in immunity.

Journal

Immunity 12:121-7 (2000)

Reference

PMID:12072446

Authors

Ozaki K, Leonard WJ.

Title

Cytokine and cytokine receptor pleiotropy and redundancy.

Journal

J Biol Chem 277:29355-8 (2002)

Reference

PMID:12039028

Authors

Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW.

Title

Signaling through the JAK/STAT pathway, recent advances and future challenges.

Journal

Gene 285:1-24 (2002)

Reference

PMID:12651221

Authors

Li X, Eriksson U.

Title

Novel PDGF family members: PDGF-C and PDGF-D.

Journal

Cytokine Growth Factor Rev 14:91-8 (2003)

Reference

PMID:11312110

Authors

Li X, Eriksson U.

Title

Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D.

Journal

Int J Biochem Cell Biol 33:421-6 (2001)

Reference

PMID:11166270

Authors

Zachary I, Gliki G.

Title

Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.

Journal

Cardiovasc Res 49:568-81 (2001)

Reference

PMID:11071910

Authors

Dey A, She H, Kim L, Boruch A, Guris DL, Carlberg K, Sebti SM, Woodley DT, Imamoto A, Li W.

Title

Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.

Journal

Mol Biol Cell 11:3835-48 (2000)

Reference

PMID:15032600

Authors

Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB.

Title

Interleukin-10 and related cytokines and receptors.

Journal

Annu Rev Immunol 22:929-79 (2004)

Reference

PMID:11796220

Authors

Bodmer JL, Schneider P, Tschopp J.

Title

The molecular architecture of the TNF superfamily.

Journal

Trends Biochem Sci 27:19-26 (2002)

Reference

PMID:9395284

Authors

Derynck R, Feng XH.

Title

TGF-beta receptor signaling.

Journal

Biochim Biophys Acta 1333:F105-50 (1997)

Reference

PMID:7791754

Authors

Liu F, Ventura F, Doody J, Massague J.

Title

Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.

Journal

Mol Cell Biol 15:3479-86 (1995)

Reference

PMID:9759503

Authors

Massague J.

Title

TGF-beta signal transduction.

Journal

Annu Rev Biochem 67:753-91 (1998)

Reference

PMID:11252892

Authors

Massague J.

Title

How cells read TGF-beta signals.

Journal

Nat Rev Mol Cell Biol 1:169-78 (2000)

Reference

PMID:12651226

Authors

Moseley TA, Haudenschild DR, Rose L, Reddi AH.

Title

Interleukin-17 family and IL-17 receptors.

Journal

Cytokine Growth Factor Rev 14:155-74 (2003)

Reference

PMID:12421671

Authors

Martin MU, Wesche H.

Title

Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family.

Journal

Biochim Biophys Acta 1592:265-80 (2002)

Reference

PMID:9862719

Authors

Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU.

Title

The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.

Journal

J Immunol 161:6871-7 (1998)

KO pathway

ko04060

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Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (267)   
   KEGG GENES (267)   
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