KEGG   PATHWAY: ptr04060Help
ptr04060                    Pathway                                

Cytokine-cytokine receptor interaction - Pan troglodytes (chimpanzee)
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
ptr04060  Cytokine-cytokine receptor interaction

Ortholog table
Pan troglodytes (chimpanzee) [GN:ptr]
740420  PPBP; platelet basic protein [KO:K10029]
471205  CXCL8; interleukin-8 [KO:K10030]
471200  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
461242  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
739195  CXCL11; C-X-C motif chemokine 11 isoform X1 [KO:K12672]
741624  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
738275  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
454451  CXCL16; C-X-C motif chemokine 16 isoform X1 [KO:K10035]
740477  PF4; platelet factor 4 [KO:K05407]
740621  PF4V1; platelet factor 4 variant [KO:K05407]
471640  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
454115  CX3CL1; fractalkine isoform X2 [KO:K05508]
748131  CCL1; C-C motif chemokine 1 [KO:K05514]
459991  CCL20; C-C motif chemokine 20 isoform X2 [KO:K14625]
743059  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
467985  CCL17; C-C motif chemokine 17 [KO:K21083]
736543  CCL22; C-C motif chemokine 22 [KO:K21095]
473220  CCL19; C-C motif chemokine 19 [KO:K05512]
746205  CCL21; C-C motif chemokine 21 isoform X2 [KO:K16062]
748205  CCL2; C-C motif chemokine 2 [KO:K14624]
454593  CCL4; C-C motif chemokine 4 [KO:K12964]
455004  C-C motif chemokine 4 isoform X2 [KO:K12964]
454592  CCL3; C-C motif chemokine 3 precursor [KO:K05408]
749948  C-C motif chemokine 3-like [KO:K05408]
748142  CCL13; C-C motif chemokine 13 [KO:K16595]
454579  CCL7; C-C motif chemokine 7 [KO:K05509]
747004  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
747591  CCL14; C-C motif chemokine 14 [KO:K21092]
455038  CCL16; C-C motif chemokine 16 isoform X3 [KO:K21093]
468209  CCL8; C-C motif chemokine 8 [KO:K16596]
468208  CCL11; eotaxin [KO:K16597]
472418  CCL24; C-C motif chemokine 24 [KO:K21097]
472417  CCL26; C-C motif chemokine 26 [KO:K21096]
735978  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
100610389  CCL27; C-C motif chemokine 27 [KO:K16598]
468224  CCL18; C-C motif chemokine 18 [KO:K21094]
463288  IL6; interleukin-6 isoform X1 [KO:K05405]
736204  IL11; interleukin-11 [KO:K05417]
736338  OSM; oncostatin-M [KO:K05418]
736309  LIF; leukemia inhibitory factor [KO:K05419]
100610090  CNTF; ciliary neurotrophic factor [KO:K05420]
107967131  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
467955  CTF1; cardiotrophin-1 isoform X2 [KO:K05422]
454641  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
449638  LEP; leptin precursor [KO:K05424]
449565  IL4; interleukin-4 isoform 1 precursor [KO:K05430]
449564  IL13; interleukin-13 precursor [KO:K05435]
460816  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
471723  IL12B; interleukin-12 subunit beta [KO:K05425]
467036  IL23A; interleukin-23 subunit alpha [KO:K05426]
471627  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
471626  IL3; interleukin-3 precursor [KO:K04736]
743963  IL5; interleukin-5 [KO:K05428]
461472  IL2; interleukin-2 [KO:K05429]
464245  IL7; interleukin-7 isoform X2 [KO:K05431]
745517  IL9; interleukin-9 [KO:K05432]
737808  IL15; interleukin-15 isoform X3 [KO:K05433]
471295  IL21; interleukin-21 [KO:K05434]
737202  TSLP; thymic stromal lymphopoietin isoform X1 [KO:K05436]
463609  EPO; erythropoietin [KO:K05437]
462468  PRL; prolactin isoform X1 [KO:K05439]
736549  THPO; thrombopoietin isoform X1 [KO:K06854]
740202  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
458844  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
736875  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
741897  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
471358  VEGFC; vascular endothelial growth factor C [KO:K05449]
465508  VEGFD; vascular endothelial growth factor D [KO:K05449]
463503  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
461435  EGF; pro-epidermal growth factor isoform X3 [KO:K04357]
457127  CSF1; macrophage colony-stimulating factor 1 isoform X5 [KO:K05453]
452114  KITLG; kit ligand isoform X4 [KO:K05461]
100610021  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
473185  IFNA21; interferon alpha-21 [KO:K05414]
473193  IFNA14; interferon alpha-14 [KO:K05414]
473196  IFNA6; interferon alpha-6 [KO:K05414]
473198  IFNA2; interferon alpha-2 [KO:K05414]
473199  IFNA8; interferon alpha-8 [KO:K05414]
741660  interferon alpha-4 [KO:K05414]
473195  IFNA5; interferon alpha-5 [KO:K05414]
741747  interferon alpha-7 [KO:K05414]
742651  interferon alpha-1/13 [KO:K05414]
741978  interferon alpha-16 [KO:K05414]
744748  interferon alpha-17 [KO:K05414]
473191  interferon alpha-17 [KO:K05414]
473183  IFNB1; interferon beta [KO:K05415]
473184  IFNW1; interferon omega-1 [KO:K05440]
473120  IFNK; interferon kappa [KO:K05441]
473203  IFNE; interferon epsilon [KO:K05442]
449517  IFNG; interferon gamma precursor [KO:K04687]
469657  IL10; interleukin-10 precursor [KO:K05443]
741423  IL22; interleukin-22 [KO:K05445]
741377  IL26; interleukin-26 [KO:K05446]
473468  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
460852  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
467353  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
100551503  TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
494186  TNF; tumor necrosis factor [KO:K03156]
494185  LTA; lymphotoxin-alpha precursor [KO:K05468]
744486  LTB; lymphotoxin-beta [KO:K03157]
468687  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
469584  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
473802  CD40LG; CD40 ligand [KO:K03161]
100615857  CD70; CD70 antigen [KO:K05470]
464686  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
107969654  TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472]
469586  TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X1 [KO:K05469]
738190  TNFSF18; tumor necrosis factor ligand superfamily member 18 isoform X1 [KO:K05479]
100551504  TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475]
467323  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
101058344  EDA; ectodysplasin-A isoform X1 [KO:K05480]
456060  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
457742  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
453054  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
100608039  AMH; muellerian-inhibiting factor isoform X2 [KO:K04665]
458090  BMP2; bone morphogenetic protein 2 [KO:K21283]
458357  BMP7; bone morphogenetic protein 7 [KO:K16621]
458202  GDF5; growth/differentiation factor 5 [KO:K04664]
470485  IL1A; interleukin-1 alpha [KO:K04383]
450200  IL1B; interleukin-1 beta [KO:K04519]
739011  IL18; interleukin-18 isoform X1 [KO:K05482]
467404  IL25; interleukin-25 [KO:K05493]
472029  IL17A; interleukin-17A [KO:K05489]
472030  IL17F; interleukin-17F [KO:K05494]
468067  IL17C; interleukin-17C [KO:K05491]
741839  IL17B; interleukin-17B isoform X1 [KO:K05490]
467221  IL17D; interleukin-17D isoform X1 [KO:K05492]
470644  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
470645  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
465704  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
450130  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
451595  CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
450138  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
460122  ACKR3; atypical chemokine receptor 3 [KO:K04304]
460321  XCR1; chemokine XC receptor 1 [KO:K04193]
460281  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
470795  CCR8; C-C chemokine receptor type 8 [KO:K04183]
100612069  CCR6; C-C chemokine receptor type 6 [KO:K04181]
470808  CCR9; C-C chemokine receptor type 9 isoform X2 [KO:K04184]
470781  CCR4; C-C chemokine receptor type 4 [KO:K04179]
454654  CCR7; C-C chemokine receptor type 7 isoform X2 [KO:K04182]
740071  CCR2; C-C chemokine receptor type 2 [KO:K04177]
450128  CCR5; C-C chemokine receptor type 5 [KO:K04180]
460323  CCR1; C-C chemokine receptor type 1 [KO:K04176]
470810  CCR3; C-C chemokine receptor type 3 isoform X1 [KO:K04178]
741917  CCR10; C-C chemokine receptor type 10 [KO:K04185]
469506  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
461866  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
100616505  IL11RA; interleukin-11 receptor subunit alpha precursor [KO:K05056]
738797  LIFR; leukemia inhibitory factor receptor isoform X2 [KO:K05058]
461908  OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057]
473218  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
456756  CSF3R; granulocyte colony-stimulating factor receptor isoform X3 [KO:K05061]
456919  LEPR; leptin receptor isoform X1 [KO:K05062]
454005  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
735671  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
455851  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
469348  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
744045  IL23R; interleukin-23 receptor [KO:K05065]
746936  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
458802  CSF2RB; cytokine receptor common subunit beta isoform X7 [KO:K04738]
107972835  uncharacterized LOC107972835 [KO:K04737]
737582  IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067]
450884  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
470203  IL2RB; interleukin-2 receptor subunit beta precursor [KO:K05069]
101059843  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
461922  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
738192  IL15RA; interleukin-15 receptor subunit alpha isoform X7 [KO:K05074]
454006  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
749758  CRLF2; cytokine receptor-like factor 2 isoform X1 [KO:K05078]
455728  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
471560  GHR; growth hormone receptor isoform X2 [KO:K05080]
461925  PRLR; prolactin receptor [KO:K05081]
747522  MPL; thrombopoietin receptor [KO:K05082]
461318  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:]
462188  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:]
452512  FLT1; vascular endothelial growth factor receptor 1 isoform X9 [KO:K05096] [EC:]
461315  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:]
462339  FLT4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:]
463671  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:]
463415  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:]
462187  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:]
461316  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:]
452508  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:]
458516  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
473965  IFNAR2; interferon alpha/beta receptor 2 isoform X4 [KO:K05131]
747276  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
470077  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
451580  IL10RA; interleukin-10 receptor subunit alpha isoform X2 [KO:K05134]
473966  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
463026  IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136]
742595  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
469224  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
472133  IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X3 [KO:K05139]
456628  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
464351  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
468560  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X4 [KO:K05147]
749145  TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160]
107968771  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
462749  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
455206  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
457968  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
466934  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
451778  LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159]
457221  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
746784  RTEL1; regulator of telomere elongation helicase 1 isoform X7 [KO:K05143]
738331  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100615583  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
451780  CD27; CD27 antigen isoform X1 [KO:K05144]
457960  TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145]
746029  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
457185  TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142]
741567  TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X3 [KO:K05154]
467905  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
744388  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150]
104003794  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
735810  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X2 [KO:K05162]
473648  EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163]
452480  TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X2 [KO:K05155]
466703  RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
460243  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:]
472992  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:]
459646  ACVR2A; activin receptor type-2A isoform X3 [KO:K04670] [EC:]
460271  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:]
470565  ACVR1; activin receptor type-1 [KO:K04675] [EC:]
451911  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:]
467005  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:]
459885  BMPR2; LOW QUALITY PROTEIN: bone morphogenetic protein receptor type-2 [KO:K04671] [EC:]
450572  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:]
461683  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:]
459460  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
460935  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
470455  IL1R2; interleukin-1 receptor type 2 isoform X5 [KO:K04387]
459463  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
744277  IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174]
458629  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
460451  IL17RB; interleukin-17 receptor B isoform X1 [KO:K05165]
460159  IL17RC; interleukin-17 receptor C isoform X2 [KO:K05166]
460158  IL17RE; interleukin-17 receptor E isoform X1 [KO:K05168]
Oppenheim JJ, Feldman M (ed).
Cytokine Reference
Academic Press (2001)
Thomson AW, Lotze MT (ed).
The Cytokine Handbook (Fourth edition)
Academic Press (2003)
Zlotnik A, Yoshie O.
Chemokines: a new classification system and their role in immunity.
Immunity 12:121-7 (2000)
Ozaki K, Leonard WJ.
Cytokine and cytokine receptor pleiotropy and redundancy.
J Biol Chem 277:29355-8 (2002)
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW.
Signaling through the JAK/STAT pathway, recent advances and future challenges.
Gene 285:1-24 (2002)
Li X, Eriksson U.
Novel PDGF family members: PDGF-C and PDGF-D.
Cytokine Growth Factor Rev 14:91-8 (2003)
Li X, Eriksson U.
Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D.
Int J Biochem Cell Biol 33:421-6 (2001)
Zachary I, Gliki G.
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.
Cardiovasc Res 49:568-81 (2001)
Dey A, She H, Kim L, Boruch A, Guris DL, Carlberg K, Sebti SM, Woodley DT, Imamoto A, Li W.
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.
Mol Biol Cell 11:3835-48 (2000)
Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB.
Interleukin-10 and related cytokines and receptors.
Annu Rev Immunol 22:929-79 (2004)
Bodmer JL, Schneider P, Tschopp J.
The molecular architecture of the TNF superfamily.
Trends Biochem Sci 27:19-26 (2002)
Derynck R, Feng XH.
TGF-beta receptor signaling.
Biochim Biophys Acta 1333:F105-50 (1997)
Liu F, Ventura F, Doody J, Massague J.
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
Mol Cell Biol 15:3479-86 (1995)
Massague J.
TGF-beta signal transduction.
Annu Rev Biochem 67:753-91 (1998)
Massague J.
How cells read TGF-beta signals.
Nat Rev Mol Cell Biol 1:169-78 (2000)
Moseley TA, Haudenschild DR, Rose L, Reddi AH.
Interleukin-17 family and IL-17 receptors.
Cytokine Growth Factor Rev 14:155-74 (2003)
Martin MU, Wesche H.
Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family.
Biochim Biophys Acta 1592:265-80 (2002)
Lang D, Knop J, Wesche H, Raffetseder U, Kurrle R, Boraschi D, Martin MU.
The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.
J Immunol 161:6871-7 (1998)
KO pathway

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