KEGG PATHWAY: ptr04060

PATHWAY: ptr04060

Entry

ptr04060 Pathway

Name

Cytokine-cytokine receptor interaction - Pan troglodytes (chimpanzee)

Description

Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.

Class

Environmental Information Processing; Signaling molecules and interaction

Pathway map

ptr04060

Cytokine-cytokine receptor interaction

Organism

Pan troglodytes (chimpanzee) [GN:ptr]

Gene

740420	PPBP; pro-platelet basic protein [KO:K10029]
471205	CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
471200	CXCL9; C-X-C motif chemokine ligand 9 [KO:K05416]
461242	CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
739195	CXCL11; C-X-C motif chemokine ligand 11 [KO:K12672]
741624	CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
738275	CXCL13; C-X-C motif chemokine ligand 13 [KO:K10032]
454451	CXCL16; C-X-C motif chemokine ligand 16 [KO:K10035]
740477	PF4; platelet factor 4 [KO:K05407]
740621	PF4V1; platelet factor 4 variant 1 [KO:K05407]
471640	CXCL14; C-X-C motif chemokine ligand 14 [KO:K10033]
454115	CX3CL1; C-X3-C motif chemokine ligand 1 [KO:K05508]
748131	CCL1; C-C motif chemokine ligand 1 [KO:K05514]
459991	CCL20; C-C motif chemokine ligand 20 [KO:K14625]
743059	CCL25; C-C motif chemokine ligand 25 [KO:K13072]
467985	CCL17; C-C motif chemokine ligand 17 [KO:K21083]
736543	CCL22; C-C motif chemokine ligand 22 [KO:K21095]
473220	CCL19; C-C motif chemokine ligand 19 [KO:K05512]
746205	CCL21; C-C motif chemokine ligand 21 [KO:K16062]
748205	CCL2; C-C motif chemokine ligand 2 [KO:K14624]
454593	CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
455004	CCL4L2; C-C motif chemokine 4 [KO:K12964]
454592	CCL3; chemokine (C-C motif) ligand 3 [KO:K05408]
749948	C-C motif chemokine 3-like [KO:K05408]
748142	CCL13; C-C motif chemokine ligand 13 [KO:K16595]
454579	CCL7; C-C motif chemokine ligand 7 [KO:K05509]
747004	CCL5; C-C motif chemokine ligand 5 [KO:K12499]
747591	CCL14; C-C motif chemokine ligand 14 [KO:K21092]
455038	CCL16; C-C motif chemokine ligand 16 [KO:K21093]
468209	CCL8; C-C motif chemokine ligand 8 [KO:K16596]
468208	CCL11; C-C motif chemokine ligand 11 [KO:K16597]
472418	CCL24; C-C motif chemokine ligand 24 [KO:K21097]
107966232	C-C motif chemokine 24 [KO:K21097]
472417	CCL26; C-C motif chemokine ligand 26 [KO:K21096]
735978	CCL28; C-C motif chemokine ligand 28 [KO:K05513]
100610389	CCL27; C-C motif chemokine ligand 27 [KO:K16598]
468224	CCL18; C-C motif chemokine ligand 18 [KO:K21094]
463288	IL6; interleukin 6 [KO:K05405]
107971706	interleukin-6 [KO:K05405]
736204	IL11; interleukin 11 [KO:K05417]
736338	OSM; oncostatin M [KO:K05418]
736309	LIF; leukemia inhibitory factor [KO:K05419]
100610090	CNTF; ciliary neurotrophic factor [KO:K05420]
107967131	CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
467955	CTF1; cardiotrophin 1 [KO:K05422]
454641	CSF3; colony stimulating factor 3 [KO:K05423]
449638	LEP; leptin [KO:K05424]
449565	IL4; interleukin 4 [KO:K05430]
449564	IL13; interleukin 13 [KO:K05435]
107974854	interleukin-13 [KO:K05435]
460816	IL12A; interleukin 12A [KO:K05406]
471723	IL12B; interleukin 12B [KO:K05425]
467036	IL23A; interleukin 23 subunit alpha [KO:K05426]
471627	CSF2; colony stimulating factor 2 [KO:K05427]
471626	IL3; interleukin 3 [KO:K04736]
743963	IL5; interleukin 5 [KO:K05428]
107966390	interleukin-5 [KO:K05428]
461472	IL2; interleukin 2 [KO:K05429]
464245	IL7; interleukin 7 [KO:K05431]
745517	IL9; interleukin 9 [KO:K05432]
737808	IL15; interleukin 15 [KO:K05433]
471295	IL21; interleukin 21 [KO:K05434]
737202	TSLP; thymic stromal lymphopoietin [KO:K05436]
463609	EPO; erythropoietin [KO:K05437]
107966164	erythropoietin [KO:K05437]
462468	PRL; prolactin [KO:K05439]
736549	THPO; thrombopoietin [KO:K06854]
740202	PDGFA; platelet derived growth factor subunit A [KO:K04359]
458844	PDGFB; platelet derived growth factor subunit B [KO:K17386]
736875	VEGFA; vascular endothelial growth factor A [KO:K05448]
741897	VEGFB; vascular endothelial growth factor B [KO:K16858]
471358	VEGFC; vascular endothelial growth factor C [KO:K05449]
465508	VEGFD; vascular endothelial growth factor D [KO:K05449]
463503	HGF; hepatocyte growth factor [KO:K05460]
461435	EGF; epidermal growth factor [KO:K04357]
457127	CSF1; colony stimulating factor 1 [KO:K05453]
452114	KITLG; KIT ligand [KO:K05461]
100610021	FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
473185	IFNA21; interferon alpha 21 [KO:K05414]
473193	IFNA14; interferon alpha 14 [KO:K05414]
473196	IFNA6; interferon alpha 6 [KO:K05414]
473198	IFNA2; interferon alpha 2 [KO:K05414]
473199	IFNA8; interferon alpha 8 [KO:K05414]
741660	IFNA17; interferon alpha-17 [KO:K05414]
473195	IFNA5; interferon alpha 5 [KO:K05414]
741747	IFNA7; interferon alpha-7 [KO:K05414]
742651	IFNA13; interferon alpha-1/13 [KO:K05414]
741978	IFNA16; interferon alpha-16 [KO:K05414]
744748	interferon alpha-17 [KO:K05414]
473191	interferon alpha-17 [KO:K05414]
473183	IFNB1; interferon beta 1 [KO:K05415]
473184	IFNW1; interferon omega 1 [KO:K05440]
473120	IFNK; interferon kappa [KO:K05441]
473203	IFNE; interferon epsilon [KO:K05442]
449517	IFNG; interferon gamma [KO:K04687]
469657	IL10; interleukin 10 [KO:K05443]
741423	IL22; interleukin 22 [KO:K05445]
741377	IL26; interleukin 26 [KO:K05446]
473468	TNFSF15; tumor necrosis factor superfamily member 15 [KO:K05478]
460852	TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
467353	TNFSF11; tumor necrosis factor superfamily member 11 [KO:K05473]
100551503	TNFSF12; tumor necrosis factor superfamily member 12 [KO:K05474]
494186	TNF; tumor necrosis factor [KO:K03156]
494185	LTA; lymphotoxin alpha [KO:K05468]
744486	LTB; lymphotoxin beta [KO:K03157]
468687	TNFSF14; tumor necrosis factor superfamily member 14 [KO:K05477]
469584	FASLG; Fas ligand [KO:K04389]
473802	CD40LG; CD40 ligand [KO:K03161]
100615857	CD70; CD70 molecule [KO:K05470]
464686	TNFSF8; tumor necrosis factor superfamily member 8 [KO:K05471]
107969654	TNFSF9; tumor necrosis factor superfamily member 9 [KO:K05472]
469586	TNFSF4; tumor necrosis factor superfamily member 4 [KO:K05469]
738190	TNFSF18; tumor necrosis factor superfamily member 18 [KO:K05479]
100551504	TNFSF13; tumor necrosis factor superfamily member 13 [KO:K05475]
467323	TNFSF13B; tumor necrosis factor superfamily member 13b [KO:K05476]
101058344	EDA; ectodysplasin A [KO:K05480]
456060	TGFB1; transforming growth factor beta 1 [KO:K13375]
457742	TGFB2; transforming growth factor beta 2 [KO:K13376]
453054	TGFB3; transforming growth factor beta 3 [KO:K13377]
100608039	AMH; anti-Mullerian hormone [KO:K04665]
458090	BMP2; bone morphogenetic protein 2 [KO:K21283]
458357	BMP7; bone morphogenetic protein 7 [KO:K16621]
458202	GDF5; growth differentiation factor 5 [KO:K04664]
470485	IL1A; interleukin 1 alpha [KO:K04383]
450200	IL1B; interleukin 1 beta [KO:K04519]
739011	IL18; interleukin 18 [KO:K05482]
467404	IL25; interleukin 25 [KO:K05493]
472029	IL17A; interleukin 17A [KO:K05489]
472030	IL17F; interleukin 17F [KO:K05494]
468067	IL17C; interleukin 17C [KO:K05491]
741839	IL17B; interleukin 17B [KO:K05490]
467221	IL17D; interleukin 17D [KO:K05492]
470644	CXCR2; C-X-C motif chemokine receptor 2 [KO:K05050]
470645	CXCR1; C-X-C motif chemokine receptor 1 [KO:K04175]
465704	CXCR3; C-X-C motif chemokine receptor 3 [KO:K04188]
450130	CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
451595	CXCR5; C-X-C motif chemokine receptor 5 [KO:K04190]
450138	CXCR6; C-X-C motif chemokine receptor 6 [KO:K04191]
460122	ACKR3; atypical chemokine receptor 3 [KO:K04304]
460321	XCR1; X-C motif chemokine receptor 1 [KO:K04193]
460281	CX3CR1; C-X3-C motif chemokine receptor 1 [KO:K04192]
470795	CCR8; C-C motif chemokine receptor 8 [KO:K04183]
100612069	CCR6; C-C motif chemokine receptor 6 [KO:K04181]
470808	CCR9; C-C motif chemokine receptor 9 [KO:K04184]
470781	CCR4; C-C motif chemokine receptor 4 [KO:K04179]
454654	CCR7; C-C motif chemokine receptor 7 [KO:K04182]
740071	CCR2; C-C motif chemokine receptor 2 [KO:K04177]
450128	CCR5; C-C motif chemokine receptor 5 [KO:K04180]
460323	CCR1; C-C motif chemokine receptor 1 [KO:K04176]
470810	CCR3; C-C motif chemokine receptor 3 [KO:K04178]
741917	CCR10; C-C motif chemokine receptor 10 [KO:K04185]
469506	IL6R; interleukin 6 receptor [KO:K05055]
461866	IL6ST; interleukin 6 signal transducer [KO:K05060]
100616505	IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
738797	LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
461908	OSMR; oncostatin M receptor [KO:K05057]
473218	CNTFR; ciliary neurotrophic factor receptor [KO:K05059]
456756	CSF3R; colony stimulating factor 3 receptor [KO:K05061]
456919	LEPR; leptin receptor [KO:K05062]
454005	IL4R; interleukin 4 receptor [KO:K05071]
735671	IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076]
455851	IL12RB1; interleukin 12 receptor subunit beta 1 [KO:K05063]
469348	IL12RB2; interleukin 12 receptor subunit beta 2 [KO:K05064]
744045	IL23R; interleukin 23 receptor [KO:K05065]
746936	CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
458802	CSF2RB; colony stimulating factor 2 receptor beta common subunit [KO:K04738]
107972836	IL3RA; interleukin-3 receptor subunit alpha-like [KO:K04737]
107972835	interleukin-3 receptor subunit alpha-like [KO:K04737]
737582	IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
450884	IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
470203	IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
101059843	IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
461922	IL7R; interleukin 7 receptor [KO:K05072]
741980	IL9R; interleukin 9 receptor [KO:K05073]
738192	IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
454006	IL21R; interleukin 21 receptor [KO:K05075]
749758	CRLF2; cytokine receptor-like factor 2 [KO:K05078]
455728	EPOR; erythropoietin receptor [KO:K05079]
471560	GHR; growth hormone receptor [KO:K05080]
461925	PRLR; prolactin receptor [KO:K05081]
747522	MPL; MPL proto-oncogene, thrombopoietin receptor [KO:K05082]
461318	PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
462188	PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
452512	FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
461315	KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
462339	FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
463671	MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
463415	EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
462187	CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
461316	KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
452508	FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
458516	IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
107972530	interferon alpha/beta receptor 1 [KO:K05130]
473965	IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
747276	IFNGR1; interferon gamma receptor 1 [KO:K05132]
470077	IFNGR2; interferon gamma receptor 2 [KO:K05133]
451580	IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
473966	IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
107972528	interleukin-10 receptor subunit beta [KO:K05135]
463026	IL20RA; interleukin 20 receptor subunit alpha [KO:K05136]
742595	IL20RB; interleukin 20 receptor subunit beta [KO:K05137]
469224	IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138]
472133	IL22RA2; interleukin 22 receptor subunit alpha 2 [KO:K05139]
456628	IFNLR1; interferon lambda receptor 1 [KO:K05140]
464351	TNFRSF11B; TNF receptor superfamily member 11b [KO:K05148]
468560	TNFRSF11A; TNF receptor superfamily member 11a [KO:K05147]
749145	TNFRSF25; TNF receptor superfamily member 25 [KO:K05160]
747558	TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
107968771	TNFRSF12A; TNF receptor superfamily member 12A [KO:K05149]
462749	TNFRSF21; TNF receptor superfamily member 21 [KO:K05157]
455206	NGFR; nerve growth factor receptor [KO:K02583]
457968	TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
466934	TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
451778	LTBR; lymphotoxin beta receptor [KO:K03159]
457221	TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
746784	TNFRSF6B; regulator of telomere elongation helicase 1 [KO:K05143]
738331	FAS; Fas cell surface death receptor [KO:K04390]
100615583	CD40; CD40 molecule [KO:K03160]
451780	CD27; CD27 molecule [KO:K05144]
457960	TNFRSF8; TNF receptor superfamily member 8 [KO:K05145]
746029	TNFRSF9; TNF receptor superfamily member 9 [KO:K05146]
457185	TNFRSF4; TNF receptor superfamily member 4 [KO:K05142]
741567	TNFRSF18; TNF receptor superfamily member 18 [KO:K05154]
467905	TNFRSF17; TNF receptor superfamily member 17 [KO:K05153]
744388	TNFRSF13B; TNF receptor superfamily member 13B [KO:K05150]
104003794	TNFRSF13C; TNF receptor superfamily member 13C [KO:K05151]
735810	EDAR; ectodysplasin A receptor [KO:K05162]
473648	EDA2R; ectodysplasin A2 receptor [KO:K05163]
452480	TNFRSF19; TNF receptor superfamily member 19 [KO:K05155]
466703	RELT; RELT tumor necrosis factor receptor [KO:K05156]
460243	TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
472992	TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
459646	ACVR2A; activin A receptor type 2A [KO:K04670] [EC:2.7.11.30]
460271	ACVR2B; activin A receptor type 2B [KO:K13596] [EC:2.7.11.30]
470565	ACVR1; activin A receptor type 1 [KO:K04675] [EC:2.7.11.30]
451911	ACVR1B; activin A receptor type 1B [KO:K13567] [EC:2.7.11.30]
467005	AMHR2; anti-Mullerian hormone receptor type 2 [KO:K04672] [EC:2.7.11.30]
459885	BMPR2; bone morphogenetic protein receptor type 2 [KO:K04671] [EC:2.7.11.30]
450572	BMPR1A; bone morphogenetic protein receptor type 1A [KO:K04673] [EC:2.7.11.30]
461683	BMPR1B; bone morphogenetic protein receptor type 1B [KO:K13578] [EC:2.7.11.30]
459460	IL1R1; interleukin 1 receptor type 1 [KO:K04386]
460935	IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
470455	IL1R2; interleukin 1 receptor type 2 [KO:K04387]
459463	IL18R1; interleukin 18 receptor 1 [KO:K05173]
744277	IL18RAP; interleukin 18 receptor accessory protein [KO:K05174]
458629	IL17RA; interleukin 17 receptor A [KO:K05164]
460451	IL17RB; interleukin 17 receptor B [KO:K05165]
460159	IL17RC; interleukin 17 receptor C [KO:K05166]
460158	IL17RE; interleukin 17 receptor E [KO:K05168]

Reference

Authors

Oppenheim JJ, Feldman M (ed).

Title

Cytokine Reference

Journal

Academic Press (2001)

Reference

Authors

Thomson AW, Lotze MT (ed).

Title

The Cytokine Handbook (Fourth edition)

Journal

Academic Press (2003)

Reference

PMID:10714678

Authors

Zlotnik A, Yoshie O.

Title

Chemokines: a new classification system and their role in immunity.

Journal

Immunity 12:121-7 (2000)
DOI:10.1016/S1074-7613(00)80165-X

Reference

PMID:12072446

Authors

Ozaki K, Leonard WJ.

Title

Cytokine and cytokine receptor pleiotropy and redundancy.

Journal

J Biol Chem 277:29355-8 (2002)
DOI:10.1074/jbc.R200003200

Reference

PMID:12039028

Authors

Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW.

Title

Signaling through the JAK/STAT pathway, recent advances and future challenges.

Journal

Gene 285:1-24 (2002)
DOI:10.1016/S0378-1119(02)00398-0

Reference

PMID:12651221

Authors

Li X, Eriksson U.

Title

Novel PDGF family members: PDGF-C and PDGF-D.

Journal

Cytokine Growth Factor Rev 14:91-8 (2003)
DOI:10.1016/S1359-6101(02)00090-4

Reference

PMID:11312110

Authors

Li X, Eriksson U.

Title

Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D.

Journal

Int J Biochem Cell Biol 33:421-6 (2001)
DOI:10.1016/S1357-2725(01)00027-9

Reference

PMID:11166270

Authors

Zachary I, Gliki G.

Title

Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.

Journal

Cardiovasc Res 49:568-81 (2001)
DOI:10.1016/S0008-6363(00)00268-6

Reference

PMID:11071910

Authors

Dey A, She H, Kim L, Boruch A, Guris DL, Carlberg K, Sebti SM, Woodley DT, Imamoto A, Li W.

Title

Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.

Journal

Mol Biol Cell 11:3835-48 (2000)
DOI:10.1091/mbc.11.11.3835

Reference

PMID:15032600

Authors

Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB.

Title

Interleukin-10 and related cytokines and receptors.

Journal

Annu Rev Immunol 22:929-79 (2004)
DOI:10.1146/annurev.immunol.22.012703.104622

Reference

PMID:11796220

Authors

Bodmer JL, Schneider P, Tschopp J.

Title

The molecular architecture of the TNF superfamily.

Journal

Trends Biochem Sci 27:19-26 (2002)
DOI:10.1016/S0968-0004(01)01995-8

Reference

PMID:9395284

Authors

Derynck R, Feng XH.

Title

TGF-beta receptor signaling.

Journal

Biochim Biophys Acta 1333:F105-50 (1997)
DOI:10.1016/S0304-419X(97)00017-6

Reference

PMID:7791754

Authors

Liu F, Ventura F, Doody J, Massague J.

Title

Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.

Journal

Mol Cell Biol 15:3479-86 (1995)
DOI:10.1128/MCB.15.7.3479

Reference

PMID:9759503

Authors

Massague J.

Title

TGF-beta signal transduction.

Journal

Annu Rev Biochem 67:753-91 (1998)
DOI:10.1146/annurev.biochem.67.1.753

Reference

PMID:11252892

Authors

Massague J.

Title

How cells read TGF-beta signals.

Journal

Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051

Reference

PMID:12651226

Authors

Moseley TA, Haudenschild DR, Rose L, Reddi AH.

Title

Interleukin-17 family and IL-17 receptors.

Journal

Cytokine Growth Factor Rev 14:155-74 (2003)
DOI:10.1016/S1359-6101(03)00002-9

Reference

PMID:12421671

Authors

Martin MU, Wesche H.

Title

Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family.

Journal

Biochim Biophys Acta 1592:265-80 (2002)
DOI:10.1016/S0167-4889(02)00320-8

Reference

PMID:9862719

Authors

Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU.

Title

The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.

Journal

J Immunol 161:6871-7 (1998)

KO pathway

ko04060

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Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (249)   
   KEGG GENES (249)   
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